Entry
Name
methanol---corrinoid protein Co-methyltransferase;
methanol cobalamin methyltransferase;
methanol:5-hydroxybenzimidazolylcobamide methyltransferase;
MT 1 (ambiguous);
methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase;
mtaB (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
methanol:5-hydroxybenzimidazolylcobamide Co-methyltransferase
Reaction(IUBMB)
methanol + a [Co(I) methanol-specific corrinoid protein] = a [methyl-Co(III) methanol-specific corrinoid protein] + H2O [RN:
R04384 ]
Reaction(KEGG)
Substrate
methanol [CPD:
C00132 ];
[Co(I) methanol-specific corrinoid protein]
Product
[methyl-Co(III) methanol-specific corrinoid protein];
H2O [CPD:
C00001 ]
Comment
The enzyme, which catalyses the transfer of methyl groups from methanol to a methanol-specific corrinoid protein (MtaC), is involved in methanogenesis from methanol. Methylation of the corrinoid protein requires the central cobalt to be in the Co(I) state. During methylation the cobalt is oxidized to the Co(III) state. Free cob(I)alamin can substitute for the corrinoid protein in vitro [2].
Inactivated by oxygen and other oxidizing agents, and reactivated by catalytic amounts of ATP and hydrogen.
History
EC 2.1.1.90 created 1989, modified 2012
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K04480 methanol---5-hydroxybenzimidazolylcobamide Co-methyltransferase
Genes
MST : Msp_0184(mtaB3) Msp_0186(mtaB2) Msp_0188(mtaB1) Msp_0819(mtaB4)
METB : AW729_03460 AW729_06185
MEIS : PXD04_04795 PXD04_04805 PXD04_09505
MBA : Mbar_A0741 Mbar_A1064 Mbar_A3638
MBY : MSBRM_0302 MSBRM_2353 MSBRM_3321
MBW : MSBRW_0261 MSBRW_1094 MSBRW_3658
MBAR : MSBR2_2078 MSBR2_2319 MSBR2_3275
MBAK : MSBR3_2096 MSBR3_2380 MSBR3_3273
MAC : MA_0455(mtaB1) MA_1616(mtaB3) MA_4392(mtaB2)
MMA : MM_0175(mtaB) MM_1074(mtaB) MM_1647
MMAZ : MmTuc01_0182 MmTuc01_1725
MMJ : MSMAS_0227 MSMAS_1126 MSMAS_3023
MMAC : MSMAC_0233 MSMAC_1415 MSMAC_2486
MVC : MSVAZ_0210 MSVAZ_0343 MSVAZ_1365
MEK : MSKOL_0204 MSKOL_0326 MSKOL_1308
MLS : MSLAZ_0239 MSLAZ_1380 MSLAZ_2955
METM : MSMTP_0258 MSMTP_1140 MSMTP_2926
MEF : MSWH1_0315 MSWH1_0524 MSWH1_1022
MEQ : MSWHS_0318 MSWHS_0538 MSWHS_1093
MSJ : MSSAC_0405 MSSAC_1598 MSSAC_4075
MSZ : MSSIH_0373 MSSIH_1187 MSSIH_3611
MSW : MSSIT_0381 MSSIT_1254 MSSIT_3664
MTHR : MSTHT_0083 MSTHT_1750 MSTHT_2137
MTHE : MSTHC_0647 MSTHC_1146 MSTHC_1539
MHOR : MSHOH_0282 MSHOH_1348 MSHOH_3746
MFZ : AOB57_002020 AOB57_005220 AOB57_007940
MHAB : RSJ42_03620(mtaB) RSJ42_14735(mtaB) RSJ42_17740(mtaB)
METW : AAY43_02655 AAY43_04770 AAY43_07440
MMET : MCMEM_0944 MCMEM_0947 MCMEM_0949
MELO : J7W08_02955 J7W08_02965
MHAZ : BHR79_08685 BHR79_08695
MPOT : BKM01_04955 BKM01_04965
MZH : Mzhil_1950 Mzhil_1952
MZI : HWN40_04050 HWN40_07075
MMAV : RE476_03440(mtaB) RE476_06200(mtaB)
MSEB : RE474_02330(mtaB) RE474_13090(mtaB)
MHZ : Metho_0775 Metho_1601
MEHF : MmiHf6_11430 MmiHf6_11480
MEES : MmiEs2_14110 MmiEs2_14160
MEAE : QEN48_01760 QEN48_07915
MER : MMINT_02820 MMINT_03160 MMINT_05920
MEUZ : KRP56_04440 KRP56_04450
MARC : AR505_0949 AR505_0951
» show all
Taxonomy
Reference
Authors
van der Meijden P, te Brommelstroet BW, Poirot CM, van der Drift C, Vogels GD.
Title
Purification and properties of methanol:5-hydroxybenzimidazolylcobamide methyltransferase from Methanosarcina barkeri.
Journal
Sequence
Reference
Authors
Sauer K, Thauer RK
Title
Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.90
ExPASy - ENZYME nomenclature database: 2.1.1.90