KEGG ENZYME: 2.1.1.59

ENZYME: 2.1.1.59

Entry

EC 2.1.1.59                 Enzyme

Name

[cytochrome c]-lysine N-methyltransferase;
cytochrome c (lysine) methyltransferase;
cytochrome c methyltransferase;
cytochrome c-specific protein methylase III;
cytochrome c-specific protein-lysine methyltransferase;
S-adenosyl-L-methionine:[cytochrome c]-L-lysine 6-N-methyltransferase

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:[cytochrome c]-L-lysine N6-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + [cytochrome c]-L-lysine = S-adenosyl-L-homocysteine + [cytochrome c]-N6-methyl-L-lysine [RN:R04145]

Reaction(KEGG)

R04145;
(other) R03875 R04866 R04867

Substrate

S-adenosyl-L-methionine [CPD:C00019];
[cytochrome c]-L-lysine

Product

S-adenosyl-L-homocysteine [CPD:C00021];
[cytochrome c]-N6-methyl-L-lysine

Comment

One of a group of enzymes methylating proteins; see also the family of histone-lysine N-methyltransferases (previously EC 2.1.1.43) and EC 2.1.1.60 calmodulin-lysine N-methyltransferase.

History

EC 2.1.1.59 created 1982, modified 1983

Pathway

ec00310

Lysine degradation

ec01100

Metabolic pathways

Orthology

K18804

[cytochrome c]-lysine N-methyltransferase

Genes

SCE:	YHR109W(CTM1)

SEUB:

DI49_2514

SPAO:

SPAR_H01510

AGO:	AGOS_AER246W

KLA:	KLLA0_E21407g

KMX:	KLMA_20447(CTM1)

LTH:	KLTH0F16390g

VPO:	Kpol_530p1

ZRO:	ZYRO0F09680g

CGR:	2889115(GVI51_I01023)

NCS:	NCAS_0H02000(NCAS0H02000)

NDI:	NDAI_0C01650(NDAI0C01650)

TPF:	TPHA_0E01820(TPHA0E01820)

TGB:	HG536_0E00850

TDL:	TDEL_0E02050(TDEL0E02050)

KAF:	KAFR_0D04990(KAFR0D04990)

ZMK:	HG535_0C04020

DHA:	DEHA2G04466g

PIC:	PICST_86656(CTM1)

PGU:	PGUG_02969

SPAA:

SPAPADRAFT_147638

LEL:	PVL30_002341(CTM1)

CAL:	CAALFM_CR10360CA(CTM1)

CTP:	CTRG_05818

COT:	CORT_0D00570

CDU:	CD36_35280

CTEN:

18249635(CTM1)

CLU:	CLUG_01538

CLUS:

A9F13_06g03619

PPA:	PAS_chr1-1_0152

PKZ:	C5L36_0A03800

BNN:	FOA43_001795

BBRX:

BRETT_004710

» show all

Reference

1 [PMID:203592]

Authors

Durban E, Nochumson S, Kim S, Paik WK, Chan SK.

Title

Cytochrome c-specific protein-lysine methyltransferase from Neurospora crassa. Purification, characterization, and substrate requirements.

Journal

J Biol Chem 253:1427-35 (1978)

Reference

2 [PMID:196592]

Authors

Nochumson S, Durban E, Kim S, Paik WK.

Title

Cytochrome c-specific protein methylase III from Neurospora crassa.

Journal

Biochem J 165:11-8 (1977)
DOI:10.1042/bj1650011

Reference

3 [PMID:6282265]

Authors

Valentine J, Pettigrew GW.

Title

A cytochrome c methyltransferase from Crithidia oncopelti.

Journal

Biochem J 201:329-38 (1982)
DOI:10.1042/bj2010329

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.59

IUBMB Enzyme Nomenclature:

2.1.1.59

ExPASy - ENZYME nomenclature database:

2.1.1.59

BRENDA, the Enzyme Database:

2.1.1.59

CAS:	82047-78-7

DBGET integrated database retrieval system