KEGG ENZYME: 2.3.1.136

ENZYME: 2.3.1.136

Entry

EC 2.3.1.136                Enzyme

Name

polysialic-acid O-acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:polysialic-acid O-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9 [RN:R04484 R07249]

Reaction(KEGG)

R04484 R07249

Substrate

acetyl-CoA [CPD:C00024];
alpha-2,8-linked polymer of sialic acid [CPD:C04466]

Product

CoA [cpd:C00010];
polysialic acid acetylated at O-7 [CPD:C04505];
polysialic acid acetylated at O-9 [CPD:C08721]

Comment

Acts only on substrates containing more than 14 sialosyl residues. Catalyses the modification of capsular polysaccharides in some strains of Escherichia coli.

History

EC 2.3.1.136 created 1992

Orthology

K22247

polysialic-acid O-acetyltransferase

Genes

ECV:	APECO1_4217

EOC:	CE10_0792(neuO)

ECI:	UTI89_C2635

ECOI:

ECOPMV1_02507b

NKF:	Nkreftii_003588

Reference

1 [PMID:2897964]

Authors

Higa HH, Varki A.

Title

Acetyl-coenzyme A:polysialic acid O-acetyltransferase from K1-positive Escherichia coli. The enzyme responsible for the O-acetyl plus phenotype and for O-acetyl form variation.

Journal

J Biol Chem 263:8872-8 (1988)

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.136

IUBMB Enzyme Nomenclature:

2.3.1.136

ExPASy - ENZYME nomenclature database:

2.3.1.136

BRENDA, the Enzyme Database:

2.3.1.136

CAS:	116412-21-6

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