Entry
Name
phosphatidylcholine---retinol O-acyltransferase;
lecithin---retinol acyltransferase;
phosphatidylcholine:retinol-(cellular-retinol-binding-protein) O-acyltransferase;
lecithin:retinol acyltransferase;
lecithin-retinol acyltransferase;
retinyl ester synthase;
LRAT;
lecithin retinol acyl transferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
phosphatidylcholine:retinol---[cellular-retinol-binding-protein] O-acyltransferase
Reaction(IUBMB)
phosphatidylcholine + retinol---[cellular-retinol-binding-protein] = 2-acylglycerophosphocholine + retinyl-ester---[cellular-retinol-binding-protein] [RN:
R04514 ]
Reaction(KEGG)
Substrate
phosphatidylcholine [CPD:
C00157 ];
retinol---[cellular-retinol-binding-protein]
Product
2-acylglycerophosphocholine;
retinyl-ester---[cellular-retinol-binding-protein]
Comment
A key enzyme in retinoid metabolism, catalysing the transfer of an acyl group from the sn-1 position of phosphatidylcholine to retinol, forming retinyl esters which are then stored. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein, but has higher affinity for the bound form. Can also esterify 11-cis-retinol.
History
EC 2.3.1.135 created 1992, modified 2011
Pathway
Orthology
K00678 phosphatidylcholine-retinol O-acyltransferase
Genes
OAS : 101104976(LRAT) 114108650
PMUA : 114604741(LRAT) 114604742
XLA : 108699284 108706650 443823(lrat.L)
NPR : 108788202 108788203(LRAT)
RTEM : 120920155 120920168
BBUF : 120990059 120990060
BGAR : 122941866 122942060
DRE : 553239(lrata) 553501(lratb) 556575(lratb.2) 566123(si:dkey-30k22.5)
SRX : 107714135 107714151 107714634 107757590 107758847 107758870
SANH : 107665938 107665945 107692632 107692634 107695853 107695864 107700276
SGH : 107564312 107564324 107572196 107572197 107590728 107590773 107598257(lrat)
CCAR : 109053612 109085059 109107035 109107036
CAUA : 113044499 113044500 113044789 113100968 113107983 113109892
CGIB : 127948524 127948525 127949611 127952665 127980198
PPRM : 120462844 120462893(lratb.2) 120487494(si:dkey-30k22.5) 120494742(lrata)
MAMB : 125271444(si:dkey-30k22.5) 125272421(lrata) 125272763 125272764(lratb.2)
CIDE : 127510685 127511716(si:dkey-30k22.5) 127519994 127520054
MASI : 127443868 127443869 127445196 127445198(si:dkey-30k22.5) 127445249
IPU : 108258976(lratb.2) 108258977 108261015(lrata)
PHYP : 113524574 113524578
SMEO : 124378050 124378533(lratb.2) 124381673(lrata)
TFD : 113634831(lrata) 113652968 113652969(lratb.2)
AMEX : 103023349 103023667 103037297(lrat)
TRU : 101076520 101076751(lrat)
TNG : GSTEN00000329G001 GSTEN00000330G001 GSTEN00013684G001 GSTEN00013685G001
LCO : 104917826 104917836(lrat) 109137012
NCC : 104949063 104966386(lrat)
CGOB : 115012347(lrat) 115012675
ELY : 117245752 117255851(si:dkey-30k22.5) 117255891(lrata) 117272810
EFO : 125883429 125884286 125886067(lrata) 125886068(si:dkey-30k22.5)
PLEP : 121941462(si:dkey-30k22.5) 121942700(lrata) 121962221(lratb.1) 121962534(lratb.2) 121963621
SLUC : 116051743 116052082 116052147
ECRA : 117941032 117954676
PFLV : 114545934 114546175 114562873
GAT : 120821314 120825187(lrata)
PPUG : 119218293(lrata) 119223041
MSAM : 119884110 119884111 119898789(lrata) 119898790(si:dkey-30k22.5) 119911806
CUD : 121504089 121504935(lratb.2) 121509047(lrata) 121509055(si:dkey-30k22.5)
ALAT : 119022749(lrata) 119023300 119026604 119027440(lratb.2)
MZE : 101468959 101469269 101485910 101486513
ONL : 100695577 100704704 100712580 109194412
OAU : 116312398(si:dkey-30k22.5) 116312412(lrata) 116326521(lratb.2) 116326574
OLA : 101158747 101162811 101172026 105356312
OML : 112137530(lrata) 112137644(si:dkey-30k22.5) 112156356 112156374(lratb.2)
XMA : 102217705 102223500 102225752
XCO : 114144069 114156863 114158010
XHE : 116719317 116732228 116733392
PRET : 103461909(lrat) 103480983 103480984
PFOR : 103149051 103149052 103156491
PLAI : 106949946 106949947 106953329(lrat)
PMEI : 106904117(lrat) 106910222 106910223
GAF : 122821042 122821063(lratb.2) 122830425
CVG : 107082284 107082299 107094918
CTUL : 119797130 119797138 119797181(si:dkey-30k22.5)
GMU : 124867780 124880260 124881075
KMR : 108228851(lrata) 108248302 108248305(lratb.2) 108249452(si:dkey-30k22.5)
ALIM : 106519616(lrat) 106529231 106529233
NWH : 119417279 119419524 119422878(lrata)
AOCE : 111575111 111575125 111582913 111582918
MCEP : 125000078(lrata) 125000083(si:dkey-30k22.5) 125009964(lratb.2) 125010096
CSEM : 103383311 103389580(lrat)
POV : 109634737 109634762 109641900 109641901
SSEN : 122766322 122771684(si:dkey-30k22.5) 122771685(lrata)
HHIP : 117751915 117760283(lrata) 117762673(si:dkey-30k22.5)
HSP : 118102938 118115361(lrata) 118115874(si:dkey-30k22.5)
LCF : 108874763 108874769 108886657 108901657 108901658(si:dkey-30k22.5)
SDU : 111216694 111216699 111237528 111237529
SLAL : 111649474 111649477 111663255 111663312(lrat)
XGL : 120797300 120797305(lratb.2) 120800556(si:dkey-30k22.5) 120800617(lrata)
HCQ : 109506952 109511520 109511521
SSCV : 125969062 125969063 125993669
BPEC : 110157705 110159451 110166097 110166259(lrat)
MALB : 109968215 109972941
BSPL : 114843882 114850357 114850374 114860244(lrata) 114862030(si:dkey-30k22.5) 121202087
SASA : 100195897(lrat) 106578168 106578182(LRAT) 106602563 106609867
STRU : 115191893 115193434 115194898 115198039 115201984 115202138
OTW : 112237687 112241754(lratb.1) 112262267 112262268 121847620
OMY : 110497453 110497454 110500951 110532986 110534421 118965977
OGO : 124002061 124002231 124008728 124008746 124013001 124028892
ONE : 115126778 115127009 115137336 115146554 115146555
SALP : 111958377 111958474 111971325 111971625
SNH : 120030189 120030694(lratb.1) 120034718 120035021 120049187 120051975 120052209
CCLU : 121558040 121558042 121558804 121558808 121572686
ELS : 105022864 105022865(lrat) 105030634 105030635
SFM : 108924362 108924447 108930780
PKI : 111833401 111837433 111837434
AANG : 118226830(lrata) 118228340(si:dkey-30k22.5) 118231467 118232461(lratb.2)
PSPA : 121295181 121300150
ARUT : 117409620 117420592 117420657
PCAN : 112574694 112576349
CRG : 105325359 105325365 109619122 117681093
ATEN : 116308361 116308362
» show all
Taxonomy
Reference
Authors
MacDonald PN, Ong DE.
Title
Evidence for a lecithin-retinol acyltransferase activity in the rat small intestine.
Journal
J Biol Chem 263:12478-82 (1988)
Sequence
Reference
Authors
Saari JC, Bredberg DL.
Title
Lecithin:retinol acyltransferase in retinal pigment epithelial microsomes.
Journal
J Biol Chem 264:8636-40 (1989)
Sequence
Reference
Authors
Saari JC, Bredberg DL, Farrell DF
Title
Retinol esterification in bovine retinal pigment epithelium: reversibility of lecithin:retinol acyltransferase.
Journal
Reference
Authors
Mata NL, Tsin AT
Title
Distribution of 11-cis LRAT, 11-cis RD and 11-cis REH in bovine retinal pigment epithelium membranes.
Journal
Reference
Authors
Ruiz A, Winston A, Lim YH, Gilbert BA, Rando RR, Bok D
Title
Molecular and biochemical characterization of lecithin retinol acyltransferase.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.135