| Entry |
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| Name |
phosphatidylcholine---retinol O-acyltransferase;
lecithin---retinol acyltransferase;
phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase;
lecithin:retinol acyltransferase;
lecithin-retinol acyltransferase;
retinyl ester synthase;
LRAT;
lecithin retinol acyl transferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase
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| Reaction(IUBMB) |
phosphatidylcholine + retinol---[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] [RN: R04514]
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| Reaction(KEGG) |
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| Substrate |
phosphatidylcholine [CPD: C00157];
retinol---[cellular-retinol-binding-protein]
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| Product |
2-acylglycerophosphocholine;
retinyl-ester---[cellular-retinol-binding-protein]
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| Comment |
A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.
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| History |
EC 2.3.1.135 created 1992, modified 2011
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| Pathway |
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| Orthology |
| K00678 | phosphatidylcholine-retinol O-acyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
MacDonald PN, Ong DE. |
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| Title |
Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine. |
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| Journal |
J Biol Chem 263:12478-82 (1988) |
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| Sequence |
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| Reference |
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| Authors |
Saari JC, Bredberg DL. |
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| Title |
Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes. |
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| Journal |
J Biol Chem 264:8636-40 (1989) |
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| Sequence |
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| Reference |
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| Authors |
Saari JC, Bredberg DL, Farrell DF |
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| Title |
Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase. |
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| Journal |
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| Reference |
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| Authors |
Mata NL, Tsin AT |
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| Title |
Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes. |
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| Journal |
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| Reference |
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| Authors |
Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D |
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| Title |
Molecular and biochemical characterization of lecithin retinol acyltransferase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.135 |
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