KEGG   ENZYME: 2.1.2.5Help
Entry
EC 2.1.2.5                  Enzyme                                 

Name
glutamate formimidoyltransferase;
FTCD (gene name);
glutamate formyltransferase;
formiminoglutamic acid transferase;
formiminoglutamic formiminotransferase;
glutamate formiminotransferase
Class
Transferases;
Transferring one-carbon groups;
Hydroxymethyl-, formyl- and related transferases
BRITE hierarchy
Sysname
5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase
Reaction(IUBMB)
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate [RN:R02287]
Reaction(KEGG)
R02287;
(other) R03189
Show
Substrate
5-formimidoyltetrahydrofolate [CPD:C00664];
L-glutamate [CPD:C00025]
Product
tetrahydrofolate [CPD:C00101];
N-formimidoyl-L-glutamate [CPD:C00439]
Comment
The enzyme also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate. In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
History
EC 2.1.2.5 created 1961, modified 2000 (EC 2.1.2.6 created 1965, incorporated 1984)
Pathway
ec00340  Histidine metabolism
ec00670  One carbon pool by folate
ec01100  Metabolic pathways
Orthology
K00603  glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase
K13990  glutamate formiminotransferase / formiminotetrahydrofolate cyclodeaminase
Genes
HSA: 10841(FTCD)
PTR: 107966286(FTCD)
PPS: 100977170(FTCD)
PON: 100938847(FTCD)
NLE: 100603041(FTCD)
MCC: 721818(FTCD)
MCF: 102134897(FTCD)
CSAB: 103220313(FTCD)
RRO: 104667617(FTCD)
RBB: 108512162(FTCD)
CJC: 100408734(FTCD)
SBQ: 101051019(FTCD)
MMU: 14317(Ftcd)
MCAL: 110303041(Ftcd)
MPAH: 110327010(Ftcd)
RNO: 89833(Ftcd)
MUN: 110546362(Ftcd)
CGE: 100754097(Ftcd)
NGI: 103739976(Ftcd)
HGL: 101712457(Ftcd)
CCAN: 109695887(Ftcd)
OCU: 100356213(FTCD)
TUP: 102471947(FTCD)
CFA: 607685(FTCD)
VVP: 112909550(FTCD)
AML: 100483097(FTCD)
UMR: 103680733(FTCD)
UAH: 113259635(FTCD)
ORO: 101375831(FTCD)
ELK: 111155802
FCA: 101080907(FTCD)
PTG: 102962298(FTCD)
PPAD: 109258090(FTCD)
AJU: 106987518(FTCD)
BTA: 535816(FTCD)
BOM: 102278178(FTCD)
BIU: 109561287(FTCD)
BBUB: 102396923(FTCD)
CHX: 102175530(FTCD)
OAS: 101106741(FTCD)
SSC: 397517(FTCD)
CFR: 102517308(FTCD)
CDK: 105090587(FTCD)
BACU: 103009100(FTCD)
LVE: 103077712(FTCD)
OOR: 101288621(FTCD)
DLE: 111186370(FTCD)
PCAD: 102987638(FTCD)
ECB: 100049972(FTCD)
EPZ: 103558414(FTCD)
EAI: 106842985(FTCD)
MYB: 102245572(FTCD)
MYD: 102761291(FTCD)
MNA: 107536217(FTCD)
HAI: 109373830(FTCD)
DRO: 112304441(FTCD)
MJV: 108409561(FTCD)
LAV: 100661017(FTCD)
TMU: 101341265
MDO: 100026368(FTCD)
SHR: 100933669(FTCD)
PCW: 110198883(FTCD)
OAA: 100083636(FTCD)
GGA: 395726(FTCD)
MGP: 100547304(FTCD)
CJO: 107316363(FTCD)
NMEL: 110399576(FTCD)
APLA: 101789783(FTCD)
ACYG: 106049608(FTCD)
TGU: 100221117(FTCD)
LSR: 110479762(FTCD)
SCAN: 103814589(FTCD) 103824679
GFR: 102031861(FTCD)
FAB: 101820680(FTCD)
PHI: 102106775(FTCD)
PMAJ: 107207263(FTCD)
CCAE: 111931826(FTCD)
CCW: 104694608(FTCD)
ETL: 114068101(FTCD)
FPG: 101910482(FTCD)
FCH: 102051629(FTCD)
CLV: 102087672(FTCD)
EGZ: 104122532(FTCD)
NNI: 104009131(FTCD)
ACUN: 113482331(FTCD)
PADL: 103914216(FTCD)
AAM: 106482291(FTCD)
ASN: 102375778(FTCD)
AMJ: 102567824(FTCD)
PSS: 102463032
CMY: 102945805(FTCD)
CPIC: 101930891(FTCD)
ACS: 100558718(ftcd)
PVT: 110090942(FTCD)
PBI: 103060660(FTCD)
PMUR: 107296221(FTCD)
TSR: 106545383(FTCD)
PMUA: 114582310(FTCD)
GJA: 107110724(FTCD)
XLA: 379483(ftcd.L)
XTR: 448617(ftcd)
NPR: 108793615(FTCD)
DRE: 394052(ftcd)
SRX: 107754243
SANH: 107687873(ftcd)
SGH: 107586964(ftcd)
CCAR: 109046911
IPU: 108259504(ftcd)
PHYP: 113524283(ftcd)
AMEX: 103024962(ftcd)
EEE: 113586840(ftcd)
TRU: 101063507(ftcd)
MZE: 101467078(ftcd)
ONL: 100690779(ftcd)
OLA: 101171459(ftcd)
XMA: 102237820(ftcd)
XCO: 114140566(ftcd)
PRET: 103481118
CVG: 107102190(ftcd)
NFU: 107384588(ftcd)
KMR: 108229546(ftcd)
ALIM: 106511228(ftcd)
AOCE: 111573008(ftcd)
CSEM: 103389813(ftcd)
POV: 109648281(ftcd)
SDU: 111235556(ftcd)
SLAL: 111646856(ftcd)
HCQ: 109510415(ftcd)
BPEC: 110173783(ftcd)
MALB: 109955652(ftcd)
SASA: 100306782(ftcd) 106575213
ELS: 105022525(ftcd)
SFM: 108924266(ftcd)
PKI: 111845397(ftcd)
LCM: 102362862(FTCD)
CMK: 103188928(ftcd)
RTP: 109935702(ftcd)
CIN: 100184708
SPU: 580057
APLC: 110973508
SKO: 100369906
ZNE: 110837014
PVM: 113810735
DPTE: 113792107
CSCU: 111625117
PTEP: 107442201
PCAN: 112565050
CRG: 105334085
MYI: 110465531
OBI: 106871263
LAK: 106175096
NVE: 5517908
EPA: 110249093
ADF: 107351438
AMIL: 114963406
PDAM: 113676526
SPIS: 111331227
DGT: 114519305
AQU: 100642146
DDI: DDB_G0287977(ftcd)
DFA: DFA_02269 DFA_10621(ftcd)
DPS: DP2350
DML: Dmul_14120(ftcD1) Dmul_14970(ftcD2)
DAT: HRM2_43160(ftcD1) HRM2_44060(ftcD2)
DTO: TOL2_C11400(ftcD)
DALK: DSCA_14380
SAT: SYN_00461
SPY: SPy_2083
SPYA: A20_1815(ftcD)
SPS: SPs1771
SPF: SpyM51730
STG: MGAS15252_1616(fctD)
STX: MGAS1882_1677(fctD)
STZ: SPYALAB49_001753(ftcD)
SPYH: L897_08810
SSA: SSA_0434
SGO: SGO_1806(ftcD)
SDS: SDEG_2057
SDA: GGS_1889
SDC: SDSE_2157(FTCD)
STK: STP_0392
SCP: HMPREF0833_11149(ftcD)
SCF: Spaf_1717
SIK: K710_1368
SKI: D7D50_05080(ftcD)
ETH: CK496_05180(ftcD)
CTC: CTC_02305
CSQ: CSCA_3654
CALE: FDN13_08360(ftcD)
CRS: FQB35_01070(ftcD) FQB35_12570(ftcD) FQB35_13075(ftcD)
CAZO: G3A45_08665(ftcD)
BHAN: CGC63_11335(ftcD)
BLAU: DQQ01_11205(ftcD)
CSO: CLS_36910
PBQ: C3V37_06710(ftcD)
STH: STH3192
SALQ: SYNTR_1301
SAY: TPY_0925
AMIJ: EQM06_00460(ftcD)
AMIC: Ami3637_06870(ftcD)
ABUT: Ami103574_01595(ftcD)
TTE: TTE0450
THX: Thet_0437
TIT: Thit_0420
CHY: CHY_0695(ftcD)
TPZ: Tph_c20440(ftcd)
TOC: Toce_1474
TTM: Tthe_2241
TSH: Tsac_0044
CAD: Curi_c03010(ftcD)
SPOA: EQM13_04095(ftcD)
PUF: UFO1_4407
PFT: JBW_02658
AIN: Acin_0279
LPIL: LIP_0268
CWO: Cwoe_3011
AFO: Afer_0329
GLJ: GKIL_4221
HAU: Haur_0263
ATM: ANT_11210
TTR: Tter_0694
TDE: TDE0296
TPED: TPE_0827
TPHG: FUT81_11925(ftcD)
ACA: ACP_0519(ftcD)
GRW: FTO74_06925(ftcD)
TALB: FTW19_15490(ftcD)
ABAS: ACPOL_1045
EDA: GWR55_04165(ftcD)
SUS: Acid_5208
EMI: Emin_0528
FPD: CTM68_09850(ftcD)
FGO: C4N16_03620(ftcD)
FNF: BSQ88_01990(ftcD)
FPEI: C4N17_03035(ftcD)
TAI: Taci_0915
TLI: Tlie_0373
GAU: GAU_0899
GBA: J421_2797
BTH: BT_2693
BFR: BF4147
BFS: BF9343_3864(ftcD)
BFG: BF638R_4006(ftcD)
BVU: BVU_0334
BXY: BXY_18190
BZG: C4H11_10240(ftcD)
BHF: C3V43_06990(ftcD)
BIS: DXK01_007975(ftcD)
PGI: PG_0329
PGN: PGN_1633
PBT: ING2E5B_1142(ftcd)
PDI: BDI_3645
PARC: CI960_01370(ftcD)
TFO: BFO_0770(ftcD)
TOH: BCB71_03440(ftcD)
DUN: FDZ78_09680(ftcD)
PSAC: PSM36_1609(ftcd)
BUY: D8S85_02370(ftcD)
PMZ: HMPREF0659_A6723(ftcD)
PDN: HMPREF9137_1323(ftcD)
PIT: PIN17_A1822(ftcD)
PJE: CRM71_10935(ftcD)
AFD: Alfi_3019
ASH: AL1_04570
BACC: BRDCF_p344(fchA)
DORI: FH5T_01095
DRC: G0Q07_07740(ftcD)
BLQ: L21SP5_03905(fchA)
MBAS: ALGA_2664
SGN: SGRA_0031
MUC: MuYL_1012
MUH: HYN43_019730(ftcD)
MGIN: FRZ54_10445(ftcD)
MGK: FSB76_22990(ftcD)
MRUB: DEO27_023285(ftcD)
MGOS: DIU38_030905(ftcD)
AUE: C5O00_10890(ftcD)
FBE: FF125_14935(ftcD)
IAL: IALB_1037
MRO: MROS_0055
CACI: CLOAM0177(ftcd)
TMA: TM0843
TMW: THMA_0864
TMQ: THMB_0864
TMX: THMC_0864
TPT: Tpet_0084
TRQ: TRQ2_0084
TNA: CTN_1732
TNP: Tnap_0084
TLE: Tlet_1282
TME: Tmel_1173
TAF: THA_1560(ftcD)
THER: Y592_06750
FNO: Fnod_0808
DTN: DTL3_1345(ftcd) DTL3_1638
KOL: Kole_1720
ASAC: ATHSA_1311
CEX: CSE_13370
CABY: Cabys_2265
NDE: NIDE4164
TAC: Ta1476
TVO: TVG0092631(TVG0092631)
PTO: PTO1242
FAI: FAD_1385
CDIV: CPM_0208
ABI: Aboo_1135
BARC: AOA65_0374
 » show all
Taxonomy
Reference
1  [PMID:13475327]
  Authors
MILLER A, WAELSCH H.
  Title
Formimino transfer from formamidinoglutaric acid to tetrahydrofolic acid.
  Journal
J Biol Chem 228:397-417 (1957)
Reference
2  [PMID:13428739]
  Authors
SILVERMAN M, KERESZTESY JC, KOVAL GJ, GARDINER RC.
  Title
Citrovorum factor and the synthesis of formylglutamic acid.
  Journal
J Biol Chem 226:83-94 (1957)
Reference
3  [PMID:13672973]
  Authors
TABOR H, WYNGARDEN L.
  Title
The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid.
  Journal
J Biol Chem 234:1830-46 (1959)
Reference
4  [PMID:10673422]
  Authors
Kohls D, Sulea T, Purisima EO, MacKenzie RE, Vrielink A
  Title
The crystal structure of the formiminotransferase domain of formiminotransferase-cyclodeaminase: implications for substrate channeling in a bifunctional enzyme.
  Journal
Structure 8:35-46 (2000)
DOI:10.1016/s0969-2126(00)00078-2
Reference
5  [PMID:15272307]
  Authors
Mao Y, Vyas NK, Vyas MN, Chen DH, Ludtke SJ, Chiu W, Quiocho FA
  Title
Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer.
  Journal
EMBO J 23:2963-71 (2004)
DOI:10.1038/sj.emboj.7600327
Reference
6  [PMID:20952389]
  Authors
Jeanguenin L, Lara-Nunez A, Pribat A, Mageroy MH, Gregory JF 3rd, Rice KC, de Crecy-Lagard V, Hanson AD
  Title
Moonlighting glutamate formiminotransferases can functionally replace 5-formyltetrahydrofolate cycloligase.
  Journal
J Biol Chem 285:41557-66 (2010)
DOI:10.1074/jbc.M110.190504
Other DBs
ExplorEnz - The Enzyme Database: 2.1.2.5
IUBMB Enzyme Nomenclature: 2.1.2.5
ExPASy - ENZYME nomenclature database: 2.1.2.5
BRENDA, the Enzyme Database: 2.1.2.5
CAS: 9032-83-1

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