KEGG   ENZYME: 2.3.1.169Help
Entry
EC 2.3.1.169                Enzyme                                 

Name
CO-methylating acetyl-CoA synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:corrinoid protein O-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + a [Co(I) corrinoid Fe-S protein] = CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] [RN:R08433]
Reaction(KEGG)
R08433;
(other) R09317 R10243
Show
Substrate
acetyl-CoA [CPD:C00024];
[Co(I) corrinoid Fe-S protein]
Product
CO [CPD:C00237];
CoA [CPD:C00010];
[methyl-Co(III) corrinoid Fe-S protein]
Comment
Contains nickel, copper and iron-sulfur clusters. Involved, together with EC 1.2.7.4, carbon-monoxide dehydrogenase (ferredoxin), in the synthesis of acetyl-CoA from CO2 and H2.
History
EC 2.3.1.169 created 2003, modified 2015
Pathway
ec00720  Carbon fixation pathways in prokaryotes
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00193  acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit beta
K14138  acetyl-CoA synthase
Genes
DAK: DaAHT2_0825
DSF: UWK_03162
DOL: Dole_3184
DML: Dmul_30850(cdhC)
DAL: Dalk_0681
DAT: HRM2_16660(cdhC)
DTO: TOL2_C11810(cdhC)
DAO: Desac_1967
DTI: Desti_0231
SFU: Sfum_2565
DAX: FDQ92_06240(cdhC)
DBR: Deba_0240
CSQ: CSCA_4551
CACE: CACET_c10320(acsB)
AMT: Amet_2028
BHAN: CGC63_07970(cdhC)
BLAU: DQQ01_09725(cdhC)
PDC: CDIF630_00844(cdhC)
DSY: DSY1652
DHD: Dhaf_2797
ELM: ELI_3601
EMT: CPZ25_018715(cdhC)
AWO: Awo_c10760(acsB1) Awo_c33680(acsB2)
CTHM: CFE_1665
TKI: TKV_c19820(acsB)
CHY: CHY_1222(acsB)
MTA: Moth_1202
ADG: Adeg_0336
TPZ: Tph_c15170(acsA)
TOC: Toce_0813
EYY: EGYY_24100(CdhC)
DEH: cbdbA652(codH)
DEV: DhcVS_604(cdhC)
DMC: btf_622(acsB)
DMD: dcmb_668(acsB)
DMG: GY50_0591(cdhC)
DUC: UCH007_05840(acsB)
DFO: Dform_00887(acsB) Dform_00914(acsB)
KST: KSMBR1_1325(codh_acsB)
THET: F1847_08575(cdhC)
CTHI: THC_1762
MMP: MMP0983(cdhB)
MMD: GYY_05740
MAE: Maeo_1171
METF: CFE53_00285(cdhC)
MTH: MTH_1710
MMG: MTBMA_c02890(cdhC)
METC: MTCT_1563
MWO: MWSIV6_0251(cdhC)
METE: tca_01657
METH: MBMB1_1563(cdhC)
MFC: BRM9_0799(cdhC)
MFI: DSM1535_0761(cdhC)
MCUB: MCBB_1819(cdhC)
METT: CIT01_07280(cdhC)
METO: CIT02_10130(cdhC)
MFV: Mfer_0525
MKA: MK0720(cdhC)
AFU: AF_0379
MAC: MA_1014(cdhC) MA_3862(cdhC)
MTHE: MSTHC_0942
MTHR: MSTHT_2338
MFZ: AOB57_003745(cdhC)
MBU: Mbur_0860
MMET: MCMEM_0992
MMH: Mmah_1168
MPY: Mpsy_2893
MTP: Mthe_0290
MCJ: MCON_1330(cdhC) MCON_1942(cdhC)
MHU: Mhun_0688
MBG: BN140_2375(acsB)
MEMA: MMAB1_3162
MPL: Mpal_0803
RCI: LRC459(cdhC)
BARC: AOA65_0452(cdhC2)
BARB: AOA66_1430(cdhC2)
LOKI: Lokiarch_15820(cdhC2)
 » show all
Taxonomy
Reference
1  [PMID:2984190]
  Authors
Ragsdale SW, Wood HG.
  Title
Acetate biosynthesis by acetogenic bacteria. Evidence that carbon monoxide dehydrogenase is the condensing enzyme that catalyzes the final steps of the synthesis.
  Journal
J Biol Chem 260:3970-7 (1985)
Reference
2  [PMID:12386327]
  Authors
Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL.
  Title
A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase.
  Journal
Science 298:567-72 (2002)
DOI:10.1126/science.1075843
  Sequence
[mta:Moth_1202]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.169
IUBMB Enzyme Nomenclature: 2.3.1.169
ExPASy - ENZYME nomenclature database: 2.3.1.169
BRENDA, the Enzyme Database: 2.3.1.169
CAS: 176591-19-8

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