KEGG   ENZYME: 2.1.3.11
Entry
EC 2.1.3.11                 Enzyme                                 
Name
N-succinylornithine carbamoyltransferase;
succinylornithine transcarbamylase;
N-succinyl-L-ornithine transcarbamylase;
SOTCase
Class
Transferases;
Transferring one-carbon groups;
Carboxy- and carbamoyltransferases
Sysname
carbamoyl phosphate:N2-succinyl-L-ornithine carbamoyltransferase
Reaction(IUBMB)
carbamoyl phosphate + N2-succinyl-L-ornithine = phosphate + N-succinyl-L-citrulline [RN:R08937]
Reaction(KEGG)
R08937
Substrate
carbamoyl phosphate [CPD:C00169];
N2-succinyl-L-ornithine [CPD:C03415]
Product
phosphate [CPD:C00009];
N-succinyl-L-citrulline [CPD:C18048]
Comment
This enzyme is specific for N-succinyl-L-ornithine and cannot use either L-ornithine (see EC 2.1.3.3, ornithine carbamoyltransferase) or N-acetyl-L-ornithine (see EC 2.1.3.9, N-acetylornithine carbamoyltransferase) as substrate. However, a single amino-acid substitution (Pro90 -> Glu90) is sufficient to switch the enzyme to one that uses N-acetyl-L-ornithine as substrate. It is essential for de novo arginine biosynthesis in the obligate anaerobe Bacteroides fragilis, suggesting that this organism uses an alternative pathway for synthesizing arginine.
History
EC 2.1.3.11 created 2008
Orthology
K13043  N-succinyl-L-ornithine transcarbamylase
Genes
BTHBT_3717
BTHOBtheta7330_04579(argF')
BFRBF0494
BFSBF9343_0422
BFGBF638R_0504(argF)
BFBVU15_01710
BHLBache_0330
BXYBXY_47780
BOABovatus_03821(argF')
BCELBcellWH2_02177(argF')
BCACCGC64_05465
BCAEA4V03_00700
BZGC4H11_08610
BHFC3V43_07990
BISDXK01_002580
BUNBun01g_03230
BEGINE88_01491(argF')
BSTEK6V31_12090
BFEK6V30_06960
BNOK8P02_20645
BVUBVU_0551
BSABacsa_1454
BDOEL88_22130
BDHGV66_02950
PCOPI6J50_13455
PBTING2E5B_0150(argF')
PMUCING2E5A_0734(argF')
PETPEIBARAKI_6622
PSACPSM36_2740(argF')
DYSG7050_14560
APSCFPG_376
PPNPalpr_1697
PDIBDI_2259
PARCCI960_17480
PMERINE87_01881(argF')
PGOLK6V26_00875
PJOLK449_01130
TFOBFO_2797(argF')
PARYA4V02_13330
DUNFDZ78_05510
BVSBARVI_08565
COPRCop2CBH44_18390(argF')
PRUPRU_2210
PDTPrede_0149
PCOILK433_00855
PHERprwr041_14290(argF')
PBYL6471_13280
ALQC7Y71_006065
AFDAlfi_1680
ASHAL1_17560
AOKA3BBH6_09890(argF')
ACOUA5CBH24_16700(argF')
ADAA5CPEGH6_14350(argF')
BACCBRDCF_p436(argF)
DORIFH5T_10030
DRCG0Q07_18965
MCOSGM418_17275
ASXCDL62_05585
ALKQM9189_02035
CPICpin_6553
CBAECOR50_21485
CHITFW415_09230
CHIHGWR21_12215
COYHF329_31700
CFILMYF79_28675
NKONiako_5692
NSONIASO_17600
NIAA8C56_00015
FLASY85_07040
FGGFSB75_01400
ARBA9P82_07475
ARKD6B99_01490
AGIFSB73_03465
ARACE0W69_016715
ATEEK9M52_04555
FLNFLA_5677
PSEGD3H65_20715
PGINFRZ67_13505
PGOFSB84_09385
FLSGLV81_14680
LACSH4075_21470
FEIK9M53_11765
FLPLK994_08370
FLCKJS93_03055
FLVKJS94_01870
HHYHalhy_4194
PHEPhep_4206
PEPAQ505_00920
PCMAY601_4308
PSTYBFS30_05765
PGSCPT03_18130
PEJFYC62_11870
PEKFFJ24_018980
PROEH9L23_07610 H9L23_19745
PEXIZT61_10940
PSNPedsa_3191
SHGSph21_1038
SHTKO02_02480
SPHNBV902_04110
SMIZ4412673_03356(argF')
SPSCE2P86_02215
SPHZE3D81_02610
SPHEGFH32_15155
SPDRG6053_02935
STHANCTC11429_01010(argF')
SSPII6J01_10595
SMUII6J00_19605
SSIYJVX97_00385
SCNSolca_3554
MUPA0256_19420
MUCMuYL_3044
MGOTMgSA37_02913(argF')
MUHHYN43_011600
MGINFRZ54_18475
MGKFSB76_31385
MRUBDEO27_007530
MGOSDIU38_007340
MMABHQ865_02665
MGIKGO620_006785
MDJLLH06_11240
AGDFRZ59_04955
OLIFKG96_02145
SBXCA265_18520
CMRCycma_4809
CAMUCA2015_4617
BBDBelba_2670
EVIEchvi_3849
ESTDN752_02595
ECHIFKX85_18095
ALMAO498_11145
MDAIPZ59_13700
CHUCHU_3085(argF)
SLISlin_1156
SRDSD10_07145
SMONAWR27_02955
SPIRCWM47_19070
SPIKEXU85_10035
SPIBG8759_32190
STAEHNV11_03975
SRHOHH216_00330
PSEZHME7025_02012(argF)
RHOZGXP67_07820
DFEDfer_4418
DSNHWI92_15695
LBYLbys_2153
RSIRunsl_2403
RUNDR864_20765
RUPDTQ70_20135
EOLEmtol_2298
FAEFAES_2044
FIBA6C57_17525
ALSDJ013_16420
FLIFleli_4070
HSWHsw_1096
HYMN008_02800
HYDPK28_05270
HYEAM218_10950
HYGAUC43_19030
HYPA0257_07455
HYZAXW84_07135
HNVDDQ68_00880
HYJFHG12_09620
HQIH9L05_12090
HRSHER32_16440
HBNGUY19_18225
HTSHMJ29_06140
HMTMTP16_12765
PKOPKOR_17815
PACTCA264_06240
RUFTH63_01975
RTIDC20_12485
RUDTH61_10750
NIBGU926_16420
ADDHUW48_11435
ASWUHUW51_20355
MTTFtrac_1532
FPFDCC35_16975
FLMMY04_2040
FLLEI427_03075
FYAKMW28_05895
FKAKM029_07605
FBTD770_20800
CHKD4L85_18350
GFOGFO_2103(argF)
GRLLPB144_01760
GFLGRFL_0166
GRSC7S20_17815
FPSZAMR72_08965
FJOFjoh_3430
FJGBB050_04250(argF')
FBRFBFL15_2069(argF)
FCOFCOL_08655
FGLEM308_14730
FCMBIW12_00435
FFAFFWV33_10975
FKIFK004_15290
FCRHYN56_14900
FSEDI487_01510
FSNGS03_02347(argF')
FNKE1750_04265
FAKFUA48_16355
FFLHYN86_12860
FENJ0383_01345
FCVAWN65_14355
FOEJJC03_05375
FSDLXD69_16665
RBIRB2501_08685
ZPRZPR_2793
FBCFB2170_08264
MARMYQ22_05880
MARTBTR34_06200
MARBCJ263_10505
MAREEJ994_16015
CAOCelal_0961
CLYCelly_0826
CLHIX49_03940
CBALM667_02655
CBATM666_02655
KDIKrodi_2173
DOKMED134_11931(argF)
DDOI597_1160(argF')
DODDCS32_00840
LANLacal_0608
LVNBWR22_13610
LACICW733_10185
ZGAZOBELLIA_1234(argF')
MRSMurru_0930
MLTVC82_1017
MUTGVT53_15070
MAQILDL77_06635
SPONHME9304_01039(argF)
PTQP700755_000057
NOJEJ995_08875
POMMED152_02640(argF)
POBLPB03_01880
PRNBW723_12605
POLABXQ17_04475
POACW731_04225
PHALH9I45_01470
PLITK8354_08795
PPECH9W90_03125
PBATJL193_00395
PCEAJ3359_04370
MYRMYRA21_1098(argF)
MPWMPR_3623
MODAS202_05135
MYZBK054_05025
MOAI6I89_17065
WINWPG_1864
SZEAW14_06025
AHZAPS56_07480
SYISB49_09870
TENLPB136_11465
TJETJEJU_1874(argF)
TMARMARIT_0480(argF')
TMPF9Y86_14365
LUTLupro_10900
LULLPB138_07010
WFUAXE80_00500
FORFORMB_03370
FOHFORMA_09780
FOPFNB79_02295
SALTAO058_10290
SMISLDL76_16430
SEONBWZ22_09010
AALGAREALGSMS7_00803(argF')
OLLCW732_02755
OAQDZC78_09860
FEKC1H87_15560
TAJC1A40_09580
KOSKORDIASMS9_04521(argF')
KANIMCC3317_38380(argF')
MARFCJ739_2110
AQBD1818_06275
AQAD1815_01105
AQDD1816_00540
EMARD1013_18225
MUREQY75_11220
PSYNE9099_07340
AFLAFHG64_04405
ANPFK178_01415
OCIFEZ18_09910
MESQC7H62_0605
GAAHX109_14515
CAGGHYG79_10520
LPALLDL79_14420
SINHLS482_16790
ASAGFGM00_00475
FLGLV716_10285
SABUMBM09_15545
ZSPMQE36_15585
FBEFF125_17845
FBAFIC_00881
FBUUJ101_02620(argF)
WVIWeevi_1596
EAOBD94_3864
EMNM876_16170
EENBBD30_07645
ELBVO54_02834(argF')
EMGBBD33_04435
EGOBBD34_08365
EGMAYC65_18585
ELZFCS00_11660
ELTFGE20_05635
CHZCHSO_1869(argF)
CGNOK18_15710
CHHA0O34_00845
CIOCEQ15_03330
CHRYCEY12_00450
CPIPCJF12_06735
CHRZCO230_05765
CARHEGY05_05920
CSHAEG350_12250
CNKEG343_23845
CJTEG359_00430
CILEG358_10790
CCAUEG346_22180
CBENEG339_14915
CGLENCTC11432_00091(argF')
CTAINCTC12078_00450(argF')
CLACEG342_14925
CSALNBC122_00017(argF')
CBPEB354_09700
CNPM0D58_00425
CCAOH5J24_13060
KDAEIB71_08895
KHIEG338_09225
EVAEIB75_15770
EZEKI430_17745
CNREB819_03715
EBVF0358_16130
EFALFH779_10920
ESTEHNV03_04065
APIBG8C43_08230
FBOJ9309_13085
SMGSMGWSS_114(argF)
SMSSMDSEM_122(argF)
SMHDMIN_01100
SUMSMCARI_134(argF)
SMVSULALF_092(argF)
SMUBIM46_202
SMUMSMML_v1c00730(argF)
SMUESMTETUND_121(argF')
SMUPSMPSPU_134(argF)
BBLBLBBGE_318(argF)
BPIBPLAN_322(argF)
BMMMADAR_053(argF)
BCPBLBCPU_299(argF)
BBGBGIGA_315(argF)
BBQBLBBOR_317
BLPBPAA_326(argF)
BLUK645_1476
BLCKDM815_01565
BPUNDM780_01520
FLUCHH17_18525
OHOOweho_3500
UDIASNER_235(argF)
 » show all
Reference
1  [PMID:16704984]
  Authors
Shi D, Morizono H, Cabrera-Luque J, Yu X, Roth L, Malamy MH, Allewell NM, Tuchman M
  Title
Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis.
  Journal
J Biol Chem 281:20623-31 (2006)
DOI:10.1074/jbc.M601229200
  Sequence
Reference
2  [PMID:17600144]
  Authors
Shi D, Yu X, Cabrera-Luque J, Chen TY, Roth L, Morizono H, Allewell NM, Tuchman M
  Title
A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase.
  Journal
Protein Sci 16:1689-99 (2007)
DOI:10.1110/ps.072919907
  Sequence
[bfr:BF0494]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.3.11
IUBMB Enzyme Nomenclature: 2.1.3.11
ExPASy - ENZYME nomenclature database: 2.1.3.11
BRENDA, the Enzyme Database: 2.1.3.11

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