| Entry |
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| Name |
protein-histidine N-methyltransferase;
protein methylase IV;
protein (histidine) methyltransferase;
actin-specific histidine methyltransferase;
S-adenosyl methionine:protein-histidine N-methyltransferase
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase
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| Reaction(IUBMB) |
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine [RN: R02627]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
protein L-histidine [CPD: C00615]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
protein Ntau-methyl-L-histidine
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| Comment |
Highly specific for histidine residues, for example, in actin.
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| History |
EC 2.1.1.85 created 1989
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| Orthology |
| K18803 | protein-histidine N-methyltransferase |
| K19199 | protein-histidine N-methyltransferase |
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| Genes |
| CIMI: | 108288071 108304094(SETD3) |
| CHX: | 102176687(SETD3) 108633232 |
| MMF: | 118630510(SETD3) 118637726 |
| MJV: | 108387757(SETD3) 108397043 |
| OAA: | 100079580 100081976(SETD3) |
| FGA: | 104073819 104084087(SETD3) |
| ASN: | 102383535(SETD3) 102388401 |
| ACS: | 100553006(setd3) 107982274 |
| XLA: | 108698743(setd3.L) 108699803(setd3.S) |
| CCAR: | 109061752(setd3) 109090084 |
| CAUA: | 113094533 113117421 |
| CGIB: | 127976360 128031711 |
| MASI: | 127411566 127454829 |
| CGOB: | 115027538 115027765 |
| CVG: | 107103217 107104286(setd3) |
| LCF: | 108890339 108897905(setd3) |
| SASA: | 100195551(setd3) 106602337 |
| STRU: | 115162056 115172324 |
| OTW: | 112233396(setd3) 112256871 |
| OMY: | 110497652(setd3) 110504226 |
| OGO: | 124001952(setd3) 124046657 |
| SALP: | 111963484 111968477(setd3) |
| SNH: | 120023048 120060469(setd3) |
| CCLU: | 121539547 121544683 |
| PSPA: | 121324125 121329689 |
| ARUT: | 117423265 117973958 |
| DSI: | Dsimw501_GD28230(Dsim_GD28230) |
| AALB: | 109419225 115261846 |
| CQU: | CpipJ_CPIJ009666 CpipJ_CPIJ018263 |
| BTAB: | 109041717 109043469 |
| CLEC: | 106670182 106673718 |
| CSAT: | 104700888 104704213 104712125 104747731 104768236 104781382 104791792 |
| EUS: | EUTSA_v10001950mg EUTSA_v10010346mg |
| BNA: | 106357705 106395537 106412135 106413941 106413964 106433978 |
| CPAP: | 110811109 110824046 |
| MINC: | 123193349 123199978 |
| GHI: | 107907473 107912845 107926068 107960984 |
| EGR: | 104421834 104422255 104437383 |
| PVU: | PHAVU_003G146300g PHAVU_007G007800g |
| CCAJ: | 109808500 109815146 |
| APRC: | 113846956 113872637 |
| PSAT: | 127091739 127138556 |
| LJA: | Lj4g3v2094890.2(Lj4g3v2094890.2) |
| AHF: | 112698177 112712339 112723551 112779652 |
| LANG: | 109346516 109355520 |
| PMUM: | 103323512 103332557 |
| PAVI: | 110745950 110746890 110753429 |
| PDUL: | 117614357 117617487 |
| PXB: | 103936743 103938107 103938108 |
| MCHA: | 111006114 111020893 |
| CMAX: | 111468639 111487233 |
| CMOS: | 111444075 111455914 |
| CPEP: | 111796201 111799128 |
| HBR: | 110632125 110640922 110651906 |
| MESC: | 110600553 110619464 |
| PALZ: | 118032476 118052394 |
| CILL: | 122290045 122316633 |
| QSU: | 111989952 112000567 112015821 112025330 112027303 |
| SPEN: | 107011312 107021651 |
| SSTN: | 125846954 125873752 |
| NTA: | 107760784 107764495 107805139 107831376 |
| SIND: | 105162846 105164894 |
| SSPL: | 121752986 121783748 121804872 121808862 |
| APAN: | 127255543 127257872 |
| ECAD: | 122596230 122605022 |
| CCAV: | 112517038 112529439 |
| CSIN: | 114308286 114323269 |
| BVG: | 104886907 104890021 104902413 |
| CQI: | 110684701 110689804 110692245 110721102 |
| MING: | 122069136 122082403 |
| PSOM: | 113284437 113299360 113355583 |
| DOSA: | Os01t0976450-00(Os01g0976450) Os08t0244400-01(Os08g0244400) |
| TDC: | 119270310 119270814 119278443 119279037 |
| TAES: | 123063317 123063747 123072296 123072906 123080531 123081057 |
| LPER: | 127301093 127346127 |
| SITA: | 101774628 101775581 |
| PVIR: | 120678816 120711917 |
| ZOF: | 121981481 121981482 121985359 122051184 122055894 |
| NCOL: | 116253606 116253887 |
| SMO: | SELMODRAFT_102436 SELMODRAFT_129035 SELMODRAFT_402746 SELMODRAFT_402971 SELMODRAFT_406852 SELMODRAFT_408134 SELMODRAFT_408995 SELMODRAFT_410177 SELMODRAFT_423083 SELMODRAFT_430007 SELMODRAFT_430576 SELMODRAFT_437298 SELMODRAFT_447801 SELMODRAFT_449044 |
| PPP: | 112275359 112280562 112295712 |
| APRO: | F751_6295 F751_6453 |
| OLU: | OSTLU_30782 OSTLU_32860 |
| OTA: | OT_ostta03g04560 OT_ostta03g04930 OT_ostta07g04610 |
| BPG: | Bathy07g02210 Bathy15g00710 |
| MIS: | MICPUN_56112 MICPUN_57588 MICPUN_60196 |
| MPP: | MICPUCDRAFT_50024 MICPUCDRAFT_50145 MICPUCDRAFT_57484 |
| GSL: | Gasu_01040 Gasu_37520 |
| AGO: | AGOS_ADL242W AGOS_ADR237C |
| CGR: | CAGL0C01331g CAGL0E04070g |
| NCS: | NCAS_0B06390(NCAS0B06390) |
| NDI: | NDAI_0B03680(NDAI0B03680) |
| TPF: | TPHA_0F00140(TPHA0F00140) TPHA_0F01200(TPHA0F01200) |
| TBL: | TBLA_0G02490(TBLA0G02490) |
| TDL: | TDEL_0C04020(TDEL0C04020) |
| KAF: | KAFR_0I01550(KAFR0I01550) KAFR_0J01520(KAFR0J01520) |
| KNG: | KNAG_0E01900(KNAG0E01900) |
| ZMK: | HG535_0D02310 HG535_0H03680 |
| DHA: | DEHA2B12870g DEHA2D03058g |
| NTE: | NEUTE1DRAFT90219(NEUTE1DRAFT_90219) |
| FVR: | FVEG_01491 FVEG_11241 |
| FOX: | FOXG_00025 FOXG_13810 |
| NHE: | NECHADRAFT_106330(SDG2109) NECHADRAFT_98633 |
| BFU: | BCIN_02g03570(Bchpm1) |
| ANG: | ANI_1_1174144(An16g08730) |
| ABP: | AGABI1DRAFT123080(AGABI1DRAFT_123080) |
| ABV: | AGABI2DRAFT225922(AGABI2DRAFT_225922) |
| SCM: | SCHCO_02633332(SCHCODRAFT_02633332) |
| ACAN: | ACA1_196310 ACA1_247260 ACA1_332350 |
| TET: | TTHERM_00259420 TTHERM_00370880 TTHERM_00563900 TTHERM_00782080 |
| PTM: | GSPATT00003961001 GSPATT00012103001 GSPATT00015535001 GSPATT00016863001 GSPATT00020579001 GSPATT00027281001 |
| SMIN: | v1.2.000802.t1(symbB.v1.2.000802.t1) v1.2.001415.t1(symbB.v1.2.001415.t1) v1.2.037528.t1(symbB.v1.2.037528.t1) |
| PIF: | PITG_02426 PITG_16197 PITG_17600 PITG_17996 |
| PSOJ: | PHYSODRAFT_251772 PHYSODRAFT_296170 PHYSODRAFT_361758 PHYSODRAFT_493969 PHYSODRAFT_553476 |
| SPAR: | SPRG_00522 SPRG_01065 SPRG_03006 SPRG_03389 SPRG_03940 SPRG_06826 SPRG_20573 |
| GTT: | GUITHDRAFT_106158 GUITHDRAFT_109433 GUITHDRAFT_110913 GUITHDRAFT_120884 GUITHDRAFT_121664 GUITHDRAFT_138732 GUITHDRAFT_141487 GUITHDRAFT_147375 |
| CFUS: | CYFUS_004333 CYFUS_005159 |
| MRM: | A7982_04140 A7982_11317 |
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| Reference |
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| Authors |
Vijayasarathy C, Rao BS. |
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| Title |
Partial purification and characterisation of S-adenosylmethionine:protein-histidine N-methyltransferase from rabbit skeletal muscle. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.85 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.85 |
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