KEGG   ENZYME: 2.1.1.95
Entry
EC 2.1.1.95                 Enzyme                                 
Name
tocopherol C-methyltransferase;
gamma-tocopherol methyltransferase;
VTE4 (gene name);
S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase (incorrect);
tocopherol O-methyltransferase (incorrect)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:gamma-tocopherol 5-C-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol  [RN:R07236];
(2) S-adenosyl-L-methionine + delta-tocopherol = S-adenosyl-L-homocysteine + beta-tocopherol  [RN:R07504];
(3) S-adenosyl-L-methionine + gamma-tocotrienol = S-adenosyl-L-homocysteine + alpha-tocotrienol  [RN:R10491];
(4) S-adenosyl-L-methionine + delta-tocotrienol = S-adenosyl-L-homocysteine + beta-tocotrienol [RN:R10492]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
gamma-tocopherol [CPD:C02483];
delta-tocopherol [CPD:C14151];
gamma-tocotrienol [CPD:C14155];
delta-tocotrienol [CPD:C14156]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
alpha-tocopherol [CPD:C02477];
beta-tocopherol [CPD:C14152];
alpha-tocotrienol [CPD:C14153];
beta-tocotrienol [CPD:C14154]
Comment
The enzymes from plants and photosynthetic bacteria have similar efficiency with the gamma and delta isomers of tocopherols and tocotrienols.
History
EC 2.1.1.95 created 1989, modified 2013, modified 2019
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05928  tocopherol O-methyltransferase
Genes
ATHAT1G64970(G-TMT)
ALY9322850
CRB17896175
CSAT104722834 104725296 104751124 104760795
EUSEUTSA_v10018768mg
BRP103852208 103853294
BNA106388189 106390439 106406285 125574762 125604823
BOE106318945 106322543
RSZ108816273
THJ104805718 104821707
CPAP110815941
CIT102628754
CICCICLE_v10005360mg CICLE_v10032026mg
PVY116113145 116128697
MINC123220265
TCC18599602
GRA105783674 105787986
GHI107920515 107951798 121215348
GAB108461158 108463606
HSYR120133705 120161646 120208181
DZI111276925 111277748 111296546
EGR104424262
GMX100778509 100792443(GAMMA-TMT) 732543
GSJ114378746 114378747 114425831
PVUPHAVU_011G017100g PHAVU_011G017200g
VRA106779509 106779693
VAR108339045 108339528
VUN114168461 114168600
VUM124827030
CCAJ109798298 109798841
APRC113864367 113864369
MTR25481971
TPRA123916282
CAM101513488
PSAT127091611
VVO131596358 131630921
LJALj3g3v3639870.1(Lj3g3v3639870.1) Lj3g3v3639870.2(Lj3g3v3639870.2)
ADU107488489 107488490
AIP107643212 107643213
AHF112749831 112749832 112801308
LANG109348558
PCIN129312705
FVE101307130
RCN112192792
PPER18769165
PMUM103339737
PAVI110753538
PDUL117633880
MDM103414721 103449390
MSYL126600160
PXB103942764 103944307 103955170
ZJU107414726
MNT21402584
CSAV115716613
CSV101205148
CMO103501078
BHJ120087680
MCHA111017272
CMAX111484262
CMOS111449074
CPEP111777902
RCU8284310
JCU105632484
HBR110659616
MESC110619928
POP7465624
PEU105139626
PALZ118053559
JRE109003796
CILL122311772
CAVE132167650 132182424
QSU111988753 111988756
QLO115960404 115960524
TWL120016222
VVI100242641
VRI117931601 117932870
SLY778248(TMT)
SPEN107028652
SOT102577815(GAMMA-TMT)
SSTN125842189
SDUL129889656
CANN107870898
LBB132635354
NTA107793279 107804296 107809106
NSY104241965 104243178 104247874
NTO104111647
NAU109211043
INI109179117
ITR116012093 116013898
SIND105174312
OEU111381589
EGT105961226
SSPL121792242 121799119
SMIL130997728
APAN127250980
HAN110872346 110872347 110890669
ECAD122603529
LSV111900764 111916272
CCAV112512163 112524460 112528192
DCR108210384
CSIN114270934 114270949 114316857
RVL131300026 131301495
AEW130767209 130789869
BVG104888087
SOE110793113
CQI110693052
ATRI130808217 130823885 130825775
MOF131159274
NNU104590834 104590835 104590913 104611563
MING122081156
TSS122646314
PSOM113347964 113349396
OSA4330437
DOSAOs02t0701600-01(Os02g0701600)
OBR102706446
OGL127764584
BDI100836877
ATS109744847
TDC119317549 119323408
TAES123128104 123137891 780621
TUA125514295
LPER127306535
LRD124692933
SBI8067143 8073167 8079111
ZMA732837
SITA101778567
SVS117834521
PVIR120656021
PHAI112881382
PDA103716652
EGU105033221
MUS104000155
ZOF121975977 122011815 122017426 122034823
DCT110115783
PEQ110031053
AOF109837030 109838387
MSIN131247894
NCOL116253313 116265400 116266046
ATR110006333 18443978
SMOSELMODRAFT_145351 SELMODRAFT_167817 SELMODRAFT_173430 SELMODRAFT_175008 SELMODRAFT_235738 SELMODRAFT_451558 SELMODRAFT_89835 SELMODRAFT_93926
PPP112288826
CRECHLRE_09g393400v5
VCNVOLCADRAFT_105162
MNGMNEG_4528
CSLCOCSUDRAFT_33371
CVRCHLNCDRAFT_26131
APROF751_6137
OLUOSTLU_40586
OTAOT_ostta16g00380
BPGBathy07g04690
MISMICPUN_59038
MPPMICPUCDRAFT_34805(JGI:MicpuC2_34805)
CMECYME_CMT560C
GSLGasu_24450
CCPCHC_T00000837001
PTIPHATRDRAFT_20470(TMT)
FCYFRACYDRAFT_238951(VTE4)
TPSTHAPSDRAFT_23931
AAFAURANDRAFT_3921
EHXEMIHUDRAFT_60986
GTTGUITHDRAFT_71036
ASIPAQUSIP_02080
TMCLMI_3088
MLDU0023_19460
PSTISOO65_08795
ALACJYE50_01160
WHROG579_02955
KISHUT16_31035
ABRYNYE86_02835
POKSMD14_05210
ALOCRK55118
MSAGGCM10017556_09930
CATICS0771_28010
DVCDvina_13845
DFUDfulv_12490
DAURDaura_12980
DMATDmats_13380
CAICaci_3249
SYNslr0089(erg6)
SYZMYO_126250(erg6)
SYYSYNGTS_2600(slr0089)
SYTSYNGTI_2599(slr0089)
SYSSYNPCCN_2598(slr0089)
SYQSYNPCCP_2598(slr0089)
SYJD082_21800(erg6)
SYOC7I86_13605
CYACYA_2254
CYBCYB_2403
SYNESyn6312_1639
SYNPSyn7502_02171
DSLDacsa_1481
WNAKA717_38800
CMPCha6605_5217
CYNCyan7425_3207
CEPCri9333_1617
AMRAM1_4540
ACAMHRE53_20135
LENLEP3755_11130
LETO77CONTIG1_00395(rebM_1)
LBOLBWT_42280
LSCKIK02_03895
LSKJ5X98_20985
HHGXM38_016580
PSEUPse7367_2506
THEUHPC62_08070
TOGHNI00_19845
TSINOXH18_01975
GLPGlo7428_4760
CHONNIES4102_02280
GDUP0S91_08870
SYPSYNPCC7002_A1791
SYVAWQ23_09130
SYLAWQ21_09475
LEPLepto7376_4312
MARMAE_24880
MPKVL20_4041
MIQB5D77_14925
MVZmyaer102_01730
HAOPCC7418_1397
ENNFRE64_10070
CYTcce_3547
CWACwatDRAFT_0798
CYPPCC8801_0328
CYHCyan8802_0335
CYCPCC7424_1808
CYJCyan7822_0007
TERTery_3884
ARPNIES39_M01550
PAGHNIES204_01290
PPSUNO713_03545(VTE4)
PRUNPCC7821_04187(VTE4)
OXYHCG48_01380
MVAGD0A34_10570
LFSHFV01_13475
OACOscil6304_3680
ONIOsc7112_4375
MPROBJP34_07905
PHORJWS08_01935
PYHNEA10_11615
MICMic7113_5161
GEIGEI7407_0067
GVIglr3090
GLJGKIL_0804(ubiE)
GMLISF26_14310
ANAalr1803
NPUNpun_R6023
NOSNos7107_1174
NOPNos7524_4363
NONNOS3756_12040
NFLCOO91_06862
NOECLI64_01445
NSHGXM_00587
NEDHUN01_03345
AVAAva_4806
NAZAazo_3463
ANBANA_C20681
ACYAnacy_5288
AWAAA650_08025
ANNEH233_12140
CSGCylst_2832
RSINB6N60_00407
HBQQI031_08810
CALOCal7507_0600
CALTCal6303_2077
CALHIJ00_11010
CALNNIES2098_40970
CALSNIES3974_45790
RIVRiv7116_6708
FISFIS3754_01290
NSPHBDGGKGIB_04206
DOUBMF77_00886
DFSHGD76_15830
DHTNG743_19520
CCURIAR63_17070
CRKL3I90_10975
AFLOHEQ12_05000
TOQHCG51_14305
NCNBZZ01_25555
CTHEChro_0307
PLPPle7327_2620
SCSSta7437_3159
STANSTA3757_20890
 » show all
Reference
1  [PMID:24253640]
  Authors
Camara B, d'Harlingue A
  Title
Demonstration and solubilization of S-adenosylmethionine: gamma-tocopherol methyltransferase from Capsicum chromoplasts.
  Journal
Plant Cell Rep 4:31-2 (1985)
DOI:10.1007/BF00285499
Reference
2  [PMID:12492478]
  Authors
Koch M, Lemke R, Heise KP, Mock HP
  Title
Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana.
  Journal
Eur J Biochem 270:84-92 (2003)
DOI:10.1046/j.1432-1033.2003.03364.x
Reference
3  [PMID:22763462]
  Authors
Zhang GY, Liu RR, Xu G, Zhang P, Li Y, Tang KX, Liang GH, Liu QQ
  Title
Increased alpha-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis gamma-tocopherol methyltransferase.
  Journal
Transgenic Res 22:89-99 (2013)
DOI:10.1007/s11248-012-9630-2
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.95
IUBMB Enzyme Nomenclature: 2.1.1.95
ExPASy - ENZYME nomenclature database: 2.1.1.95
BRENDA, the Enzyme Database: 2.1.1.95
CAS: 84788-82-9

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