KEGG   ENZYME: 2.3.1.108
Entry
EC 2.3.1.108                Enzyme                                 

Name
alpha-tubulin N-acetyltransferase;
alpha-tubulin acetylase;
TAT;
alpha-tubulin acetyltransferase;
tubulin N-acetyltransferase;
acetyl-CoA:alpha-tubulin-L-lysine N-acetyltransferase;
acetyl-CoA:[alpha-tubulin]-L-lysine 6-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:[alpha-tubulin]-L-lysine N6-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + [alpha-tubulin]-L-lysine = CoA + [alpha-tubulin]-N6-acetyl-L-lysine [RN:R04192]
Reaction(KEGG)
R04192
Substrate
acetyl-CoA [CPD:C00024];
[alpha-tubulin]-L-lysine [CPD:C03318]
Product
CoA [CPD:C00010];
[alpha-tubulin]-N6-acetyl-L-lysine [CPD:C04149]
Comment
The enzyme from Chlamydomonas flagella also acetylates mammalian brain alpha-tubulin.
History
EC 2.3.1.108 created 1989
Orthology
K19573  alpha-tubulin N-acetyltransferase 1
Genes
HSA: 79969(ATAT1)
PTR: 100612548(ATAT1)
PPS: 100975033(ATAT1)
GGO: 101125931(ATAT1)
PON: 100190967(ATAT1)
NLE: 100595319(ATAT1)
MCC: 100141388(ATAT1)
MCF: 102135176(ATAT1)
CSAB: 103221829(ATAT1)
CATY: 105600029(ATAT1)
PANU: 101025462(ATAT1)
RRO: 104666191(ATAT1)
RBB: 108522570(ATAT1)
TFN: 117088379(ATAT1)
PTEH: 111534440(ATAT1)
CJC: 100388531(ATAT1)
SBQ: 101037052(ATAT1)
MMUR: 105855392(ATAT1)
MMU: 73242(Atat1)
MCAL: 110284357(Atat1)
MPAH: 110335546(Atat1)
RNO: 361789(Atat1)
MCOC: 116074613(Atat1)
MUN: 110557137(Atat1)
CGE: 100764669(Atat1)
PLEU: 114687012(Atat1)
NGI: 103740567(Atat1)
HGL: 101705887(Atat1)
CCAN: 109693536(Atat1)
OCU: 100358006(ATAT1)
TUP: 102486128(ATAT1)
CFA: 477580(ATAT1) 609464
VVP: 112913564(ATAT1)
VLG: 121501255(ATAT1)
AML: 100473989(ATAT1)
UMR: 103664999(ATAT1)
UAH: 113264359(ATAT1)
ORO: 101368740(ATAT1)
ELK: 111152370
MPUF: 101679281(ATAT1)
EJU: 114199234(ATAT1)
MLX: 118027369(ATAT1)
FCA: 101093356(ATAT1)
PTG: 102966181(ATAT1)
PPAD: 109249510(ATAT1)
AJU: 106966611(ATAT1)
HHV: 120222646(ATAT1)
BTA: 786491(ATAT1)
BOM: 102275558(ATAT1)
BIU: 109577111(ATAT1)
BBUB: 102405703(ATAT1)
CHX: 102183555(ATAT1)
OAS: 101106803(ATAT1)
ODA: 120870501(ATAT1)
SSC: 100144480(ATAT1)
CFR: 102504889(ATAT1)
CBAI: 105074093(ATAT1)
CDK: 105087501(ATAT1) 116147121
BACU: 103016955(ATAT1)
LVE: 103083275(ATAT1)
OOR: 101273516(ATAT1)
DLE: 111170678(ATAT1)
PCAD: 102974761(ATAT1)
ECB: 100055595(ATAT1)
EPZ: 103567174(ATAT1)
EAI: 106825481(ATAT1)
MYB: 102240400(ATAT1)
MYD: 102762964(ATAT1)
MMYO: 118679502
MNA: 107538522(ATAT1)
HAI: 109376104(ATAT1)
DRO: 112302335(ATAT1)
SHON: 118987617(ATAT1)
AJM: 119046339(ATAT1)
MMF: 118620698(ATAT1)
PALE: 102879916(ATAT1)
PGIG: 120593370(ATAT1)
RAY: 107498064(ATAT1)
TOD: 119252107(ATAT1)
LAV: 100664992(ATAT1)
TMU: 101361158
MDO: 100024215(ATAT1)
SHR: 100919522(ATAT1)
PCW: 110199408(ATAT1)
OAA: 103166272(ATAT1)
TGU: 115492253(ATAT1)
LSR: 110482313(ATAT1)
PMOA: 120503966
PHI: 102104188(ATAT1)
CCAE: 111942560(ATAT1)
ASN: 102379630(ATAT1)
AMJ: 102573069(ATAT1)
PSS: 102444571(ATAT1)
CMY: 102941891(ATAT1)
CPIC: 101936201(ATAT1)
TST: 117870426(ATAT1)
CABI: 116836708(ATAT1)
ACS: 100561358(atat1)
PVT: 110089317(ATAT1)
PMUR: 107297734(ATAT1)
TSR: 106550119(ATAT1)
PGUT: 117667981(ATAT1)
PMUA: 114588270(ATAT1)
ZVI: 118081085(ATAT1)
GJA: 107111806(ATAT1)
XLA: 734258(atat1.L) 735057(atat1.S)
XTR: 100038151(atat1)
NPR: 108790405(ATAT1)
DRE: 406389(atat1)
IPU: 108272794(atat1)
PHYP: 113543803(atat1)
AMEX: 103043739(atat1)
EEE: 113590338(atat1)
TRU: 101074501 115251809(atat1)
LCO: 104931069(atat1)
NCC: 104951400
CGOB: 115015403(atat1)
ELY: 117263696(atat1)
PLEP: 121957568(atat1)
SLUC: 116035741(atat1)
ECRA: 117957345(atat1)
PFLV: 114568380(atat1)
GAT: 120826705(atat1)
MSAM: 119907190(atat1)
CUD: 121524078(atat1)
MZE: 101473057(atat1)
ONL: 100698811(atat1)
OAU: 116317007(atat1)
OLA: 101172832(atat1)
OML: 112137782(atat1)
XMA: 102224331(atat1)
XCO: 114156469(atat1)
XHE: 116731875(atat1)
PRET: 103471914(atat1)
CVG: 107105221(atat1)
CTUL: 119784059(atat1)
NFU: 107383265(atat1)
KMR: 108248583(atat1)
ALIM: 106531007(atat1)
AOCE: 111575171(atat1)
CSEM: 103384383 103394495(atat1)
POV: 109643172(atat1)
LCF: 108896379(atat1)
SDU: 111220869(atat1)
SLAL: 111645636(atat1)
XGL: 120786372(atat1)
HCQ: 109515158(atat1)
BPEC: 110161191(atat1)
MALB: 109974587(atat1)
SASA: 106570679 106589060(atat1)
OMY: 110496896(atat1)
SALP: 111974506
SNH: 120021996(atat1) 120027367
ELS: 105012343(atat1)
SFM: 108935682(atat1)
PKI: 111842741(atat1)
AANG: 118234692(atat1)
PSPA: 121298671(atat1)
LCM: 102353700(ATAT1)
RTP: 109912442(atat1)
BFO: 118407743
BBEL: 109462042
CIN: 100180842
SCLV: 120344733
APLC: 110976410
SKO: 100372923
DME: Dmel_CG17003(CG17003) Dmel_CG3967(Tat)
DSE: 6605026
DSI: Dsimw501_GD12926(Dsim_GD12926) Dsimw501_GD15558(Dsim_GD15558)
DAN: 6506373
DGR: 6557341
DVI: 6623141
LCQ: 111684277
ACOZ: 120947541
AARA: 120898274
AAG: 5570947
CPII: 120428697
AME: 726664
ACER: 107994214
BIM: 100743036
BBIF: 117210303
BTER: 100649139
CCAL: 108628030
OBB: 114880120
MGEN: 117228575
NMEA: 116424230
CGIG: 122403630
SOC: 105201818
MPHA: 105838369
AEC: 105145755
ACEP: 105624179
PBAR: 105428664
VEM: 105567303
HST: 105190371
DQU: 106742357
CFO: 105252940
FEX: 115239043
LHU: 105678633
PGC: 109859797
OBO: 105282139
PCF: 106787522
NVI: 100121551
CSOL: 105365137
MDL: 103573516
CCIN: 107273868
TCA: 660866
DPA: 109541846
AGB: 108911158
NVL: 108569703
PPYR: 116175155
BMOR: 101741407
BMAN: 114246874
MSEX: 115441429
BANY: 112047971
PRAP: 110999361
ZCE: 119835601
HAW: 110381403
BTAB: 109031895
DCI: 103517182
HHAL: 106691548
ZNE: 110831576
CSEC: 111875230
FCD: 110855937
DMK: 116933661
PVM: 113827729
HAME: 121861834
EAF: 111707382
DSV: 119435395
RMP: 119177238
VDE: 111243297
VJA: 111264289
TUT: 107361133
DPTE: 113797776
CSCU: 111618355
PTEP: 107436987
SDM: 118197569
CEL: CELE_F57H12.7(mec-17) CELE_W06B11.1(atat-2)
CBR: CBG14763 CBG17726(Cbr-mec-17)
PCAN: 112575932
BGT: 106059352
GAE: 121383091
CRG: 105336584
MYI: 110464956
PMAX: 117321625
OBI: 106875308
EGL: EGR_05466
NVE: 5507200
EPA: 110243359
ATEN: 116298261
AMIL: 114963356
PDAM: 113686094
SPIS: 111327067
DGT: 114518815
HMG: 101237472
MNG: MNEG_1043
SMIN: v1.2.037027.t1(symbB.v1.2.037027.t1) v1.2.037027.t2(symbB.v1.2.037027.t2)
SPAR: SPRG_08206
 » show all
Reference
1  [PMID:4066751]
  Authors
Greer K, Maruta H, L'Hernault SW, Rosenbaum JL.
  Title
Alpha-tubulin acetylase activity in isolated Chlamydomonas flagella.
  Journal
J Cell Biol 101:2081-4 (1985)
DOI:10.1083/jcb.101.6.2081
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.108
IUBMB Enzyme Nomenclature: 2.3.1.108
ExPASy - ENZYME nomenclature database: 2.3.1.108
BRENDA, the Enzyme Database: 2.3.1.108
CAS: 99889-90-4

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