KEGG ENZYME: 2.1.1.44

ENZYME: 2.1.1.44

Entry

EC 2.1.1.44                 Enzyme

Name

L-histidine Nalpha-methyltransferase;
dimethylhistidine N-methyltransferase;
dimethylhistidine methyltransferase;
histidine-alpha-N-methyltransferase;
S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase;
S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine Nalpha-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:L-histidine Nalpha-methyltransferase (hercynine-forming)

Reaction(IUBMB)

3 S-adenosyl-L-methionine + L-histidine = 3 S-adenosyl-L-homocysteine + hercynine (overall reaction) [RN:R01169];
(1a) S-adenosyl-L-methionine + L-histidine = S-adenosyl-L-homocysteine + Nalpha-methyl-L-histidine [RN:R10523];
(1b) S-adenosyl-L-methionine + Nalpha-methyl-L-histidine = S-adenosyl-L-homocysteine + Nalpha,Nalpha-dimethyl-L-histidine [RN:R10524];
(1c) S-adenosyl-L-methionine + Nalpha,Nalpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + hercynine [RN:R04436]

Reaction(KEGG)

R01169 R04436 R10523 R10524

Substrate

S-adenosyl-L-methionine [CPD:C00019];
L-histidine [CPD:C00135];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
hercynine [CPD:C05575];
Nalpha-methyl-L-histidine;
Nalpha,Nalpha-dimethyl-L-histidine [CPD:C04259]

Comment

Part of the biosynthetic pathway of ergothioneine.

History

EC 2.1.1.44 created 1976, modified 2013

Pathway

ec00340

Histidine metabolism

ec01100

Metabolic pathways

Orthology

K18911

L-histidine Nalpha-methyltransferase

K20246

L-histidine Nalpha-methyltransferase / hercynylcysteine S-oxide synthase

Genes

QSU:

111995461

NCR:	NCU04343(egt-1)

NTE:	NEUTE1DRAFT145472(NEUTE1DRAFT_145472)

SMP:	SMAC_01803

MTM:	MYCTH_2074210

CTHR:

CTHT_0030600

MGR:	MGG_00020 MGG_13219

PPEI:

PpBr36_02899

TMN:	UCRPA7_3011

SSCK:

SPSK_08945

FGR:	FGSG_03421 FGSG_11987 FGSG_12773

FPU:	FPSE_06241 FPSE_08378 FPSE_11477

FVR:	FVEG_15947

FOX:	FOXG_20012

NHE:	NECHADRAFT_70968 NECHADRAFT_97208

TRE:	TRIREDRAFT_81410

TRR:	M419DRAFT_103267

MAW:

MAC_09617

MAJ:

MAA_04856

CMT:

CCM_07351

PLJ:	VFPFJ_01447

VDA:	VDAG_10242

CFJ:	CFIO01_13296

CLUP:

CLUP02_15291

CHIG:

CH63R_04852

SAPO:

SAPIO_CDS7015

PFY:	PFICI_05616

BFU:	BCIN_12g04180

MBE:

MBM_01989

PSCO:

LY89DRAFT_586353

GLZ:	GLAREA_08265

ANI:

AN7620.2

AFM:	AFUA_2G15650

ACT:	ACLA_074540

NFI:	NFIA_090880

AOR:	AO090012000265 AO090023000415

ANG:	ANI_1_792134(An15g05880)

AFV:	AFLA_001980 AFLA_006763

ALUC:

AKAW2_60182A

ACHE:

ACHE_10907A ACHE_60451S

APUU:

APUU_80300A

PDP:	PDIP_81160

TMF:	PMAA_036630

TRG:	TRUGW13939_05155

CIM:	CIMG_00276

CPW:	CPC735_059060

URE:	UREG_00352

PBL:	PAAG_03909

PBN:	PADG_11594

ABE:

ARB_02453

TVE:

TRV_08045

AJE:	HCAG_01026

BGH:	BDBG_06484

PNO:	SNOG_13930(SNOG_13929)

PTE:

PTT_06791

BZE:	COCCADRAFT_109454

BSC:	COCSADRAFT_32544

BOR:	COCMIDRAFT_95519

AALT:

CC77DRAFT_949140

ZTR:	MYCGRDRAFT_75935

PFJ:	MYCFIDRAFT_56905

FFU:	CLAFUR5_11164

BCOM:

BAUCODRAFT_116776

NPA:	UCRNP2_8392

SPO:	SPBC1604.01(mug158)

CNE:

CNJ01670

CNB:

CNBJ1790

CNG:	CNAG_04737

CGI:	CGB_I2320W

TMS:	TREMEDRAFT_42626

TASA:

A1Q1_06211

TVS:	TRAVEDRAFT_64341

DSQ:	DICSQDRAFT_55495

PCO:	PHACADRAFT_212229

SHS:	STEHIDRAFT_66030

HIR:	HETIRDRAFT_156207

PSQ:	PUNSTDRAFT_131244

ADL:	AURDEDRAFT_115403

FME:	FOMMEDRAFT_78835

GTR:	GLOTRDRAFT_139012

LBC:	LACBIDRAFT_188236

CCI:	CC1G_02949

ABP:	AGABI1DRAFT120644(AGABI1DRAFT_120644)

ABV:	AGABI2DRAFT186400(AGABI2DRAFT_186400)

PCUB:

JR316_0007212

MRR:	Moror_1006

E1B28_012164

SCM:	SCHCO_02619710(SCHCODRAFT_02619710)

CPUT:

CONPUDRAFT_77468 CONPUDRAFT_85801

SLA:	SERLADRAFT_470869

WSE:	WALSEDRAFT_60925

WIC:	J056_001286

PGR:	PGTG_04084

MLR:	MELLADRAFT_110519

XCT:	J151_00302

XCJ:	J158_00300

XCU:	J159_00300

XCN:	J169_00298

XCW:	J162_00299

XCR:	J163_00299

XCM:	J164_00299

XCF:	J172_00293

XOY:	AZ54_01380

XOZ:	BE73_23120

XFR:	BER92_18705

XVE:	BJD12_13500

XPE:	BJD13_16140

XHR:	XJ27_16615

XGA:	BI317_23860

XPH:	XppCFBP6546_11000(egtD)

XVA:	C7V42_00720(egtD) C7V42_00735(egtD)

XAN:	AC801_00745

XAR:	XB05_17615

LUM:	CNR27_02125(egtD)

LUS:	E5843_00855(egtD)

LUG:	FPZ22_03180(egtD)

PFW:	PF1751_v1c25760

PFF:	PFLUOLIPICF724150

SWD:

Swoo_2444

PLZ:	S4054249_09460

TTU:	TERTU_3974

LLG:	44548918_01364(egtD)

LSS:	NCTC12082_00682(egtD)

MMOB:

F6R98_12630

MEJ:	Q7A_3010(egtD)

PSAL:

PSLF89_1164

THIS:

HZT40_03135 HZT40_04295

TGR:

Tgr7_2473

TKM:

TK90_0941

TVR:

TVD_07835

APRS:

BI364_03780

ABO:

ABO_0654

ALN:	AS19_06710

ADI:

B5T_03346

AXE:

P40_15710

ACII:

C4901_08395(egtD)

ATY:	A9R16_009445(egtD)

SALN:

SALB1_3448

RSL:	RPSI07_2433

RSE:

F504_929

RPF:	Rpic12D_0892

RPJ:	N234_15270

RPU:	CDC45_04875(egtD)

REH:	H16_A2701(h16_A2701)

CNC:	CNE_1c25990

CUH:	BJN34_14555

REU:	Reut_A0917

RME:

Rmet_2566

CTI:	RALTA_A2191

CBW:	RR42_m2994

CGD:

CR3_1928

CCUP:

BKK81_15190

CUP:	BKK80_16140

CUU:	BKK79_16810

CPAU:

EHF44_10300(egtD)

COX:	E0W60_22780(egtD)

CCAM:

M5D45_11930(egtD)

CCAX:

KZ686_14395(egtD)

BTHA:

DR62_4162

BTHL:

BG87_4458(egtD)

BVE:	AK36_732(egtD)

BCEO:

I35_3269

BMUL:

NP80_157(egtD)

BCEP:

APZ15_04060

BPYR:

ABD05_06170

BCON:

NL30_19380

BDF:	WI26_00140

BLAT:

WK25_02555

BTEI:

WS51_10965

BSEM:

WJ12_00170

BPSL:

WS57_13120

BMEC:

WJ16_00135

BSTG:

WT74_00250

BSTL:

BBJ41_09710

BGU:	KS03_4158(egtD)

BGO:	BM43_5978(egtD)

BUE:	BRPE67_BCDS00910

BUQ:	AC233_26305

BGP:	BGL_2c23700

BPLA:

bpln_2g24000

BUD:	AQ610_27135

BUZ:	AYM40_35415

BFN:	OI25_5492(egtD)

BCAI:

K788_0000696

PSPW:

BJG93_21620(egtD)

PARA:

BTO02_22315

PARB:

CJU94_28475(egtD)

PHS:	C2L64_18440(egtD)

PTER:

C2L65_16275(egtD)

PGP:	CUJ91_29930(egtD)

PCJ:	CUJ87_28135(egtD)

PTS:	CUJ90_23585(egtD)

PMEG:

FNZ07_04790(egtD)

PTRO:

G5S35_20685(egtD)

PGIS:

I6I06_27965(egtD)

PACP:

FAZ97_23670(egtD)

PACS:

FAZ98_19070(egtD)

AJS:

Ajs_2288

ACRA:

BSY15_3490(egtD)

DAC:

Daci_4835

DEL:	DelCs14_2019

DTS:	BI380_31530

DHK:	BO996_22075

ADN:	Alide_2608

ADK:	Alide2_2925

LIH:	L63ED372_02888(egtD)

HYR:	BSY239_2998(egtD)

HYB:

Q5W_16970

HTN:	KI616_07160(egtD)

HCZ:	G9Q37_12970(egtD)

DPY:	BA022_06180

DIH:	G7047_22070(egtD)

DIA:	Dtpsy_1586

MELA:

C6568_01560(egtD)

MJE:	LVC68_10285(egtD)

UND:	UNDKW_5371

LCH:

Lcho_1724

NIZ:	NNRS527_02106

SPLB:

SFPGR_16830

TAK:	Tharo_2010

ATW:	C0099_07925

GEM:

GM21_2631

GEO:

Geob_1692

GBM:

Gbem_1582

GBN:	GEOBRER4_25530

MXA:

MXAN_7473

MSD:	MYSTI_08113

MYM:	A176_007054

MFB:	MFUL124B02_43145

CCX:	COCOR_08068

MFU:	LILAB_08960

MMAS:

MYMAC_007189

SUR:	STAUR_8338

AGE:	AA314_00409

AVM:	JQX13_14735(egtD)

MBD:	MEBOL_003284

CFUS:

CYFUS_009890

VIN:	AKJ08_3635

CCRO:

CMC5_025140

MRM:	A7982_07704

BSED:

DN745_18535(egtD)

RBT:	NOVO_04395 NOVO_05715

MESM:

EJ066_13070

BJP:	RN69_41265

STAR:

G3545_14755(egtD)

MPHY:

MCBMB27_00380

METX:

A3862_26640

MMES:

MMSR116_19855(egtD)

CMB:	CSW64_04980(egtD)

NRE:	BES08_23380

NOV:	TQ38_002330(egtD)

NOG:	GKE62_07105(egtD)

SPHK:

SKP52_19325

SPHP:

LH20_18580

SMAG:

AN936_19175

SMAZ:

LH19_23055

STER:

AOA14_09935

SGI:	SGRAN_4049(egtD)

SPHQ:

BWQ93_14620

SPHO:

C3E99_16660(egtD)

SPHX:

E5675_00900(egtD)

SPHU:

SPPYR_1207(egtD) SPPYR_3476

SPHD:

HY78_22775

SPHI:

TS85_16705

SSAN:

NX02_16490

SNJ:	A7E77_06940

SMY:	BJP26_02510

SPAN:

AWL63_03915

SPLM:

BXU08_15120

SPLK:

AV944_01330

SPHC:

CVN68_15810(egtD)

SPHF:

DM480_05990(egtD)

SPAU:

DRN02_014595(egtD)

SRHI:

H9L12_11100(egtD)

SPAP:

H3Z74_19915(egtD)

SXA:	FMM02_05405(egtD)

SPAI:

FPZ24_01285(egtD)

SARI:

H5J25_18495(egtD)

SAER:

NEF64_00085(egtD)

SINB:

SIDU_15825

SYB:	TZ53_01600

SBD:	ATN00_09735

SPMI:

K663_03035

SPHB:

EP837_01893(egtD)

SPHT:

K426_19995

SYA:	A6768_25175(egtD)

SPYG:

YGS_C1P2050

SUFL:

FIL70_13120(egtD)

SAMI:

SAMIE_1000900

CIJ:	WG74_14665

SPHG:

AZE99_02630

SFLA:

SPHFLASMR4Y_01850(egtD)

SPHY:

CHN51_02940(egtD)

BLAS:

BSY18_3729(egtD)

BFW:	B5J99_08985

SPHJ:

BSL82_14530

SPZR:

G5C33_18965(egtD)

PALG:

HFP57_11255(egtD)

PARJ:

J4G78_14170(egtD)

AEP:	AMC99_01598

ALB:

AEB_P1475

ALH:	G6N82_13730(egtD)

AAY:	WYH_01210(egtD)

AMX:	AM2010_463

ANH:	A6F65_01268(egtD)

ADO:	A6F68_01856(egtD)

CNA:	AB433_11925

CMAN:

A9D14_10260

ERY:	CP97_06905

EGN:	BMF35_a1447

EFV:	CHH26_05895(egtD)

ELQ:	Ga0102493_112097

ERK:	CD351_12280(egtD)

ERR:	DVR09_12255(egtD)

ERF:	FIU90_12290(egtD)

EMV:	HQR01_02070(egtD)

PNS:	A9D12_00190

PORL:

BG023_112356

POT:	E2E27_09150(egtD)

ACIM:

GT370_10905(egtD)

HAX:	BALOs_0888

MTU:	Rv3701c(egtD)

MTV:	RVBD_3701c

MTC:

MT3804

MRA:

MRA_3737

MTF:	TBFG_13732

MTB:	TBMG_03744

MTK:	TBSG_03768

MTZ:	TBXG_003715

MTG:	MRGA327_22795

MTI:	MRGA423_23340

MTE:	CCDC5079_3432

MTUR:

CFBS_3922

MTL:	CCDC5180_3383

MTO:	MTCTRI2_3771

MTD:

UDA_3701c

MTN:	ERDMAN_4054

MTJ:	J112_19890

MTUB:

MT7199_3766

MTUE:

J114_19770

MTX:	M943_19015

MTUL:

TBHG_03636

MTUT:

HKBT1_3906

MTUU:

HKBT2_3916

MTQ:	HKBS1_3919

MBO:	BQ2027_MB3727C

MBB:

BCG_3760c

MBT:

JTY_3762

MBM:	BCGMEX_3761c

MBK:	K60_038400

MBX:

BCGT_3563

MAF:

MAF_37090

MMIC:

RN08_4081

MCE:	MCAN_37221

MCQ:	BN44_120099

MCV:	BN43_90208

MCX:	BN42_90217

MCZ:	BN45_110057

MPA:

MAP_0303c

MAO:

MAP4_3568

MAVI:

RC58_17730

MAVU:

RE97_17760

MAV:

MAV_0402

MIT:

OCO_03550

MIA:

OCU_03620

MID:

MIP_00739

MYO:

OEM_03670

MCHI:

AN480_01810

MIR:

OCQ_03570

MMAL:

CKJ54_01715(egtD)

MMAN:

MMAN_46310(egtD)

MSA:	Mycsm_06027

MUL:

MUL_4285

MMI:

MMAR_5212

MMAE:

MMARE11_50350

MLI:	MULP_05489

MPSE:

MPSD_02570(egtD)

MSHO:

MSHO_10450(egtD)

MMC:

Mmcs_4879

MKM:

Mkms_4968

MJL:

Mjls_5247

MMM:

W7S_01745

MKN:	MKAN_13320

MYV:	G155_27720

MYE:	AB431_27325

MGO:	AFA91_03445

MHAD:

B586_03755

MDX:	BTO20_03110

MSHG:

MSG_04705(egtD)

MFJ:	MFLOJ_39080(egtD)

MSTO:

MSTO_42940(egtD)

MSIM:

MSIM_27490(egtD)

MSAK:

MSAS_31070(egtD)

MKU:	I2456_26520(egtD)

MGRO:

FZ046_03785(egtD)

MXE:	MYXE_03650(egtD)

MNV:	MNVI_14030(egtD)

MPAG:

C0J29_28780(egtD)

MNM:	MNVM_22180(egtD)

MGOR:

H0P51_26675(egtD)

MCOO:

MCOO_28640(egtD)

MBAI:

MB901379_04622(egtD)

MSEO:

MSEO_36210(egtD)

MHEK:

JMUB5695_00322(egtD)

MGAU:

MGALJ_40180(egtD)

MLJ:	MLAC_45740(egtD)

MBRD:

MBRA_18310(egtD)

MSHJ:

MSHI_37090(egtD)

MKR:	MKOR_31800(egtD)

MDF:	K0O62_26740(egtD)

MMAM:

K3U93_23410(egtD)

MHOL:

K3U96_02225(egtD)

MHER:

K3U94_21785(egtD)

MSEN:

K3U95_26770(egtD)

MPAE:

K0O64_26850(egtD)

MSPG:

F6B93_21305(egtD)

MOT:	LTS72_26800(egtD)

MVM:	MJO54_21640(egtD)

MRF:	MJO55_25020(egtD)

MPAA:

MKK62_01140(egtD)

MCRO:

MI149_27185(egtD)

MSM:	MSMEG_6247

MSG:	MSMEI_6086

MSB:	LJ00_30890

MSN:	LI99_30895

MSH:	LI98_30900

MVA:

Mvan_5483

MGI:

Mflv_1318

MSP:	Mspyr1_48610

MCB:	Mycch_4828

MNE:	D174_25555

MYN:	MyAD_25095

MFT:	XA26_56020

MPHL:

MPHLCCUG_00354(egtD)

MVQ:

MYVA_5373

MLL:	B1R94_26505

MRH:	MycrhN_2101

MTHN:

4412656_04306(egtD)

MHAS:

MHAS_03906(egtD)

MDU:	MDUV_47520(egtD)

MCHT:

MCHIJ_17980(egtD)

MDR:	MDOR_34080(egtD)

MAUU:

NCTC10437_05228(egtD)

MMAG:

MMAD_50010(egtD)

MMOR:

MMOR_09310(egtD)

MFX:	MFAL_07420(egtD)

MAIC:

MAIC_03600(egtD)

MIJ:	MINS_21350(egtD)

MALV:

MALV_39950(egtD)

MTY:	MTOK_19920(egtD)

MPSC:

MPSYJ_14330(egtD)

MARZ:

MARA_45920(egtD)

MGAD:

MGAD_39070(egtD)

MHEV:

MHEL_26110(egtD)

MSAR:

MSAR_12290(egtD)

MANY:

MANY_34890(egtD)

MAUB:

MAUB_28590(egtD)

MPOF:

MPOR_01120(egtD)

MPHU:

MPHO_41590(egtD)

MMUC:

C1S78_026760(egtD)

MMAT:

MMAGJ_31210(egtD)

MBOK:

MBOE_07330(egtD)

MFG:	K6L26_04015(egtD)

MSEI:

MSEDJ_04750(egtD)

MFLV:

NCTC10271_00327(egtD)

MCEE:

MCEL_35690(egtD)

MMON:

EWR22_26360(egtD)

MAB:

MAB_0372

MMV:	MYCMA_0196

MABB:

MASS_0368

MABL:

MMASJCM_0364

MCHE:

BB28_01815

MIZ:	BAB75_02380

MSTE:

MSTE_00331(egtD)

MSAO:

MYCSP_01630

MSAL:

DSM43276_00322(egtD)

MJD:	JDM601_3981

MTER:

4434518_03928(egtD)

MMIN:

MMIN_14010(egtD)

MHIB:

MHIB_32410(egtD)

ASD:

AS9A_2107

MPAK:

MIU77_00525(egtD)

CORY:

FQV43_01340

NFA:

NFA_48840

NFR:	ERS450000_05025(egtD)

NCY:	NOCYR_4670

NBR:	O3I_036990

NNO:	NONO_c66340(egtD)

NSL:	BOX37_13640 BOX37_27025

NSR:	NS506_01661(egtD)

NTP:	CRH09_33200(egtD) CRH09_34695(egtD)

NOZ:	DMB37_15930(egtD)

NOD:	FOH10_01820(egtD)

NAH:	F5544_39490(egtD)

NAD:	NCTC11293_06258(egtD)

NWL:	NWFMUON74_10250(egtD)

NIE:	KV110_36240(egtD)

NTC:	KHQ06_11080(egtD)

NHU:	H0264_10245(egtD)

NYA:	LTV02_22535(egtD)

NGP:	LTT66_17710(egtD)

RHA:	RHA1_ro05703

RER:

RER_43170

REY:

O5Y_20230

REB:	XU06_20400

RQI:	C1M55_21745(egtD)

ROP:

ROP_57720

ROA:	Pd630_LPD02318

RPY:	Y013_21565

RBY:	CEJ39_08085(egtD)

RHB:

NY08_2330

RAV:	AAT18_07305

RFA:	A3L23_00519(egtD)

RHS:	A3Q41_02834(egtD)

RHW:	BFN03_01865

RRZ:	CS378_22375(egtD)

RHU:	A3Q40_02531(egtD)

RHQ:	IM25_11355

RHOD:

AOT96_01790

RRT:	4535765_01117(egtD)

RCR:	NCTC10994_01623(egtD)

RTM:	G4H71_04775(egtD)

RKO:	JWS14_31235(egtD)

RGO:	KYT97_28820(egtD)

ROZ:	CBI38_22555

RPSK:

JWS13_13060(egtD)

RGOR:

NMQ04_04980(egtD)

REQ:

REQ_12490

GTA:	BCM27_03245

GRU:	GCWB2_02880(egtD)

GOM:	D7316_02909(egtD)

GAV:	C5O27_02155(egtD)

GOD:	GKZ92_02680(egtD)

GJI:	H1R19_02530(egtD)

GOI:	LK459_06365(egtD)

GHN:	MVF96_03025(egtD)

GAMI:

IHQ52_01895(egtD)

GMG:	NWF22_13205(egtD)

SPIN:

KV203_14460(egtD)

TPUL:

TPB0596_00170(egtD)

SRT:

Srot_1375

DIT:	C3V38_03550

DIZ:	CT688_14125(egtD)

DPC:	A6048_14775

DLU:	A6035_14115

DKN:	NHB83_14345(egtD)

TOY:	FO059_06635(egtD)

SCO:	SCO0913(SCM1.46)

SALB:

XNR_5669

SMA:	SAVERM_7338(egtD)

SGR:

SGR_698

SGB:

WQO_31700

SCB:	SCAB_11241

SSX:	SACTE_6222

SVL:	Strvi_4089

SHY:

SHJG_7892

SHO:	SHJGH_7654

SRC:	M271_04975

SMAL:

SMALA_7430

SSOI:

I1A49_40910(egtD)

SFA:

Sfla_0407

SBH:	SBI_01721 SBI_04408

SVE:

SVEN_6867

SDV:	BN159_1332

SALS:

SLNWT_7175

STRP:

F750_6592

SFI:

SFUL_6743

SCI:	B446_32005

SLV:	SLIV_33365(egtD)

SGU:	SGLAU_29355(egtD)

SVT:	SVTN_34045

STRE:

GZL_01890

SCW:	TU94_30465

SLD:

T261_1097

SLC:	SL103_16955 SL103_23145

SXI:	SXIM_40600

STRM:

M444_29575

SAMB:

SAM23877_6627(egtD)

SPRI:

SPRI_0731

SCZ:	ABE83_02240

SCX:	AS200_07595

SRW:	TUE45_00191(egtD)

STRF:

ASR50_31985

SLE:	sle_06860(sle_06860)

SRN:	A4G23_05242(egtD)

SPAV:

Spa2297_29065

STRT:

A8713_28665

SCLF:

BB341_01715

SGS:	AVL59_16350

STSI:

A4E84_35860

SKY:	D0C37_30425(egtD)

SALW:

CP975_32100(egtD)

SGM:	GCM10017557_08730(egtD)

SCAD:

DN051_06580(egtD)

SPHW:

NFX46_13770(egtD)

SLS:	SLINC_7405

SNR:	SNOUR_08415(egtD)

SALU:

DC74_173 DC74_6876

SALL:

SAZ_01310 SAZ_35720

SPLU:

LK06_001550

STRD:

NI25_03155

SNW:	BBN63_03445

SAUO:

BV401_40770

SSIA:

A7J05_03980

SVU:	B1H20_32545

SPUN:

BFF78_04725

SGV:	B1H19_34870

SLAU:

SLA_6648

SALF:

SMD44_07734

SALJ:

SMD11_0418 SMD11_0807 SMD11_5689

SLX:	SLAV_06120(egtD)

STRO:

STRMOE7_32360

SFK:

KY5_7465c

SNZ:	DC008_30815(egtD)

SGE:	DWG14_01147(egtD)

SRJ:

SRO_0888

SLK:	SLUN_35075(egtD)

SDX:	C4B68_03760(egtD)

SGD:	ELQ87_04140(egtD)

SQZ:	FQU76_31345(egtD)

SCYA:

EJ357_04515(egtD)

SAST:

CD934_31540(egtD)

SNQ:	CP978_05165(egtD)

STIR:

DDW44_28475(egtD)

SKA:	CP970_02865(egtD)

SGZ:	C0216_12610(egtD)

SVN:	CP980_05110(egtD)

SNK:	CP967_00615(egtD)

SHAW:

CEB94_36715(egtD)

SRK:	FGW37_04875 FGW37_27930(egtD) FGW37_32380

SFIC:

EIZ62_03285(egtD)

SGAL:

CP966_32080(egtD)

SSPO:

DDQ41_29455(egtD)

SVR:	CP971_05385(egtD)

SPAD:

DVK44_31770(egtD)

SFY:	GFH48_07305(egtD)

SAQU:

EJC51_40705(egtD)

SGF:	HEP81_00867(egtD)

SCAV:

CVT27_31290(egtD)

SSEO:

D0Z67_26295(egtD)

SBY:	H7H31_32630(egtD)

SRIM:

CP984_04955(egtD)

SSUB:

CP968_05400(egtD)

SPHV:

F9278_42705(egtD)

SCIN:

CP977_30670(egtD)

SFUG:

CNQ36_03160(egtD)

SPAC:

B1H29_03980

STSU:

B7R87_31255

SCHA:

CP983_04580(egtD)

SGX:	H4W23_35695(egtD)

SCOE:

CP976_38155(egtD)

SBAT:

G4Z16_03275(egtD)

SSPB:

CP982_35760(egtD)

SNF:	JYK04_07182(egtD)

SPLA:

CP981_32920(egtD)

SBRO:

GQF42_38855(egtD)

STUI:

GCM10017668_06280(egtD)

SATA:

C5746_37015(egtD)

SCHF:

IPT68_32685(egtD)

SHUN:

DWB77_01279(egtD)

SHAR:

HUT13_20305

SCYG:

S1361_34720(egtD)

SFEU:

IM697_19420(egtD)

SLIA:

HA039_02865(egtD)

SDW:	K7C20_31590(egtD)

SCAL:

I6J39_32345(egtD)

SAUH:

SU9_029815(egtD)

SFB:	CP974_27935(egtD)

SMOB:

J7W19_29430(egtD)

SPRA:

CP972_32040(egtD)

SPEU:

CGZ69_32680(egtD)

SROI:

IAG44_35305(egtD)

SXN:	IAG42_04110(egtD)

SGJ:	IAG43_01385(egtD)

SHK:	J2N69_33970(egtD)

SANU:

K7396_05830(egtD)

STRY:

EQG64_32490(egtD)

SDD:	D9753_03475(egtD)

SACT:

DMT42_33780(egtD)

SMAO:

CAG99_16355

SGOB:

test1122_11450(egtD)

SINE:

KI385_37410(egtD)

SLF:	JEQ17_07335(egtD)

SDEC:

L3078_39935(egtD)

SAOV:

G3H79_03210(egtD)

SDUR:

M4V62_05430(egtD)

SYAN:

NRK68_30035(egtD)

SRUG:

F0345_02150(egtD)

SAKB:

K1J60_03885(egtD) K1J60_05755(egtD)

STAA:

LDH80_06200(egtD)

SCT:

SCAT_4662

SCY:	SCATT_46540

KSK:

KSE_64540

KAB:	B7C62_33770

KAU:	B6264_00790

KIT:	CFP65_6446

KIS:	HUT16_30585(egtD)

STRI:

C7M71_003900(egtD)

YIA:	LO772_26255(egtD)

STRH:

GXP74_23635(egtD)

ABRY:

NYE86_31875(egtD)

ARTP:

E5206_18075(egtD)

LMOI:

VV02_12415

JTE:	ASJ30_00890

JLI:	EXU32_14490(egtD)

JAY:	H7A72_00935(egtD)

PHW:	G7075_16285(egtD)

MICG:

GJV80_10935(egtD)

NCA:

Noca_1639

NDK:	I601_1452(egtD)

NBE:	Back2_08840(egtD)

NARO:

CFH99_00195(egtD)

NAQU:

ENKNEFLB_01971(egtD)

NCQ:	K6T13_00790(egtD)

NPC:	KUV85_08465(egtD)

NPS:	KRR39_12860(egtD)

PSIM:

KR76_00175

AEB:	C6I20_01175(egtD)

KFL:

Kfla_5160

KQI:	F1D05_08725(egtD)

NDA:	Ndas_0640 Ndas_3470

NAL:

B005_3535

NGV:	CDO52_21005(egtD)

NEX:	NE857_10265(egtD)

STRR:

EKD16_07235(egtD)

SNAH:

OUQ99_23975(egtD)

TCU:

Tcur_3638

ACTW:

F7P10_32765(egtD)

AGRA:

AGRA3207_006138(egtD)

SRO:

Sros_0329

NOA:	BKM31_30895

NOW:	GBF35_07835(egtD)

NCX:	Nocox_11935(egtD)

NGN:	LCN96_14315(egtD)

TBI:

Tbis_2648

FRA:	Francci3_4514

FRE:	Franean1_7303

FRI:	FraEuI1c_6654 FraEuI1c_7155

FAL:

FRAAL6843

FSY:	FsymDg_4504

NML:

Namu_1079

GOB:

Gobs_0202

SEN:

SACE_3823

SACG:

FDZ84_35805(egtD)

SVI:	Svir_22440

SACC:

EYD13_12490(egtD)

AMD:

AMED_4961

AMN:

RAM_25255

AMM:

AMES_4902

AMZ:

B737_4902

AOI:

AORI_3755

AJA:	AJAP_20380(egtD)

AMQ:	AMETH_3014

AMYC:

CU254_17960(egtD)

AMYB:

BKN51_11250

AAB:	A4R43_11135

AMYY:

YIM_27645(egtD)

AORI:

SD37_19260

AACD:

LWP59_15000(egtD)

APRT:

MUY14_12805(egtD)

AROO:

NQK81_03805(egtD)

ATHM:

L1857_17965(egtD)

PDX:	Psed_2366 Psed_3380

PSEA:

WY02_03165 WY02_08125

PSEE:

FRP1_09630

PSEH:

XF36_09105

PSEQ:

AD006_17190

PECQ:

AD017_25025

PHH:	AFB00_25190

PAUT:

Pdca_32250 Pdca_32260

PBRO:

HOP40_24490(egtD)

PPEL:

H6H00_23195(egtD)

APRE:

CNX65_10835(egtD)

AMI:

Amir_2125

SESP:

BN6_30880

SSYI:

EKG83_34685(egtD)

KAL:

KALB_2953

KPHY:

AOZ06_20030

LED:	BBK82_27285

AHM:	TL08_10815

ACTI:

UA75_11540

ACAD:

UA74_11455

AHG:	AHOG_10790(egtD)

ACTA:

C1701_22040(egtD)

ALO:	CRK56189 CRK60771

PMAD:

BAY61_17175

SACE:

GIY23_01060 GIY23_10335(egtD)

ACTU:

Actkin_04014(egtD)

STP:	Strop_2116

SAQ:

Sare_2259

MAU:	Micau_3408

MIL:

ML5_4986

MICB:

MicB006_2465

MTUA:

CSH63_08020(egtD)

MICH:

FJK98_16750(egtD)

MTEM:

GCE86_12995(egtD)

MCAB:

HXZ27_18525(egtD)

MSAG:

GCM10017556_54360(egtD)

VMA:	VAB18032_23555

MCRA:

ID554_01375(egtD)

VER:	HUT12_20330(egtD)

ASE:

ACPL_6424

AMS:	AMIS_61670

ACTN:

L083_5287 L083_7398

AFS:

AFR_38625

ACTS:

ACWT_6291

AIH:	Aiant_21050(egtD)

ACTR:

Asp14428_55950(egtD)

PLK:	CIK06_14635(egtD)

PLAB:

C6361_00300 C6361_04525(egtD)

PLAT:

C6W10_01050(egtD) C6W10_21350

PFLA:

Pflav_033920(egtD)

PSUU:

Psuf_076980(egtD)

ATL:	Athai_00980(egtD)

ASER:

Asera_06490(egtD)

CATI:

CS0771_27270(egtD)

DVC:	Dvina_39830(egtD)

DFU:	Dfulv_30250(egtD)

DROS:

Drose_22740(egtD)

DAUR:

Daura_38940(egtD)

DMAT:

Dmats_34710(egtD)

NHY:	JQS43_04875(egtD)

CCAZ:

COUCH_05015(egtD)

CAI:

Caci_8031

SNA:	Snas_5171 Snas_5803

NAV:	JQS30_12780(egtD)

GLY:	K3N28_07610(egtD) K3N28_10175(egtD)

AEY:	CDG81_09260(egtD)

EKE:	EK0264_15145(egtD)

RXY:

Rxyl_0685

RUB:	GBA63_15145(egtD)

RMAR:

GBA65_19465(egtD)

BSOL:

FSW04_08720(egtD)

CWO:

Cwoe_4694

PARN:

NBH00_09420(egtD)

SBAE:

DSM104329_01348(egtD)

IAM:	HC251_03785(egtD)

EUZ:	DVS28_a3893

SYP:	SYNPCC7002_G0154

SYND:

KR52_01880

SYH:	Syncc8109_0137

SYV:	AWQ23_15405

SYL:	AWQ21_15715

PMT:

PMT_0151

CMP:	Cha6605_0924 Cha6605_6115

TVN:	NIES2134_106700

SLW:	BRW62_12105

THEC:

FFX45_11880(egtD)

LEN:	LEP3755_31680

LBO:	LBWT_13420 LBWT_55940

HHG:	XM38_007130(egtD)

PSER:

ABRG53_3845

GEN:	GM3709_2693

GEE:	GM3708_149

CHON:

NIES4102_00650

MPK:

VL20_3603

MIQ:	B5D77_07710

MVZ:	myaer102_16740

CYL:	AA637_04885(egtD)

CWA:	CwatDRAFT_0669

TER:

Tery_0701

PAGH:

NIES204_04670

OXY:	HCG48_02440(egtD)

NON:	NOS3756_18750

NFL:	COO91_06060

NOE:	CLI64_23850(egtD)

NSH:

GXM_06079

NED:	HUN01_13950(egtD) HUN01_34300(egtD)

AWA:	AA650_10900

ANN:	EH233_01630(egtD)

RSIN:

B6N60_02309

CALH:

IJ00_06490

FIS:	FIS3754_37670

DOU:	BMF77_04280(egtD)

DFS:	HGD76_19445(egtD)

CCUR:

IAR63_17435(egtD)

AFLO:

HEQ12_04420(egtD)

TOQ:	HCG51_33475(egtD)

NCN:	BZZ01_15770

ROO:	G5S37_03015

MEAP:

MTHMO_2343

IPA:

Isop_1456

AGV:	OJF2_75020

KST:	KSMBR1_0240

JET:	L3J17_13845(egtD)

ALUS:

STSP2_03355(egtD)

GRW:	FTO74_14805(egtD)

GRB:	GOB94_11770(egtD)

TALB:

FTW19_05985(egtD)

ABAS:

ACPOL_0188

EDA:	GWR55_18315(egtD)

EDG:	H7846_05980(egtD)

ADIN:

H7849_05225(egtD)

ORP:	MOP44_07125(egtD)

PFER:

IRI77_13455(egtD) IRI77_22240(egtD)

ABAC:

LuPra_04570(egtD)

GBA:

J421_1882

DRC:	G0Q07_15200

CPI:	Cpin_4447 Cpin_4965

CHIT:

FW415_12130(egtD)

CHIH:

GWR21_00275

CFIL:

MYF79_15200

ATEE:

K9M52_02965

FLN:

FLA_2378

HHY:	Halhy_2585

PEP:	AQ505_15340

PCM:	AY601_2311

PEK:	FFJ24_009340

PROE:

H9L23_11640

SHG:	Sph21_2565

SHT:	KO02_15555

SPHN:

BV902_12545

SMUI:

I6J00_01530

MUP:	A0256_07290

MUC:

MuYL_0155

MUH:	HYN43_022905

MGIN:

FRZ54_04635(egtD)

MGK:	FSB76_15585

MRUB:

DEO27_024390

MGOS:

DIU38_025485

MMAB:

HQ865_22855

MGIK:

GO620_012470

AGD:	FRZ59_14650

OLI:	FKG96_10190

CMR:	Cycma_1973

CAMU:

CA2015_1910

ECHI:

FKX85_05685 FKX85_14085(egtD)

SLI:

Slin_6101

SRD:	SD10_22655

SMON:

AWR27_04340

SPIR:

CWM47_26965(egtD)

SPIK:

EXU85_31130(egtD)

SPIB:

G8759_33700(egtD)

STAE:

HNV11_02835(egtD)

RHOZ:

GXP67_11005(egtD)

DFE:

Dfer_1252

FIB:	A6C57_03350

ALS:	DJ013_18510(egtD)

HSW:

Hsw_2886

HYD:	PK28_12240

HYE:	AM218_04215

HYG:	AUC43_12115

HYP:	A0257_00755

HYZ:	AXW84_13805

HNV:	DDQ68_08390(egtD)

HYH:	D3Y59_01875(egtD)

HYJ:	FHG12_15230(egtD)

HQI:	H9L05_13610

HRS:	HER32_03815(egtD)

HBN:	GUY19_00185(egtD)

PKO:	PKOR_03290 PKOR_17700

PACT:

CA264_06360

RUF:	TH63_08500

RTI:	DC20_20060

RUD:	TH61_14095

NIB:	GU926_01585(egtD)

ADD:	HUW48_10820(egtD)

ASWU:

HUW51_18210(egtD)

FPF:	DCC35_11840

FLM:	MY04_3419(egtD)

FLL:	EI427_19140(egtD)

FYA:	KMW28_19645(egtD)

FKA:	KM029_12135(egtD)

FBT:	D770_20210

CHK:	D4L85_23840(egtD)

GFO:

GFO_0284

GRL:	LPB144_07785

GRS:	C7S20_07230(egtD) C7S20_09335(egtD)

FPSZ:

AMR72_10505

FFA:	FFWV33_03980

FAT:	DVK85_06410

FKI:	FK004_03995

FALB:

HYN59_04110(egtD)

FAK:	FUA48_04405

FLO:	K1I41_03580

RBI:	RB2501_03225

ZPR:

ZPR_3669

CAT:	CA2559_13323

MARM:

YQ22_04400

MART:

BTR34_04565

MARB:

CJ263_13035(egtD)

MARE:

EJ994_00390

CAO:	Celal_4080

CLY:	Celly_3136

CLH:	IX49_15855

CBAL:

M667_16770

CBAT:

M666_16790

KDI:	Krodi_0782

DOK:	MED134_00085

DDO:	I597_0250(egtD)

DOD:	DCS32_08115

LAN:	Lacal_2554

LVN:	BWR22_12070

ZGA:	ZOBELLIA_872

MLT:

VC82_2021

SPON:

HME9304_02218(egtD)

ASL:	Aeqsu_0715

AEV:	EI546_15300

AIC:	JK629_02930

PTQ:	P700755_003062

NDO:

DDD_1043

NOM:	AAT17_05470

NSD:	BST91_00410

NOB:	CW736_06240

NOJ:	EJ995_04110

POM:	MED152_03665

POB:	LPB03_03815

POLA:

BXQ17_02435

AHZ:	APS56_15390

SYI:	SB49_15115

FOP:	FNB79_11360

SALT:

AO058_01100

SMIS:

LDL76_08135

SEON:

BWZ22_14315

AALG:

AREALGSMS7_03795(egtD)

OLL:	CW732_14405

OAQ:	DZC78_03490

AUE:	C5O00_03170

AQB:	D1818_10675(egtD)

AQA:	D1815_20260(egtD)

AQD:	D1816_12085

EMAR:

D1013_05185

PSYN:

E9099_14785

AFLA:

FHG64_05855

ANP:	FK178_09555

MGEL:

G5B37_11835

GAA:	HX109_09310

CAGG:

HYG79_03660(egtD)

ALTI:

ALE3EI_1337

MARX:

INR76_02015

FLG:	LV716_03675

FLB:	LV704_04555

BIA:	GMA17_10805

CIO:	CEQ15_10625(egtD)

CHRY:

CEY12_01740

CPIP:

CJF12_06060

CSHA:

EG350_11215(egtD)

CIL:	EG358_16925

CCAU:

EG346_14120(egtD)

CGLE:

NCTC11432_01867(egtD)

CLAC:

EG342_21865(egtD)

CSAL:

NBC122_00935(egtD)

CJG:	NCTC13459_02067(egtD)

CCAS:

EIB73_10320

CANT:

NCTC13489_02180(egtD)

KDA:	EIB71_04545

FTE:	Fluta_3843

OHO:	Oweho_0985

CPB:	Cphamn1_1309

CLI:

Clim_1148

PROS:

CHL67_06190(egtD)

MMH:

Mmah_1747

MHAZ:

BHR79_04945

MZH:	Mzhil_1067

MPY:

Mpsy_2947

MZI:	HWN40_01430(egtD)

NIR:	NSED_03365

NKR:	NKOR_03390

NID:	NPIRD3C_1612

NIW:	Nisw_01635(egtD)

NCL:	C5F47_05795(egtD)

NOX:	C5F49_05645(egtD)

NUE:	C5F50_04790(egtD)

NCT:

NMSP_1036

NIC:	DSQ20_03505(egtD)

CSY:	CENSYa_0372

TAA:	NMY3_02528(egtD)

NBV:	T478_0971(egtD)

» show all

Reference

1 [PMID:5484456]

Authors

Ishikawa Y, Melville DB.

Title

The enzymatic alpha-N-methylation of histidine.

Journal

J Biol Chem 245:5967-73 (1970)
DOI:10.1016/S0021-9258(18)62649-3

Reference

2 [PMID:20420449]

Authors

Seebeck FP

Title

In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.

Journal

J Am Chem Soc 132:6632-3 (2010)
DOI:10.1021/ja101721e

Sequence

[msm:MSMEG_6247]

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.44

IUBMB Enzyme Nomenclature:

2.1.1.44

ExPASy - ENZYME nomenclature database:

2.1.1.44

BRENDA, the Enzyme Database:

2.1.1.44

CAS:	62213-53-0

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