KEGG   ENZYME: 2.1.1.56Help
Entry
EC 2.1.1.56                 Enzyme                                 

Name
mRNA (guanine-N7)-methyltransferase;
messenger ribonucleate guanine 7-methyltransferase;
guanine-7-methyltransferase;
messenger RNA guanine 7-methyltransferase;
S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:mRNA (guanine-N7)-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [RN:R03805]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
5'-(5'-triphosphoguanosine)-[mRNA] [CPD:C02031]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA] [CPD:C02339]
Comment
The nucleoside next to the terminal guanosine may be either guanosine or adenosine.
History
EC 2.1.1.56 created 1981
Orthology
K00565  mRNA (guanine-N7-)-methyltransferase
K21316  RNA-directed RNA polymerase
Genes
HSA: 8731(RNMT)
PTR: 455501(RNMT)
PPS: 100988843(RNMT)
GGO: 101142637(RNMT)
PON: 100437717(RNMT)
NLE: 100607421(RNMT)
MCC: 100430132(RNMT)
MCF: 101865006(RNMT)
CSAB: 103222831(RNMT)
RRO: 104671855(RNMT)
RBB: 108533099(RNMT)
CJC: 100407846(RNMT)
SBQ: 101031438(RNMT)
MMU: 67897(Rnmt)
RNO: 291534(Rnmt)
CGE: 100757713(Rnmt)
NGI: 103727857(Rnmt)
HGL: 101699229(Rnmt)
CCAN: 109699696(Rnmt)
OCU: 100340576(RNMT)
TUP: 102489875(RNMT)
CFA: 476200(RNMT)
AML: 100483692(RNMT)
UMR: 103680479(RNMT)
ORO: 101381298(RNMT)
FCA: 101093649(RNMT)
PTG: 102970051(RNMT)
AJU: 106979645(RNMT)
BTA: 511555(RNMT)
BOM: 102280289(RNMT)
BIU: 109577746(RNMT)
PHD: 102342172(RNMT)
CHX: 102181456(RNMT)
OAS: 101110469(RNMT)
SSC: 100621823(RNMT)
CFR: 102504344(RNMT)
CDK: 105086464(RNMT)
BACU: 103006867(RNMT)
LVE: 103084436(RNMT)
OOR: 101280922(RNMT)
ECB: 100050190(RNMT)
EPZ: 103555003(RNMT)
EAI: 106828646(RNMT)
MYB: 102243455(RNMT)
MYD: 102753772(RNMT)
HAI: 109396444(RNMT)
RSS: 109438695(RNMT)
PALE: 102878222(RNMT)
LAV: 100668042(RNMT)
TMU: 101343829
MDO: 100018821(RNMT)
SHR: 100914618(RNMT)
OAA: 100084869 100090335(RNMT)
GGA: 421046(RNMT)
MGP: 100544230(RNMT)
CJO: 107309950(RNMT)
APLA: 101799369(RNMT)
ACYG: 106034918(RNMT)
TGU: 100223646 100231685(RNMT)
GFR: 102043694(RNMT)
FAB: 101818439(RNMT)
PHI: 102111981(RNMT)
PMAJ: 107199738(RNMT)
CCAE: 111925004(RNMT)
CCW: 104687259(RNMT)
FPG: 101915639(RNMT)
FCH: 102054253(RNMT)
CLV: 102087781(RNMT)
EGZ: 104132861(RNMT)
AAM: 106484224(RNMT)
ASN: 102387848(RNMT)
AMJ: 102566708(RNMT)
PSS: 102455001(RNMT)
CMY: 102930802(RNMT)
CPIC: 101938869(RNMT)
ACS: 100552388(rnmt)
PVT: 110078039(RNMT)
PBI: 103051637(RNMT)
GJA: 107119718(RNMT)
XLA: 398173(rnmt.L)
XTR: 549807(rnmt)
NPR: 108787317(RNMT)
DRE: 562801(rnmt)
SANH: 107668718
IPU: 108257296(rnmt)
AMEX: 103047826(rnmt)
TRU: 101070447(rnmt)
LCO: 104931889(rnmt)
NCC: 104944570(rnmt)
MZE: 101483419(rnmt)
OLA: 101173558(rnmt)
XMA: 102235108(rnmt)
PRET: 103472609(rnmt)
NFU: 107394499(rnmt)
KMR: 108243893(rnmt)
CSEM: 103393757(rnmt)
LCF: 108889946(rnmt)
SDU: 111223288(rnmt)
HCQ: 109513467(rnmt)
BPEC: 110172365(rnmt)
MALB: 109972569(rnmt)
SASA: 100195852(rnmt)
OTW: 112229374(rnmt)
ELS: 105030541(rnmt)
SFM: 108927854(rnmt)
LCM: 102366784(RNMT)
CMK: 103179648(rnmt)
CIN: 100184027
SPU: 580278
APLC: 110981334
SKO: 100378111
DME: Dmel_CG3688(l(2)35Bd)
DER: 6541296
DPE: 6593698
DSI: Dsimw501_GD23987(Dsim_GD23987)
DWI: 6643487
MDE: 101888902
AAG: 110681192
AME: 412277
BIM: 100746883
BTER: 100643818
SOC: 105197283
AEC: 105151731
ACEP: 105623624
PBAR: 105426467
HST: 105183571
DQU: 106742890
CFO: 105250315
LHU: 105676793
PGC: 109856456
PCF: 106784614
NVI: 100118581
MDL: 103577154
TCA: 659894
DPA: 109543632
NVL: 108561860
BMOR: 101745600
PMAC: 106713297
PRAP: 111002638
HAW: 110373131
PXY: 105381370
API: 100159670
DNX: 107161417
CLEC: 106665753
ZNE: 110831141
FCD: 110860757
TUT: 107360362
CEL: CELE_C25A1.3(tag-72)
CBR: CBG12234(Cbr-tag-72)
TSP: Tsp_08271
CRG: 105345793
MYI: 110447042
OBI: 106873871
LAK: 106174166
SHX: MS3_08662
EGL: EGR_02332
ADF: 107352229
HMG: 100212538
AQU: 100638295
LJA: Lj0g3v0195589.1(Lj0g3v0195589.1) Lj0g3v0239139.2(Lj0g3v0239139.2)
DOSA: Os02t0780600-01(Os02g0780600) Os08t0180000-01(Os08g0180000)
ATS: 109764347(LOC109764347) 109776134(LOC109776134) 109777325(LOC109777325)
PPP: 112275541
SCE: YBR236C(ABD1)
ERC: Ecym_2270
KMX: KLMA_20236(ABD1)
NCS: NCAS_0H01290(NCAS0H01290)
NDI: NDAI_0F02000(NDAI0F02000)
TPF: TPHA_0N01140(TPHA0N01140)
TBL: TBLA_0D03510(TBLA0D03510)
TDL: TDEL_0B04070(TDEL0B04070)
KAF: KAFR_0G03470(KAFR0G03470)
PIC: PICST_66228(ABD1)
CAL: CAALFM_C307710WA(ABD1)
CDU: CD36_87590(ABD1)
CAUR: QG37_07452
SLB: AWJ20_4892(ABD1)
NCR: NCU03971
NTE: NEUTE1DRAFT132027(NEUTE1DRAFT_132027)
MGR: MGG_06505
MAW: MAC_03464
MAJ: MAA_02243
CMT: CCM_04520
BFU: BCIN_13g01620(Bcabd1)
MBE: MBM_05178
ANI: AN1916.2
ANG: ANI_1_1742094(An11g02520)
ABE: ARB_02941
TVE: TRV_00533
PTE: PTT_10296
SPO: SPCC330.10(pcm1)
CNE: CNC01440
CNB: CNBC5820
MGL: MGL_2068
EHI: EHI_040480 EHI_095040(313.t00006)
SMIN: v1.2.029685.t2(symbB.v1.2.029685.t2) v1.2.029685.t3(symbB.v1.2.029685.t3)
 » show all
Taxonomy
Reference
1  [PMID:1058472]
  Authors
Ensinger MJ, Martin SA, Paoletti E, Moss B.
  Title
Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.
  Journal
Proc Natl Acad Sci U S A 72:2525-9 (1975)
DOI:10.1073/pnas.72.7.2525
Reference
2  [PMID:629955]
  Authors
Groner Y, Gilboa E, Aviv H.
  Title
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.
  Journal
Biochemistry 17:977-82 (1978)
Reference
3  [PMID:1194287]
  Authors
Martin SA, Moss B.
  Title
Modification of RNA by mRNA guanylyltransferase and mRNA (guanine-7-)methyltransferase from vaccinia virions.
  Journal
J Biol Chem 250:9330-5 (1975)
Reference
4  [PMID:1194286]
  Authors
Martin SA, Paoletti E, Moss B.
  Title
Purification of mRNA guanylyltransferase and mRNA (guanine-7-) methyltransferase from vaccinia virions.
  Journal
J Biol Chem 250:9322-9 (1975)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.56
IUBMB Enzyme Nomenclature: 2.1.1.56
ExPASy - ENZYME nomenclature database: 2.1.1.56
BRENDA, the Enzyme Database: 2.1.1.56
CAS: 56941-25-4

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