KEGG   ENZYME: 2.1.1.85
Entry
EC 2.1.1.85                 Enzyme                                 
Name
protein-histidine N-methyltransferase;
protein methylase IV;
protein (histidine) methyltransferase;
actin-specific histidine methyltransferase;
S-adenosyl methionine:protein-histidine N-methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein Ntau-methyl-L-histidine [RN:R02627]
Reaction(KEGG)
R02627
Substrate
S-adenosyl-L-methionine [CPD:C00019];
protein L-histidine [CPD:C00615]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
protein Ntau-methyl-L-histidine
Comment
Highly specific for histidine residues, for example, in actin.
History
EC 2.1.1.85 created 1989
Orthology
K18803  protein-histidine N-methyltransferase
K19199  protein-histidine N-methyltransferase
Genes
HSA84193(SETD3)
PTR467549(SETD3)
PPS100977239(SETD3)
GGO101140608(SETD3)
PON100439891(SETD3)
NLE100603708(SETD3)
MCC705369(SETD3)
MCF102138432(SETD3)
CSAB103229679(SETD3)
CATY105596680(SETD3)
PANU100137585(SETD3)
TGE112628953(SETD3)
RRO104654468(SETD3)
RBB108519107(SETD3)
TFN117071402(SETD3)
PTEH111538287(SETD3)
CJC100403104(SETD3)
SBQ101047794(SETD3)
CSYR103277039(SETD3)
MMUR105864072(SETD3)
OGA100966115(SETD3)
MMU52690(Setd3)
MCAL110306407(Setd3)
MPAH110324179(Setd3)
RNO299295(Setd3)
MCOC116080858(Setd3)
MUN110555734(Setd3)
CGE100768717(Setd3)
PLEU114701900(Setd3)
NGI103727659(Setd3)
HGL101710371(Setd3)
CPOC100728937(Setd3)
CCAN109694351(Setd3)
DORD105983298(Setd3)
DSP122118710(Setd3)
NCAR124976996
OCU100355090(SETD3)
OPI101521706(SETD3)
TUP102480630(SETD3)
CFA490852(SETD3)
VVP112930227(SETD3)
VLG121493029(SETD3)
AML100471346(SETD3)
UMR103669534(SETD3)
UAH113267284(SETD3)
UAR123778199(SETD3)
ELK111148657
LLV125104260
MPUF101688373(SETD3)
ORO101363968(SETD3)
EJU114205841(SETD3)
ZCA113909001(SETD3)
MLX118002375(SETD3)
FCA101092371(SETD3)
PYU121032269(SETD3)
PBG122469518(SETD3)
PTG102958882(SETD3)
PPAD109274539(SETD3)
AJU106972180(SETD3)
HHV120245734(SETD3)
BTA512324(SETD3)
BOM102269635(SETD3)
BIU109575390(SETD3)
BBUB102398479(SETD3)
CHX102176687(SETD3) 108633232
OAS101122556(SETD3)
ODA120875210(SETD3)
CCAD122419656(SETD3)
SSC100152552(SETD3)
CFR102523504(SETD3)
CBAI105079918(SETD3)
CDK105095440(SETD3)
VPC102524952(SETD3)
BACU103015203(SETD3)
LVE103069543(SETD3)
OOR101279009(SETD3)
DLE111176095(SETD3)
PCAD102976119(SETD3)
PSIU116746410(SETD3)
ECB100049970(SETD3)
EPZ103550565(SETD3)
EAI106839666(SETD3)
MYB102245861(SETD3)
MYD102760459(SETD3)
MMYO118660218(SETD3)
MLF102442542(SETD3)
MNA107542734(SETD3)
PKL118704269(SETD3)
HAI109381047(SETD3)
DRO112311141(SETD3)
SHON118976672(SETD3)
AJM119037905(SETD3)
PDIC114492124(SETD3)
PHAS123808693(SETD3)
MMF118630510(SETD3) 118637726
RFQ117023452(SETD3)
PALE102881774(SETD3)
PGIG120619684
PVP105302293(SETD3)
RAY107518572(SETD3)
MJV108387757(SETD3) 108397043
TOD119239404(SETD3)
SARA101545124(SETD3)
LAV100676128(SETD3)
TMU101354256
DNM101422009(SETD3)
MDO100018523(SETD3)
GAS123237589(SETD3)
SHR100914247(SETD3)
PCW110222364(SETD3)
OAA100079580 100081976(SETD3)
GGA423445(SETD3)
PCOC116228858(SETD3)
MGP100545787(SETD3)
CJO107315338(SETD3)
NMEL110401809(SETD3)
APLA101804331(SETD3)
ACYG106036108(SETD3)
AFUL116489404(SETD3)
TGU100228706(SETD3)
LSR110481201(SETD3)
SCAN103826437(SETD3)
PMOA120503727(SETD3)
OTC121333383(SETD3)
PRUF121358258(SETD3)
GFR102043840(SETD3)
FAB101815405(SETD3)
PHI102100168(SETD3)
PMAJ107205918(SETD3)
CCAE111929832(SETD3)
CCW104686411(SETD3)
ETL114061694(SETD3)
ZAB102070993(SETD3)
FPG101915079(SETD3)
FCH102053464(SETD3)
CLV102088926(SETD3)
EGZ104124524 104127808
NNI104014813(SETD3)
ACUN113480442(SETD3)
TALA104365616(SETD3)
PADL103920472(SETD3)
ACHC115337193(SETD3)
AAM106482955(SETD3)
AROW112972617(SETD3)
NPD112956944(SETD3)
DNE112989926(SETD3)
ASN102383535(SETD3) 102388401
AMJ102561527(SETD3)
CPOO109321740(SETD3)
GGN109298469(SETD3)
PSS102447925(SETD3)
CMY102936831(SETD3)
CPIC101951555(SETD3)
TST117876152(SETD3)
CABI116821834(SETD3)
MRV120404865(SETD3)
ACS100553006(setd3) 107982274
PVT110089663(SETD3)
SUND121932181(SETD3)
PBI103064961(SETD3)
PMUR107291307(SETD3)
TSR106543038(SETD3)
PGUT117665971(SETD3)
VKO123026349(SETD3)
PMUA114588962(SETD3)
ZVI118080715(SETD3)
GJA107118192(SETD3)
XLA108698743(setd3.L) 108699803(setd3.S)
XTR549331(setd3)
NPR108786862 108795060
RTEM120920486(SETD3)
BBUF120982413(SETD3)
BGAR122921537(SETD3)
DRE337193(setd3)
SRX107740583 107751782
SANH107668608
SGH107583493 107588283
CCAR109061752(setd3) 109090084
CAUA113094533 113117421
IPU108270323(setd3)
PHYP113534077(setd3)
SMEO124389833(setd3)
TFD113651111(setd3)
AMEX103046172(setd3)
EEE113579776(setd3)
TRU101067589
TNGGSTEN00015770G001
LCO104939535(setd3)
NCC104962846
CGOB115027538 115027765
ELY117267083(setd3)
PLEP121953468(setd3)
SLUC116036764(setd3)
ECRA117935902(setd3)
PFLV114547116(setd3)
GAT120832929(setd3)
PPUG119227822(setd3)
MSAM119909934(setd3)
CUD121526663(setd3)
MZE101474251(setd3)
ONL100696833(setd3)
OAU116318056(setd3)
OLA101172704(setd3)
OML112144153(setd3)
XMA102233827(setd3)
XCO114133888(setd3)
XHE116708558(setd3)
PRET103458979(setd3)
PFOR103138750(setd3)
PLAI106954738(setd3)
PMEI106932149(setd3)
GAF122846285(setd3)
CVG107103217 107104286(setd3)
CTUL119787054(setd3)
GMU124855427(setd3)
NFU107373630(setd3)
KMR108245057(setd3)
ALIM106519983(setd3)
NWH119427878(setd3)
AOCE111563635(setd3)
CSEM103387866(setd3)
POV109639555(setd3)
SSEN122783064(setd3)
HHIP117755776(setd3)
LCF108890339 108897905 108897920
SDU111225721(setd3)
SLAL111667254(setd3)
XGL120795257(setd3)
HCQ109527120(setd3)
BPEC110166338(setd3)
MALB109969048(setd3)
SASA100195551(setd3) 106602337
OTW112233396(setd3) 112256871
OMY110497652(setd3) 110504226
OGO124001952(setd3) 124046657
ONE115138721 115145977
SALP111963484 111968477(setd3)
SNH120023048 120060469(setd3)
ELS105024724(setd3)
SFM108919650(setd3)
PKI111852651(setd3)
AANG118233521(setd3)
LOC102686006(setd3)
PSPA121324125 121329689
ARUT117423265 117973958
LCM102366932(SETD3)
CMK103188502(setd3)
RTP109934725
BFO118429789
BBEL109482638
CIN100183922
SCLV120336700
SPU593983
APLC110983209
SKO102801644
DMEDmel_CG32732(Setd3)
DER6551552
DSE6618946
DSIDsimw501_GD28230(Dsim_GD28230)
DYADyak_GE17555
DSR110180359
DPODpse_GA17108
DPE6600124
DMN108162469
DWI6644622
DGR6565101
DMODmoj_GI21676
DNV115564112
DHE111592995
CCAT101451795
BOD106618052
MDE101899078
SCAC106085136
LCQ111680745
AGAAgaP_AGAP002018
ACOZ120949539
AARA120893903
AAG5580263
AALB109419225 115261846
CQUCpipJ_CPIJ009666 CpipJ_CPIJ018263
CPII120413951
CNS116349082
AME410155
ACER108001191
ALAB122710450
BIM100740861
BBIF117209632
BVK117234611
BVAN117158617
BTER100648643
BPYO122572200
CCAL108625639
OBB114880041
MGEN117223532
NMEA116426110
CGIG122402531
SOC105195548
MPHA105830514
AEC105150180
ACEP105618430
PBAR105426196
VEM105569797
HST105189460
DQU106752321
CFO105250153
FEX115234244
LHU105673958
PGC109863710
OBO105280058
PCF106784335
PFUC122520619
VPS122638102
NVI100123991
CSOL105366915
TPRE106652751
MDL103576334
FAS105272417
DAM107038715
AGIF122852838
CCIN107263890
TCA664524
DPA109545041
SOY115874529
ATD109596472
CSET123309374
AGB108917476
LDC111510212
NVL108566832
APLN108742732
PPYR116174683
OTU111414810
BMOR101740875
BMAN114240942
MSEX115443554
DPLKGM_206684A
BANY112052358
PMAC106711339
PPOT106104404
PXU106121762
PRAP110995897
ZCE119833107
HAW110384555
TNL113494515
OFU114350072
PXY105380076 105390321
API100161611 100162428
DNX107166664
AGS114124176
RMD113551956 113558427
BTAB109041717 109043469
CLEC106670182 106673718
HHAL106687659
NLU111058141
PHUPhum_PHUM131480
FOC113218175
ZNE110829503
CSEC111875713
FCD110844463
DPXDAPPUDRAFT_317395
DMK116929057
PVM113801943
PJA122256956
PCHN125045652
HAME121879706
PCLA123755740
PTRU123520808
HAZT108682166
EAF111709508
ISCIscW_ISCW011867
DSV119464127
RSAN119401576
RMP119164144
VDE111246287
VJA111269692
TUT107362113
DPTE113794207
DFR124498721
CSCU111628528
PTEP107455546
SDM118190539
LOALOAG_18955
NAINECAME_09238
HROHELRODRAFT_192484
LGILOTGIDRAFT_118649
PCAN112570941
BGT106067813
GAE121371696
HRF124141962
HRJ124287368
CRG105343892
MYI110446451
PMAX117324023
MMER123544976
OBI106881421
OSN115217004
LAK106164777 106180236
SMMSmp_148360
OVIT265_06994
EGLEGR_01531
NVE5512921
EPA110234875 110253898
ATEN116306806
ADF107334989
AMIL114962532
PDAM113673409
SPIS111340096
DGT114527045
XEN124434152
AQU105312696
ATHAT2G18850
ALY9312353 9320256
CRB17886070 17893713
CSAT104700888 104704213 104712125 104747731 104768236 104781382 104791792
EUSEUTSA_v10001950mg EUTSA_v10010346mg
BRP103828366 103841421
BNA106357705 106395537 106412135 106413941 106413964 106433978
BOE106303600 106312374
RSZ108806792 108862090
THJ104803499 104809996
CPAP110811109 110824046
CIT102606634 102611704
CICCICLE_v10007836mg
PVY116107994 116113471
MINC123193349 123199978
TCC18586294 18589313
GRA105779833 105790945
GHI107907473 107912845 107926068 107960984
GAB108460172 108465148
DZI111286311 111310257
EGR104421834 104422255 104437383
GMX100778605 100818002
GSJ114372218 114392461
PVUPHAVU_003G146300g PHAVU_007G007800g
VRA106767297 106772584
VAR108322195 108329069
VUN114175624 114190218
CCAJ109808500 109815146
APRC113846956 113872637
MTRMTR_1g115980 MTR_4g128240
CAM101493991 101503944
LJALj4g3v2094890.2(Lj4g3v2094890.2)
ADU107460024 107467646
AIP107618672 107642310
AHF112698177 112712339 112723551 112779652
LANG109346516 109355520
FVE101308917 101314653
RCN112182535 112196087
PPER18785290 18788909
PMUM103323512 103332557
PAVI110745950 110746890 110753429
PDUL117614357 117617487
MDM103406296 103445821
PXB103936743 103938107 103938108
ZJU107410546 107413584
MNT21396026
CSV101212907 105434390
CMO103492948 103501651
BHJ120079325 120079668
MCHA111006114 111020893
CMAX111468639 111487233
CMOS111444075 111455914
CPEP111796201 111799128
RCU8264810 8285817
JCU105635060 105635593
HBR110632125 110640922 110651906
MESC110600553 110619464
POP18100504 18101376
PEU105114625 105121466
PALZ118032476 118052394
JRE108998805 109013068
QSU111989952 112000567 112015821 112025330 112027303
QLO115958532 115977419
TWL119996068 120005876
VVI100256524 100263808
VRI117925576 117928049
SLY101257971 101262759
SPEN107011312 107021651
SOT102594470 102606019
NTA107760784 107764495 107805139 107831376
NSY104210898 104234804
NTO104092100 104093841
NAU109207989 109237732
INI109148045 109177335
ITR115998669 116000979
SIND105162846 105164894
OEU111368715 111406491
EGT105975371 105976769
SSPL121752986 121783748 121804872 121808862
HAN110886138 110904978
ECAD122596230 122605022
LSV111888300 111894962
CCAV112517038 112529439
DCR108209919 108215813
CSIN114308286 114323269
BVG104886907 104890021 104902413
SOE110789652 110798769
CQI110684701 110689804 110692245 110721102
NNU104594687 104599142
MING122069136 122082403
TSS122659276 122662327
PSOM113284437 113299360 113355583
NCOL116253606 116253887
OSA107276114 4345051
DOSAOs01t0976450-00(Os01g0976450) Os08t0244400-01(Os08g0244400)
OBR102716240 102720370
BDI100821398 100826570
ATS109763966 109766789
TDC119270310 119270814 119278443 119279037
TAES123063317 123063747 123072296 123072906 123080531 123081057
SBI8073252
ZMA100285423
SITA101774628 101775581
SVS117855052 117861144
PVIR120678816 120711917
PDA103701561 103710048
EGU105039260 105044522
MUS103972325 103990587
DCT110091896 110092290
PEQ110026574 110033101
AOF109841323 109843285
ATR18435523 18446207
SMOSELMODRAFT_102436 SELMODRAFT_129035 SELMODRAFT_402746 SELMODRAFT_402971 SELMODRAFT_406852 SELMODRAFT_408134 SELMODRAFT_408995 SELMODRAFT_410177 SELMODRAFT_423083 SELMODRAFT_430007 SELMODRAFT_430576 SELMODRAFT_437298 SELMODRAFT_447801 SELMODRAFT_449044
PPP112275359 112280562 112295712
CRECHLRE_12g524500v5
MNGMNEG_2664
CSLCOCSUDRAFT_3634
CVRCHLNCDRAFT_139846
APROF751_6295 F751_6453
OLUOSTLU_30782 OSTLU_32860
OTAOT_ostta03g04560 OT_ostta03g04930 OT_ostta07g04610
BPGBathy07g02210 Bathy15g00710
MISMICPUN_56112 MICPUN_57588 MICPUN_60196
MPPMICPUCDRAFT_50024 MICPUCDRAFT_50145 MICPUCDRAFT_57484
GSLGasu_01040 Gasu_37520
CCPCHC_T00004925001
SCEYIL110W(HPM1)
AGOAGOS_ADL242W AGOS_ADR237C
ERCEcym_3297
KLAKLLA0_F03663g
KMXKLMA_80158(HPM1)
LTHKLTH0G09768g
VPOKpol_1039p28
ZROZYRO0D02376g
CGRCAGL0C01331g CAGL0E04070g
NCSNCAS_0B06390(NCAS0B06390)
NDINDAI_0B03680(NDAI0B03680)
TPFTPHA_0F00140(TPHA0F00140) TPHA_0F01200(TPHA0F01200)
TBLTBLA_0G02490(TBLA0G02490)
TDLTDEL_0C04020(TDEL0C04020)
TGBHG536_0B03180
KAFKAFR_0I01550(KAFR0I01550) KAFR_0J01520(KAFR0J01520)
ZMKHG535_0D02310 HG535_0H03680
PPAPAS_chr3_0616
DHADEHA2B12870g DEHA2D03058g
PICPICST_43721
PGUPGUG_05110
SPAASPAPADRAFT_61422
LELLELG_00321
CTPCTRG_03243
COTCORT_0A04230
CDUCD36_08530
CTENCANTEDRAFT_128933
YLIYALI0F05258g
CLUCLUG_05039
CLUSA9F13_03g01925
CAURCJI97_001229
SLBAWJ20_783(HPM1)
PKZC5L36_0B10250
BNNFOA43_003934
BBRXBRETT_000658
NCRNCU00956
NTENEUTE1DRAFT90219(NEUTE1DRAFT_90219)
SMPSMAC_00233
PANPODANSg5835
TTTTHITE_111049
MTMMYCTH_2296096
CTHRCTHT_0060940
MGRMGG_17436
TMNUCRPA7_7702
SSCKSPSK_09111
FGRFGSG_01355
FPUFPSE_11523
FVRFVEG_01491 FVEG_11241
FOXFOXG_00025 FOXG_13810
NHENECHADRAFT_106330(SDG2109) NECHADRAFT_98633
TRETRIREDRAFT_104659
TRRM419DRAFT_80008
MAWMAC_04586
MAJMAA_00238
CMTCCM_06667
PLJVFPFJ_03226
VALVDBG_04898
VDAVDAG_04443
CFJCFIO01_08606
SAPOSAPIO_CDS0795
ELAUCREL1_1263
PFYPFICI_01775 PFICI_08462
BFUBCIN_02g03570(Bchpm1)
MBEMBM_02255 MBM_07663
PSCOLY89DRAFT_739323
GLZGLAREA_05651
ANIAN1445.2
AFMAFUA_8G04330
ACTACLA_057680
NFINFIA_097060
AORAO090103000050
ANGANI_1_1174144(An16g08730)
AFVAFLA_013468
ALUCAKAW2_70696S
ACHEACHE_60686S
APUUAPUU_21782S
PCSPc21g05440
PDPPDIP_61070
TMFPMAA_059910
TRGTRUGW13939_01116
CIMCIMG_02215
CPWCPC735_038830
UREUREG_01503
PBLPAAG_04699
PBNPADG_02455
ABEARB_06471
TVETRV_07091
AJEHCAG_02709
BGHBDBG_04217
PNOSNOG_14205
PTEPTT_17862
BZECOCCADRAFT_111781
BSCCOCSADRAFT_30302
BORCOCMIDRAFT_9862
AALTCC77DRAFT_1019355
ZTRMYCGRDRAFT_106949
PFJMYCFIDRAFT_136838
BCOMBAUCODRAFT_146131
NPAUCRNP2_9645
TMLGSTUM_00009641001
SPOSPAC1071.05
CNECNA06680
CNBCNBA6500
CGICGB_A7490W
TMSTREMEDRAFT_35357
TASAA1Q1_08143
TVSTRAVEDRAFT_67672
DSQDICSQDRAFT_46383
SHSSTEHIDRAFT_124794
HIRHETIRDRAFT_162541
ADLAURDEDRAFT_66492
FMEFOMMEDRAFT_118786
GTRGLOTRDRAFT_44989
LBCLACBIDRAFT_189982
MRRMoror_17144
CCICC1G_03289
SCMSCHCODRAFT_58788
ABPAGABI1DRAFT123080(AGABI1DRAFT_123080)
ABVAGABI2DRAFT225922(AGABI2DRAFT_225922)
CPUTCONPUDRAFT_133063
SLASERLADRAFT_457235
WSEWALSEDRAFT_27897
WICJ056_004793
UMAUMAG_02979
PFPPFL1_04902
MGLMGL_2988
MRTMRET_3595
PGRPGTG_12504
MBRMONBRDRAFT_16278
SREPTSG_09157
DDIDDB_G0269768(cnrI)
DPPDICPUDRAFT_57488
DFADFA_01560 DFA_09480
ACANACA1_196310 ACA1_247260 ACA1_332350
TETTTHERM_00259420 TTHERM_00370880 TTHERM_00563900 TTHERM_00782080
PTMGSPATT00003961001 GSPATT00012103001 GSPATT00015535001 GSPATT00016863001 GSPATT00020579001 GSPATT00027281001
SMINv1.2.000802.t1(symbB.v1.2.000802.t1) v1.2.001415.t1(symbB.v1.2.001415.t1) v1.2.037528.t1(symbB.v1.2.037528.t1)
AAFAURANDRAFT_72732
PIFPITG_02426 PITG_16197 PITG_17600 PITG_17996
PSOJPHYSODRAFT_251772 PHYSODRAFT_296170 PHYSODRAFT_361758 PHYSODRAFT_493969 PHYSODRAFT_553476
SPARSPRG_00522 SPRG_01065 SPRG_03006 SPRG_03389 SPRG_03940 SPRG_06826 SPRG_20573
GTTGUITHDRAFT_106158 GUITHDRAFT_109433 GUITHDRAFT_110913 GUITHDRAFT_120884 GUITHDRAFT_121664 GUITHDRAFT_138732 GUITHDRAFT_141487 GUITHDRAFT_147375
AGEAA314_04887
MBDMEBOL_006754
CFUSCYFUS_004333 CYFUS_005159
MRMA7982_04140 A7982_11317
 » show all
Reference
1  [PMID:3801515]
  Authors
Vijayasarathy C, Rao BS.
  Title
Partial purification and characterisation of S-adenosylmethionine:protein-histidine N-methyltransferase from rabbit skeletal muscle.
  Journal
Biochim Biophys Acta 923:156-65 (1987)
DOI:10.1016/0304-4165(87)90139-5
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.85
IUBMB Enzyme Nomenclature: 2.1.1.85
ExPASy - ENZYME nomenclature database: 2.1.1.85
BRENDA, the Enzyme Database: 2.1.1.85
CAS: 108022-17-9

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