KEGG ENZYME: 2.3.1.101

ENZYME: 2.3.1.101

Entry

EC 2.3.1.101                Enzyme

Name

formylmethanofuran---tetrahydromethanopterin N-formyltransferase;
formylmethanofuran-tetrahydromethanopterin formyltransferase;
formylmethanofuran:tetrahydromethanopterin formyltransferase;
N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase;
FTR;
formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase

Reaction(IUBMB)

formylmethanofuran + 5,6,7,8-tetrahydromethanopterin = methanofuran + 5-formyl-5,6,7,8-tetrahydromethanopterin [RN:R03390]

Reaction(KEGG)

R03390

Substrate

formylmethanofuran [CPD:C01001];
5,6,7,8-tetrahydromethanopterin [CPD:C01217]

Product

methanofuran [CPD:C00862];
5-formyl-5,6,7,8-tetrahydromethanopterin [CPD:C01274]

Comment

Methanofuran is a complex 4-substituted furfurylamine and is involved in the formation of methane from CO2 in Methanobacterium thermoautotrophicum.

History

EC 2.3.1.101 created 1989

Pathway

ec00680

Methane metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K00672

formylmethanofuran--tetrahydromethanopterin N-formyltransferase

Genes

MCA:

MCA2858

METU:

GNH96_03555(fhcD)

MMEO:

OOT43_14040(fhcD)

MEEF:

JWZ97_17405(fhcD)

MMT:	Metme_0668

MDN:	JT25_013495

MDH:	AYM39_03060

MKO:	MKLM6_0653

METL:

U737_20590(fhcD)

MPAD:

KEF85_01265(fhcD)

MELL:

IVG45_17720(fhcD)

MRP:	NM686_019565(fhcD)

MMOT:

QZJ86_03530(fhcD)

MEEP:

JWZ98_18885(fhcD)

MEEC:

PL263_11500(fhcD)

MEUP:

QC632_06005(fhcD)

MAH:	MEALZ_1269(ffsA)

MBUR:

EQU24_08945(fhcD)

MPSY:

CEK71_00135(fhcD)

MMAI:

sS8_3401

MSZE:

MSZNOR_2922(fhcD)

MMOB:

F6R98_03265(fhcD)

MEIN:

methR_P2636

MOZ:	MoryE10_28940(ffsA)

MISZ:

MishRS11D_09940(ffsA)

MESL:

KKZ03_06770(fhcD)

MECH:

Q9L42_009130(fhcD)

MLAU:

ACEPPP_12150(fhcD)

MEIY:

MIN45_P1471

MCAU:

MIT9_P1920

MEJ:	Q7A_285(fhcD)

MEC:

Q7C_1963

MPIN:

LGT42_001495(fhcD)

MMAF:

GCM100_14930(ffsA)

MTHA:

VSX76_02695(fhcD)

TIG:

THII_0586

BLEP:

AL038_10680(fhcD)

NOC:

Noc_0023

NHL:

Nhal_0013

NWA:

Nwat_0021

NWR:	E3U44_04045(fhcD)

NTT:

TAO_0008

TSY:	THSYN_31575

NTG:	NSCAC_0006(ffsA)

SEDS:

AAY24_01630

COX:	E0W60_32005(fhcD)

BUG:	BC1001_3973

BGF:	BC1003_5429

BYI:	BYI23_B014210

BUQ:	AC233_22160

BURT:

BTHE68_38700(ffsA)

BXE:	Bxe_B2463(fhcD)

BXB:	DR64_4790(fhcD)

BPH:	Bphy_5933 Bphy_6506

BGE:	BC1002_3198

BPX:	BUPH_00557

BCAI:

K788_0001570 K788_0007403

PSPW:

BJG93_19520(fhcD)

PARA:

BTO02_23520

PARB:

CJU94_31065(fhcD)

PHS:	C2L64_21750(fhcD) C2L64_38180(fhcD)

PTER:

C2L65_26245(fhcD) C2L65_34175(fhcD)

PGP:	CUJ91_21370(fhcD)

PCJ:	CUJ87_23550(fhcD)

PTS:	CUJ90_27940(fhcD)

PGIS:

I6I06_22595(fhcD)

PEW:	KZJ38_24950(fhcD)

PDIO:

PDMSB3_0602.1(ffsA)

PSAA:

QEN71_32700(fhcD) QEN71_34020(fhcD)

PKF:	RW095_18675(fhcD)

PPAI:

E1956_20525(fhcD)

PHUN:

U0042_02440(fhcD)

PLAD:

PPGU16_69780(ffsA)

PAZZ:

PBP221_72290(fhcD)

BUO:	BRPE64_BCDS01290

CABK:

NK8_41610(fhcD)

BUE:	BRPE67_BCDS01180(ffsA)

TCAR:

U0034_17405(fhcD)

VAP:	Vapar_3065

VPD:	VAPA_1c31300

MPT:

Mpe_A2625

METP:

C1M51_15015(fhcD)

RGE:	RGE_40410(fhcD)

SMIO:

CATMQ487_35820(ffsA)

ATER:

MW290_07045(fhcD)

LCH:

Lcho_3134

AON:	DEH84_18925(fhcD)

METR:

BSY238_3298(fhcD)

MFA:

Mfla_1664

MMB:

Mmol_0859

MEH:

M301_0910

MEI:	Msip34_1508

MEP:	MPQ_1571(ftr)

MBAC:

BN1209_0741(ffsA)

MEU:	ACJ67_06825

MMEC:

FIU01_05425(fhcD)

MEDZ:

MTDW_15990(fhcD)

MPAU:

ZMTM_11780(ffsA)

SPLB:

SFPGR_26040(ffsA)

AZA:	AZKH_p0240(fhcD)

THU:	AC731_004915

THAU:

C4PIVTH_3712(ffsA)

THK:	CCZ27_13180(fhcD)

THAG:

CKCBHOJB_02566(fhcD)

DDZ:	DSYM_25630

MCI:	Mesci_4253

MCIC:

A4R28_05790

MESW:

A9K65_023585

MESM:

EJ066_29685(fhcD)

MOH:	IHQ72_13910(fhcD)

MMEI:

LRP31_14040(fhcD)

MEAA:

ACG873_04790(fhcD)

PHT:	BLM14_23755

PMEL:

LLE53_018390(fhcD)

RGA:	RGR602_PC01561(ffsA)

NPM:	QEO92_19185(fhcD)

XAU:

Xaut_1794

STAR:

G3545_09745(fhcD)

LNE:	FZC33_09305(fhcD)

SNO:

Snov_0757

ANC:	GBB76_00785(fhcD)

APRA:

G3A50_16530(fhcD)

APOL:

K9D25_20155(fhcD)

AQI:	J5J86_17180(fhcD)

MEA:	Mex_1p1756(fhcD)

MDI:	METDI2508(fhcD)

MEX:

Mext_1825

MCH:

Mchl_2160

MPO:

Mpop_1776

MZA:	B2G69_16785

METQ:

MSPGM_18630(ffsA)

MRD:	Mrad2831_0524

MET:

M446_5774

MNO:

Mnod_5998

MOR:	MOC_0679(fhcD)

META:

Y590_08740

MAQU:

Maq22A_c16440(fhcD)

MPHY:

MCBMB27_00101

MEE:	DA075_05675(fhcD)

METD:

C0214_10495(fhcD)

METX:

A3862_28330

METS:

DK389_20625(fhcD)

METI:

DK427_18415(fhcD)

MMES:

MMSR116_16660(fhcD)

MTEA:

DK419_10765(fhcD)

MIND:

mvi_45840(ffsA)

MOG:	MMB17_20055(fhcD)

MTAD:

M6G65_13695(fhcD)

MECL:

CLZ_08260(fhcD)

MFUJ:

ABC766_06655(fhcD)

MENI:

GU700_08260(fhcD)

MENS:

LOK46_02850(fhcD)

MSL:

Msil_2402

MTUN:

MTUNDRAET4_2739(ffsA)

MLG:	CWB41_06010(fhcD)

MEHY:

MHY1_02183(fhcD)

MEDK:

QEV83_11690(fhcD)

MPOL:

RZS28_14040(fhcD)

BBAI:

CU048_00750(fhcD)

HDN:

Hden_1609

HDT:	HYPDE_29918

HMC:	HYPMC_1887(ffsA)

HNI:	W911_13340

FIL:	BN1229_v1_0555(fhcD)

FIY:	BN1229_v1_0557(fhcD)

MCG:

GL4_1794

METG:

HT051_10145(fhcD)

MSC:

BN69_0584

MBRY:

B1812_16145

MROS:

EHO51_08980(fhcD)

MHEY:

H2LOC_018910(fhcD)

MPAR:

F7D14_18745(fhcD)

MIWA:

SS37A_26180(ffsA)

MESZ:

LNB28_16095(fhcD)

MECI:

RVU70_01105(fhcD)

MEMC:

OGR47_12435(fhcD)

MTW:	CQW49_03835(fhcD)

MECQ:

MSC49_09120(ffsA)

MSPR:

MSP5_002441(fhcD)

CMET:

K6K41_25510(fhcD)

PLEO:

OHA_1_00509(fhcD)

HDI:	HDIA_2304(fhcD)

AALA:

IGS74_05810(fhcD)

AALM:

LUX29_06565(fhcD)

AUZ:	Sa4125_38460(ffsA)

AUB:	LXB15_01015(fhcD)

JAV:	OXU80_18165(fhcD)

MFLG:

ABS361_01770(fhcD)

GBE:	GbCGDNIH1_0780

GBH:	GbCGDNIH2_0780

GBC:	GbCGDNIH3_0780

GBS:	GbCGDNIH4_0780

ALI:	AZOLI_p10692(ffsA1) AZOLI_p10895(ffsA2)

ABS:	AZOBR_p270089(ffsA)

ABQ:	ABAZ39_25435

ABF:	AMK58_22365

ATI:	AL072_27050

AHU:	A6A40_18500(fhcD) A6A40_28890(fhcD)

AZT:	TSH58p_01170(fhcD)

AZM:	DM194_17105(fhcD)

AOZ:	HUE56_08950(fhcD)

AARE:

D3093_24995(fhcD)

AZS:	E6C72_18275(fhcD) E6C72_22430(fhcD)

AZP:	E6C67_07200(fhcD)

SOLI:

ACP59X_03800(fhcD)

RBA:	RB9835(ffsA)

RHOI:

PSR62_04070(fhcD)

PSL:

Psta_0715

PIR:	VN12_16340(fhcD_1) VN12_25910(fhcD_2)

RUL:	UC8_09150(fhcD_1) UC8_33780(fhcD_2)

RML:	FF011L_22160(fhcD_1) FF011L_54310(fhcD_2)

MFF:	MFFC18_20420(fhcD)

ROL:	CA51_12000(fhcD_1) CA51_13910(fhcD_2)

RUV:	EC9_12750(fhcD)

RCF:	Poly24_09810(fhcD)

AHEL:

Q31a_04500(fhcD_1) Q31a_36640(fhcD_2)

LCRE:

Pla8534_21150(fhcD)

AAGG:

ETAA8_53250(fhcD)

BVO:	Pan97_37010(fhcD)

BREM:

PSR63_19775(fhcD)

RLC:	K227x_47420(fhcD_1) K227x_49350(fhcD_2)

SMAM:

Mal15_58920(fhcD)

SNEP:

Enr13x_27230(fhcD)

SMAE:

TBK1r_22040(fhcD)

LPAV:

PLANPX_0512

LLH:	I41_05710(fhcD)

AMUC:

Pan181_03870(fhcD)

PND:	Pla175_42740(fhcD)

AMOB:

HG15A2_01040(fhcD)

BMEI:

Spa11_06120(fhcD)

BGOK:

Pr1d_11660(fhcD)

PLM:

Plim_0767

PEH:	Spb1_16490(fhcD)

PBS:	Plabr_2746

PLS:	VT03_25050(fhcD_1) VT03_26560(fhcD_2)

PLH:	VT85_05450(fhcD)

FMR:	Fuma_04732(fhcD)

GMR:	GmarT_39510(fhcD)

GIM:	F1728_26355(fhcD)

GPN:	Pan110_38360(fhcD)

GFM:	Enr17x_40580(fhcD)

GAZ:	Pan241w_39920(fhcD)

GAW:	V144x_21320(fhcD)

GAX:	Pan161_40360(fhcD)

MRI:	Mal4_35610(fhcD_1) Mal4_53660(fhcD_2)

SDYN:

Mal52_51090(fhcD)

PLON:

Pla110_03360(fhcD_1) Pla110_31860(fhcD_2)

ACAF:

CA12_24050(fhcD)

SVP:	Pan189_26260(fhcD)

TPOL:

Mal48_48890(fhcD)

CHYA:

V22_03900(fhcD)

CCOS:

Pan44_18510(fhcD_1) Pan44_22860(fhcD_2)

PVAR:

SH412_001346(fhcD) SH412_001659(fhcD)

CCOP:

Mal65_10730(fhcD_1) Mal65_19530(fhcD_2)

SCHL:

QJS52_02735(fhcD) QJS52_21050(fhcD)

SSPE:

ACGY09_00985(fhcD) ACGY09_08750(fhcD)

GES:	VT84_05645(fhcD_1) VT84_15260(fhcD_2)

GOG:	C1280_03970(fhcD) C1280_18540(fhcD)

GMS:	SOIL9_37840 SOIL9_85360

TIM:	GMBLW1_15700 GMBLW1_28450

LRS:	PX52LOC_00703 PX52LOC_07047(fhcD)

FTJ:	FTUN_4729 FTUN_5703

ULI:	ETAA1_01420(fhcD_1) ETAA1_48410(fhcD_2)

TSPH:

KIH39_17475(fhcD)

IPA:

Isop_0523

SACI:

Sinac_1239

SING:

V5E97_39165(fhcD)

PBOR:

BSF38_00166(fhcD)

AGV:	OJF2_59260(fhcD)

TPLA:

ElP_43950(fhcD)

KNV:	Pan216_40240(fhcD)

CMIC:

caldi_15540

FWA:	DCMF_03905 DCMF_14865

HAS:	Halsa_0945

AMO:	Anamo_1138

ARAM:

KAR29_10140(fhcD)

APRP:

KIH16_10065(fhcD)

MOX:	DAMO_0459(fhcD)

MJA:

MJ_0318

MFE:	Mefer_1275

MVU:	Metvu_0497

MFS:	MFS40622_1090

MIF:	Metin_0870

MJH:	JH146_0889

MESG:

MLAUSG7_1535(ftr)

MESA:

MLASG1_1139(ftr)

MIG:	Metig_0697

MMP:	MMP1609(ftr)

MMQ:	MmarC5_1799

MMX:	MmarC6_1060

MMZ:	MmarC7_0857

MMD:

GYY_08900

MMAK:

MMKA1_18400(ftr)

MMAO:

MMOS7_17220(ftr)

MMAD:

MMJJ_12270(fhcD)

MAE:

Maeo_0224

MVN:	Mevan_0919

MVO:

Mvol_1497

MOK:	Metok_0159

METF:

CFE53_06700(fhcD)

MTH:	MTH_1259 MTH_403

MMG:	MTBMA_c08020(ehaS) MTBMA_c16460(ftr)

MWO:	MWSIV6_0792(ehaS) MWSIV6_1651(ftr)

MTEE:

MTTB_01700 MTTB_07390

METC:

MTCT_0346 MTCT_1150

METE:

tca_00370(fhcD_1) tca_01215(fhcD_2)

METZ:

METMT2_0534 METMT2_1264

METK:

FVF72_00375 FVF72_05280(fhcD)

MTHM:

FZP57_03785 FZP57_08075(fhcD)

METJ:

FZP68_02705(fhcD) FZP68_08825

MST:	Msp_0070(ftr2) Msp_1502(ftr1)

METB:

AW729_06880 AW729_07855

MEIS:

PXD04_03210(fhcD) PXD04_04160

MRU:	mru_1393(ftr1) mru_2022(ftr2)

MSI:	Msm_0308 Msm_1092

MEB:	Abm4_0936(ftr1) Abm4_1598(ftr2)

MMIL:

sm9_0727(ftr1) sm9_2108(ftr2)

MEYE:

TL18_03515 TL18_09675

MOL:	YLM1_0892 YLM1_1463

MARO:

MarbSA_03240 MarbSA_10120

METV:

K4897_02055 K4897_06005(fhcD)

MEL:	Metbo_0252 Metbo_1272

MEW:	MSWAN_0958 MSWAN_2195

METH:

MBMB1_1128(ehaS) MBMB1_1832(ftr)

MFC:	BRM9_1337(ftr) BRM9_2162(ftr2)

MFI:	DSM1535_1101(ftr) DSM1535_2022(ehaS)

MCUB:

MCBB_1014(ehaS) MCBB_2124(ftr)

MSUB:

BK009_02535 BK009_08310

METN:

BK008_03985 BK008_10190

METT:

CIT01_00445 CIT01_04260(fhcD)

METO:

CIT02_02460 CIT02_08420(fhcD)

MEME:

HYG87_01525 HYG87_05445(fhcD)

MFEG:

GCM10025860_04640 GCM10025860_19180

MEER:

NKF70_05760(fhcD) NKF70_14275

MRID:

FGU46_00770 FGU46_05810(fhcD)

MFV:	Mfer_0535 Mfer_1096

MKA:	MK0116(ftr_1) MK0816(ftr_2)

AFU:	AF_2073 AF_2207

AFG:	AFULGI_00023420 AFULGI_00024790

APO:	Arcpr_0160

AVE:	Arcve_0336 Arcve_1202

AST:	Asulf_00215 Asulf_00752

FPL:	Ferp_0657 Ferp_1323

GAC:	GACE_0426 GACE_2049

GAH:	GAH_00633 GAH_01298

MBA:	Mbar_A0980

MBY:	MSBRM_3513

MBW:	MSBRW_3742

MBAR:

MSBR2_3465

MBAK:

MSBR3_3472

MAC:	MA_0010(ftr)

MMA:

MM_1321

MMAZ:

MmTuc01_1368

MMJ:	MSMAS_3341

MMAC:

MSMAC_3365

MVC:	MSVAZ_3505

MEK:	MSKOL_3473

MLS:	MSLAZ_3094

METM:

MSMTP_3245

MEF:	MSWH1_3192

MEQ:	MSWHS_3401

MSJ:	MSSAC_4333

MSZ:	MSSIH_3834

MSW:	MSSIT_3904

MTHR:

MSTHT_1825

MTHE:

MSTHC_1461

MHOR:

MSHOH_4088

MFZ:	AOB57_008395(fhcD)

MHAB:

RSJ42_16020(fhcD)

METW:

AAY43_03120

MBU:	Mbur_1728(ftr)

MMET:

MCMEM_2199

MELO:

J7W08_10015(fhcD)

MMH:

Mmah_2027

MHAZ:

BHR79_03500

MPOT:

BKM01_10405

MEV:	Metev_1828

MZH:	Mzhil_2022

MPY:

Mpsy_1734

MZI:	HWN40_01035(fhcD)

MMAV:

RE476_10105(fhcD)

MSEB:

RE474_06690(fhcD)

MHZ:	Metho_2457

MTP:

Mthe_1643

MCJ:	MCON_1472(fhcD)

MHI:

Mhar_2214

MHU:

Mhun_1808

MRTJ:

KHC33_05365(fhcD)

MLA:

Mlab_0215

MEM:	Memar_0628

MBG:	BN140_1723(ftr)

MEMA:

MMAB1_2217(ftr)

MCHK:

MchiMG62_07570

MSUM:

OH143_09860(fhcD)

MRC:	R6Y96_02575(fhcD)

MPI:	Mpet_1069 Mpet_2482

MEND:

L6E24_09260(fhcD) L6E24_12315(fhcD)

MEFW:

F1737_00640(fhcD) F1737_05040(fhcD)

MAQE:

RJ40_06020(fhcD)

MFK:	E2N92_06150(fhcD)

MOU:	OU421_03625(fhcD)

MESB:

L1S32_07225(fhcD) L1S32_10650(fhcD)

MANQ:

L1994_01115(fhcD) L1994_04945(fhcD)

MBN:	Mboo_0593 Mboo_0993

MFO:	Metfor_1973 Metfor_2598

MESK:

METHP_00373

MPL:

Mpal_2244

MPD:	MCP_1033(ftr)

MEZ:	Mtc_1916(ftr)

RCI:	LRC202(ftr)

MJK:	N2V74_01535(fhcD) N2V74_04325(fhcD) N2V74_07165

MELU:

MTLP_04500(fhcD) MTLP_05130

MEAM:

MU439_06340

MEAE:

QEN48_03805

BARC:

AOA65_1220(ftr_1) AOA65_2064(ftr_2)

BARB:

AOA66_0598(ftr)

LOKI:

Lokiarch_11730(ftr_1) Lokiarch_20800(ftr_2)

LOB:	NEF87_004808

PSYT:

DSAG12_02401

» show all

Reference

1 [PMID:3097011]

Authors

Donnelly MI, Wolfe RS.

Title

The role of formylmethanofuran: tetrahydromethanopterin formyltransferase in methanogenesis from carbon dioxide.

Journal

J Biol Chem 261:16653-9 (1986)

Reference

Authors

Leigh JA, Rinehart KL, Wolfe RS.

Title

Structure of methanofuran, the carbon-dioxide reduction factor of Methanobacterium thermoautotrophicum.

Journal

J Am Chem Soc 106:3636-3640 (1984)

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.101

IUBMB Enzyme Nomenclature:

2.3.1.101

ExPASy - ENZYME nomenclature database:

2.3.1.101

UM-BBD (Biocatalysis/Biodegradation Database):

2.3.1.101

BRENDA, the Enzyme Database:

2.3.1.101

CAS:	105669-83-8

DBGET integrated database retrieval system