| Entry |
|
|---|
| Name |
tetrahydrocolumbamine 2-O-methyltransferase;
tetrahydrocolumbamine methyltransferase
|
|---|
| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
|
|---|
| Sysname |
S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase
|
|---|
| Reaction(IUBMB) |
S-adenosyl-L-methionine + 5,8,13,13a-tetrahydrocolumbamine = S-adenosyl-L-homocysteine + tetrahydropalmatine [RN: R04077]
|
|---|
| Reaction(KEGG) |
|
|---|
| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
5,8,13,13a-tetrahydrocolumbamine [CPD: C04118]
|
|---|
| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
tetrahydropalmatine [CPD: C02890]
|
|---|
| Comment |
Involved in the biosynthesis of the berberine alkaloids.
|
|---|
| History |
EC 2.1.1.89 created 1989
|
|---|
| Pathway |
| ec00950 | Isoquinoline alkaloid biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
|
|---|
| Reference |
1 |
|---|
| Authors |
Beecher CWW, Kelleher WJ. |
|---|
| Title |
Enzymatic study of the late stages of protoberberine alkaloid biosynthesis. |
|---|
| Journal |
Tetrahedron Lett 25:4595-4598 (1984) |
|---|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.89 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.89 |
|
|---|
