Entry
Name
2-hydroxy-3-oxoadipate synthase;
2-hydroxy-3-oxoadipate glyoxylate-lyase (carboxylating);
alpha-ketoglutaric-glyoxylic carboligase;
oxoglutarate: glyoxylate carboligase
Class
Transferases;
Transferring aldehyde or ketonic groups;
Transketolases and transaldolases
BRITE hierarchy
Sysname
2-oxoglutarate:glyoxylate succinaldehydetransferase (decarboxylating)
Reaction(IUBMB)
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2 [RN:
R00474 ]
Reaction(KEGG)
Substrate
Product
Comment
The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate.
History
EC 2.2.1.5 created 1972 as EC 4.1.3.15, transferred 2002 to EC 2.2.1.5
Pathway
ec00630 Glyoxylate and dicarboxylate metabolism
Orthology
K01616 multifunctional 2-oxoglutarate metabolism enzyme
Genes
MBO : BQ2027_MB1280C(sucA)
MBAI : MB901379_03656(kgd)
MHEK : JMUB5695_01618(kgd)
MPHL : MPHLCCUG_04016(kgd)
MAUU : NCTC10437_04206(kgd)
MFLV : NCTC10271_01260(kgd)
MSAL : DSM43276_01254(kgd)
CDIP : ERS451417_00905(sucA)
CUN : Cul210932_0885(odhA)
CUQ : Cul210931_0847(odhA)
CUJ : CUL131002_0863c(odhA)
CMIN : NCTC10288_01533(kgd)
CCYS : SAMEA4530656_1418(kgd)
NFR : ERS450000_05232(kgd)
NAD : NCTC11293_05991(kgd)
RCR : NCTC10994_01417(sucA)
SLE : sle_24580(sle_24580)
SGM : GCM10017557_26170(kgd)
STUI : GCM10017668_48040(kgd)
SXT : KPP03845_105052(kgd)
SCYN : N8I84_26620 N8I84_39270
SCAJ : O1G22_08830 O1G22_14200
AGLA : OIE69_15100 OIE69_36040
MSUW : GCM10025863_13310(kgd)
FSB : GCM10025867_33630(kgd)
AMAU : DSM26151_09670(kgd)
AMAV : GCM10025877_27790(kgd)
MALK : MalAC0309_2119(kgd)
PSEV : USB125703_01540(kgd)
GMN : GMOLON4_1176(kgd) GMOLON4_444(kgd)
AAGI : NCTC2676_1_01961(kgd)
GCR : GcLGCM259_1015(sucA)
RDN : HMPREF0733_10027(sucA)
DCO : SAMEA4475696_2236(kgd)
DSS : GCM25873_00560 GCM25873_28350
PAK : HMPREF0675_4325(sucA)
PAV : TIA2EST22_06270(kgd)
PAX : TIA2EST36_06245(kgd)
PACN : TIA1EST1_06235(kgd)
PPC : HMPREF9154_1400(sucA)
NAQU : ENKNEFLB_01828(kgd)
ARHD : VSH64_16515 VSH64_29065
AMOG : QRX60_19705 QRX60_30370
MSAG : GCM10017556_14800(kgd)
ACTR : Asp14428_58520(kgd)
MCU : HMPREF0573_10393(sucA)
TBW : NCTC13354_01464(kgd)
ANE : ATCC27039_15350(kgd)
AHW : NCTC11636_02448(kgd)
AIR : NCTC12972_00272(kgd)
ASLA : NCTC11923_02436(kgd)
AVC : NCTC10951_01404(kgd)
ACAP : MANAM107_04180(kgd)
PLAN : A1s21148_01145(kgd)
PLAK : A1s21155_00950(kgd)
PLIM : PHILAsVB114_06035(kgd)
ABAM : B1s21122_05265(kgd)
BALA : DSM104299_00626(odhA)
» show all
Taxonomy
Reference
Authors
Schlossberg MA, Bloom RJ, Richert DA, Westerfeld WW.
Title
Carboligase activity of alpha-ketoglutarate dehydrogenase.
Journal
Reference
Authors
Schlossberg MA, Richert DA, Bloom RJ, Westerfeld WW.
Title
Isolation and identification of 5-hydroxy-4-ketovaleric acid as a product of alpha-ketoglutarate: glyoxylate carboligase.
Journal
Reference
Authors
Stewart PR, Quayle JR.
Title
The synergistic decarboxylation of glyoxylate and 2-oxoglutarate by an enzyme system from pig-liver mitochondria.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.2.1.5
ExPASy - ENZYME nomenclature database: 2.2.1.5
BRENDA, the Enzyme Database: 2.2.1.5