Entry
Name
methyltransferase cap1;
FTSJD2 (gene name);
messenger ribonucleate nucleoside 2'-methyltransferase;
messenger RNA (nucleoside-2'-)-methyltransferase;
MTR1;
cap1-MTase;
mRNA (nucleoside-2'-O)-methyltransferase (ambiguous);
S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA] [RN:
R03922 ]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:
C00019 ];
5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA]
Product
S-adenosyl-L-homocysteine [CPD:
C00021 ];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Comment
This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules. This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine [6].
History
EC 2.1.1.57 created 1981 (EC 2.1.1.58 created 1981, incorporated 1984), modified 2014, modified 2021
Orthology
K21516 Poxviridae cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
K25332 Flavivirus RNA-directed RNA polymerase NS5
K26439 Alphabaculovirus cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
Genes
PLEU : 114703984(Cmtr1) 114705719
MYB : 102239315(CMTR1) 102261455(UBAC2)
MMYO : 118649597(UBAC2) 118659923(CMTR1)
MLF : 102416806(UBAC2) 102436523(CMTR1)
MDT : 132228506(UBAC2) 132237380(CMTR1)
AFZ : 127548545 127561332 127561619
XLA : 108716524(cmtr1.L) 443938(cmtr1.S)
SANH : 107664240(cmtr1) 107697840
SGH : 107593988(cmtr1) 107599383
CAUA : 113041549 113065734 113072759
CGIB : 127944368 128011264
PSPA : 121316190 121317323
ARUT : 117403072 117410581
DSI : Dsimw501_GD16313(Dsim_GD16313)
AALB : 109405510 109428513 109430091
ASUA : 134205283 134207668
CQU : CpipJ_CPIJ006982 CpipJ_CPIJ015411
CPII : 120413355 120429010
CNS : 116340373 116343796 116344118
BCOO : 119073836 119075779
BAFF : 126925206 126927443
BPYO : 122565973 122569899 122577500
BPAS : 132914355 132915674
VCAN : 122415877 122416389 122416390 122416624
PPYR : 116171752 116180531
FCD : 110843640 110843758 110852909 110860647 110861994
CEL : CELE_Y53F4B.13(cmtr-1)
TSP : Tsp_03060 Tsp_12519a
DPOL : 127872341 127874801
SPAR : SPRG_13665 SPRG_15961
LMAT : 92510865(LSCM1_00711)
LOI : 92356721(LSCM4_00712)
LEIS : 94176359(GH5_00723)
LENR : 94168006(CUR178_00717)
LEIN : 94184483(JIQ42_00723)
PHET : 94287086(JKF63_00960)
NGR : NAEGRDRAFT_46720 NAEGRDRAFT_65760
» show all
Taxonomy
Reference
Authors
Barbosa E, Moss B.
Title
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Purification and physical properties.
Journal
J Biol Chem 253:7692-7 (1978)
Reference
Authors
Barbosa E, Moss B.
Title
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity.
Journal
J Biol Chem 253:7698-702 (1978)
Reference
Authors
Boone RF, Ensinger MJ, Moss B.
Title
Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus.
Journal
Reference
Authors
Ensinger MJ, Martin SA, Paoletti E, Moss B.
Title
Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.
Journal
Reference
Authors
Groner Y, Gilboa E, Aviv H.
Title
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.
Journal
Reference
Authors
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
Title
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.57
ExPASy - ENZYME nomenclature database: 2.1.1.57