KEGG ENZYME: 2.3.1.108

ENZYME: 2.3.1.108

Entry

EC 2.3.1.108                Enzyme

Name

alpha-tubulin N-acetyltransferase;
ATAT1 (gene name);
MEC17 (gene name);
alpha-tubulin acetylase;
TAT;
alpha-tubulin acetyltransferase;
tubulin N-acetyltransferase (ambiguous);
acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase;
acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine [RN:R04192]

Reaction(KEGG)

R04192

Substrate

acetyl-CoA [CPD:C00024];
[alpha-tubulin]-L-lysine [CPD:C03318]

Product

CoA [CPD:C00010];
[alpha-tubulin]-N6-acetyl-L-lysine [CPD:C04149]

Comment

The enzyme is conserved from protists to mammals and is present in flowering plants. In most organisms it acetylates L-lysine at position 40 of alpha-tubulin.

History

EC 2.3.1.108 created 1989, modified 2021

Orthology

K19573

alpha-tubulin N-acetyltransferase 1

Genes

HSA:	79969(ATAT1)

PTR:	100612548(ATAT1)

PPS:	100975033(ATAT1)

GGO:	101125931(ATAT1)

PON:	100190967(ATAT1)

NLE:	100595319(ATAT1)

HMH:	116460080(ATAT1)

MCC:	100141388(ATAT1)

MTHB:

126953104

MNI:	105498610(ATAT1)

CSAB:

103221829(ATAT1)

CATY:

105600029(ATAT1)

PANU:

101025462(ATAT1)

TGE:	112622364 112623033

MLEU:

105553117(ATAT1)

RRO:	104666191(ATAT1)

RBB:	108522570(ATAT1)

TFN:	117088379(ATAT1)

PTEH:

111534440(ATAT1)

CANG:

105513991(ATAT1)

CJC:	100388531(ATAT1)

SBQ:	101037052(ATAT1)

CIMI:

108290611(ATAT1)

CSYR:

103249229(ATAT1)

MMUR:

105855392(ATAT1)

LCAT:

123631692(ATAT1)

PCOQ:

105817287(ATAT1)

OGA:	100950093(ATAT1)

MMU:	73242(Atat1)

MCAL:

110284357(Atat1)

MPAH:

110335546(Atat1)

RNO:	361789(Atat1)

MCOC:

116074613(Atat1)

ANU:	117724213(Atat1)

MUN:	110557137(Atat1)

CGE:	100764669(Atat1)

MAUA:

101826157(Atat1)

PROB:

127224374(Atat1)

PLEU:

114687012(Atat1)

MORG:

121435419(Atat1)

MFOT:

126494399

AAMP:

119822967(Atat1)

NGI:	103740567(Atat1)

HGL:	101705887(Atat1)

CPOC:

100719818(Atat1)

CCAN:

109693536(Atat1)

DORD:

105996955(Atat1)

DSP:	122111311(Atat1)

NCAR:

124988608

OCU:

100358006

OPI:	101531705(ATAT1)

TUP:	102486128(ATAT1)

GVR:	103592545(ATAT1)

CFA:	477580(ATAT1) 609464

CLUD:

112641245(ATAT1) 112656233

VVP:	112913564(ATAT1)

VLG:	121501255(ATAT1)

AML:	100473989(ATAT1)

UMR:	103664999(ATAT1)

UAH:	113264359(ATAT1)

UAR:	123794284(ATAT1)

ELK:

111152370

LLV:

125101805

MPUF:

101679281(ATAT1)

NVS:	122912100(ATAT1)

ORO:	101368740(ATAT1)

EJU:	114199234(ATAT1)

ZCA:	113926329(ATAT1)

MLX:	118027369(ATAT1)

NSU:	110578840 110586666(ATAT1)

LWW:

102741914

FCA:	101093356(ATAT1)

PYU:	121023110(ATAT1)

PBG:	122489321(ATAT1)

LRUF:

124528532

PTG:	102966181(ATAT1)

PPAD:

109249510(ATAT1)

PUC:

125938492

AJU:	106966611(ATAT1)

HHV:	120222646(ATAT1)

BTA:	786491(ATAT1)

BOM:	102275558(ATAT1)

BIU:	109577111(ATAT1)

BBUB:

102405703(ATAT1)

BBIS:

104994570(ATAT1)

CHX:	102183555(ATAT1)

OAS:	101106803(ATAT1)

ODA:	120870501(ATAT1)

SSC:	100144480(ATAT1)

CFR:	102504889(ATAT1)

CBAI:

105074093(ATAT1)

CDK:	105087501(ATAT1) 116147121

VPC:	102534879(ATAT1)

BACU:

103016955(ATAT1)

LVE:	103083275(ATAT1)

OOR:	101273516(ATAT1)

DLE:	111170678(ATAT1)

PCAD:

102974761(ATAT1)

PSIU:

116761964(ATAT1)

ECB:	100055595(ATAT1)

EPZ:	103567174(ATAT1)

EAI:	106825481(ATAT1)

MYB:	102240400(ATAT1)

MYD:	102762964(ATAT1)

MMYO:

118679502

MLF:	102437350(ATAT1)

MNA:	107538522(ATAT1)

PKL:	118714058(ATAT1)

HAI:	109376104(ATAT1)

DRO:	112302335(ATAT1)

SHON:

118987617(ATAT1)

AJM:	119046339(ATAT1)

PDIC:

114494485(ATAT1)

PHAS:

123810481(ATAT1)

MMF:	118620698(ATAT1)

RFQ:	117020239(ATAT1)

PALE:

102879916(ATAT1)

PGIG:

120593370(ATAT1)

PVP:	105308145(ATAT1)

RAY:	107498064(ATAT1)

MJV:	108384338 108394139

TOD:	119252107(ATAT1)

SARA:

101545003(ATAT1)

LAV:	100664992(ATAT1)

TMU:

101361158

ETF:	101647457(ATAT1)

DNM:

101421604

MDO:	100024215(ATAT1)

GAS:	123245054(ATAT1)

SHR:	100919522(ATAT1)

AFZ:

127561043

PCW:	110199408(ATAT1)

OAA:	103166272(ATAT1)

TGU:	115492253(ATAT1)

LSR:	110482313(ATAT1)

PMOA:

120503966

PHI:	102104188(ATAT1)

CCAE:

111942560(ATAT1)

CBRC:

108448297(ATAT1)

SVG:	106863338(ATAT1)

ACHC:

115337893(ATAT1)

HLE:	104838035(ATAT1)

AGEN:

126034975

SHAB:

115618858(ATAT1)

ASN:	102379630(ATAT1)

AMJ:	102573069(ATAT1)

PSS:	102444571(ATAT1)

CMY:	102941891(ATAT1)

CPIC:

101936201(ATAT1)

TST:	117870426(ATAT1)

CABI:

116836708(ATAT1)

MRV:	120383876(ATAT1)

ACS:	100561358(atat1)

PVT:	110089317(ATAT1)

SUND:

121920245(ATAT1)

PBI:	103048020 103064160

PMUR:

107297734(ATAT1)

CTIG:

120307286(ATAT1)

TSR:	106550119(ATAT1)

PGUT:

117667981(ATAT1)

VKO:	123019525(ATAT1)

PMUA:

114588270(ATAT1)

ZVI:	118081085(ATAT1)

GJA:	107111806(ATAT1)

STOW:

125427701(ATAT1) 125427707

XLA:	734258(atat1.L) 735057(atat1.S)

XTR:	100038151(atat1)

NPR:	108790405(ATAT1)

RTEM:

120913493(ATAT1)

BBUF:

121009153(ATAT1)

BGAR:

122946163(ATAT1)

DRE:	406389(atat1)

SRX:	107711335 107754836

SANH:

107677465 107677472 107694337

SGH:	107584296 107595600

CCAR:

109063750 109063757

CAUA:

113090768 113119529

CGIB:

127935572 127979007

PPRM:

120485060(atat1)

MAMB:

125274767(atat1)

CIDE:

127500518

MASI:

127421051 127425466

IPU:	108272794(atat1)

PHYP:

113543803(atat1)

SMEO:

124381921(atat1)

TFD:	113634692(atat1)

AMEX:

103043739(atat1)

EEE:	113590338(atat1)

TRU:	101074501 115251809(atat1)

TNG:	GSTEN00004688G001

LCO:	104931069(atat1)

NCC:

104951400

CGOB:

115015403(atat1)

ELY:	117263696(atat1)

EFO:	125904576(atat1)

PLEP:

121957568(atat1)

SLUC:

116035741(atat1)

ECRA:

117957345(atat1)

ESP:	116701254(atat1)

PFLV:

114568380(atat1)

GAT:	120826705(atat1)

PPUG:

119218791(atat1)

MSAM:

119907190(atat1)

CUD:	121524078(atat1)

ALAT:

119016821(atat1)

MZE:	101473057(atat1)

ONL:	100698811(atat1)

OAU:	116317007(atat1)

OLA:	101172832(atat1)

OML:	112137782(atat1)

XMA:	102224331(atat1)

XCO:	114156469(atat1)

XHE:	116731875(atat1)

PRET:

103471914(atat1)

PFOR:

103142785(atat1)

PLAI:

106937899(atat1)

PMEI:

106912443(atat1)

GAF:	122843996(atat1)

CVG:	107105221(atat1)

CTUL:

119784059(atat1)

GMU:	124879430(atat1)

NFU:	107383265(atat1)

KMR:	108248583(atat1)

ALIM:

106531007(atat1)

NWH:	119426110(atat1)

AOCE:

111575171(atat1)

MCEP:

125019810(atat1)

CSEM:

103384383 103394495(atat1)

POV:	109643172(atat1)

SSEN:

122783133 122786311(atat1)

HHIP:

117771129(atat1)

HSP:	118125029(atat1)

LCF:

108896379

SDU:	111220869(atat1)

SLAL:

111645636(atat1)

XGL:	120786372(atat1)

HCQ:	109515158(atat1)

BPEC:

110161191(atat1)

MALB:

109974587(atat1)

BSPL:

114865643(atat1)

SASA:

106570679 106589060(atat1)

STRU:

115174126 115175310(atat1)

OTW:	112238603 112247208

OMY:	110496896(atat1)

OGO:	124012771 124043077

ONE:	115116544 115125001

SALP:

111974506

SNH:	120021996(atat1) 120027367

CCLU:

121572234 121586834

ELS:	105012343(atat1)

SFM:	108935682(atat1)

PKI:	111842741(atat1)

AANG:

118234692(atat1)

PSPA:

121298671(atat1)

ARUT:

117433594 117964778

PSEX:

120539678(atat1)

LCM:	102353700(ATAT1)

RTP:	109912442(atat1)

BFO:

118407743

BBEL:

109462042

CIN:

100180842

SCLV:

120344733

SPU:	115929226 581275

APLC:

110976410

SKO:

100372923

DME:	Dmel_CG17003(CG17003) Dmel_CG3967(Atat)

DER:	6545641 6550395

DSE:

6605026

DSI:	Dsimw501_GD12926(Dsim_GD12926) Dsimw501_GD15558(Dsim_GD15558)

DYA:	Dyak_GE17347 Dyak_GE21245

DAN:

6506373

DSR:	110184175 110190629

DPO:	6900997 6900998 6901295

DPE:	113566753 6598554 6599632

DMN:	108151967 108151969 108156830

DWI:	6638791 6644873

DGR:

6557341

DMO:	Dmoj_GI13265 Dmoj_GI14817

DAZ:	108613148 108618396

DNV:	108650490 108655956

DHE:	111602819 111603737

DVI:

6623141

CCAT:

101451142 101452477

BOD:	106621507 106624106

RZE:

108359899

MDE:	101894333 101897175

SCAC:

106084962

LCQ:

111684277

LSQ:

119606319

AGA:	AgaP_AGAP005828

ACOZ:

120947541

AARA:

120898274

ASTE:

118511483

AAG:

5570947

AALB:

109409698 109411441

CQU:	CpipJ_CPIJ002083

CPII:

120428697

CNS:

116352492

BCOO:

119082181 119082516

AME:

726664

ACER:

107994214

ALAB:

122719667

BIM:

100743036

BBIF:

117210303

BVK:

117242106

BVAN:

117159463

BTER:

100649139

BPYO:

122569280

CCAL:

108628030

OBB:

114880120

MGEN:

117228575

NMEA:

116424230

CGIG:

122403630

SOC:

105201818

MPHA:

105838369

AEC:

105145755

ACEP:

105624179

PBAR:

105428664

VEM:

105567303

HST:

105190371

DQU:

106742357

CFO:

105252940

FEX:

115239043

LHU:

105678633

PGC:

109859797

OBO:

105282139

PCF:

106787522

PFUC:

122524124

VPS:

122637338

NVI:

100121551

CSOL:

105365137

TPRE:

106652111

MDL:

103573516

CGLO:

123266445

FAS:

105274088

DAM:

107045275

AGIF:

122859577

CINS:

118072198

LHT:

122500283

CCIN:

107273868

TCA:

660866

DPA:

109541846

SOY:

115885965

ATD:	109602224 109608541 109608563 109608617

AGB:

108911158

NVL:

108569703

PPYR:

116175155

BMOR:

101741407

BMAN:

114246874

MSEX:

115441429

DPL:	KGM_200100

BANY:

112047971

PMAC:

106719746 106719891

PPOT:

106102600 106102989

PXU:	106113651 106113885

PRAP:

110999361

ZCE:

119835601

HAW:

110381403

HZE:

124645118

SLIU:

111360630

OFU:

114359327

CFEL:

113369258 113377702 113385498

API:	100162553 100168047 100169461 100570380 100570471 100570672 100575498

DNX:	107164488 107173589 107173592 107174168 107174192

AGS:	114123315 114123904 114125016 114132529 114132549

RMD:	113548079 113549333 113556182 113556835 113557143 113557201

BTAB:

109031895

DCI:

103517182

CLEC:

106668236 106668237

HHAL:

106691548

NLU:	111050069 120349759

PHU:	Phum_PHUM581120

FOC:	113206970 113212172

TPAL:

117653839 117654003

ZNE:

110831576

CSEC:

111875230

SGRE:

126365854

FCD:

110855937

DPX:	DAPPUDRAFT_304907

DMK:

116933661

DPZ:

124336719

PVM:

113827729

PJA:

122251437

PCHN:

125039015

HAME:

121861834

PCLA:

123775095

PTRU:

123514809

EAF:

111707382

LSM:

121123646

PPOI:

119100937

DSV:

119435395

RSAN:

119378785 119406384

RMP:

119177238

VDE:

111243297

VJA:

111264289

TUT:

107361133

DPTE:

113797776

DFR:

124499996

CSCU:

111618355

PTEP:

107436987

SDM:

118197569

CEL:	CELE_F57H12.7(mec-17) CELE_W06B11.1(atat-2)

CBR:	CBG_14763(Cbr-atat-2) CBG_17726(Cbr-mec-17)

BMY:	BM_BM6206(Bm6206)

LOA:	LOAG_13260

NAI:	NECAME_01566

HRO:	HELRODRAFT_188468

LGI:	LOTGIDRAFT_109299 LOTGIDRAFT_148609

PCAN:

112575932

BGT:

106059352

GAE:

121383091

HRF:

124139272

HRJ:

124275917

CRG:

105336584

MYI:

110464956

PMAX:

117321625

OBI:

106875308

OSN:

115222942

LAK:	106151826 106173555

SMM:	Smp_166660

OVI:	T265_11140

EGL:

EGR_05466

NVE:

5507200

EPA:

110243359

ATEN:

116298261

AMIL:

114963356

PDAM:

113686094

SPIS:

111327067

DGT:

114518815

XEN:

124439183

HMG:

101237472

TAD:	TRIADDRAFT_35009 TRIADDRAFT_53139

AQU:	100640763 105315491 109587786

SMO:	SELMODRAFT_420234

PPP:	112285127 112285208

VCN:	VOLCADRAFT_90683

MNG:

MNEG_1043

MIS:	MICPUN_85323

MPP:	MICPUCDRAFT_6581

SRE:	PTSG_01905

PFD:	PFDG_01359

PFH:	PFHG_01378

PKN:	PKNH_0722800

PVX:	PVX_099660

PCY:	PCYB_073250

TET:	TTHERM_00355780

PTM:	GSPATT00035333001 GSPATT00035468001 GSPATT00036506001 GSPATT00037844001 GSPATT00038558001

SMIN:

v1.2.037027.t1(symbB.v1.2.037027.t1) v1.2.037027.t2(symbB.v1.2.037027.t2)

NGD:	NGA_0112700

PIF:	PITG_13069

PSOJ:

PHYSODRAFT_347190

SPAR:

SPRG_08206

EHX:	EMIHUDRAFT_204370

GTT:	GUITHDRAFT_72899

TBR:	Tb927.3.1400

TBG:	TbgDal_III1150

TCR:	467287.10 509233.160

LMA:	LMJF_25_1150

LIF:	LINJ_25_1190

LDO:	LDBPK_251190

LMI:	LMXM_25_1150

LBZ:	LBRM_25_1130

LPAN:

LPMP_251180

NGR:	NAEGRDRAFT_58582

TVA:	TVAG_2v0166300 TVAG_2v0307470

GLA:	GL50803_0016348

» show all

Reference

1 [PMID:4066751]

Authors

Greer K, Maruta H, L'Hernault SW, Rosenbaum JL.

Title

Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella.

Journal

J Cell Biol 101:2081-4 (1985)
DOI:10.1083/jcb.101.6.2081

Reference

2 [PMID:20829795]

Authors

Akella JS, Wloga D, Kim J, Starostina NG, Lyons-Abbott S, Morrissette NS, Dougan ST, Kipreos ET, Gaertig J

Title

MEC-17 is an alpha-tubulin acetyltransferase.

Journal

Nature 467:218-22 (2010)
DOI:10.1038/nature09324

Reference

3 [PMID:21068373]

Authors

Shida T, Cueva JG, Xu Z, Goodman MB, Nachury MV

Title

The major alpha-tubulin K40 acetyltransferase alphaTAT1 promotes rapid ciliogenesis and efficient mechanosensation.

Journal

Proc Natl Acad Sci U S A 107:21517-22 (2010)
DOI:10.1073/pnas.1013728107

Reference

4 [PMID:23071318]

Authors

Taschner M, Vetter M, Lorentzen E.

Title

Atomic resolution structure of human alpha-tubulin acetyltransferase bound to acetyl-CoA.

Journal

Proc Natl Acad Sci U S A 109:19649-54 (2012)
DOI:10.1073/pnas.1209343109

Reference

5 [PMID:23071314]

Authors

Friedmann DR, Aguilar A, Fan J, Nachury MV, Marmorstein R.

Title

Structure of the alpha-tubulin acetyltransferase, alphaTAT1, and implications for tubulin-specific acetylation.

Journal

Proc Natl Acad Sci U S A 109:19655-60 (2012)
DOI:10.1073/pnas.1209357109

Reference

6 [PMID:23748901]

Authors

Kalebic N, Sorrentino S, Perlas E, Bolasco G, Martinez C, Heppenstall PA.

Title

alphaTAT1 is the major alpha-tubulin acetyltransferase in mice.

Journal

Nat Commun 4:1962 (2013)
DOI:10.1038/ncomms2962

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.108

IUBMB Enzyme Nomenclature:

2.3.1.108

ExPASy - ENZYME nomenclature database:

2.3.1.108

BRENDA, the Enzyme Database:

2.3.1.108

CAS:	99889-90-4

DBGET integrated database retrieval system