KEGG   ENZYME: 2.1.1.95Help
Entry
EC 2.1.1.95                 Enzyme                                 

Name
tocopherol O-methyltransferase;
gamma-tocopherol methyltransferase;
VTE4 (gene name)
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
BRITE hierarchy
Sysname
S-adenosyl-L-methionine:gamma-tocopherol 5-O-methyltransferase
Reaction(IUBMB)
(1) S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol  [RN:R07236];
(2) S-adenosyl-L-methionine + delta-tocopherol = S-adenosyl-L-homocysteine + beta-tocopherol  [RN:R07504];
(3) S-adenosyl-L-methionine + gamma-tocotrienol = S-adenosyl-L-homocysteine + alpha-tocotrienol  [RN:R10491];
(4) S-adenosyl-L-methionine + delta-tocotrienol = S-adenosyl-L-homocysteine + beta-tocotrienol [RN:R10492]
Reaction(KEGG)
Substrate
S-adenosyl-L-methionine [CPD:C00019];
gamma-tocopherol [CPD:C02483];
delta-tocopherol [CPD:C14151];
gamma-tocotrienol [CPD:C14155];
delta-tocotrienol [CPD:C14156]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
alpha-tocopherol [CPD:C02477];
beta-tocopherol [CPD:C14152];
alpha-tocotrienol [CPD:C14153];
beta-tocotrienol [CPD:C14154]
Comment
The enzymes from plants and photosynthetic bacteria have similar efficiency with the gamma and delta isomers of tocopherols and tocotrienols.
History
EC 2.1.1.95 created 1989, modified 2013
Pathway
ec00130  Ubiquinone and other terpenoid-quinone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K05928  tocopherol O-methyltransferase
Genes
ATH: AT1G64970(G-TMT)
ALY: ARALYDRAFT_475500
CRB: 17896175
CSAT: 104722834 104725296 104751124 104760795
EUS: EUTSA_v10018768mg
BRP: 103852208(TMT) 103853294
BNA: 106388189 106390439 106406285
BOE: 106318945 106322543
THJ: 104805718 104821707
CPAP: 110815941
CIT: 102628754
TCC: 18599602
EGR: 104424262
GMX: 100778509(gTMT1) 100792443(G-TMT) 732543(gTMT2)
CAM: 101513488
LJA: Lj3g3v3639870.1(Lj3g3v3639870.1) Lj3g3v3639870.2(Lj3g3v3639870.2)
LANG: 109348558
FVE: 101307130
PPER: 18769165
PMUM: 103339737
PAVI: 110753538
CSV: 101205148
CMO: 103501078
MCHA: 111017272
CMAX: 111484262
CMOS: 111449074
CPEP: 111777902
RCU: 8284310
JCU: 105632484
HBR: 110659616
POP: 7465624
JRE: 109003796
VVI: 100242641
SLY: 778248(TMT)
SPEN: 107028652
SOT: 102577815(GAMMA-TMT)
CANN: 107870898
NTO: 104111647
INI: 109179117
SIND: 105174312
DCR: 108210384
BVG: 104888087
SOE: 110793113
OSA: 4330437
DOSA: Os02t0701600-01(Os02g0701600)
OBR: 102706446
BDI: 100836877
ATS: 109744847(LOC109744847)
ZMA: 732837(cl364_1)
SITA: 101778567
PDA: 103716652
EGU: 105033221
MUS: 104000155
DCT: 110115783
PPP: 112288826
CRE: CHLREDRAFT_129990(VTE4)
MNG: MNEG_4528
APRO: F751_6137
MGR: MGG_04901
PTI: PHATRDRAFT_20470(TMT)
FCY: FRACYDRAFT_238951(VTE4)
TMC: LMI_3088
RVA: Rvan_2344
SSAN: NX02_23295
SPMI: K663_17016
SPHT: K426_22279
ART: Arth_1026
SESP: BN6_50360
ALL: CRK55118
CAI: Caci_3249
SYN: slr0089(erg6)
SYZ: MYO_126250(erg6)
SYY: SYNGTS_2600(slr0089)
SYT: SYNGTI_2599(slr0089)
SYS: SYNPCCN_2598(slr0089)
SYQ: SYNPCCP_2598(slr0089)
SYJ: D082_21800(erg6)
CYA: CYA_2254
CYB: CYB_2403
LET: O77CONTIG1_00395(rebM_1)
AMR: AM1_4540
MAR: MAE_24880
MPK: VL20_4041
CYT: cce_3547
TER: Tery_3884
GVI: glr3090
GLJ: GKIL_0804(ubiE)
ANA: alr1803
AVA: Ava_4806
NAZ: Aazo_3463
CALH: IJ00_11010
CTHE: Chro_0307
TRA: Trad_1513
PIR: VN12_16875(rebM_2)
 » show all
Taxonomy
Reference
1
  Authors
Camara, B. and D'Harlingue, A.
  Title
Demonstration and solubilization of S-adenosylmethionine - gamma-tocopherol methyltransferase from capsicum chromoplasts.
  Journal
Plant Cell Rep 4:31-32 (1985)
Reference
2  [PMID:12492478]
  Authors
Koch M, Lemke R, Heise KP, Mock HP
  Title
Characterization of gamma-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana.
  Journal
Eur J Biochem 270:84-92 (2003)
DOI:10.1046/j.1432-1033.2003.03364.x
Reference
3  [PMID:22763462]
  Authors
Zhang GY, Liu RR, Xu G, Zhang P, Li Y, Tang KX, Liang GH, Liu QQ
  Title
Increased alpha-tocotrienol content in seeds of transgenic rice overexpressing Arabidopsis gamma-tocopherol methyltransferase.
  Journal
Transgenic Res 22:89-99 (2013)
DOI:10.1007/s11248-012-9630-2
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.95
IUBMB Enzyme Nomenclature: 2.1.1.95
ExPASy - ENZYME nomenclature database: 2.1.1.95
BRENDA, the Enzyme Database: 2.1.1.95
CAS: 84788-82-9

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