Entry |
|
Name |
L-histidine Nalpha-methyltransferase;
dimethylhistidine N-methyltransferase;
dimethylhistidine methyltransferase;
histidine-alpha-N-methyltransferase;
S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase;
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase
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Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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Sysname |
S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase (hercynine-forming)
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Reaction(IUBMB) |
3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction) [RN: R01169];
(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine [RN: R10523];
(1b) S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine [RN: R10524];
(1c) S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine [RN: R04436]
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Reaction(KEGG) |
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Substrate |
S-adenosyl-L-methionine [CPD: C00019];
L-histidine [CPD: C00135];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD: C04259]
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Product |
S-adenosyl-L-homocysteine [CPD: C00021];
hercynine [CPD: C05575];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD: C04259]
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Comment |
Part of the biosynthetic pathway of ergothioneine.
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History |
EC 2.1.1.44 created 1976, modified 2013
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Pathway |
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Orthology |
K18911 | L-histidine Nalpha-methyltransferase |
K20246 | L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase |
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Genes |
NTE: | NEUTE1DRAFT145472(NEUTE1DRAFT_145472) |
FGR: | FGSG_03421 FGSG_11987 FGSG_12773 |
FPU: | FPSE_06241 FPSE_08378 FPSE_11477 |
NHE: | NECHADRAFT_70968 NECHADRAFT_97208 |
AOR: | AO090012000265 AO090023000415 |
ANG: | ANI_1_792134(An15g05880) |
AFV: | AFLA_001980 AFLA_006763 |
ACHE: | ACHE_10907A ACHE_60451S |
PNO: | SNOG_13930(SNOG_13929) |
ABP: | AGABI1DRAFT120644(AGABI1DRAFT_120644) |
ABV: | AGABI2DRAFT186400(AGABI2DRAFT_186400) |
SCM: | SCHCO_02619710(SCHCODRAFT_02619710) |
CPUT: | CONPUDRAFT_77468 CONPUDRAFT_85801 |
XPH: | XppCFBP6546_11000(egtD) |
XVA: | C7V42_00720(egtD) C7V42_00735(egtD) |
LLG: | 44548918_01364(egtD) |
LSS: | NCTC12082_00682(egtD) |
THIS: | HZT40_03135 HZT40_04295 |
REH: | H16_A2701(h16_A2701) |
LIH: | L63ED372_02888(egtD) |
RBT: | NOVO_04395 NOVO_05715 |
MMES: | MMSR116_19855(egtD) |
SPHU: | SPPYR_1207(egtD) SPPYR_3476 |
SFLA: | SPHFLASMR4Y_01850(egtD) |
MBAI: | MB901379_04622(egtD) |
MHEK: | JMUB5695_00322(egtD) |
MPHL: | MPHLCCUG_00354(egtD) |
MTHN: | 4412656_04306(egtD) |
MAUU: | NCTC10437_05228(egtD) |
MFLV: | NCTC10271_00327(egtD) |
MSAL: | DSM43276_00322(egtD) |
MTER: | 4434518_03928(egtD) |
NFR: | ERS450000_05025(egtD) |
NSL: | BOX37_13640 BOX37_27025 |
NTP: | CRH09_33200(egtD) CRH09_34695(egtD) |
NAD: | NCTC11293_06258(egtD) |
NWL: | NWFMUON74_10250(egtD) |
RCR: | NCTC10994_01623(egtD) |
TPUL: | TPB0596_00170(egtD) |
SLC: | SL103_16955 SL103_23145 |
SAMB: | SAM23877_6627(egtD) |
SLE: | sle_06860(sle_06860) |
SGM: | GCM10017557_08730(egtD) |
SALL: | SAZ_01310 SAZ_35720 |
SALJ: | SMD11_0418 SMD11_0807 SMD11_5689 |
SRK: | FGW37_04875 FGW37_27930(egtD) FGW37_32380 |
STUI: | GCM10017668_06280(egtD) |
SGOB: | test1122_11450(egtD) |
SAKB: | K1J60_03885(egtD) K1J60_05755(egtD) |
NAQU: | ENKNEFLB_01971(egtD) |
AGRA: | AGRA3207_006138(egtD) |
FRI: | FraEuI1c_6654 FraEuI1c_7155 |
PSEA: | WY02_03165 WY02_08125 |
PAUT: | Pdca_32250 Pdca_32260 |
SACE: | GIY23_01060 GIY23_10335(egtD) |
MSAG: | GCM10017556_54360(egtD) |
ACTN: | L083_5287 L083_7398 |
ACTR: | Asp14428_55950(egtD) |
PLAB: | C6361_00300 C6361_04525(egtD) |
PLAT: | C6W10_01050(egtD) C6W10_21350 |
GLY: | K3N28_07610(egtD) K3N28_10175(egtD) |
SBAE: | DSM104329_01348(egtD) |
CMP: | Cha6605_0924 Cha6605_6115 |
LBO: | LBWT_13420 LBWT_55940 |
NED: | HUN01_13950(egtD) HUN01_34300(egtD) |
PFER: | IRI77_13455(egtD) IRI77_22240(egtD) |
ECHI: | FKX85_05685 FKX85_14085(egtD) |
PKO: | PKOR_03290 PKOR_17700 |
GRS: | C7S20_07230(egtD) C7S20_09335(egtD) |
SPON: | HME9304_02218(egtD) |
AALG: | AREALGSMS7_03795(egtD) |
CGLE: | NCTC11432_01867(egtD) |
CJG: | NCTC13459_02067(egtD) |
CANT: | NCTC13489_02180(egtD) |
» show all
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Reference |
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Authors |
Ishikawa Y, Melville DB. |
Title |
The enzymatic alpha-N-methylation of histidine. |
Journal |
|
Reference |
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Authors |
Seebeck FP |
Title |
In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.1.1.44 |
ExPASy - ENZYME nomenclature database: | 2.1.1.44 |
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