KEGG ENZYME: 2.1.1.67

ENZYME: 2.1.1.67

Entry

EC 2.1.1.67                 Enzyme

Name

thiopurine S-methyltransferase;
mercaptopurine methyltransferase;
thiopurine methyltransferase;
6-thiopurine transmethylase;
TPMT

Class

Transferases;
Transferring one-carbon groups;
Methyltransferases

Sysname

S-adenosyl-L-methionine:thiopurine S-methyltransferase

Reaction(IUBMB)

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether [RN:R03701]

Reaction(KEGG)

R03701 > R08236 R08239 R08246

Substrate

S-adenosyl-L-methionine [CPD:C00019];
thiopurine [CPD:C01756]

Product

S-adenosyl-L-homocysteine [CPD:C00021];
thiopurine S-methylether [CPD:C16614]

Comment

Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not identical with EC 2.1.1.9 thiol S-methyltransferase.

History

EC 2.1.1.67 created 1984

Pathway

ec00983

Drug metabolism - other enzymes

Orthology

K00569

thiopurine S-methyltransferase

Genes

HSA:	7172(TPMT)

PTR:	471863(TPMT)

PPS:	100994993(TPMT)

GGO:	101127379(TPMT)

PON:	100172405(TPMT) 100458866

NLE:	100592079(TPMT)

HMH:	116459994(TPMT)

MCC:	704564(TPMT)

MCF:	102145415(TPMT)

MTHB:

126953256

MNI:	105482630(TPMT)

CSAB:

103222104(TPMT)

CATY:

105572584(TPMT)

PANU:

101018546(TPMT)

TGE:	112623523(TPMT)

MLEU:

105530175(TPMT)

RRO:	104653661(TPMT)

RBB:	108531021(TPMT)

TFN:	117086773(TPMT)

PTEH:

111541124(TPMT)

CANG:

105526679(TPMT)

CJC:	100393498(TPMT)

SBQ:	101043427(TPMT)

CIMI:

108299385(TPMT)

CSYR:

103258868(TPMT)

MMUR:

105865217(TPMT)

LCAT:

123638316(TPMT)

PCOQ:

105809456(TPMT) 105815211

OGA:	100967186(TPMT)

MMU:	22017(Tpmt)

MCAL:

110307964(Tpmt)

MPAH:

110334049(Tpmt)

RNO:	690050(Tpmt)

MCOC:

116082427(Tpmt)

ANU:	117714360(Tpmt)

MUN:	110549714(Tpmt)

CGE:	100767055(Tpmt)

MAUA:

101835820(Tpmt)

PROB:

127229274(Tpmt)

PLEU:

114692065(Tpmt)

MORG:

121434052(Tpmt) 121443252

MFOT:

126502529

AAMP:

119816405(Tpmt)

NGI:	103733006 103745166(Tpmt)

HGL:	101703237(Tpmt)

CPOC:

100722156(Tpmt)

CCAN:

109696860(Tpmt)

DORD:

105988652 105996366(Tpmt)

DSP:	122107017(Tpmt)

NCAR:

124988797

OCU:	100009411(TPMT)

OPI:	101516451(TPMT)

TUP:	102492405(TPMT)

GVR:	103587072(TPMT)

CFA:	403536(TPMT)

CLUD:

112657677(TPMT)

VVP:	112920517(TPMT)

VLG:	121499303(TPMT)

AML:	100480933(TPMT)

UMR:	103664879(TPMT)

UAH:	113264505(TPMT)

UAR:	123801564(TPMT)

ELK:

111156711

LLV:

125103044

MPUF:

101671446(TPMT)

NVS:	122913043(TPMT)

ORO:	101377517(TPMT)

EJU:	114212639(TPMT)

ZCA:	113926906(TPMT)

MLX:	117997447(TPMT)

NSU:	110586636(TPMT)

LWW:	102743966(TPMT)

FCA:	493759(TPMT)

PYU:	121020394(TPMT)

PBG:	122489195(TPMT)

LRUF:

124528976

PTG:	102956395(TPMT)

PPAD:

109249582(TPMT)

PUC:

125939531

AJU:	106989525(TPMT)

HHV:	120242670(TPMT)

BTA:	511644(TPMT)

BOM:	102267418(TPMT)

BIU:	109576982(TPMT)

BBUB:

102408385(TPMT)

BBIS:

104995077(TPMT)

CHX:	100860988(TPMT)

OAS:	101123418(TPMT)

ODA:	120869956(TPMT)

CCAD:

122429388(TPMT)

SSC:	100157630(TPMT)

CFR:	102513327(TPMT)

CBAI:

105084208(TPMT)

CDK:	105089112(TPMT)

VPC:	102544626(TPMT)

BACU:

103011724(TPMT)

LVE:	103089277(TPMT)

OOR:	101271523(TPMT)

DLE:	111181394(TPMT)

PCAD:

102979248(TPMT)

PSIU:

116761509(TPMT)

ECB:	100034066(TPMT)

EPZ:	103549165(TPMT)

EAI:	106841596(TPMT)

MYB:	102259230(TPMT)

MYD:	102770832(TPMT)

MMYO:

118675213(TPMT)

MLF:	102417017(TPMT)

MNA:	107531200(TPMT)

PKL:	118724851(TPMT)

HAI:	109375167(TPMT)

DRO:	112309266(TPMT)

SHON:

118981269(TPMT)

AJM:	119058700(TPMT)

PDIC:

114496719(TPMT)

PHAS:

123823993(TPMT)

MMF:	118626476(TPMT)

RFQ:	117027757(TPMT)

PALE:

102889393(TPMT)

PGIG:

120605579(TPMT)

PVP:	105293932(TPMT)

RAY:	107512649 107516277(TPMT)

MJV:	108403580(TPMT)

TOD:	119251671(TPMT)

SARA:

101558349(TPMT)

LAV:	100658033(TPMT)

TMU:

101354199

ETF:	101643853(TPMT)

DNM:	101413606(TPMT)

MDO:	100025242(TPMT)

GAS:	123240115(TPMT)

SHR:	100913479(TPMT)

AFZ:

127544135

PCW:	110208707(TPMT)

OAA:	100077195(TPMT)

GGA:	420830(TPMT)

PCOC:

116239997(TPMT)

MGP:	104910140(TPMT)

CJO:	107309711(TPMT)

NMEL:

110394727(TPMT)

APLA:

101797003(TPMT)

ACYG:

106041713(TPMT)

AFUL:

116485534(TPMT)

TGU:	100230777(TPMT)

LSR:	110483442(TPMT)

SCAN:

103819408(TPMT)

PMOA:

120503514(TPMT)

OTC:	121340479(TPMT)

PRUF:

121357749(TPMT)

GFR:	102033831(TPMT)

FAB:	101821511(TPMT)

PHI:	102100607(TPMT)

PMAJ:

107200979(TPMT)

CCAE:

111923751(TPMT)

CCW:	104691429(TPMT)

CBRC:

103613159(TPMT)

ETL:	114059461(TPMT)

ZAB:	102064288(TPMT)

ACHL:

103811363(TPMT)

SVG:	106854273(TPMT)

FPG:	101918207(TPMT)

FCH:	102050950(TPMT)

CLV:	102088741(TPMT)

EGZ:	104125483(TPMT)

NNI:	104021881(TPMT)

PLET:

104614562(TPMT)

PCRI:

104032627(TPMT)

PCAO:

104050639(TPMT)

ACUN:

113476986(TPMT)

TALA:

104360416(TPMT)

PADL:

103919050(TPMT)

AFOR:

103894358(TPMT)

ACHC:

115352968(TPMT)

HALD:

104318908(TPMT)

HLE:	104835271(TPMT)

AGEN:

126048776

GCL:

127013015

CCRI:

104166649

CSTI:

104554787(TPMT)

EHS:	104503427(TPMT)

CMAC:

104473400(TPMT)

MUI:	104544494(TPMT)

FGA:	104074687(TPMT)

GSTE:

104261804(TPMT)

LDI:	104340828(TPMT)

MNB:	103780694(TPMT)

OHA:	104333845(TPMT)

NNT:	104399851(TPMT)

SHAB:

115605958(TPMT)

DPUB:

104305704(TPMT)

PGUU:

104458448(TPMT)

ACAR:

104528313(TPMT)

CPEA:

104392860(TPMT)

AVIT:

104277839(TPMT)

CVF:	104295982(TPMT)

CUCA:

104062131(TPMT)

TEO:	104372011(TPMT)

BRHI:

104496690

AAM:	106483409(TPMT)

AROW:

112962940(TPMT)

NPD:	112953890(TPMT)

TGT:	104577832(TPMT)

DNE:	112990786(TPMT)

SCAM:

104153071(TPMT)

ASN:	102370323(TPMT)

AMJ:	102568993(TPMT)

CPOO:

109315893(TPMT)

GGN:	109301909(TPMT)

PSS:	102444217(TPMT)

CMY:	102931736(TPMT)

CPIC:

101938755(TPMT)

TST:	117873240(TPMT)

CABI:

116822827(TPMT)

MRV:	120399613(TPMT)

ACS:	100562746(tpmt)

PVT:	110081687(TPMT)

SUND:

121927933(TPMT)

PBI:	103053601(TPMT)

PMUR:

107286342(TPMT)

CTIG:

120298679(TPMT)

TSR:	106544362(TPMT)

PGUT:

117672524(TPMT)

PMUA:

114600863(TPMT)

ZVI:	118090522(TPMT)

GJA:	107107479(TPMT)

STOW:

125438944(TPMT)

XLA:	108704455 447769(tpmt.L)

XTR:	549164(tpmt)

NPR:	108789578(TPMT)

RTEM:

120940748 120940750

BBUF:

121001577(TPMT)

BGAR:

122937878(TPMT)

DRE:	436842(tpmt.1) 573111(tpmt.2)

SRX:	107706163(tpmt)

SANH:

107654730(tpmt) 107688424

SGH:

107591974

CCAR:

109068140 109071417

CAUA:

113062300 113119247

CGIB:

127935394 127978543

PPRM:

120470647 120470760

MAMB:

125275125

CIDE:

127501553

MASI:

127420637 127424969

IPU:	108257434(tpmt.1)

PHYP:

113535912(tpmt)

SMEO:

124375903

TFD:	113644013(tpmt.1)

AMEX:

103022146(tpmt)

EEE:	113591569(tpmt)

TRU:	101064328(tpmt)

LCO:	104931680(tpmt)

NCC:	104959325(tpmt)

CGOB:

115016187(tpmt)

ELY:

117263651

EFO:

125904486

PLEP:

121940400 121958039

SLUC:

116047240

ECRA:

117956794

ESP:	116701188(tpmt)

PFLV:

114567816(tpmt)

GAT:

120826327

PPUG:

119218883

MSAM:

119907875

CUD:	121524171 121524563

ALAT:

119017229

MZE:	101486771(tpmt) 106674475

ONL:	100707189 100707454

OAU:	116318911 116318912

OLA:	101168968(tpmt)

OML:

112162630

XMA:	102219778(tpmt)

XHE:	116730628(tpmt)

PRET:

103473038(tpmt)

PFOR:

103143498(tpmt)

PLAI:

106957534(tpmt)

PMEI:

106927634(tpmt)

GAF:

122844266

CVG:	107102011(tpmt)

CTUL:

119778630

GMU:

124879902

NFU:	107394967(tpmt)

KMR:

108250170

ALIM:

106536398(tpmt)

NWH:

119425327

AOCE:

111582489(tpmt)

MCEP:

125019587

CSEM:

103393993(tpmt)

POV:	109639990(tpmt)

SSEN:

122786075

HHIP:

117770093

HSP:

118124561

LCF:

108889567

SDU:	111223374(tpmt)

SLAL:

111671816(tpmt)

XGL:

120786593

HCQ:	109518056(tpmt)

SSCV:

125986800

BPEC:

110153762 110173329

MALB:

109958687(tpmt)

BSPL:

114866306

SASA:

100196246(tpmt) 106570045

STRU:

115175993

OTW:

112229927

OMY:

110489313

OGO:

124042821

ONE:	115132758(tpmt)

SALP:

111955315(tpmt)

SNH:

120027360

CCLU:

121571480 121571481

ELS:	105012761(tpmt)

SFM:	108921991(tpmt)

PKI:	111843854(tpmt)

AANG:

118234581

LOC:	102690483(tpmt)

PSPA:

121314816

ARUT:

117394941

PSEX:

120515962

LCM:	102365205(TPMT)

CMK:	103184899(tpmt)

RTP:	109910682 109910683

BFO:	118410211 118410212 118410249 118410447 118432699

BBEL:

109468965 109482630 109485962

CIN:	100181136 100185586

SCLV:

120325471 120325513 120336567 120341498 120341527 120344512 120345631 120345635 120345905 120346479 120346892

SPU:	100892034 100893811 105444398 582278 590906 753964 754275

APLC:

110978641 110978643 110978708 110978778 110979813

AJC:

117122452

SKO:	100369695 100375429 102808967 102809337

BCOO:

119075689 119080397

FCD:

110844198

DPX:	DAPPUDRAFT_225254 DAPPUDRAFT_304984 DAPPUDRAFT_319878

DMK:

116918060

DPZ:

124314475

PVM:	113804456 113828399

PJA:	122255670 122255676 122256334 122267631

PCHN:

125036160 125036161 125046039 125046246

PMOO:

119590807

HAME:

121871217 121876234

PCLA:

123764495 123771898

PTRU:

123504271 123504289 123504783

HAZT:

108668889 108682732 108682733

EAF:	111709176 111709303

PPOI:

119093195 119098074 119106532

ISC:	IscW_ISCW009603

DSV:	119437328 119441015 119458377 119459100 119466516

RSAN:

119372214 119374327 119386511 119395858 119396004 119397319 119400542

RMP:	119163124 119168102 119173438 119177780 119179867

TUT:

107368104

CSCU:

111641984 111641986

HRO:	HELRODRAFT_185947

LGI:	LOTGIDRAFT_112328 LOTGIDRAFT_166471 LOTGIDRAFT_223159 LOTGIDRAFT_67729

PCAN:

112573593

BGT:	106060592 106077621

GAE:	121374059 121374481 121375833 121376009 121376140

HRF:	124141499 124141542 124141591 124142181 124143181

HRJ:	124275397 124275399 124275400 124275401 124275402 124275403 124275404 124275405 124292306

CRG:	105335515 105341993 105343239 105343241 117684753

MYI:	110441108 110442842 110445542 110445543

PMAX:

117320154 117325055 117326038 117334184 117334682 117339085 117339086 117340104 117340105

MCAF:

127730679

MMER:

123524685 123524686 123525422

DPOL:

127850133 127850202 127855585 127864084 127874304 127874321

OBI:	106874096 106874826 106874827

OSN:	115212383 115212408

LAK:	106157649 106157650 106157652 106157653 106157654 106157665 106157695 106157696 106157697

OVI:	T265_11545

NVE:	5507125 5507136 5520239 5520857

EPA:	110240010 110247266 110247279

ATEN:

116288372 116304075 116304076 116308911

ADF:	107336759 107336760 107356482

AMIL:

114948851 114953601 114953602 114977728 114977738

PDAM:

113664623 113671393 113682887 113684462 113685520

SPIS:

111324775 111343284 111345253 111347609

DGT:

114521460

XEN:	124446704 124446705

HMG:	101234527 105848790 105848791

TAD:	TRIADDRAFT_53840 TRIADDRAFT_58744 TRIADDRAFT_58745 TRIADDRAFT_58746 TRIADDRAFT_60799 TRIADDRAFT_60801 TRIADDRAFT_60802

AQU:	100632142 100639349 105316917

MIS:	MICPUN_107894

YLI:	YALI0E05467g

SMIN:

v1.2.029745.t1(symbB.v1.2.029745.t1)

FCY:	FRACYDRAFT_179170

AAF:	AURANDRAFT_34650

EHX:	EMIHUDRAFT_233559 EMIHUDRAFT_254305 EMIHUDRAFT_95720

XCC:	XCC1394(tpmT)

XCB:

XC_2843

XCA:	xcc-b100_2903

XCP:

XCR_1663

XCV:	XCV1496(tpmT)

XAX:	XACM_1427(tpmT)

XAC:	XAC1439(tpmT)

XCI:	XCAW_02904(smtA)

XCT:	J151_01586

XCJ:	J158_01582

XCU:	J159_01582

XCN:	J169_01582

XCW:	J162_01582

XCR:	J163_01582

XCM:	J164_01582

XCF:	J172_01577

XFU:	XFF4834R_chr30580

XAO:	XAC29_07265

XOO:	XOO1995(tpmT)

XVE:	BJD12_20615

XPE:	BJD13_09370

XHR:	XJ27_07810

XGA:	BI317_08430

XVA:	C7V42_07825

XAR:	XB05_02190

XEU:	XSP_001474

XHD:	LMG31886_28710(tpm)

XPR:	MUG10_02490

SACZ:

AOT14_24700(tpmT)

STEK:

AXG53_03160

PSU:	Psesu_0920

PSUW:

WQ53_12875

PSD:

DSC_11105

PMEX:

H4W19_07705

PJP:	LAG73_04120

PDD:	MNQ95_11440

LMB:	C9I47_1133

LYT:	DWG18_06900

LYJ:	FKV23_11385

LSOL:

GOY17_06175

LSX:	H8B22_12360

LHX:	LYSHEL_21460(tpm)

LCAS:

LYSCAS_21470(tpm)

LCIC:

INQ41_09260

LAVI:

INQ42_08735

LLZ:	LYB30171_01723(tpm)

LUM:	CNR27_07165

LUG:	FPZ22_01545

THES:

FHQ07_13210

THEH:

G7079_05740

TCN:	H9L16_15955

TBV:	H9L17_03625

RHD:	R2APBS1_0442

RGL:	CS053_09690

RTH:	LRK53_17595

DTX:	ATSB10_34800

VCH:

VC_1226

VCF:	IR04_11450

VCS:

MS6_1011

VCE:	Vch1786_I0733

VCQ:	EN18_09440

VCJ:	VCD_003121

VCI:

O3Y_05715

VCO:	VC0395_A0849

VCR:	VC395_1345

VCM:	VCM66_1181

VCL:	VCLMA_A1074

VCX:	VAA049_2516(tmpT)

VCZ:	VAB027_1907(tmpT)

VVU:

VV1_2377

VVY:

VV1964

VVM:	VVMO6_01257

VVL:	VV93_v1c17240

VPA:

VP1296

VPB:

VPBB_1220

VPK:	M636_15325

VPF:	M634_08390

VPH:	VPUCM_1922

VHA:	VIBHAR_02114

VCA:	M892_02730

VAG:

N646_0333

VEX:	VEA_003701

VDB:	AL552_14715

VHR:	AL538_02005

VNA:	PN96_07115

VOW:	A9237_01380

VRO:	BSZ04_14370

VSP:

VS_1718

VEJ:	VEJY3_06250

VFU:	vfu_A02132

VNI:	VIBNI_A1413

VAN:

VAA_03104

LAG:	N175_07045

VAU:	VANGNB10_cI1545c(tpm)

VCY:	IX92_06225

VCT:	JV59_32475

VTU:	IX91_06835

VEU:	IXK98_15270

VSI:	MTO69_07450

VFL:	AL536_14380

VMI:	AL543_15455

VSC:	VSVS12_01591(tpmT)

VGA:	BSQ33_02385

VSH:	BSZ05_15315

VQI:	CCZ37_05310

VTA:	A0742(tpm)

VAF:	D1115_08130

VNL:	D3H41_06440

VCC:	FAZ90_08515

VAS:	GT360_07630

VAQ:	FIV01_06665(tpm)

VSR:	Vspart_02021(tpm)

VKA:	BTD91_12880

VZI:	G5S32_05985

VNV:	IF132_08830

VGI:	MID13_06730

VSL:	LTQ54_01810

VPL:	SA104470976_00977(tpm)

VJP:	NP165_07235

VPG:	LZI70_13390

VOS:	KNV97_11915

VTI:	CEQ48_12635

VCRA:

IS519_03370

VFI:	VF_1512(tpm)

VFM:	VFMJ11_1605

VSA:	VSAL_I1814

AWD:	AWOD_I_1601(tpm)

PPR:	PBPRA1684(PA2832)

PGB:	H744_2c1912

PDS:	CAY62_06895

PGH:	FH974_08185

GHO:	AL542_16270

SALY:

E8E00_06240

SKS:	FCN78_07140

SCOT:

HBA18_07455

SPRO:

N7E60_07600

PAE:	PA2832(tpm)

PAEV:

N297_2934(tmpT)

PAEI:

N296_2934(tmpT)

PAU:	PA14_27460(tpm)

PAP:	PSPA7_2323(tpm)

PAG:	PLES_22331(tpm)

PAF:	PAM18_2131(tpm)

PNC:	NCGM2_3937(tpm)

PAEB:

NCGM1900_3484(tpm)

PDK:	PADK2_10215

PSG:	G655_10645

PRP:	M062_15185

PAER:

PA1R_gp0663

PAEM:

U769_10795

PAEL:

T223_11265

PAES:

SCV20265_2278

PAEU:

BN889_03159(tpm)

PAEG:

AI22_22615

PAEC:

M802_2931(tmpT)

PAEO:

M801_2799(tmpT)

PMY:

Pmen_2525

PMK:

MDS_2238

PRE:	PCA10_33430(tpm)

PPSE:

BN5_2198(tpm)

PFUW:

KF707C_23530

PALC:

A0T30_03610

PCQ:	PcP3B5_20630(tpm)

PMUI:

G4G71_19365

PNT:	G5B91_21355

PPAA:

B7D75_10975

PPU:	PP_1870(tpm)

PPF:

Pput_3845

PPG:	PputGB1_1445

PPW:	PputW619_1479

PPT:

PPS_1507

PPB:	PPUBIRD1_3745

PPI:

YSA_02015

PPX:

T1E_0503

PPUH:

B479_07285

PPUT:

L483_06865

PPUN:

PP4_39140(tpm)

PPUD:

DW66_1794

PFV:	Psefu_2696

PMON:

X969_05490

PMOT:

X970_05465

PMOS:

O165_003085

PPJ:	RK21_03523

PMOL:

CLJ08_05095

PST:	PSPTO_1777(tpm)

PSB:

Psyr_3617

PAVL:

BKM03_20855

PVD:	CFBP1590__1652(tpm)

PAST:

N015_19105

PFL:	PFL_4249(tpm)

PPRC:

PFLCHA0_c43130(tpm)

PPRO:

PPC_4348(tpm)

PFE:	PSF113_1708

PFN:	HZ99_27470

PFO:	Pfl01_3985(tpm)

PFS:	PFLU_1728(tpm)

PFC:	PflA506_1775(tpm)

PPZ:	H045_05015

PFB:

VO64_4841

PMAN:

OU5_1537(tpm)

PTV:	AA957_05480

PCG:	AXG94_24090

PVR:	PverR02_08930

PAZO:

AYR47_15820

POI:	BOP93_08200

PRX:	HRH33_09525

PMED:

E3Z27_08685

PFW:	PF1751_v1c16970(tpm)

PFF:	PFLUOLIPICF728310

PFX:	A7318_07670

PEN:	PSEEN1581(tpm)

PLUL:

FOB45_16785

PBA:	PSEBR_a1627

PBC:	CD58_09040

PPUU:

PputUW4_01439

PDR:	H681_15630

PSV:	PVLB_06965

PSK:	U771_09715

PKC:	PKB_3647(tpm)

PCH:	EY04_21475

PCZ:	PCL1606_19270

PCP:	JM49_09725

PFZ:	AV641_06885

PLQ:	AA042_03220

PALK:

PSAKL28_14580

PSW:	LK03_21185

PPV:	NJ69_03565

PSES:

PSCI_0320(tpm)

PSEM:

TO66_22265

PSEC:

CCOS191_3800(tpm)

PPSY:

AOC04_03595

PSOS:

POS17_4325(tpm)

PKR:	AYO71_21740

PFK:	PFAS1_03115

PANR:

A7J50_1878

PSET:

THL1_2319

PSIL:

PMA3_07055

PYM:	AK972_4094

PKE:	DLD99_20020

PALL:

UYA_13270

PUM:	HGP31_23430

POJ:	PtoMrB4_32300(tpm)

PGG:	FX982_00076

PPSH:

G5J76_10260

PGY:	AWU82_23950

PLAL:

FXN65_16850

PSEJ:

HNQ25_12120

PVK:	EPZ47_08825

PEZ:	HWQ56_20965

PBZ:	GN234_09595

PTY:	JWV26_23160

PMAO:

PMYSY11_2753(tpm)

PATA:

JWU58_08930

PDW:

BV82_4095

PZE:	HU754_021170

PMOE:

HV782_020370

PSEP:

C4K39_6169

PVW:	HU752_024030

PTRT:

HU722_0009590

PXA:	KSS93_10880

PSAM:

HU731_024590

PTZ:	HU718_021525

PQI:	KH389_19490

PSHH:

HU773_010265

PXN:	HU772_007315

PHV:	HU739_020575

PPRG:

HU725_006715

PANH:

HU763_007500

PASG:

KSS96_09125

PFAK:

KSS94_07525

PMUY:

KSS95_10205

PMAM:

KSS90_18740

PAZE:

KSS91_08125

PALV:

KSS97_20365

PPHA:

BVH74_17165

PORY:

EJA05_07925

PWZ:	J7655_11750

PTK:	EXN22_19985

PTW:	TUM18999_37170(tpm)

PZA:	HU749_009740

PIE:	HU724_019995

PWY:	HU734_018390

PTAE:

NCTC10697_01302(tpm)

PGF:	J0G10_21395

PJU:	L1P09_18695

PHF:	NLY38_10370

PPHN:

HU825_17685

PIZ:	LAB08_R43340

PPEG:

KUA23_08990

PSII:

NF676_18960

PSIH:

LOY51_07815

PCAS:

LOY40_20135

PASI:

LG197_12465

PSA:	PST_1312(tpmA) PST_2541

PSZ:	PSTAB_2521

PSR:	PSTAA_2650

PSC:	A458_13475

PSJ:	PSJM300_06065

PSH:	Psest_1768

PSTU:

UIB01_08325

PSTT:

CH92_14045

PSED:

DM292_06040

PCHL:

LLJ08_07875

PBM:	CL52_12290

PKG:	LW136_14335

SDEG:

GOM96_04690

AVN:	Avin_15380

AVL:	AvCA_15380

AVD:	AvCA6_15380

ACX:	Achr_27400 Achr_5960(tpmA)

PBB:	AKN87_10940

PAGR:

E2H98_03860

HPEG:

EAO82_08245

HAES:

LO767_04640

HARR:

HV822_02890

DCE:	O6P33_09685

PBAU:

OS670_06350

MAQ:

Maqu_3055

MHC:	MARHY2994(tpm)

MAD:	HP15_2932(tpm)

MBS:	MRBBS_3116(tpm)

MSR:	AU15_11950

MPQ:	ABA45_14775

MARI:

ACP86_04895

MLQ:	ASQ50_06505

MSQ:	BKP64_00190

MARA:

D0851_07995(tmpT)

MARJ:

MARI_00940(tpm)

MALL:

PBN92_15360(tmpT)

PCR:	Pcryo_1333 Pcryo_2244

PRW:	PsycPRwf_0288

PSO:	PSYCG_07000 PSYCG_12115

PUR:	AOC03_01465 AOC03_05260

PALI:

A3K91_2494

PSPG:

AK823_12310

PSYG:

AK825_12760

PSYC:

DABAL43B_1152(tpm1) DABAL43B_2557

PSYA:

AOT82_2113

PSYY:

DLE54_01435

PSYP:

E5677_00955(tmpT)

PKY:	PKHYL_36900(tpm_2)

ACI:	ACIAD2922(tpm)

AHL:	AHTJS_03980

AJN:	BVL33_13635

ASOL:

BEN76_00455

ALA:	BFG52_04230

AUG:

URS_1913

AVZ:	HWI77_03955(tmpT)

SON:	SO_0582(tpmT)

SDN:

Sden_0541

SFR:

Sfri_3498

SAZ:

Sama_0543

SBL:

Sbal_0541

SBM:	Shew185_3784

SBN:	Sbal195_3910

SBP:	Sbal223_3727

SBT:	Sbal678_3940

SBS:	Sbal117_0643

SBB:	Sbal175_3705

SLO:

Shew_3261

SPC:	Sputcn32_3296

SHP:	Sput200_3423

SSE:

Ssed_4010

SPL:

Spea_0588

SHE:	Shewmr4_0581

SHM:	Shewmr7_3449

SHN:	Shewana3_0580

SHW:	Sputw3181_0645

SHL:

Shal_0675

SWD:	Swoo_3438 Swoo_4153

SWP:

swp_4515

SVO:	SVI_3702(tpm)

SHF:	CEQ32_13210

SJA:	SJ2017_0675

SPSW:

Sps_02915

SBJ:	CF168_17945

SMAV:

CFF01_16065

SHEW:

CKQ84_04635

SALG:

BS332_11180

SLJ:	EGC82_19370

SMAI:

EXU30_07010

SPOL:

FH971_17680

SBK:	SHEWBE_4389(tpm)

SKH:	STH12_00081(tpm)

SAES:

HBH39_15410

SLIT:

JQC75_02545

SCAA:

TUM17387_32510(tpm)

SPSH:

FM037_24055

SEUR:

FM038_003255

SCYP:

JYB88_15685

SAVI:

JYB87_02440

SSEM:

JYB85_16175

SGLA:

FJ709_02620

SINV:

K8B83_05270

SXM:	MKD32_18100

SVM:	KDH10_003634

SHEJ:

MZ182_17510

SSEH:

N7V09_20605

SCHK:

GII14_18675

IPI:	CEW91_11585(tmpT)

IDI:	CWC33_04740(tmpT)

IDT:	C5610_00575(tmpT)

IAB:	K5X84_00805(tmpT)

CPS:

CPS_3096

COLW:

A3Q33_15890

COLA:

DBO93_11350

CBER:

B5D82_16120

THT:	E2K93_01995

THAP:

FNC98_10050

THAB:

LP316_09815

THAT:

H3N35_09655

TACT:

SG35_009965

TVD:	SG34_019275

PAT:

Patl_1524

PDJ:	D0907_18190(tmpT)

PXI:	J5O05_12105(tmpT)

AMC:	MADE_1006970

AMH:	I633_07450

AMAA:

amad1_07430

AMAL:

I607_06655

AMAE:

I876_06945

AMAO:

I634_07065

AMAD:

I636_07510

AMAI:

I635_07415

AMAG:

I533_06975

AMAC:

MASE_06545

AMB:	AMBAS45_06840

AMG:	AMEC673_06600

AMK:	AMBLS11_06590

ALT:	ambt_11580

AAL:	EP13_07340

AAUS:

EP12_07440

ASP:	AOR13_2105

ASQ:	AVL57_09235

AAW:	AVL56_08125

ALR:	DS731_03875(tmpT)

ALE:	AV939_08250

ALZ:	AV940_08070

APEL:

CA267_005765(tmpT)

SALM:

D0Y50_02820(tmpT)

SALK:

FBQ74_14325(tmpT)

SMAA:

IT774_14140(tmpT)

GAG:	Glaag_2807

GNI:	GNIT_3613(tpmT)

PMES:

FX988_01111

LAL:	AT746_11230

AGQ:	LQZ07_10975(tmpT)

ALKM:

NKI27_15585(tmpT)

ASEM:

NNL22_11985(tmpT)

PSY:	PCNPT3_07620

FBL:

Fbal_3334

FES:	HER31_03150(tmpT)

MVS:	MVIS_2157(tpm)

TTU:	TERTU_2055

SAGA:

M5M_09720

SNAN:

I6N98_18275(tmpT)

ZAL:	AZF00_17470

MTHD:

A3224_12340

MICC:

AUP74_02666(tpm)

MAGA:

Mag101_09120

MII:	BTJ40_07325(tmpT)

MICT:

FIU95_14390(tpm)

MHYD:

GTQ55_09590(tmpT)

MCEL:

LPW13_06590(tmpT)

MICZ:

GL2_27760(tpm)

MVB:	MJO52_06835(tmpT)

HJA:	BST95_12560

HALC:

EY643_09930

KIM:	G3T16_06690(tmpT)

LPN:	lpg2835(tpm)

LPH:	LPV_3190(tpm)

LPO:	LPO_3131(tpm)

LPU:	LPE509_00193

LPM:	LP6_2864(tpm)

LPF:

lpl2747

LPP:

lpp2892

LPC:	LPC_3119(tpm)

LPA:

lpa_04116

LPE:

lp12_2825

LFA:	LFA_3565(tpm)

LHA:	LHA_3084(tpm)

LOK:

Loa_01360

LSH:	CAB17_12615(tmpT)

LLG:	44548918_02584(tpm)

LJR:	NCTC11533_02734(tpm)

LWA:	SAMEA4504053_3364(tpm)

LSS:	NCTC12082_00344(tpm)

LADL:

NCTC12735_00471(tpm)

LANT:

TUM19329_33570(tpm)

LCAD:

PXX05_14400

MCA:

MCA0794

METU:

GNH96_04550

MMT:	Metme_3860

MDN:	JT25_002700 JT25_018650 JT25_022470

MDH:	AYM39_00230

MKO:	MKLM6_0082

METL:

U737_11165

MPAD:

KEF85_04950 KEF85_14105

MELL:

IVG45_02225 IVG45_09070

MRP:	NM686_017490

MAH:	MEALZ_0176(tpm)

MBUR:

EQU24_00980

MPSY:

CEK71_14105(tmpT) CEK71_14550

MMOB:

F6R98_08265(tmpT) F6R98_18660

MEIN:

methR_P3434

MISZ:

MishRS11D_05430(tpm)

MESL:

KKZ03_08275 KKZ03_14055

FTU:	FTT_1661(tmpT)

FTQ:

RO31_1958

FTF:	FTF1661(tmpT)

FTW:

FTW_1959

FTR:	NE061598_09350

FTT:	FTV_1581(tmpT)

FTG:	FTU_1666(tmpT)

FTL:

FTL_0032

FTH:	FTH_0031(tpmT)

FTA:

FTA_0039

FTS:

F92_00190

FTI:	FTS_0030(tmpT)

FTO:	X557_00195

FTC:

DA46_705

FTV:

CH67_288

FTZ:

CH68_25

FTM:	FTM_0011(tmpT)

FTN:	FTN_0023(tmpT)

FTX:

AW25_179

FTD:

AS84_674

FTY:

CH70_89

FCF:	FNFX1_0030

FCN:	FN3523_0024

FHI:	FSC454_00085

FPH:

Fphi_0803

FPT:

BZ13_1242

FPI:

BF30_1016

FPM:

LA56_1382

FPX:

KU46_539

FPZ:

LA55_16

FPJ:

LA02_485

FRT:	F7308_0025

FRF:	LO80_05915

FHA:	CDV26_00520

FRX:	F7310_00160

FAD:	CDH04_01420

FMI:	F0R74_08535

FNN:	FSC774_09500

FSR:	KQR59_00080

TCX:

Tcr_1758

HTR:	EPV75_09425(tmpT)

HMAR:

HVMH_0490(tpm)

THIO:

AYJ59_04510

CYQ:	Q91_0223(tpm)

CZA:	CYCME_2449(tmpT)

CYY:	CPC19_00275

THIG:

FE785_09235

TXA:	HQN79_09835

TIB:	THMIRHAM_18400(tpm)

TSE:	THMIRHAS_05470(tpm)

TZO:	THMIRHAT_18920(tpm)

BLEP:

AL038_02490

THIS:

HZT40_18360

TUN:	J9260_16540

TLO:	J9253_17080

TSB:	HMY34_10770

TANI:

J8380_04290

TWN:	L2Y54_05165

ALV:	Alvin_1548

TVI:	Thivi_3116 Thivi_3120

TMB:	Thimo_0851

TSY:	THSYN_06280

RHH:	E0Z06_04900(tmpT)

THIP:

N838_31640

THIM:

KFB96_22995(tmpT)

TBOG:

LT988_06145(tmpT) LT988_06215

APRS:

BI364_03555

WMA:	WM2015_1683

WOC:	BA177_02860

GAI:	IMCC3135_31820(tpm)

TTC:	FOKN1_1779

THIC:

TspCOW1_08740(tpm)

HCH:

HCH_01328

HAHE:

ENC22_23830(tmpT)

CSA:

Csal_2332

HEL:	HELO_3387(tpm)

HCS:	FF32_11965

HAK:	KO116_01714

HAM:

HALO1824

HHU:	AR456_05395

HCO:	LOKO_00889(tpm)

HSI:	BOX17_02900

HALO:

BWR19_13085

HHH:	CLM76_12520

HBE:

BEI_0869

HAG:	BB497_09270

HAF:	C8233_08045(tmpT)

HALK:

CUU95_00170

HVN:	EI420_06365

HOL:	HORIV_44590(tpm)

HSR:	HSBAA_42610 HSBAA_42620

HMD:	CTT34_06340

HAXI:

HAALTHF_45950n

HTT:	HZS52_13570

HCAM:

I4484_14575

HPIZ:

GYM47_06055

HSX:	HNO51_14305

HSV:	HNO53_14990

HTX:	EKK97_16190

HPRO:

LMS44_14580

HQD:	K1Y77_05630

HBH:	E4T21_05260

HAA:	A5892_14075

CMAI:

BFX80_14085

CAMH:

LCW13_03150(tmpT)

COBE:

CLAM6_06150(tpm)

KUS:	B9G99_00405

KMA:	B9H00_14860

KUY:	FY550_10480

PAUR:

FGL86_15945

ADI:

B5T_04328

APAC:

S7S_00765

MMW:	Mmwyl1_1365

MME:	Marme_1231

MPC:	Mar181_2438

MPRI:

MP3633_2683

MARD:

IBG28_05640

MFOI:

JSY38_04155(tmpT)

MPRF:

J8N69_13375(tmpT)

MRHI:

KDW99_05945

TOL:

TOL_0889

TOR:	R615_12920

TWAN:

HUF19_05150(tmpT)

OAI:	OLEAN_C26930

MSEC:

LN244_15085(tmpT)

MARL:

HH196_07175

BSAN:

CHH28_10900(tmpT)

NCU:	F0U83_15575

NIK:	F5I99_09585

BMAR:

HF888_04660(tmpT)

VCW:	GJQ55_03500(tmpT)

BACZ:

KFF03_11795(tmpT)

OME:	OLMES_1674

ENW:	MJO57_09815

AHA:	AHA_1996(tpm)

AHY:	AHML_12925

AHD:	AI20_07210

AHR:	V428_13355

AHP:	V429_13375

AHJ:	V469_09730

AHH:	RY45_12690

AHI:	VU14_09605

AAJ:	BOQ57_12510

ASA:	ASA_1874(tpm)

AEO:	O23A_p1164

AVR:

B565_2233

AVO:	AMS64_10925

AMED:

B224_2594

ASR:	WL1483_3062(tpm)

ADH:	CK627_13845

AEM:	CK911_08200

AEA:	C2U39_09740

ARV:	C7N77_15355

AES:	C2U30_04005

AEL:	NCTC12917_01885(tpm)

ASIM:

FE240_08945

AALL:

I6G90_03885

AJD:	I6H43_20260

ARIV:

KYK33_10455

ASAA:

KXJ75_10710

AEJ:	E5E97_17455

ABES:

IU367_12290

TAU:

Tola_1476

OCE:

GU3_11585

OCM:	CBP12_02455

OPF:	CBP31_01180

ZDF:	AN401_09865

KKO:

Kkor_0779

KGE:

TQ33_0627

KSD:	KS2013_1666 KS2013_661

KPD:	CW740_03540(tmpT)

SDF:	ACG33_12060

ACII:

C4901_04120

ATY:	A9R16_012345

SALN:

SALB1_2623

TBN:

TBH_C0502

SEDS:

AAY24_06875

TSN:	W908_06040

THIN:

CRN91_04295

THO:	SP60_06950

REV:	HUE57_01480

REO:	HUE58_03370

EPS:	L0Y14_07715

EBH:	BSEPE_0462(tpmT)

BTHG:

MS2017_0690

GPB:	HDN1F_05740(tpm)

IFO:	CVFO_1000(tpmT)

NBA:	CUN60_08330(tmpT)

AQL:	BXU06_04130

PLG:	NCTC10937_03926(tpm)

BPE:	BP0873(tpm)

BPC:	BPTD_0870(tpm)

BPER:

BN118_1454(tpm)

BPET:

B1917_2951(tpm)

BPEU:

Q425_8080(tpm)

BPAR:

BN117_1319(tpm)

BPA:	BPP2160(tpm)

BBH:	BN112_1899(tpm)

BBR:	BB1557(tpm)

BBM:	BN115_1511(tpm)

BBX:	BBS798_1516(tpm)

BPT:	Bpet3841(tpm)

BAV:	BAV1018(tpm)

BHZ:	ACR54_01734(tpm)

BTRM:

SAMEA390648702476(tpm)

BBRO:

BAU06_18865

BPDZ:

BBN53_13135

BOH:	AKI39_18075

BGM:	CAL15_17285

AXY:	AXYL_04870(tpm)

AXO:	NH44784_036511

AXN:	AX27061_4708

AXX:	ERS451415_04742(tpm)

ADT:	APT56_21750

AIS:	BUW96_13340

ASW:	CVS48_14110

ACHR:

C2U31_27420

ACHB:

DVB37_20375

ADY:	HLG70_29255

ACHO:

H4P35_19730

AMUI:

PE062_16400

PUT:

PT7_3609

PUS:	CKA81_10290

CDN:	BN940_17261

PARK:

LSG25_11340

COF:	FOZ74_15760

HSE:	Hsero_3797(tpm)

HSZ:	ACP92_18945

HHT:	F506_17995

HRB:	Hrubri_3767(tpm)

HEE:	hmeg3_07440

HHF:	E2K99_19430

HFR:	G5S34_20735

CFU:	CFU_0019(tmp)

CPRA:

CPter91_0017(tmpT)

MASS:

CR152_23540(tmpT)

MANC:

IV454_23630(tmpT)

NET:

Neut_2272

NII:	Nit79A3_0664 Nit79A3_1504

NCO:	AAW31_00745 AAW31_14325

NUR:	ATY38_08895

NST:	Nstercoris_01363

NMU:	Nmul_A2259

NLC:	EBAPG3_010675

NIZ:	NNRS527_00740

MMB:

Mmol_2155

MEH:

M301_0221

MEI:	Msip34_1933

MEP:

MPQ_1948

MEU:	ACJ67_01085

SLT:

Slit_1144

FAM:	OYT1_ch0551

NIM:	W01_01380(tpm_1) W01_22400(tpm_2)

NARC:

NTG6680_2023(tpm) NTG6680_2738(tpm)

SEME:

MIZ01_0746

SNIV:

SFSGTM_09190(tpm)

RBU:	PG1C_08195

ABRE:

pbN1_18850(tpm)

APET:

ToN1_26960(tpm)

DAR:

Daro_0514

DEY:	HYN24_06640

DDEN:

KI615_08410

QAU:	KI612_04760

FLE:	KI610_08675

AZA:	AZKH_p0637(tpmT)

AZI:	AzCIB_0135

AZD:	CDA09_00790

AZR:	CJ010_17790

HOE:	IMCC20628_01989

XAU:

Xaut_2726

XDI:	EZH22_14855(tmpT)

SNO:

Snov_2584

ANC:	GBB76_07635(tmpT)

APRA:

G3A50_04405(tmpT)

APOL:

K9D25_12110(tmpT)

MLG:	CWB41_14285(tmpT)

HDN:

Hden_3185

HDT:	HYPDE_39108

HMC:	HYPMC_4429(tpm)

HNI:	W911_05405

FIL:	BN1229_v1_0793(tpm)

FIY:	BN1229_v1_0797(tpm)

CMET:

K6K41_26130

LMD:	METH_09945

LEJ:	ETW24_09145(tmpT)

LAQU:

R2C4_08070(tmpT)

LEV:	ETW23_09000(tmpT)

LCAE:

K3721_09120(tmpT)

RMM:	ROSMUCSMR3_02080(tpm)

ROK:	RAK1035_1106

SECH:

B18_27115

GOX:

GOX0680

GOY:	GLS_c07670(tpm)

GAL:	A0U94_00825

GSP:	IGS75_04020(tmpT)

GXY:

GLX_02300

GXL:

H845_1382

KNA:	B0W47_01495

KEU:	S101446_00516(tpmT)

KSC:	CD178_02887(tpm)

KRE:	GWK63_05930(tmpT)

APT:	APA01_14450

APF:	APA03_14450

APU:	APA07_14450

APG:	APA12_14450

APQ:	APA22_14450

APX:	APA26_14450

APZ:	APA32_14450

APK:	APA386B_305

ASZ:

ASN_3383

ASV:	WG31_07610

APOM:

CPF11_12940(tmpT)

ATO:	CIW82_14540(tmpT)

AASC:

A4S02_05260

ACET:

DS739_07490(tmpT)

AOT:	AcetOri_orf00696

AOY:	EOV40_006665(tmpT)

KHA:	IFJ82_09020(tmpT)

TMO:

TMO_c0547

MGM:

Mmc1_0515

ATX:	GCD22_02889(tpm)

ACIY:

MQE22_09095

HTL:	HPTL_2018(tpm)

SMAS:

HUE87_03230(tmpT)

ARC:

ABLL_0111

PACO:

AACT_0099

ALK:

ALEK_0067

DVE:	DESUT3_32810(tpm)

DES:	DSOUD_0775

VIN:	AKJ08_3128

CCRO:

CMC5_083250

SAMY:

DB32_002974

LLU:	AKJ09_02692

HOH:

Hoch_2473

BMX:	BMS_1763(tpm)

HAX:	BALOs_1523

BSTO:

C0V70_08780

PARH:

I5S86_08220

MVQ:	MYVA_2215(tpm)

JME:	EEW87_006365

APRE:

CNX65_10945

AMI:

Amir_2144

SSYI:

EKG83_29050

ACTN:

L083_4157

HHG:	XM38_044710(tpm)

CEP:	Cri9333_0690

HAU:

Haur_3057

UAM:	UABAM_03772

LBJ:

LBJ_0800

LAJ:	A0128_13055

LMAY:

DPV73_10090(tmpT)

LWL:	FHG68_04840(tmpT)

LKB:	LPTSP3_g03900(tpm)

SCOR:

J3U87_17540(tmpT)

SLI:

Slin_6497

SRD:	SD10_03260

SPIB:

G8759_11010

STAE:

HNV11_18095

RUP:	DTQ70_29090

CPRV:

CYPRO_0302

NDE:	NIDE2804(tpm)

NMV:	NITMOv2_1719(tpm)

NJA:	NSJP_3684(tpm)

NKF:	Nkreftii_000930

NIF:	W02_09200(tpm)

» show all

Reference

1 [PMID:13981612]

Authors

REMY CN.

Title

Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues.

Journal

J Biol Chem 238:1078-84 (1963)

Reference

2 [PMID:6633508]

Authors

Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM.

Title

Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.

Journal

Mol Pharmacol 24:471-8 (1983)

Reference

3 [PMID:6838629]

Authors

Woodson LC, Weinshilboum RM.

Title

Human kidney thiopurine methyltransferase. Purification and biochemical properties.

Journal

Biochem Pharmacol 32:819-26 (1983)
DOI:10.1016/0006-2952(83)90582-8

Other DBs

ExplorEnz - The Enzyme Database:

2.1.1.67

IUBMB Enzyme Nomenclature:

2.1.1.67

ExPASy - ENZYME nomenclature database:

2.1.1.67

BRENDA, the Enzyme Database:

2.1.1.67

CAS:	67339-09-7

DBGET integrated database retrieval system