KEGG   ENZYME: 2.1.1.9Help
Entry
EC 2.1.1.9                  Enzyme                                 

Name
thiol S-methyltransferase;
S-methyltransferase;
thiol methyltransferase;
TMT
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:thiol S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a methyl thioether [RN:R01235]
Reaction(KEGG)
R01235;
(other) R04931
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Substrate
S-adenosyl-L-methionine [CPD:C00019];
thiol [CPD:C00145]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
methyl thioether [CPD:C20791]
Comment
H2S and a variety of alkyl, aryl and heterocyclic thiols and hydroxy thiols can act as acceptors.
History
EC 2.1.1.9 created 1965
Reference
1  [PMID:623768]
  Authors
Borchardt RT, Cheng CF.
  Title
Purification and characterization of rat liver microsomal thiol methyltransferase.
  Journal
Biochim Biophys Acta 522:340-53 (1978)
DOI:10.1016/0005-2744(78)90068-2
Reference
2
  Authors
Bremer, J. and Greenberg, D.M.
  Title
Enzymic methylation of foreign sulfhydryl compounds.
  Journal
Biochim Biophys Acta 46:217-224 (1961)
Reference
3  [PMID:485170]
  Authors
Weisiger RA, Jakoby WB.
  Title
Thiol S-methyltransferase from rat liver.
  Journal
Arch Biochem Biophys 196:631-7 (1979)
DOI:10.1016/0003-9861(79)90317-5
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.9
IUBMB Enzyme Nomenclature: 2.1.1.9
ExPASy - ENZYME nomenclature database: 2.1.1.9
UM-BBD (Biocatalysis/Biodegradation Database): 2.1.1.9
BRENDA, the Enzyme Database: 2.1.1.9
CAS: 9029-81-6

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