KEGG   ENZYME: 2.1.4.1
Entry
EC 2.1.4.1                  Enzyme                                 

Name
glycine amidinotransferase;
arginine-glycine amidinotransferase;
arginine-glycine transamidinase;
glycine transamidinase
Class
Transferases;
Transferring one-carbon groups;
Amidinotransferases
Sysname
L-arginine:glycine amidinotransferase
Reaction(IUBMB)
L-arginine + glycine = L-ornithine + guanidinoacetate [RN:R00565]
Reaction(KEGG)
R00565;
(other) R01686 R01989
Substrate
L-arginine [CPD:C00062];
glycine [CPD:C00037]
Product
L-ornithine [CPD:C00077];
guanidinoacetate [CPD:C00581]
Comment
Canavanine can act instead of arginine.
History
EC 2.1.4.1 created 1961 as EC 2.6.2.1, transferred 1965 to EC 2.1.4.1
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K00613  glycine amidinotransferase
Genes
HSA: 2628(GATM)
PTR: 453401(GATM)
PPS: 100982293(GATM)
GGO: 101144802(GATM)
PON: 100171513(GATM)
NLE: 100597895(GATM)
MCC: 713306(GATM)
MCF: 102138299(GATM)
CSAB: 103245698(GATM)
RRO: 104653899(GATM)
RBB: 108530126(GATM)
CJC: 100408432(GATM)
SBQ: 101041854(GATM)
MMU: 67092(Gatm)
MCAL: 110284514(Gatm)
MPAH: 110318211(Gatm)
RNO: 81660(Gatm)
MUN: 110553249(Gatm)
CGE: 100771783(Gatm)
NGI: 103746955(Gatm)
HGL: 101696418(Gatm)
CCAN: 109692720(Gatm)
OCU: 100338260(GATM)
TUP: 102470318(GATM)
CFA: 414733(GATM)
VVP: 112920029(GATM)
AML: 100468782(GATM)
UMR: 103656589(GATM)
UAH: 113269569(GATM)
ORO: 101386117(GATM)
ELK: 111160090
FCA: 414734(GATM)
PTG: 102969260(GATM)
PPAD: 109263041(GATM)
BTA: 414732(GATM)
BOM: 102274253(GATM)
BIU: 109565164(GATM)
BBUB: 102405715(GATM)
CHX: 102184628(GATM)
OAS: 100174904(GATM)
SSC: 100126844(GATM)
CFR: 102507646(GATM)
CDK: 105101687(GATM)
BACU: 103002160(GATM)
LVE: 103073454(GATM)
OOR: 101281194(GATM)
DLE: 111181639(GATM)
PCAD: 102980202(GATM)
ECB: 100070511(GATM)
EPZ: 103554027(GATM)
EAI: 106834989(GATM)
MYB: 102241381(GATM)
MYD: 102770940(GATM)
MNA: 107535779(GATM)
HAI: 109396664(GATM)
DRO: 112311763(GATM)
PALE: 102894268(GATM)
RAY: 107514958(GATM)
MJV: 108400260(GATM)
LAV: 100660916(GATM)
TMU: 101346149
MDO: 100012229(GATM)
SHR: 100933609(GATM)
PCW: 110223693(GATM)
OAA: 100073477(GATM)
GGA: 395504(GATM)
MGP: 100542487(GATM)
CJO: 107318710(GATM)
NMEL: 110404020(GATM)
APLA: 101796257(GATM)
ACYG: 106043350(GATM)
TGU: 100224553(GATM)
LSR: 110474262(GATM)
SCAN: 103816037(GATM)
GFR: 102039697(GATM)
FAB: 101808276(GATM)
PHI: 102107354(GATM)
PMAJ: 107209582(GATM)
CCAE: 111934089(GATM)
CCW: 104684102(GATM)
ETL: 114059938(GATM)
FPG: 101924010(GATM)
FCH: 102054671(GATM)
CLV: 102083453(GATM)
EGZ: 104130797(GATM)
NNI: 104017255(GATM)
ACUN: 113484026(GATM)
PADL: 103922781(GATM)
AAM: 106496407(GATM)
ASN: 102388460(GATM)
AMJ: 102568516(GATM)
PSS: 102462002(GATM)
CMY: 102929788
CPIC: 101937786(GATM)
ACS: 100560810(gatm)
PVT: 110077278(GATM)
PBI: 103064593(GATM)
PMUR: 107302512(GATM)
TSR: 106543998(GATM)
PMUA: 114584508(GATM)
GJA: 107123452(GATM)
XLA: 108712892(gatm.S) 379386(gatm.L)
XTR: 394568(gatm)
NPR: 108804813(GATM)
DRE: 266799(gatm)
SRX: 107726335 107727396(gatm)
SANH: 107665388 107703934(gatm)
SGH: 107569972 107595361(gatm)
CCAR: 109070558 109083988(gatm)
PHYP: 113526986(gatm)
AMEX: 103044592(gatm)
EEE: 113577297(gatm)
TRU: 101070450(gatm)
LCO: 104919779(gatm)
NCC: 104953028(gatm)
MZE: 101463884(gatm)
ONL: 100689888(gatm)
OLA: 101156236(gatm)
XMA: 102228536(gatm)
XCO: 114142460(gatm)
PRET: 103462051(gatm)
CVG: 107085365(gatm)
NFU: 107381709(gatm)
KMR: 108251614(gatm)
ALIM: 106533979(gatm)
AOCE: 111563874(gatm)
CSEM: 103379055(gatm)
POV: 109625190(gatm)
LCF: 108887928(gatm)
SDU: 111224823(gatm)
SLAL: 111656863(gatm)
HCQ: 109525754(gatm)
BPEC: 110173080(gatm)
OTW: 112238738(gatm)
SALP: 112072607(gatm)
ELS: 105025337(gatm)
SFM: 108941032(gatm)
PKI: 111844938(gatm)
LCM: 102352460(GATM)
CMK: 103186480(gatm)
RTP: 109914139(gatm)
BFO: 118411990
CIN: 100186832
SPU: 581473
LAK: 106169635
SHX: MS3_04855
NVE: 5507403
PDAM: 113679841
SPIS: 111335280
AQU: 100639745
NCR: NCU07176(amt)
NTE: NEUTE1DRAFT35080(NEUTE1DRAFT_35080)
MAW: MAC_04410
MAJ: MAA_09776
CMT: CCM_04987
SPAR: SPRG_05189
EAM: EAMY_0520(hsvA)
EAY: EAM_2910(hsvA)
EPY: EpC_01150(hsvA) EpC_31010(hsvA)
EPR: EPYR_00119(hsvA) EPYR_03348(hsvA)
ERJ: EJP617_12770(hsvA) EJP617_16790(hsvA)
PSTW: DSJ_25115
PLU: plu0158
PAY: PAU_00111
XBV: XBW1_3292(gatm)
XNE: XNC1_2236
XNM: XNC2_2162
XDO: XDD1_2127
LGU: LG3211_3686(gatm)
PPR: PBPRA0993(AT)
PSEM: TO66_08450
PANR: A7J50_2183
SHL: Shal_0690
ASIP: AQUSIP_22650(strB1)
MMAI: sS8_0925
LHK: LHK_03077
BOK: DM82_841(gatm)
BOC: BG90_89
MES: Meso_2108
BJA: blr2071
NWI: Nwi_2321
MEA: Mex_1p3682(gatm)
MDI: METDI4255(gatm)
MEX: Mext_3451
MCH: Mchl_3760
MPO: Mpop_3649
MET: M446_6335
MNO: Mnod_7150
MOR: MOC_1194
META: Y590_16950
BID: Bind_1964
MSC: BN69_0965
RBM: TEF_16145
JAN: Jann_0016
RDE: RD1_1472(gatM)
PUB: SAR11_0688(gatM)
LME: LEUM_0821
LMM: MI1_03790
LMK: LMES_0744
SBH: SBI_09248
SDV: BN159_6038(gatm)
SALU: DC74_7768
SALL: SAZ_40100
STRE: GZL_00895
SLD: T261_7858
SLE: sle_17590(sle_17590)
PAC: PPA0632
PAW: PAZ_c06700(gatm)
PACC: PAC1_03290
PACH: PAGK_1497
CACN: RN83_03680
SEN: SACE_4336
AMD: AMED_6240
AMN: RAM_32010
AMM: AMES_6150
AMZ: B737_6150
AMI: Amir_2021
ACTI: UA75_05160
ACAD: UA74_05155
SAQ: Sare_2924
TPYO: X956_02185
AHW: NCTC11636_00331(strB1)
AIR: NCTC12972_02110(strB1_1) NCTC12972_02114(strB1_2)
CWO: Cwoe_2444
GPA: GPA_26090
CBAC: JI75_05715
AMR: AM1_0523
MAR: MAE_21180
TER: Tery_3130
BRM: Bmur_0416
BPW: WESB_1480
SBR: SY1_02940
 » show all
Reference
1
  Authors
Borsook, H. and Dubnoff, J.W.
  Title
The formation of glycocyamine in animal tissues.
  Journal
J Biol Chem 138:389-403 (1941)
Reference
2  [PMID:14304853]
  Authors
CONCONI F, GRAZI E.
  Title
TRANSAMIDINASE OF HOG KIDNEY. I. PURIFICATION AND PROPERTIES.
  Journal
J Biol Chem 240:2461-4 (1965)
Reference
3  [PMID:6766137]
  Authors
McGuire DM, Tormanen CD, Segal IS, Van Pilsum JF.
  Title
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats. Purification and some properties of rat kidney transamidinase.
  Journal
J Biol Chem 255:1152-9 (1980)
  Sequence
[rno:81660]
Reference
4
  Authors
Ratner, S.
  Title
Transamidination.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 6, Academic Press, New York, 1962, p. 267-275.
Reference
5  [PMID:13355454]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  I.  Purification and properties of transamidinase.
  Journal
Arch Biochem Biophys 63:277-95 (1956)
DOI:10.1016/0003-9861(56)90044-3
Reference
6  [PMID:13355455]
  Authors
RATNER S, ROCHOVANSKY O.
  Title
Biosynthesis of guanidinoacetic acid.  II.  Mechanism of amidine group transfer.
  Journal
Arch Biochem Biophys 63:296-315 (1956)
DOI:10.1016/0003-9861(56)90045-5
Reference
7  [PMID:13278360]
  Authors
WALKER JB.
  Title
Biosynthesis of arginine from canavanine and ornithine in kidney.
  Journal
J Biol Chem 218:549-56 (1956)
Reference
8  [PMID:13398387]
  Authors
WALKER JB.
  Title
Studies on the mechanism of action of kidney transamidinase.
  Journal
J Biol Chem 224:57-66 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.4.1
IUBMB Enzyme Nomenclature: 2.1.4.1
ExPASy - ENZYME nomenclature database: 2.1.4.1
BRENDA, the Enzyme Database: 2.1.4.1
CAS: 9027-35-4

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