Entry |
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Name |
6-methylsalicylic-acid synthase;
MSAS;
6-methylsalicylic acid synthase
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Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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Sysname |
acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl-reducing, thioester-hydrolysing and cyclizing)
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Reaction(IUBMB) |
acetyl-CoA + 3 malonyl-CoA + NADPH + H+ = 6-methylsalicylate + 4 CoA + 3 CO2 + NADP+ + H2O [RN: R07253]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A multienzyme complex with a 4'-phosphopantetheine prosthetic group on the acyl carrier protein. It has a similar sequence to vertebrate type I fatty acid synthase. Acetoacetyl-CoA can also act as a starter molecule.
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History |
EC 2.3.1.165 created 2002
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Pathway |
ec01059 | Biosynthesis of enediyne antibiotics |
ec01110 | Biosynthesis of secondary metabolites |
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Orthology |
K15320 | 6-methylsalicylic acid synthase |
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Genes |
» show all
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Reference |
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Authors |
Spencer JB, Jordan PM. |
Title |
Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum. |
Journal |
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Reference |
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Authors |
Child CJ, Spencer JB, Bhogal P, Shoolingin-Jordan PM. |
Title |
Structural similarities between 6-methylsalicylic acid synthase from Penicillium patulum and vertebrate type I fatty acid synthase: evidence from thiol modification studies. |
Journal |
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Reference |
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Authors |
Richardson MT, Pohl NL, Kealey JT, Khosla C. |
Title |
Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase. |
Journal |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 2.3.1.165 |
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