KEGG ENZYME: 2.3.1.105

ENZYME: 2.3.1.105

Entry

EC 2.3.1.105                Enzyme

Name

alkylglycerophosphate 2-O-acetyltransferase;
alkyllyso-GP:acetyl-CoA acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:1-alkyl-sn-glycero-3-phosphate 2-O-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate = CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate [RN:R03455]

Reaction(KEGG)

R03455

Substrate

acetyl-CoA [CPD:C00024];
1-alkyl-sn-glycero-3-phosphate [CPD:C03968]

Product

CoA [CPD:C00010];
1-alkyl-2-acetyl-sn-glycero-3-phosphate [CPD:C01264]

Comment

Involved in the biosynthesis of thrombocyte activating factor in animal tissues.

History

EC 2.3.1.105 created 1989

Pathway

ec00565

Ether lipid metabolism

ec01100

Metabolic pathways

Reference

1 [PMID:3007498]

Authors

Lee TC, Malone B, Snyder F.

Title

A new de novo pathway for the formation of 1-alkyl-2-acetyl-sn-glycerols, precursors of platelet activating factor. Biochemical characterization of 1-alkyl-2-lyso-sn-glycero-3-P:acetyl-CoA acetyltransferase in rat spleen.

Journal

J Biol Chem 261:5373-7 (1986)

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.105

IUBMB Enzyme Nomenclature:

2.3.1.105

ExPASy - ENZYME nomenclature database:

2.3.1.105

BRENDA, the Enzyme Database:

2.3.1.105

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
All databases (11)   

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