KEGG   ENZYME: 2.1.1.67
Entry
EC 2.1.1.67                 Enzyme                                 
Name
thiopurine S-methyltransferase;
mercaptopurine methyltransferase;
thiopurine methyltransferase;
6-thiopurine transmethylase;
TPMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:thiopurine S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether [RN:R03701]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
thiopurine [CPD:C01756]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
thiopurine S-methylether [CPD:C16614]
Comment
Also acts, more slowly, on thiopyrimidines and aromatic thiols. Not identical with EC 2.1.1.9 thiol S-methyltransferase.
History
EC 2.1.1.67 created 1984
Pathway
ec00983  Drug metabolism - other enzymes
Orthology
K00569  thiopurine S-methyltransferase
Genes
HSA7172(TPMT)
PTR471863(TPMT)
PPS100994993(TPMT)
GGO101127379(TPMT)
PON100172405(TPMT) 100458866
NLE100592079(TPMT)
HMH116459994(TPMT)
MCC704564(TPMT)
MCF102145415(TPMT)
MTHB126953256
MNI105482630(TPMT)
CSAB103222104(TPMT)
CATY105572584(TPMT)
PANU101018546(TPMT)
TGE112623523(TPMT)
MLEU105530175(TPMT)
RRO104653661(TPMT)
RBB108531021(TPMT)
TFN117086773(TPMT)
PTEH111541124(TPMT)
CANG105526679(TPMT)
CJC100393498(TPMT)
SBQ101043427(TPMT)
CIMI108299385(TPMT)
CSYR103258868(TPMT)
MMUR105865217(TPMT)
LCAT123638316(TPMT)
PCOQ105809456(TPMT) 105815211
OGA100967186(TPMT)
MMU22017(Tpmt)
MCAL110307964(Tpmt)
MPAH110334049(Tpmt)
RNO690050(Tpmt)
MCOC116082427(Tpmt)
ANU117714360(Tpmt)
MUN110549714(Tpmt)
CGE100767055(Tpmt)
MAUA101835820(Tpmt)
PROB127229274(Tpmt)
PLEU114692065(Tpmt)
MORG121434052(Tpmt) 121443252
MFOT126502529
AAMP119816405(Tpmt)
NGI103733006 103745166(Tpmt)
HGL101703237(Tpmt)
CPOC100722156(Tpmt)
CCAN109696860(Tpmt)
DORD105988652 105996366(Tpmt)
DSP122107017(Tpmt)
PLOP125352988(Tpmt) 125363028
NCAR124988797
MMMA107149281(Tpmt)
OCU100009411(TPMT)
OPI101516451(TPMT)
TUP102492405(TPMT)
GVR103587072(TPMT)
CFA403536(TPMT)
CLUD112657677(TPMT)
VVP112920517(TPMT)
VLG121499303(TPMT)
NPO129508133(TPMT)
AML100480933(TPMT)
UMR103664879(TPMT)
UAH113264505(TPMT)
UAR123801564(TPMT)
ELK111156711
LLV125103044
MPUF101671446(TPMT)
MNP132017630(TPMT)
MLK131834790(TPMT)
NVS122913043(TPMT)
ORO101377517(TPMT)
EJU114212639(TPMT)
ZCA113926906(TPMT)
MLX117997447(TPMT)
NSU110586636(TPMT)
LWW102743966(TPMT)
FCA493759(TPMT)
PYU121020394(TPMT)
PCOO112853510(TPMT)
PBG122489195(TPMT)
LRUF124528976
PTG102956395(TPMT)
PPAD109249582(TPMT)
PUC125939531
AJU106989525
HHV120242670(TPMT)
BTA511644(TPMT)
BOM102267418(TPMT)
BIU109576982(TPMT)
BBUB102408385(TPMT)
BBIS104995077(TPMT)
CHX100860988(TPMT)
OAS101123418(TPMT)
BTAX128056477(TPMT)
ODA120869956(TPMT)
CCAD122429388(TPMT)
MBEZ129543584(TPMT)
SSC100157630(TPMT)
CFR102513327(TPMT)
CBAI105084208(TPMT)
CDK105089112(TPMT)
VPC102544626(TPMT)
BACU103011724(TPMT)
LVE103089277(TPMT)
OOR101271523(TPMT)
DLE111181394(TPMT)
PCAD102979248(TPMT)
PSIU116761509(TPMT)
NASI112407450(TPMT)
ECB100034066(TPMT)
EPZ103549165(TPMT)
EAI106841596(TPMT)
MYB102259230(TPMT)
MYD102770832(TPMT)
MMYO118675213(TPMT)
MLF102417017(TPMT)
PKL118724851(TPMT)
EFUS103290215(TPMT)
MNA107531200(TPMT)
DRO112309266(TPMT)
SHON118981269(TPMT)
AJM119058700(TPMT)
PDIC114496719(TPMT)
PHAS123823993(TPMT)
MMF118626476(TPMT)
PPAM129085481(TPMT)
HAI109375167(TPMT)
RFQ117027757(TPMT)
PALE102889393(TPMT)
PGIG120605579(TPMT)
PVP105293932(TPMT)
RAY107512649 107516277(TPMT)
MJV108403580(TPMT)
TOD119251671(TPMT)
SARA101558349(TPMT)
LAV100658033(TPMT)
TMU101354199
ETF101643853(TPMT)
DNM101413606(TPMT)
MDO100025242(TPMT)
GAS123240115(TPMT)
SHR100913479(TPMT)
AFZ127544135
PCW110208707(TPMT)
OAA100077195(TPMT)
GGA420830(TPMT)
PCOC116239997(TPMT)
MGP104910140(TPMT)
CJO107309711(TPMT)
TPAI128087852(TPMT)
LMUT125691374(TPMT)
NMEL110394727(TPMT)
APLA101797003(TPMT)
ACYG106041713(TPMT)
CATA118249687(TPMT)
AFUL116485534(TPMT)
TGU100230777(TPMT)
LSR110483442(TPMT)
SCAN103819408(TPMT)
PMOA120503514(TPMT)
OTC121340479(TPMT)
PRUF121357749(TPMT)
GFR102033831(TPMT)
FAB101821511(TPMT)
OMA130249301(TPMT)
PHI102100607(TPMT)
PMAJ107200979(TPMT)
CCAE111923751(TPMT)
CCW104691429(TPMT)
CBRC103613159(TPMT)
ETL114059461(TPMT)
ZAB102064288(TPMT)
ACHL103811363(TPMT)
SVG106854273(TPMT)
MMEA130573135(TPMT)
HRT120751017(TPMT)
FPG101918207(TPMT)
FCH102050950(TPMT)
CLV102088741(TPMT)
EGZ104125483(TPMT)
NNI104021881(TPMT)
PCRI104032627(TPMT)
PLET104614562(TPMT)
EHS104503427(TPMT)
PCAO104050639(TPMT)
ACUN113476986(TPMT)
TALA104360416(TPMT)
PADL103919050(TPMT)
AFOR103894358(TPMT)
ACHC115352968(TPMT)
HALD104318908(TPMT)
HLE104835271(TPMT)
AGEN126048776
GCL127013015
CCRI104166649
CSTI104554787(TPMT)
CMAC104473400(TPMT)
MUI104544494(TPMT)
BREG104633279(TPMT)
FGA104074687(TPMT)
GSTE104261804(TPMT)
LDI104340828(TPMT)
MNB103780694(TPMT)
OHA104333845(TPMT)
NNT104399851(TPMT)
SHAB115605958(TPMT)
DPUB104305704(TPMT)
PGUU104458448(TPMT)
ACAR104528313(TPMT)
CPEA104392860(TPMT)
AVIT104277839(TPMT)
CVF104295982(TPMT)
RTD128906411(TPMT)
CUCA104062131(TPMT)
TEO104372011(TPMT)
BRHI104496690
AAM106483409(TPMT)
AROW112962940(TPMT)
NPD112953890(TPMT)
TGT104577832(TPMT)
DNE112990786(TPMT)
SCAM104153071(TPMT)
ASN102370323(TPMT)
AMJ102568993(TPMT)
CPOO109315893(TPMT)
GGN109301909(TPMT)
PSS102444217(TPMT)
CMY102931736(TPMT)
CCAY125632184(TPMT)
DCC119851194(TPMT)
CPIC101938755(TPMT)
TST117873240(TPMT)
CABI116822827(TPMT)
MRV120399613(TPMT)
ACS100562746(tpmt)
ASAO132774624(TPMT)
PVT110081687(TPMT)
SUND121927933(TPMT)
PBI103053601(TPMT)
PMUR107286342(TPMT)
CTIG120298679(TPMT)
TSR106544362(TPMT)
PGUT117672524(TPMT)
APRI131195731(TPMT)
PTEX113435599(TPMT)
NSS113413603(TPMT)
PMUA114600863(TPMT)
PRAF128417738(TPMT)
ZVI118090522(TPMT)
HCG128323749(TPMT)
GJA107107479(TPMT)
STOW125438944(TPMT)
EMC129333019(TPMT)
XLA108704455 447769(tpmt.L)
XTR549164(tpmt)
NPR108789578(TPMT)
RTEM120940748 120940750
BBUF121001577(TPMT)
BGAR122937878(TPMT)
MUO115460296 115475582
GSH117355675(TPMT)
DRE436842(tpmt.1) 573111(tpmt.2)
SRX107706163(tpmt)
SANH107654730(tpmt) 107688424
SGH107591974
CCAR109068140 109071417
CAUA113062300 113119247
CGIB127935394 127978543
PTET122323257
LROH127181904
OMC131525466
PPRM120470647 120470760
MAMB125275125
CIDE127501553
MASI127420637 127424969
TROS130567205
TDW130415203
MANU129455652 129455883
IPU108257434
IFU128600705(tpmt.1)
PHYP113535912(tpmt)
SMEO124375903
TFD113644013(tpmt.1)
TVC132863803(tpmt.1)
AMEX103022146(tpmt)
CMAO118805671(tpmt.1)
EEE113591569(tpmt)
CHAR105909033
TRU101064328(tpmt)
TFS130518114
LCO104931680(tpmt)
NCC104959325(tpmt)
TBEN117477664
CGOB115016187(tpmt)
PGEO117455639
GACU117545392
EMAC134874994
ELY117263651
EFO125904486
PLEP121940400 121958039
SLUC116047240
ECRA117956794
ESP116701188(tpmt)
PFLV114567816(tpmt)
GAT120826327
PPUG119218883
AFB129096811
CLUM117738621 117739155
PSWI130193627
MSAM119907875
SCHU122863827
CUD121524171 121524563
ALAT119017229
MZE101486771(tpmt) 106674475
ONL100707189 100707454
OAU116318911 116318912
OLA101168968(tpmt)
OML112162630
CSAI133461169
XMA102219778(tpmt)
XHE116730628(tpmt)
PRET103473038(tpmt)
PFOR103143498(tpmt)
PLAI106957534(tpmt)
PMEI106927634(tpmt)
GAF122844266
PPRL129375744
CVG107102011(tpmt)
CTUL119778630
GMU124879902
NFU107394967(tpmt)
KMR108250170
ALIM106536398(tpmt)
NWH119425327
AOCE111582489(tpmt)
MCEP125019587
CSEM103393993(tpmt)
POV109639990(tpmt)
SSEN122786075
HHIP117770093
HSP118124561
SMAU118292324
LCF108889567
SDU111223374(tpmt)
SLAL111671816(tpmt)
XGL120786593
HCQ109518056(tpmt)
SSCV125986800
SBIA133503423
PEE133395654
PTAO133471210
BPEC110153762 110173329
MALB109958687(tpmt)
BSPL114866306
SJO128374741
SASA100196246(tpmt) 106570045
STRU115175993
OTW112229927
OMY110489313
OGO124042821
ONE115132758(tpmt)
OKI109903702
OKE118398278
SALP111955315(tpmt)
SNH120027360
CCLU121571480 121571481
ELS105012761(tpmt)
SFM108921991(tpmt)
PKI111843854(tpmt)
AANG118234581
LOC102690483(tpmt)
PSPA121314816
ARUT117394941
PSEX120515962
LCM102365205(TPMT)
CMK103184899(tpmt)
RTP109910683
CPLA122564369 122564372
HOC132832198 132832216
LERI129708722
PMRN116945136(TPMT)
LRJ133353357(TPMT)
BFO118410211 118410212 118410249 118410447 118432699
BBEL109468965 109482630 109485962
CIN100181136 100185586
SCLV120325471 120325513 120336567 120341498 120341527 120344512 120345631 120345635 120345905 120346479 120346892
SPU100892034 100893811 105444398 582278 590906 753964 754275
LPIC129253580 129253619 129254852 129256423 129257533 129276270 129279796 129282506
APLC110978641 110978643 110978708 110978778 110979813
AJC117122452
SKO100369695 100375429 102808967 102809337
BCOO119075689 119080397
FCD110844198
DPXDAPPUDRAFT_225254 DAPPUDRAFT_304984 DAPPUDRAFT_319878
DMK116918060
DPZ124314475
PVM113804456 113828399
PJA122255670 122255676 122256334 122267631
PCHN125036160 125036161 125046039 125046246
PMOO119590756 119590807 119594028 119594029 119594030
HAME121871217 121876234
PCLA123764495 123771898
CQD128695858
PTRU123504271 123504289 123504783
ESN126996556 127006121
HAZT108668889 108682732 108682733
EAF111709176 111709303
TCF131879398 131887381
PPOI119093195 119098074 119106532
DSV119437328 119441015 119458377 119459100 119466516
RSAN119372214 119374327 119386511 119395858 119396004 119397319 119400542
RMP119163124 119168102 119173438 119177780 119179867
TUT107368104
CSCU111641984 111641986
LPOL106460326
HROHELRODRAFT_185947
LGILOTGIDRAFT_112328 LOTGIDRAFT_166471 LOTGIDRAFT_223159 LOTGIDRAFT_67729
PVUL126819760 126820581
PCAN112573593
BGT106060592 106077621
GAE121374059 121374481 121375833 121376009 121376140
HRF124141499 124141542 124141591 124142181 124143181
HRJ124275397 124275399 124275400 124275401 124275402 124275403 124275404 124275405 124292306
CRG105335515 105341993 105343239 105343241 117684753
CVN111119129 111119130 111119306 111119308 111119309 111122055 111132977 111132978
CANU128167387 128167388 128167696 128186627 128187739 128190687
OED125664843 125671202 125671576 125671579 125680511
MYI110441108 110442842 110445542 110445543
PMAX117320154 117325055 117326038 117334184 117334682 117339085 117339086 117340104 117340105
MCAF127730679
MMER123524685 123524686 123525422
RPHI132714214 132716043 132728826
DPOL127850133 127850202 127855585 127864084 127874304 127874321
OBI106874096 106874826 106874827
OSN115212383 115212408
LAK106157649 106157650 106157652 106157653 106157654 106157665 106157695 106157696 106157697
OVIT265_11545
NVE5507125 5507136 5520239 5520857
EPA110240010 110247266 110247279
ATEN116288372 116304075 116304076 116308911
ADF107336759 107336760 107356482
AMIL114948851 114953601 114953602 114977728 114977738
PDAM113664623 113671393 113682887 113684462 113685520
SPIS111324775 111343284 111345253 111347609
DGT114521460
XEN124446704 124446705
HMG101234527 105848790 105848791
HSY130613438 130613439 130613441 130614269 130614271 130614490 130640900 130641513
TADTRIADDRAFT_53840 TRIADDRAFT_58744 TRIADDRAFT_58745 TRIADDRAFT_58746 TRIADDRAFT_60799 TRIADDRAFT_60801 TRIADDRAFT_60802
AQU100632142 100639349 105316917
MISMICPUN_107894
YLIYALI0E05467g
SMINv1.2.029745.t1(symbB.v1.2.029745.t1)
FCYFRACYDRAFT_179170
AAFAURANDRAFT_34650
EHXEMIHUDRAFT_233559 EMIHUDRAFT_254305 EMIHUDRAFT_95720
GKNPVT67_01970(tmpT)
XCCXCC1394(tpmT)
XCBXC_2843
XCAxcc-b100_2903
XCPXCR_1663
XCVXCV1496(tpmT)
XAXXACM_1427(tpmT)
XACXAC1439(tpmT)
XCIXCAW_02904(smtA)
XCTJ151_01586
XCJJ158_01582
XCUJ159_01582
XCNJ169_01582
XCWJ162_01582
XCRJ163_01582
XCMJ164_01582
XCFJ172_01577
XFUXFF4834R_chr30580
XAOXAC29_07265
XOOXOO1995(tpmT)
XVEBJD12_20615
XPEBJD13_09370
XHRXJ27_07810
XGABI317_08430
XVAC7V42_07825
XARXB05_02190
XEUXSP_001474
XHDLMG31886_28710(tpm)
XPRMUG10_02490
XDYNYR95_08735
SACZAOT14_24700(tpmT)
STEKAXG53_03160
PSUPsesu_0920
PSUWWQ53_12875
PSDDSC_11105
PMEXH4W19_07705
PJPLAG73_04120
PDDMNQ95_11440
PWIMWN52_07125
LMBC9I47_1133
LYTDWG18_06900
LYJFKV23_11385
LSOLGOY17_06175
LSXH8B22_12360
LHXLYSHEL_21460(tpm)
LCASLYSCAS_21470(tpm)
LCICINQ41_09260
LAVIINQ42_08735
LLZLYB30171_01723(tpm)
LAUXLA521A_11820
LUMCNR27_07165
LUGFPZ22_01545
THESFHQ07_13210
THEHG7079_05740
TCNH9L16_15955
TBVH9L17_03625
RHDR2APBS1_0442
RGLCS053_09690
RTHLRK53_17595
DTXATSB10_34800
VCHVC_1226
VCFIR04_11450
VCSMS6_1011
VCEVch1786_I0733
VCQEN18_09440
VCJVCD_003121
VCIO3Y_05715
VCOVC0395_A0849
VCRVC395_1345
VCMVCM66_1181
VCLVCLMA_A1074
VCXVAA049_2516(tmpT)
VCZVAB027_1907(tmpT)
VVUVV1_2377
VVYVV1964
VVMVVMO6_01257
VVLVV93_v1c17240
VPAVP1296
VPBVPBB_1220
VPKM636_15325
VPFM634_08390
VPHVPUCM_1922
VHAVIBHAR_02114
VCAM892_02730
VAGN646_0333
VEXVEA_003701
VDBAL552_14715
VHRAL538_02005
VNAPN96_07115
VOWA9237_01380
VROBSZ04_14370
VSPVS_1718
VEJVEJY3_06250
VFUvfu_A02132
VNIVIBNI_A1413
VANVAA_03104
LAGN175_07045
VAUVANGNB10_cI1545c(tpm)
VCYIX92_06225
VCTJV59_32475
VTUIX91_06835
VEUIXK98_15270
VSIMTO69_07450
VFLAL536_14380
VMIAL543_15455
VSCVSVS12_01591(tpmT)
VGABSQ33_02385
VSHBSZ05_15315
VQICCZ37_05310
VTAA0742(tpm)
VAFD1115_08130
VNLD3H41_06440
VCCFAZ90_08515
VASGT360_07630
VAQFIV01_06665(tpm)
VSRVspart_02021(tpm)
VKABTD91_12880
VZIG5S32_05985
VNVIF132_08830
VGIMID13_06730
VSLLTQ54_01810
VPLSA104470976_00977(tpm)
VJPNP165_07235
VPGLZI70_13390
VOSKNV97_11915
VTICEQ48_12635
VCRAIS519_03370
VLEISX51_13960
VSYK08M4_12970(tpm)
VRURND59_12575
VMTQYQ96_07790
VFIVF_1512(tpm)
VFMVFMJ11_1605
VSAVSAL_I1814
AWDAWOD_I_1601(tpm)
PPRPBPRA1684(PA2832)
PGBH744_2c1912
PDSCAY62_06895
PGHFH974_08185
GHOAL542_16270
GKDK6Q96_09785
SALYE8E00_06240
SKSFCN78_07140
SCOTHBA18_07455
SPRON7E60_07600
PAEPA2832(tpm)
PAEVN297_2934(tmpT)
PAEIN296_2934(tmpT)
PAUPA14_27460(tpm)
PAPPSPA7_2323(tpm)
PAGPLES_22331(tpm)
PAFPAM18_2131(tpm)
PNCNCGM2_3937(tpm)
PAEBNCGM1900_3484(tpm)
PDKPADK2_10215
PSGG655_10645
PRPM062_15185
PAERPA1R_gp0663
PAEMU769_10795
PAELT223_11265
PAESSCV20265_2278
PAEUBN889_03159(tpm)
PAEGAI22_22615
PAECM802_2931(tmpT)
PAEOM801_2799(tmpT)
PMYPmen_2525
PMKMDS_2238
PREPCA10_33430(tpm)
PPSEBN5_2198(tpm)
PFUWKF707C_23530
PALCA0T30_03610
PCQPcP3B5_20630(tpm)
PMUIG4G71_19365
PNTG5B91_21355
PPAAB7D75_10975
PPUPP_1870(tpm)
PPFPput_3845
PPGPputGB1_1445
PPWPputW619_1479
PPTPPS_1507
PPBPPUBIRD1_3745
PPIYSA_02015
PPXT1E_0503
PPUHB479_07285
PPUTL483_06865
PPUNPP4_39140(tpm)
PPUDDW66_1794
PFVPsefu_2696
PMONX969_05490
PMOTX970_05465
PPJRK21_03523
PMOLCLJ08_05095
PALDLU682_021520
PIXRIN61_18845
PMOSO165_003085
PSTPSPTO_1777(tpm)
PSBPsyr_3617
PAVLBKM03_20855
PVDCFBP1590__1652(tpm)
PASTN015_19105
PFLPFL_4249(tpm)
PPRCPFLCHA0_c43130(tpm)
PPROPPC_4348(tpm)
PFEPSF113_1708
PFNHZ99_27470
PFOPfl01_3985(tpm)
PFSPFLU_1728(tpm)
PFCPflA506_1775(tpm)
PPZH045_05015
PFBVO64_4841
PMANOU5_1537(tpm)
PTVAA957_05480
PCGAXG94_24090
PVRPverR02_08930
PAZOAYR47_15820
POIBOP93_08200
PRXHRH33_09525
PMEDE3Z27_08685
PKRAYO71_21740
PMUDNCTC8068_01839(tpm)
PTOLI7845_08455
PFWPF1751_v1c16970(tpm)
PFFPFLUOLIPICF728310
PFXA7318_07670
PENPSEEN1581(tpm)
PLULFOB45_16785
PBAPSEBR_a1627
PBCCD58_09040
PPUUPputUW4_01439
PDRH681_15630
PSVPVLB_06965
PSKU771_09715
PKCPKB_3647(tpm)
PCHEY04_21475
PCZPCL1606_19270
PCPJM49_09725
PCHPC4K32_4409
PFZAV641_06885
PLQAA042_03220
PALKPSAKL28_14580
PSWLK03_21185
PPVNJ69_03565
PSESPSCI_0320(tpm)
PSEMTO66_22265
PSECCCOS191_3800(tpm)
PPSYAOC04_03595
PSOSPOS17_4325(tpm)
PFKPFAS1_03115
PANRA7J50_1878
PSETTHL1_2319
PSILPMA3_07055
PYMAK972_4094
PKEDLD99_20020
PALLUYA_13270
PUMHGP31_23430
POJPtoMrB4_32300(tpm)
PGGFX982_00076
PPSHG5J76_10260
PGYAWU82_23950
PLALFXN65_16850
PSEJHNQ25_12120
PVKEPZ47_08825
PEZHWQ56_20965
PBZGN234_09595
PTYJWV26_23160
PMAOPMYSY11_2753(tpm)
PATAJWU58_08930
PDWBV82_4095
PZEHU754_021170
PMOEHV782_020370
PSEPC4K39_6169
PPIIQL104_21990
PVWHU752_024030
PTRTHU722_0009590
PXAKSS93_10880
PSAMHU731_024590
PTZHU718_021525
PQIKH389_19490
PSHHHU773_010265
PXNHU772_007315
PHVHU739_020575
PPRGHU725_006715
PANHHU763_007500
PASGKSS96_09125
PFAKKSS94_07525
PMUYKSS95_10205
PMAMKSS90_18740
PAZEKSS91_08125
PALVKSS97_20365
PORYEJA05_07925
PWZJ7655_11750
PTKEXN22_19985
PTWTUM18999_37170(tpm)
PZAHU749_009740
PIEHU724_019995
PWYHU734_018390
PTAENCTC10697_01302(tpm)
PGFJ0G10_21395
PJUL1P09_18695
PHFNLY38_10370
PPHNHU825_17685
PIZLAB08_R43340
PPEGKUA23_08990
PSIINF676_18960
PSIHLOY51_07815
PCASLOY40_20135
PASILG197_12465
PKMPZ739_07245
PNBNK667_04350
PSOAPSm6_58530(tpm)
PTAIICN73_13595
PKKQQ992_07480
PKJQ1W70_18280
PHYGJTY93_09310
PHOMKJF94_17810
PCHEQYM18_20940
PCUCPSH97_19820
PTRLOU419_18980
PPAELDL65_19835
PPAOK3169_21900
PRHZCRX69_13345
PSJYAA098_07995
PSKUKUIN1_35810(tpm)
PSAPST_1312(tpmA) PST_2541
PSZPSTAB_2521
PSRPSTAA_2650
PSCA458_13475
PSJPSJM300_06065
PSHPsest_1768
PSTTCH92_14045
PSTUUIB01_08325
PSEDDM292_06040
PCHLLLJ08_07875
PBMCL52_12290
PKGLW136_14335
SDEGGOM96_04690
PZDKQ248_12545
AVNAvin_15380
AVLAvCA_15380
AVDAvCA6_15380
ACXAchr_27400 Achr_5960(tpmA)
PBBAKN87_10940
PAGRE2H98_03860
HPEGEAO82_08245
HAESLO767_04640
PDENF1C79_13000
HARRHV822_02890
PPHABVH74_17165
DCEO6P33_09685
PBAUOS670_06350
MAQMaqu_3055
MHCMARHY2994(tpm)
MADHP15_2932(tpm)
MBSMRBBS_3116(tpm)
MSRAU15_11950
MPQABA45_14775
MARIACP86_04895
MLQASQ50_06505
MSQBKP64_00190
MARAD0851_07995(tmpT)
MARJMARI_00940(tpm)
MALLPBN92_15360(tmpT)
MSHEMAALD49_30510(tpm)
MANPEHN06_16190(tmpT)
MSANLPB19_00270(tmpT)
PCRPcryo_1333 Pcryo_2244
PRWPsycPRwf_0288
PSOPSYCG_07000 PSYCG_12115
PURAOC03_01465 AOC03_05260
PALIA3K91_2494
PSPGAK823_12310
PSYGAK825_12760
PSYCDABAL43B_1152(tpm1) DABAL43B_2557
PSYAAOT82_2113
PSYYDLE54_01435
PSYPE5677_00955(tmpT)
PKYPKHYL_36900(tpm_2)
PCIAQ6344_13145(tmpT)
ACIACIAD2922(tpm)
AHLAHTJS_03980
AJNBVL33_13635
ASOLBEN76_00455
ALABFG52_04230
AUGURS_1913
AVZHWI77_03955(tmpT)
SONSO_0582(tpmT)
SDNSden_0541
SFRSfri_3498
SAZSama_0543
SBLSbal_0541
SBMShew185_3784
SBNSbal195_3910
SBPSbal223_3727
SBTSbal678_3940
SBSSbal117_0643
SBBSbal175_3705
SLOShew_3261
SPCSputcn32_3296
SHPSput200_3423
SSESsed_4010
SPLSpea_0588
SHEShewmr4_0581
SHMShewmr7_3449
SHNShewana3_0580
SHWSputw3181_0645
SHLShal_0675
SWDSwoo_3438 Swoo_4153
SWPswp_4515
SVOSVI_3702(tpm)
SHFCEQ32_13210
SJASJ2017_0675
SPSWSps_02915
SBJCF168_17945
SMAVCFF01_16065
SHEWCKQ84_04635
SALGBS332_11180
SLJEGC82_19370
SMAIEXU30_07010
SPOLFH971_17680
SBKSHEWBE_4389(tpm)
SKHSTH12_00081(tpm)
SAESHBH39_15410
SLITJQC75_02545
SCAATUM17387_32510(tpm)
SPSHFM037_24055
SEURFM038_003255
SCYPJYB88_15685
SAVIJYB87_02440
SSEMJYB85_16175
SGLAFJ709_02620
SINVK8B83_05270
SXMMKD32_18100
SVMKDH10_003634
SHEJMZ182_17510
SSEHN7V09_20605
SCHKGII14_18675
SACHK0H61_02190
SAEGK0H80_16630
SDEOD0436_03735
SMESK0I73_16430
SHAOK0H81_16975
SZHK0H63_02885
SSPAK0I31_16865
SHNSK0J45_16705
SRHSK0I63_16840
SPSJK0I62_16440
SMAYK0H60_03190
SOGRA178_19110
SPSREGC80_07625
IPICEW91_11585(tmpT)
IDICWC33_04740(tmpT)
IDTC5610_00575(tmpT)
IABK5X84_00805(tmpT)
CPSCPS_3096
COLWA3Q33_15890
COLADBO93_11350
CBERB5D82_16120
THTE2K93_01995
THAPFNC98_10050
THABLP316_09815
THATH3N35_09655
TACTSG35_009965
TVDSG34_019275
PDJD0907_18190(tmpT)
PXIJ5O05_12105(tmpT)
AMCMADE_1006970
AMHI633_07450
AMAAamad1_07430
AMALI607_06655
AMAEI876_06945
AMAOI634_07065
AMADI636_07510
AMAII635_07415
AMAGI533_06975
AMACMASE_06545
AMBAMBAS45_06840
AMGAMEC673_06600
AMKAMBLS11_06590
ALTambt_11580
AALEP13_07340
AAUSEP12_07440
ASPAOR13_2105
ASQAVL57_09235
AAWAVL56_08125
ALRDS731_03875(tmpT)
ALEAV939_08250
ALZAV940_08070
APELCA267_005765(tmpT)
SALMD0Y50_02820(tmpT)
SALKFBQ74_14325(tmpT)
SMAAIT774_14140(tmpT)
GAGGlaag_2807
GNIGNIT_3613(tpmT)
PMESFX988_01111
PATPatl_1524
LALAT746_11230
AGQLQZ07_10975(tmpT)
ALKMNKI27_15585(tmpT)
ASEMNNL22_11985(tmpT)
ALIIQR722_09310(tmpT)
PSYPCNPT3_07620
FBLFbal_3334
FESHER31_03150(tmpT)
MVSMVIS_2157(tpm)
TTUTERTU_2055
SAGAM5M_09720
SNANI6N98_18275(tmpT)
ZALAZF00_17470
MTHDA3224_12340
MICCAUP74_02666(tpm)
MAGAMag101_09120
MIIBTJ40_07325(tmpT)
MICTFIU95_14390(tpm)
MHYDGTQ55_09590(tmpT)
MCELLPW13_06590(tmpT)
MICZGL2_27760(tpm)
MVBMJO52_06835(tmpT)
MPAFR5R33_01040(tmpT)
MBRGPVT68_01315(tmpT)
HJABST95_12560
HALCEY643_09930
KIMG3T16_06690(tmpT)
LPNlpg2835(tpm)
LPHLPV_3190(tpm)
LPOLPO_3131(tpm)
LPULPE509_00193
LPMLP6_2864(tpm)
LPFlpl2747
LPPlpp2892
LPCLPC_3119(tpm)
LPAlpa_04116
LPElp12_2825
LFALFA_3565(tpm)
LHALHA_3084(tpm)
LOKLoa_01360
LSHCAB17_12615(tmpT)
LLG44548918_02584(tpm)
LJRNCTC11533_02734(tpm)
LWASAMEA4504053_3364(tpm)
LSSNCTC12082_00344(tpm)
LADLNCTC12735_00471(tpm)
LANTTUM19329_33570(tpm)
LCADPXX05_14400
MCAMCA0794
METUGNH96_04550
MMEOOOT43_06835
MMTMetme_3860
MDNJT25_002700 JT25_018650 JT25_022470
MDHAYM39_00230
MKOMKLM6_0082
METLU737_11165
MPADKEF85_04950 KEF85_14105
MELLIVG45_02225 IVG45_09070
MRPNM686_017490
MMOTQZJ86_02610
MAHMEALZ_0176(tpm)
MBUREQU24_00980
MPSYCEK71_14105(tmpT) CEK71_14550
MMOBF6R98_08265(tmpT) F6R98_18660
MEINmethR_P3434
MISZMishRS11D_05430(tpm)
MESLKKZ03_08275 KKZ03_14055
FTUFTT_1661(tmpT)
FTQRO31_1958
FTFFTF1661(tmpT)
FTWFTW_1959
FTRNE061598_09350
FTTFTV_1581(tmpT)
FTGFTU_1666(tmpT)
FTLFTL_0032
FTHFTH_0031(tpmT)
FTAFTA_0039
FTSF92_00190
FTIFTS_0030(tmpT)
FTOX557_00195
FTCDA46_705
FTVCH67_288
FTZCH68_25
FTMFTM_0011(tmpT)
FTNFTN_0023(tmpT)
FTXAW25_179
FTDAS84_674
FTYCH70_89
FCFFNFX1_0030
FCNFN3523_0024
FHIFSC454_00085
FPHFphi_0803
FPTBZ13_1242
FPIBF30_1016
FPMLA56_1382
FPXKU46_539
FPZLA55_16
FPJLA02_485
FRTF7308_0025
FRFLO80_05915
FHACDV26_00520
FRXF7310_00160
FADCDH04_01420
FMIF0R74_08535
FNNFSC774_09500
FSRKQR59_00080
FRLFIP56_00095
TCXTcr_1758
HTREPV75_09425(tmpT)
HMARHVMH_0490(tpm)
THIOAYJ59_04510
CYQQ91_0223(tpm)
CZACYCME_2449(tmpT)
CYYCPC19_00275
THIGFE785_09235
TXAHQN79_09835
TIBTHMIRHAM_18400(tpm)
TLHNR989_09665
TSETHMIRHAS_05470(tpm)
TZOTHMIRHAT_18920(tpm)
BLEPAL038_02490
THISHZT40_18360
TUNJ9260_16540
TLOJ9253_17080
TSBHMY34_10770
TANIJ8380_04290
TWNL2Y54_05165
TLCRCF98_09640
TDUQJT80_01175
ALVAlvin_1548
TVIThivi_3116 Thivi_3120
TMBThimo_0851
TSYTHSYN_06280
RHHE0Z06_04900(tmpT)
THIPN838_31640
THIMKFB96_22995(tmpT)
TBOGLT988_06145(tmpT) LT988_06215
TWGThiowin_02108(tpm)
SHAILMH63_10605
APRSBI364_03555
AAEOBJI67_12420
AFYBW247_14830
WMAWM2015_1683
GAIIMCC3135_31820(tpm)
TBNTBH_C0502
EPSL0Y14_07715
SEDSAAY24_06875
WOCBA177_02860
TTCFOKN1_1779
THICTspCOW1_08740(tpm)
HCHHCH_01328
HAHEENC22_23830(tmpT)
HAHHO5O45_19485(tmpT)
CSACsal_2332
CCAGSR908_02440(tmpT)
HELHELO_3387(tpm)
HCSFF32_11965
HAKKO116_01714
HAMHALO1824
HHUAR456_05395
HCOLOKO_00889(tpm)
HSIBOX17_02900
HALOBWR19_13085
HHHCLM76_12520
HBEBEI_0869
HAGBB497_09270
HAFC8233_08045(tmpT)
HMDCTT34_06340
HAXIHAALTHF_45950n
HSVHNO53_14990
HPROLMS44_14580
HQDK1Y77_05630
HBHE4T21_05260
HBPHPTD01_3777
HALFQEN58_12360
HHAOQWG60_12595
HASOB2G49_03980
HALWB6N23_15035
HASHHXW73_11480
HPISP1P91_10460
HALKCUU95_00170
HVNEI420_06365
HOLHORIV_44590(tpm)
HSRHSBAA_42610 HSBAA_42620
HPIZGYM47_06055
HNPSR894_12895
HTTHZS52_13570
HCAMI4484_14575
HSXHNO51_14305
HTXEKK97_16190
HAAA5892_14075
CMAIBFX80_14085
CAMHLCW13_03150(tmpT)
COBECLAM6_06150(tpm)
COBBH2O77_03040(tmpT)
KUSB9G99_00405
KMAB9H00_14860
KUYFY550_10480
PAURFGL86_15945
SAJSQO259_06875 QO259_13685(tmpT)
ALCAASALC70_02494(tpm)
ADIB5T_04328
APACS7S_00765
MMWMmwyl1_1365
MMEMarme_1231
MPCMar181_2438
MPRIMP3633_2683
MARDIBG28_05640
MFOIJSY38_04155(tmpT)
MPRFJ8N69_13375(tmpT)
MRHIKDW99_05945
MPONMACH16_09570(tpm)
TOLTOL_0889
TORR615_12920
TWANHUF19_05150(tmpT)
OAIOLEAN_C26930
MSECLN244_15085(tmpT)
MARLHH196_07175
BSANCHH28_10900(tmpT)
NCUF0U83_15575
NIKF5I99_09585
BMARHF888_04660(tmpT)
VCWGJQ55_03500(tmpT)
BACZKFF03_11795(tmpT)
OMEOLMES_1674
ENWMJO57_09815
ENGO2T12_19505
PLEIQ9312_06050
AHAAHA_1996(tpm)
AHYAHML_12925
AHDAI20_07210
AHRV428_13355
AHPV429_13375
AHJV469_09730
AHHRY45_12690
AHIVU14_09605
AAJBOQ57_12510
ASAASA_1874(tpm)
AEOO23A_p1164
AVRB565_2233
AVOAMS64_10925
AMEDB224_2594
ASRWL1483_3062(tpm)
ADHCK627_13845
AEMCK911_08200
AEAC2U39_09740
ARVC7N77_15355
AESC2U30_04005
AELNCTC12917_01885(tpm)
ASIMFE240_08945
AALLI6G90_03885
AJDI6H43_20260
ARIVKYK33_10455
ASAAKXJ75_10710
AEJE5E97_17455
ABESIU367_12290
TAUTola_1476
OCEGU3_11585
OPEPU634_05915
OCMCBP12_02455
OPFCBP31_01180
ZDFAN401_09865
KKOKkor_0779
KGETQ33_0627
KSDKS2013_1666 KS2013_661
KPDCW740_03540(tmpT)
KAMSR900_10745(tmpT)
SDFACG33_12060
ACIIC4901_04120
ATYA9R16_012345
SALNSALB1_2623
TSNW908_06040
THINCRN91_04295
THOSP60_06950
REVHUE57_01480
REOHUE58_03370
EBHBSEPE_0462(tpmT)
BTHGMS2017_0690
GPBHDN1F_05740(tpm)
IFOCVFO_1000(tpmT)
NBACUN60_08330(tmpT)
AQLBXU06_04130
PLGNCTC10937_03926(tpm)
BPEBP0873(tpm)
BPCBPTD_0870(tpm)
BPERBN118_1454(tpm)
BPETB1917_2951(tpm)
BPEUQ425_8080(tpm)
BPARBN117_1319(tpm)
BPABPP2160(tpm)
BBHBN112_1899(tpm)
BBRBB1557(tpm)
BBMBN115_1511(tpm)
BBXBBS798_1516(tpm)
BPTBpet3841(tpm)
BAVBAV1018(tpm)
BHZACR54_01734(tpm)
BTRMSAMEA390648702476(tpm)
BBROBAU06_18865
BPDZBBN53_13135
BOHAKI39_18075
BGMCAL15_17285
BGVCAL12_19785
AXYAXYL_04870(tpm)
AXONH44784_036511
AXNAX27061_4708
AXXERS451415_04742(tpm)
ADTAPT56_21750
AISBUW96_13340
ASWCVS48_14110
ACHRC2U31_27420
ACHBDVB37_20375
ADYHLG70_29255
ACHOH4P35_19730
AMUIPE062_16400
APESFOC84_21585
AAEGRA224_07980
PUTPT7_3609
PUSCKA81_10290
POLLOEG81_03280
CDNBN940_17261
PARKLSG25_11340
COFFOZ74_15760
HSEHsero_3797(tpm)
HSZACP92_18945
HHTF506_17995
HRBHrubri_3767(tpm)
HEEhmeg3_07440
HHFE2K99_19430
HFRG5S34_20735
CFUCFU_0019(tmp)
CPRACPter91_0017(tmpT)
MASSCR152_23540(tmpT)
MANCIV454_23630(tmpT)
NETNeut_2272
NIINit79A3_0664 Nit79A3_1504
NCOAAW31_00745 AAW31_14325
NURATY38_08895
NSTNstercoris_01363
NMUNmul_A2259
NLCEBAPG3_010675
NIZNNRS527_00740
RBUPG1C_08195
MMBMmol_2155
MEHM301_0221
MEIMsip34_1933
MEPMPQ_1948
MEUACJ67_01085
SLTSlit_1144
FAMOYT1_ch0551
NIMW01_01380(tpm_1) W01_22400(tpm_2)
NARCNTG6680_2023(tpm) NTG6680_2738(tpm)
SEMEMIZ01_0746
SNIVSFSGTM_09190(tpm)
ABREpbN1_18850(tpm)
APETToN1_26960(tpm)
DARDaro_0514
DEYHYN24_06640
DDENKI615_08410
QAUKI612_04760
FLEKI610_08675
AZAAZKH_p0637(tpmT)
AZIAzCIB_0135
AZDCDA09_00790
AZRCJ010_17790
HOEIMCC20628_01989
XAUXaut_2726
XDIEZH22_14855(tmpT)
SNOSnov_2584
ANCGBB76_07635(tmpT)
APRAG3A50_04405(tmpT)
APOLK9D25_12110(tmpT)
MLGCWB41_14285(tmpT)
HDNHden_3185
HDTHYPDE_39108
HMCHYPMC_4429(tpm)
HNIW911_05405
FILBN1229_v1_0793(tpm)
FIYBN1229_v1_0797(tpm)
CMETK6K41_26130
LMDMETH_09945
LEJETW24_09145(tmpT)
LAQUR2C4_08070(tmpT)
LEVETW23_09000(tmpT)
LCAEK3721_09120(tmpT)
RMMROSMUCSMR3_02080(tpm)
ROKRAK1035_1106
SECHB18_27115
GOXGOX0680
GOYGLS_c07670(tpm)
GALA0U94_00825
GSPIGS75_04020(tmpT)
GXYGLX_02300
GXLH845_1382
KNAB0W47_01495
KEUS101446_00516(tpmT)
KSCCD178_02887(tpm)
KREGWK63_05930(tmpT)
KOILV478_12925(tmpT)
APTAPA01_14450
APFAPA03_14450
APUAPA07_14450
APGAPA12_14450
APQAPA22_14450
APXAPA26_14450
APZAPA32_14450
APKAPA386B_305
ASZASN_3383
ASVWG31_07610
APOMCPF11_12940(tmpT)
ATOCIW82_14540(tmpT)
AASCA4S02_05260
ACETDS739_07490(tmpT)
AOTAcetOri_orf00696
AOYEOV40_006665(tmpT)
KHAIFJ82_09020(tmpT)
TMOTMO_c0547
MGMMmc1_0515
ATXGCD22_02889(tpm)
ACIYMQE22_09095
HTLHPTL_2018(tpm)
SMASHUE87_03230(tmpT)
ARCABLL_0111
PACOAACT_0099
AROSNJU99_00325(tmpT)
ALKALEK_0067
DVEDESUT3_32810(tpm)
DESDSOUD_0775
VINAKJ08_3128
CCROCMC5_083250
SAMYDB32_002974
LLUAKJ09_02692
HOHHoch_2473
BMXBMS_1763(tpm)
HAXBALOs_1523
BSTOC0V70_08780
PSTISOO65_17795(tmpT)
PIJQEJ31_05145(tmpT)
PARHI5S86_08220
MVQMYVA_2215(tpm)
BEIGCM100_00830(tpm)
JMEEEW87_006365
APRECNX65_10945
AMIAmir_2144
SSYIEKG83_29050
ACTNL083_4157
CEPCri9333_0690
HHGXM38_044710(tpm)
HAUHaur_3057
UAMUABAM_03772
LBJLBJ_0800
LAJA0128_13055
LMAYDPV73_10090(tmpT)
LWLFHG68_04840(tmpT)
LKBLPTSP3_g03900(tpm)
SCORJ3U87_17540(tmpT)
SLISlin_6497
SRDSD10_03260
SPIBG8759_11010
STAEHNV11_18095
SOQLQ777_06855
SENFGJR95_14070
RUPDTQ70_29090
TPELP0M28_28655(tmpT)
CPRVCYPRO_0302
NDENIDE2804(tpm)
NMVNITMOv2_1719(tpm)
NJANSJP_3684(tpm)
NKFNkreftii_000930
NIFW02_09200(tpm)
NTIDNFV4_00134
NALLPP769_19060(tmpT)
 » show all
Reference
1  [PMID:13981612]
  Authors
REMY CN.
  Title
Metabolism of thiopyrimidines and thiopurines. S-Methylation with S-adenosylmethionine transmethylase and catabolism in mammalian tissues.
  Journal
J Biol Chem 238:1078-84 (1963)
Reference
2  [PMID:6633508]
  Authors
Woodson LC, Ames MM, Selassie CD, Hansch C, Weinshilboum RM.
  Title
Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.
  Journal
Mol Pharmacol 24:471-8 (1983)
Reference
3  [PMID:6838629]
  Authors
Woodson LC, Weinshilboum RM.
  Title
Human kidney thiopurine methyltransferase. Purification and biochemical properties.
  Journal
Biochem Pharmacol 32:819-26 (1983)
DOI:10.1016/0006-2952(83)90582-8
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.67
IUBMB Enzyme Nomenclature: 2.1.1.67
ExPASy - ENZYME nomenclature database: 2.1.1.67
BRENDA, the Enzyme Database: 2.1.1.67
CAS: 67339-09-7

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