| Entry |
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| Name |
tocopherol C-methyltransferase;
gamma-tocopherol methyltransferase;
VTE4 (gene name);
S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase (incorrect);
tocopherol O-methyltransferase (incorrect)
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| Class |
Transferases;
Transferring one-carbon groups;
Methyltransferases
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| Sysname |
S-adenosyl-L-methionine:gamma-tocopherol 5-C-methyltransferase
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| Reaction(IUBMB) |
(1) S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol [RN: R07236];
(2) S-adenosyl-L-methionine + delta-tocopherol = S-adenosyl-L-homocysteine + beta-tocopherol [RN: R07504];
(3) S-adenosyl-L-methionine + gamma-tocotrienol = S-adenosyl-L-homocysteine + alpha-tocotrienol [RN: R10491];
(4) S-adenosyl-L-methionine + delta-tocotrienol = S-adenosyl-L-homocysteine + beta-tocotrienol [RN: R10492]
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| Reaction(KEGG) |
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| Substrate |
S-adenosyl-L-methionine [CPD: C00019];
gamma-tocopherol [CPD: C02483];
delta-tocopherol [CPD: C14151];
gamma-tocotrienol [CPD: C14155];
delta-tocotrienol [CPD: C14156]
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| Product |
S-adenosyl-L-homocysteine [CPD: C00021];
alpha-tocopherol [CPD: C02477];
beta-tocopherol [CPD: C14152];
alpha-tocotrienol [CPD: C14153];
beta-tocotrienol [CPD: C14154]
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| Comment |
The enzymes from plants and photosynthetic bacteria have similar efficiency with the gamma and delta isomers of tocopherols and tocotrienols.
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| History |
EC 2.1.1.95 created 1989, modified 2013, modified 2019
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| Pathway |
| ec00130 | Ubiquinone and other terpenoid-quinone biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K05928 | tocopherol O-methyltransferase |
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| Genes |
| CSAT: | 104722834 104725296 104751124 104760795 |
| BNA: | 106388189 106390439 106406285 |
| CIC: | CICLE_v10005360mg CICLE_v10032026mg |
| GHI: | 107920515 107951798 121215348 |
| DZI: | 111276925 111277748 111296546 |
| GMX: | 100778509 100792443(GAMMA-TMT) 732543 |
| GSJ: | 114378746 114378747 114425831 |
| PVU: | PHAVU_011G017100g PHAVU_011G017200g |
| CCAJ: | 109798298 109798841 |
| APRC: | 113864367 113864369 |
| LJA: | Lj3g3v3639870.1(Lj3g3v3639870.1) Lj3g3v3639870.2(Lj3g3v3639870.2) |
| AHF: | 112749831 112749832 112801308 |
| PXB: | 103942764 103944307 103955170 |
| SOT: | 102577815(GAMMA-TMT) |
| NTA: | 107793279 107804296 107809106 |
| NSY: | 104241965 104243178 104247874 |
| SSPL: | 121792242 121799119 |
| HAN: | 110872346 110872347 110890669 |
| CCAV: | 112512163 112524460 112528192 |
| CSIN: | 114270934 114270949 114316857 |
| NNU: | 104590834 104590835 104590913 104611563 |
| PSOM: | 113347964 113349396 |
| DOSA: | Os02t0701600-01(Os02g0701600) |
| TAES: | 123128104 123137891 780621 |
| SBI: | 8067143 8073167 8079111 |
| ZOF: | 121975977 122011815 122017426 122034823 |
| NCOL: | 116253313 116265400 116266046 |
| SMO: | SELMODRAFT_145351 SELMODRAFT_167817 SELMODRAFT_173430 SELMODRAFT_175008 SELMODRAFT_235738 SELMODRAFT_451558 SELMODRAFT_89835 SELMODRAFT_93926 |
| NTE: | NEUTE1DRAFT75477(NEUTE1DRAFT_75477) |
| PTI: | PHATRDRAFT_20470(TMT) |
| FCY: | FRACYDRAFT_238951(VTE4) |
| MMT: | Metme_4393 Metme_4394 |
| AAGI: | NCTC2676_1_00373(rebM) |
| CATI: | CS0771_28010 CS0771_29070 |
| SYY: | SYNGTS_2600(slr0089) |
| SYT: | SYNGTI_2599(slr0089) |
| SYS: | SYNPCCN_2598(slr0089) |
| SYQ: | SYNPCCP_2598(slr0089) |
| LET: | O77CONTIG1_00395(rebM_1) |
| LCRE: | Pla8534_26500(rebM_1) |
| AMUC: | Pan181_19030(rebM_2) |
| GPN: | Pan110_15790(rebM_1) |
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| Reference |
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| Authors |
Camara B, d'Harlingue A |
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| Title |
Demonstration and solubilization of S-adenosylmethionine: gamma-tocopherol methyltransferase from Capsicum chromoplasts. |
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| Journal |
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| Reference |
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| Authors |
Koch M, Lemke R, Heise KP, Mock HP |
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| Title |
Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana. |
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| Journal |
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| Reference |
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| Authors |
Zhang GY, Liu RR, Xu G, Zhang P, Li Y, Tang KX, Liang GH, Liu QQ |
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| Title |
Increased alpha-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis gamma-tocopherol methyltransferase. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.1.1.95 |
| ExPASy - ENZYME nomenclature database: | 2.1.1.95 |
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