KEGG   ENZYME: 2.1.2.14
Entry
EC 2.1.2.14                 Enzyme                                 
Name
GDP-perosamine N-formyltransferase;
wbkC (gene name)
Class
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
Sysname
10-formyltetrahydrofolate:GDP-alpha-D-perosamine N-formyltransferase
Reaction(IUBMB)
10-formyltetrahydrofolate + GDP-alpha-D-perosamine = tetrahydrofolate + GDP-N-formyl-alpha-D-perosamine [RN:R12790]
Reaction(KEGG)
R12790
Substrate
10-formyltetrahydrofolate [CPD:C00234];
GDP-alpha-D-perosamine [CPD:C20638]
Product
tetrahydrofolate [CPD:C00101];
GDP-N-formyl-alpha-D-perosamine [CPD:C22397]
Comment
The enzyme, characterized from the bacterium Brucella melitensis, synthesizes a building block of the O antigen produced by Brucella species.
History
EC 2.1.2.14 created 2021
Pathway
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K00607  GDP-perosamine N-formyltransferase
Genes
CNVCNZW441b_1265
BMEBMEI1418
BMELDK63_2070
BMIBMEA_A0555
BMZBM28_A0534
BMGBM590_A0536
BMWBMNI_I0525
BMEEDK62_884
BMFBAB1_0540
BMBBruAb1_0540
BMCBAbS19_I05060
BAABAA13334_I03106
BABODK55_547
BABRDO74_1339
BABTDK49_311
BABBDK48_1578
BABUDK53_537
BABSDK51_923
BABCDO78_454
BMSBR0517
BSIBS1330_I0516
BSFBSS2_I0504
BSUIBSSP1_I1186
BSUPBSPT1_I1197
BSUVBSPT2_I1182
BSUCBSSP2_I0533
BMTBSUIS_A0548(arnA)
BSZDK67_1446
BSVBSVBI22_A0516
BSWIY71_02635
BSGIY72_02360
BOVBOV_0521
BCSBCAN_A0529(arnA)
BSKBCA52141_I0862
BOLBCOUA_I0517
BCARDK60_600
BCASDA85_02475
BMRBMI_I519
BPPBPI_I548
BPVDK65_842
BVLBF3285c1_0240
BRUBFS01_02560
 » show all
Reference
1  [PMID:11081580]
  Authors
Godfroid F, Cloeckaert A, Taminiau B, Danese I, Tibor A, de Bolle X, Mertens P, Letesson JJ.
  Title
Genetic organisation of the lipopolysaccharide O-antigen biosynthesis region of brucella melitensis 16M (wbk).
  Journal
Res Microbiol 151:655-68 (2000)
DOI:10.1016/s0923-2508(00)90130-x
  Sequence
[bme:BMEI1418]
Reference
2  [PMID:28636341]
  Authors
Riegert AS, Chantigian DP, Thoden JB, Tipton PA, Holden HM.
  Title
Biochemical Characterization of WbkC, an N-Formyltransferase from Brucella melitensis.
  Journal
Biochemistry 56:3657-3668 (2017)
DOI:10.1021/acs.biochem.7b00494
  Sequence
[bme:BMEI1418]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.2.14
IUBMB Enzyme Nomenclature: 2.1.2.14
ExPASy - ENZYME nomenclature database: 2.1.2.14
BRENDA, the Enzyme Database: 2.1.2.14

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