KEGG   ENZYME: 2.1.1.8
Entry
EC 2.1.1.8                  Enzyme                                 
Name
histamine N-methyltransferase;
histamine 1-methyltransferase;
histamine methyltransferase;
histamine-methylating enzyme;
imidazolemethyltransferase;
S-adenosylmethionine-histamine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:histamine N-tele-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + Ntau-methylhistamine [RN:R02155]
Reaction(KEGG)
R02155
Substrate
S-adenosyl-L-methionine [CPD:C00019];
histamine [CPD:C00388]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
Ntau-methylhistamine [CPD:C05127]
History
EC 2.1.1.8 created 1965
Pathway
ec00340  Histidine metabolism
ec01100  Metabolic pathways
Orthology
K00546  histamine N-methyltransferase
Genes
HSA3176(HNMT)
PTR742204(HNMT)
PPS100970136(HNMT)
GGO101141216(HNMT)
PON100174618(HNMT)
HMH116462939(HNMT)
MCC703857 706713(HNMT)
MCF101867462(HNMT)
MTHB126932244
MNI105492589(HNMT) 105498647
CSAB103217003(HNMT)
CATY105575026 105590363
TGE112636099 112636474
MLEU105550223(HNMT) 105553680
RRO104672066(HNMT)
TFN117095061(HNMT)
PTEH111528181(HNMT)
CANG105507253(HNMT)
CJC100405862(HNMT)
SBQ101041589(HNMT)
CIMI108300473(HNMT)
CSYR103276269(HNMT)
MMUR105857643(HNMT)
LCAT123643525(HNMT)
PCOQ105806874 105815351
OGA100946532(HNMT)
MMU140483(Hnmt)
MCAL110287683(Hnmt)
MPAH110319128(Hnmt)
RNO81676(Hnmt)
MCOC116089779(Hnmt)
ANU117710970(Hnmt)
MUN110563412(Hnmt)
CGE100759779 100761300
MAUA101839605(Hnmt)
PROB127222552(Hnmt)
PLEU114692749(Hnmt)
MORG121462799(Hnmt)
MFOT126500206
AAMP119819086(Hnmt)
NGI103726551(Hnmt)
HGL101702942(Hnmt)
CPOC100135537(Hnmt)
CCAN109681803 109681804
DORD105996105(Hnmt)
DSP122110849(Hnmt)
PLOP125350724(Hnmt)
NCAR124980212
MMMA107136821(Hnmt)
OCU100347399
OPI101521079(HNMT)
TUP102469391
GVR103608726(HNMT)
CFA476133(HNMT)
CLUD112648833(HNMT)
VVP112909578(HNMT)
VLG121481974(HNMT)
NPO129495561 129514605
AML100481941(HNMT)
UMR103667681(HNMT)
UAH113263407(HNMT)
UAR123782459(HNMT)
ELK111143222
LLV125095920
MPUF101687140(HNMT)
MNP132013051(HNMT)
MLK131826968(HNMT)
NVS122902695(HNMT)
ORO101368085(HNMT)
EJU114207302(HNMT)
ZCA113920985(HNMT)
MLX118012493(HNMT)
NSU110585668(HNMT)
LWW102733782(HNMT)
FCA101093704(HNMT)
PYU121030502(HNMT)
PCOO112871215(HNMT)
PBG122481293(HNMT)
LRUF124516223
PTG102954667(HNMT)
PPAD109270411(HNMT)
PUC125911651
AJU106969447
HHV120220316(HNMT)
BTA613413(HNMT)
BOM102279160(HNMT)
BIU109568122(HNMT)
BBUB102395473(HNMT)
BBIS104998511(HNMT)
CHX102169059(HNMT)
OAS101102876(HNMT)
BTAX128043691(HNMT)
ODA120854497(HNMT)
CCAD122453760(HNMT)
MBEZ129537738(HNMT)
SSC100624677(HNMT)
CFR102506628(HNMT)
CBAI105083386(HNMT)
CDK105092265(HNMT)
VPC102543745(HNMT)
BACU102997526(HNMT)
LVE103075160(HNMT)
OOR101278018 101281948(HNMT)
DLE111172721(HNMT)
PCAD102996034(HNMT)
PSIU116756298(HNMT) 116760948
NASI112412417(HNMT)
ECB100051119(HNMT)
EPZ103553344(HNMT)
EAI106845596(HNMT)
MYB102249926(HNMT)
MYD102774069(HNMT)
MMYO118662268(HNMT)
MLF102421337(HNMT)
MNA107531142(HNMT)
PKL118709789(HNMT)
EFUS103287771(HNMT)
HAI109372885(HNMT) 109374605
DRO112313104(HNMT)
SHON118975029(HNMT)
AJM119040294(HNMT)
PDIC114494348(HNMT)
PHAS123832492(HNMT)
MMF118625533(HNMT)
RFQ117026346(HNMT)
PPAM129061962(HNMT)
PALE102888765(HNMT)
PGIG120611952(HNMT)
PVP105288335(HNMT)
RAY107511202(HNMT)
MJV108398856(HNMT)
TOD119255798(HNMT)
SARA101546126(HNMT)
LAV100674300(HNMT)
TMU101349793
ETF101657707(HNMT)
DNM101430514(HNMT)
MDO100012612(HNMT)
GAS123242278(HNMT)
SHR100914453(HNMT)
AFZ127554366
PCW110223777(HNMT)
OAA100080018
GGA424298(HNMT)
PCOC116227438
MGP100542432
CJO107316986
TPAI128077114
LMUT125697023
NMEL110400130
APLA101795218
ACYG106039378
CATA118252588
AFUL116490827
TGU100228106
LSR110480615
SCAN103814270
PMOA120498640
OTC121337545
PRUF121356775
GFR102040696
FAB101817812
OMA130255399
PHI102114649
PMAJ107207179(HNMT)
CCAE111932325
CCW104694077
CBRC103619651
ETL114057695
ZAB102074954
ACHL103808894
SVG106849897
MMEA130573795
HRT120755398
FPG101917359
FCH102055002(HNMT)
CLV102087354
EGZ104129540
NNI104009763
PCRI104028028(HNMT)
PLET104613687(HNMT)
EHS104509242(HNMT)
PCAO104043569(HNMT)
ACUN113482038(HNMT)
TALA104365700
PADL103912632
AFOR103899260(HNMT)
ACHC115343201
HALD104318026(HNMT)
HLE104836532
AGEN126039923
GCL127018488
CCRI104162747(HNMT)
CSTI104556365
CMAC104482961
MUI104542051
BREG104641906(HNMT)
FGA104069094(HNMT)
GSTE104257472(HNMT)
LDI104342639
MNB103776435(HNMT)
OHA104333258
NNT104409170(HNMT)
SHAB115608906(HNMT)
DPUB104306702
PGUU104457463
ACAR104523791(HNMT)
CPEA104391140(HNMT)
AVIT104273077
CVF104292343
RTD128912424
CUCA104065207(HNMT)
TEO104376947(HNMT)
BRHI104495937
AAM106498438
AROW112977108
NPD112948591
TGT104580280(HNMT)
DNE112997450
SCAM104145709
ASN102388667
AMJ102572645
CPOO109322991
GGN109301351
PSS102449429(HNMT)
CMY102948037(HNMT)
CCAY125645170(HNMT)
DCC119863406(HNMT)
CPIC101935284(HNMT)
TST117884846(HNMT)
CABI116834811(HNMT)
MRV120374640(HNMT)
ACS100567693
ASAO132775363
PVT110086141
SUND121917764
PBI103058167(HNMT)
PMUR107285856(HNMT)
CTIG120299297(HNMT)
TSR106557223(HNMT)
PGUT117669707(HNMT)
APRI131203482(HNMT)
PTEX113449716(HNMT)
NSS113415916(HNMT)
VKO123027561
PMUA114604687
PRAF128422148
ZVI118092546(HNMT)
HCG128326989
GJA107120669(HNMT)
STOW125427339
EMC129323361
XLA380306(hnmt.S) 495426(hnmt.L)
XTR779808(hnmt)
NPR108796922(HNMT)
RTEM120944138 120944139 120944140
BBUF121008099 121008100 121008103 121008826 121008827 121008828
BGAR122944677 122945170 122945627 122945635 122945676
MUO115474055(HNMT)
GSH117361327(HNMT)
DRE445242(hnmt)
SRX107720324 107751616
SANH107658225 107663827
SGH107558040 107577691
CCAR109051662
CAUA113076734
CGIB128019674
PTET122351174(hnmt)
LROH127170632(hnmt)
OMC131547230(hnmt)
PPRM120466712(hnmt)
RKG130076591(hnmt) 130083761
MAMB125270035(hnmt)
CIDE127518446
TROS130555782(hnmt) 130555823
TDW130427073(hnmt)
MANU129438594 129438632 129452501 129452502 129452505 129452506
IPU100528906(hnmt) 108276868
IFU128608440(hnmt) 128620641
PHYP113526256(hnmt) 113544802
SMEO124383082 124383170(hnmt) 124383298 124393633 124393634
TFD113650194 113650195 113650196 113653115 113653116 125139718
TVC132850446 132850447(hnmt) 132863300 132863594 132863595 132863596 132863767 132863768
AMEX103033680 103033996
CMAO118812068
EEE113577948 113584942 113585227 113585243
CHAR105902674(hnmt)
TRU101066023
TFS130531548
TNGGSTEN00020755G001
LCO104926342 104926343
NCC104963990 104965736(hnmt)
TBEN117485990(hnmt)
CGOB115026531
PGEO117467056
GACU117560070 117560107
ELY117249266
EFO125899943
PLEP121949368(hnmt) 121949542
SLUC116037798
ECRA117952955(hnmt)
ESP116698060(hnmt)
PFLV114564332
GAT120834198
PPUG119228666
AFB129104744
CLUM117750964
MSAM119903791 119903905 119903906
SCHU122886117(hnmt)
CUD121522302
ALAT119026437(hnmt)
MZE101475481 101475778
ONL100703530(hnmt) 100704419
OAU116316553 116316556
OLA101158841 101174335
OML112154869
XMA102234300 102235596
XCO114148898 114148899
XHE116723633
PRET103460754 103460763
PFOR103150649
PLAI106934825
PMEI106923411(hnmt)
GAF122840104(hnmt)
CVG107099305 107099306
CTUL119776831
GMU124871875
NFU107389879 107390214 107390215
KMR108238570
ALIM106525772(hnmt)
NWH119419052(hnmt)
AOCE111571844 111571846
MCEP125017164
CSEM103392316(hnmt)
POV109631194 109631203
SSEN122765462
HHIP117754829
HSP118120086
LCF108886889 108886891
SDU111218535 111218536
SLAL111668738 111668746
XGL120802039 120802041
HCQ109523407 109523408
SSCV125973188
SBIA133512671
PEE133410536(hnmt)
PTAO133486717(hnmt)
BPEC110156105 110156182 110156194 110160769 110165649 110173352 110173658
MALB109957092 109959613
BSPL114847444 114847446 114847447
SJO128367826
SASA100196123(hnmt)
STRU115155375 115155377 115164641
OTW112239669 112239670
OMY110501994 110501995
OGO124037206 124037289
ONE115114247 115124003
OKI109875241 109877269
OKE118370362
SALP112074908 112074909
SNH120064048 120064049
CCLU121534555 121560621
ELS105009037 105009038
SFM108927911 108937993
PKI111834433 111834438 111834439 111842325
AANG118213670(hnmt) 118223933
LOC102684020(hnmt) 102684614
PSPA121323636(hnmt)
ARUT117409074 117409089
PSEX120531712(hnmt)
LCM102356420(HNMT) 102356694 102361094 102365060 102365327 106703836
CMK103180417(hnmt)
CPLA122551716 122551717
HOC132817333 132817405
BFO118405123 118413352 118414123 118414189 118416229 118423053 118427802 118427861 118428039 118429296 118429364
BBEL109463342 109466566 109472447 109473261 109473546 109474887 109475022 109476229 109477812 109479703 109479704 109480067 109480121 109483095 109483890 109484391 109484758 109487789
SPU100888125 100888796 100889342 100891191 100892228 115926043 115927194 115928132 115929228 576540 581824 582038 584390 587894 764668
LPIC129254475 129255058 129257507 129257825 129258566 129258568 129258594 129259581 129260159 129261046 129263264 129266024 129266784 129272879 129272994 129273436 129273437 129275093 129276149 129277206 129277254 129278326 129279801 129280968
APLC110973248 110973250 110973581 110973582 110973635 110973718 110973719 110973747 110973752 110977804 110977805 110983465 110985102 110986424 110986425 110986434
SKO100313634 100369335 100369757 100370527 100372250 100372330 100373828 100373875 100376946 100377097 100377821 102801665 102801851 102803272 102803795 102804990 102805965 102807442 102807875 102809059 102809174 102809929 102810340
NVE116614128 116614129 116619812 5500978 5510493 5513259
EPA110231613 110231614 110232231 110237463 110238561 110242372 110242373 110245025 110246401 110247714 110248237 110248426 110250668
ATEN116286436 116287043 116290127 116296836 116300426 116301610 116301611 116306456
ADF107338158 107343921 107343922 107347573 107347579
AMIL114953965 114964256 114964257 114964262 114964267 114971044
PDAM113672896 113677551 113678227 113678235
SPIS111320298 111326664 111333303 111333487 111334769 111334779 111338539 111345286
DGT114520662 114527607 114528324 114534460 114534461 114534462 114534463 114534464 114534465 114534467 114534468 114534469 114534470 114534471 114534472 114536842
XEN124446317 124454151 124454153 124454154 124454155 124454733
HMG100214195
HSY130622864
 » show all
Reference
1  [PMID:13804910]
  Authors
BROWN DD, TOMCHICK R, AXELROD J.
  Title
The distribution and properties of a histamine-methylating enzyme.
  Journal
J Biol Chem 234:2948-50 (1959)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.8
IUBMB Enzyme Nomenclature: 2.1.1.8
ExPASy - ENZYME nomenclature database: 2.1.1.8
BRENDA, the Enzyme Database: 2.1.1.8
CAS: 9029-80-5

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