EC                 Enzyme                                 

methyltransferase cap1;
messenger ribonucleate nucleoside 2'-methyltransferase;
messenger RNA (nucleoside-2'-)-methyltransferase;
mRNA (nucleoside-2'-O)-methyltransferase (ambiguous);
S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
Transferring one-carbon groups;
BRITE hierarchy
S-adenosyl-L-methionine:5-(N7-methyl 5-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] 2-O-methyltransferase
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] [RN:R03922]
S-adenosyl-L-methionine [CPD:C00019];
5'-(N7-methyl 5'-triphosphoguanosine)-(purine-ribonucleotide)-[mRNA] [CPD:C02339]
S-adenosyl-L-homocysteine [CPD:C00021];
5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-purine-ribonucleotide)-[mRNA] [CPD:C04802]
This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules, which may be either guanosine or adenosine. This methylation event is known as cap1, and occurrs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine [6].
EC created 1981 (EC created 1981, incorporated 1984), modified 2014
K14589  cap1 methyltransferase
K21516  Orthopoxvirus cap-specific mRNA (nucleoside-2'-O-)-methyltransferase
HSA: 23070(CMTR1)
PTR: 471998(CMTR1)
PPS: 100973075(CMTR1)
GGO: 101137720(CMTR1)
PON: 100172922(CMTR1)
NLE: 100603379(CMTR1)
MCC: 719402(CMTR1)
MCF: 102122892(CMTR1)
CSAB: 103221567(CMTR1)
RRO: 104682893(CMTR1)
RBB: 108528352(CMTR1)
CJC: 100388430(CMTR1)
SBQ: 101048288(CMTR1)
MMU: 74157(Cmtr1)
MCAL: 110284181(Cmtr1)
MPAH: 110337841(Cmtr1)
RNO: 309656(Cmtr1)
MUN: 110546567(Cmtr1)
CGE: 100755381(Cmtr1)
NGI: 103739641(Cmtr1)
HGL: 101702635(Cmtr1)
CCAN: 109694147(Cmtr1)
OCU: 100350011(CMTR1)
TUP: 102486149(CMTR1)
CFA: 100683999(CMTR1)
VVP: 112913952(CMTR1)
AML: 100464010(CMTR1)
UMR: 103665432(CMTR1)
UAH: 113243879(CMTR1)
ORO: 101370834(CMTR1)
ELK: 111147878
FCA: 101082907(CMTR1)
PTG: 102959389(CMTR1)
PPAD: 109271551(CMTR1)
AJU: 106972787(CMTR1)
BTA: 509620(CMTR1)
BOM: 102286518(CMTR1)
BIU: 109577167(CMTR1)
BBUB: 102416543(CMTR1)
CHX: 102183833(CMTR1)
OAS: 101123242(CMTR1)
SSC: 100154061(CMTR1)
CFR: 102519501(CMTR1)
CDK: 105087036(CMTR1)
BACU: 102999368(CMTR1)
LVE: 103084086(CMTR1)
OOR: 101285678(CMTR1)
DLE: 111178760(CMTR1)
PCAD: 102979678(CMTR1)
ECB: 100064496(CMTR1)
EPZ: 103565234(CMTR1)
EAI: 106824556(CMTR1)
MYB: 102239315(CMTR1) 102261455(UBAC2)
MYD: 102752437(CMTR1)
MNA: 107545617(CMTR1)
HAI: 109395523(CMTR1)
DRO: 112302112(CMTR1)
PALE: 102890551(CMTR1)
RAY: 107514694(CMTR1)
MJV: 108384511(CMTR1)
LAV: 100676382(CMTR1)
TMU: 101344306
MDO: 100029458(CMTR1)
SHR: 100932113(CMTR1)
PCW: 110217306(CMTR1)
OAA: 100080325(CMTR1)
GGA: 421434(CMTR1)
MGP: 100550686(CMTR1)
CJO: 107311264(CMTR1)
NMEL: 110395644(CMTR1)
APLA: 101791717(CMTR1)
ACYG: 106029753(CMTR1)
TGU: 100221592(CMTR1)
LSR: 110481715(CMTR1)
SCAN: 103817971(CMTR1)
GFR: 102034324(CMTR1)
FAB: 101813808(CMTR1)
PHI: 102100817(CMTR1)
PMAJ: 107201841(CMTR1)
CCAE: 111927547(CMTR1)
CCW: 104684420(CMTR1)
ETL: 114059329(CMTR1)
FPG: 101914346(CMTR1)
FCH: 102046517 102046764(CMTR1)
CLV: 102095138(CMTR1)
EGZ: 104124848(CMTR1)
NNI: 104021512(CMTR1)
ACUN: 113477838(CMTR1)
PADL: 103922862(CMTR1)
AAM: 106485494(CMTR1)
ASN: 102369625(CMTR1)
AMJ: 102558730(CMTR1)
PSS: 102451122(CMTR1)
CMY: 102946212(CMTR1)
CPIC: 101934896(CMTR1)
ACS: 100553490(cmtr1)
PVT: 110074654(CMTR1)
PBI: 103059677(CMTR1)
PMUR: 107294666(CMTR1)
TSR: 106539335(CMTR1)
PMUA: 114594548(CMTR1)
GJA: 107115268(CMTR1)
XLA: 108716524(cmtr1.L) 443938(cmtr1.S)
XTR: 100170565(cmtr1)
NPR: 108801553(CMTR1)
DRE: 393102(cmtr1)
SGH: 107593988(cmtr1) 107599383
IPU: 108275821(cmtr1)
PHYP: 113545617(cmtr1)
AMEX: 103047841(cmtr1)
EEE: 113591183(cmtr1)
TRU: 101074289(cmtr1)
LCO: 104921992(cmtr1)
NCC: 104941960(cmtr1)
MZE: 101469980(cmtr1)
ONL: 100704706(cmtr1)
OLA: 101158070(cmtr1)
XMA: 102216684(cmtr1)
XCO: 114158805(cmtr1)
PRET: 103457551(cmtr1)
CVG: 107083924(cmtr1)
NFU: 107377611(cmtr1)
KMR: 108240058(cmtr1)
ALIM: 106519759(cmtr1)
AOCE: 111587098(cmtr1) 111588414
CSEM: 103380848(cmtr1)
POV: 109636200(cmtr1)
LCF: 108895626(cmtr1)
SDU: 111235503(cmtr1)
SLAL: 111650577(cmtr1)
HCQ: 109518088(cmtr1)
BPEC: 110175704(cmtr1)
MALB: 109954305(cmtr1)
SASA: 106608025(cmtr1)
SALP: 111972589(cmtr1)
ELS: 105006028(cmtr1)
SFM: 108936559(cmtr1)
PKI: 111834731(cmtr1)
LCM: 102345363(CMTR1)
CMK: 103177927(cmtr1)
RTP: 109933378(cmtr1)
CIN: 100185668
SPU: 580281
APLC: 110977650
SKO: 100375537
DME: Dmel_CG6379(CG6379)
DER: 6551111
DSI: Dsimw501_GD16313(Dsim_GD16313)
DSR: 110183056
DPE: 6597607
DMN: 108164611
DWI: 6638083
DAZ: 108618572
DNV: 115564487
DHE: 111605614
MDE: 101893056
LCQ: 111681637
AAG: 5568541
AALB: 109405510
AME: 411249
BIM: 100749013
BTER: 100644808
OBB: 114875749
SOC: 105207987
MPHA: 105830441
AEC: 105154551
ACEP: 105619524
PBAR: 105423978
VEM: 105559144
HST: 105191016
DQU: 106751073
CFO: 105249141
LHU: 105677554
PGC: 109857956
OBO: 105286512
PCF: 106784014
NVI: 100123042
CSOL: 105368320
MDL: 103568254
TCA: 655843
DPA: 109546456
ATD: 109594050
NVL: 108561637
BMOR: 101744431
BMAN: 114249896
PMAC: 106717956
PRAP: 110995115
HAW: 110372813
TNL: 113498702
PXY: 105387481
API: 100165143
DNX: 107169461
AGS: 114126460
RMD: 113557339
BTAB: 109039234
CLEC: 106667095
ZNE: 110833726
CSCU: 111623980
PTEP: 107454091
CEL: CELE_Y53F4B.13(Y53F4B.13)
BMY: Bm1_31430
PCAN: 112569770
CRG: 105339251
OBI: 106877177
LAK: 106177770
SHX: MS3_10131
EGL: EGR_03163
EPA: 110244207
ADF: 107347445
AMIL: 114957115
PDAM: 113671461
SPIS: 111336909
DGT: 114531518
HMG: 100209744
DFA: DFA_05394
SMIN: v1.2.011137.t1(symbB.v1.2.011137.t1)
 » show all
1  [PMID:701281]
Barbosa E, Moss B.
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Purification and physical properties.
J Biol Chem 253:7692-7 (1978)
2  [PMID:701282]
Barbosa E, Moss B.
mRNA(nucleoside-2'-)-methyltransferase from vaccinia virus. Characteristics and substrate specificity.
J Biol Chem 253:7698-702 (1978)
3  [PMID:833934]
Boone RF, Ensinger MJ, Moss B.
Synthesis of mRNA guanylyltransferase and mRNA methyltransferases in cells infected with vaccinia virus.
J Virol 21:475-83 (1977)
4  [PMID:1058472]
Ensinger MJ, Martin SA, Paoletti E, Moss B.
Modification of the 5'-terminus of mRNA by soluble guanylyl and methyl transferases from vaccinia virus.
Proc Natl Acad Sci U S A 72:2525-9 (1975)
5  [PMID:629955]
Groner Y, Gilboa E, Aviv H.
Methylation and capping of RNA polymerase II primary transcripts by HeLa nuclear homogenates.
Biochemistry 17:977-82 (1978)
6  [PMID:21310715]
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family.
Nucleic Acids Res 39:4756-68 (2011)
Other DBs
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
CAS: 61970-02-3

DBGET integrated database retrieval system