This is a large group of enzymes, most of which form so-called 'restriction-modification systems' with nucleases that possess similar site specificity [the nucleases are listed as either EC
3.1.21.3 (type 1 site-specific deoxyribonuclease), EC
3.1.21.4 (type II site-specific deoxyribonuclease) or EC
3.1.21.5 (type III site-specific deoxyribonuclease)]. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase.neb.com/rebase/rebase.html.