KEGG   ENZYME: 2.3.1.174
Entry
EC 2.3.1.174                Enzyme                                 
Name
3-oxoadipyl-CoA thiolase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
succinyl-CoA:acetyl-CoA C-succinyltransferase
Reaction(IUBMB)
succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA [RN:R00829]
Reaction(KEGG)
R00829
Substrate
succinyl-CoA [CPD:C00091];
acetyl-CoA [CPD:C00024]
Product
CoA [CPD:C00010];
3-oxoadipyl-CoA [CPD:C02232]
Comment
The enzyme from the bacterium Escherichia coli also has the activity of EC 2.3.1.223 (3-oxo-5,6-dehydrosuberyl-CoA thiolase).
History
EC 2.3.1.174 created 2005, modified 2013
Pathway
ec00360  Phenylalanine metabolism
ec00362  Benzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K02615  3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase
K07823  3-oxoadipyl-CoA thiolase
Genes
ECOb1397(paaJ)
ECJJW1392(paaJ)
ECDECDH10B_1522(paaJ)
EBWBWG_1226(paaJ)
EOIECO111_1791(paaJ)
EOJECO26_2001(paaJ)
EOHECO103_1534(paaJ)
ESLO3K_13485
ESOO3O_12145
ESMO3M_13460
ECKEC55989_1533(paaE)
ELHETEC_1472
ECWEcE24377A_1582(pcaF)
EUNUMNK88_1804(pcaF)
ECOAAPECO78_10720
ECXEcHS_A1484(pcaF)
ECYECSE_1482
ECRECIAI1_1397(paaE)
ECLEcolC_2258
EKOEKO11_2416
EKFKO11_15245(paaJ)
EDHEcDH1_2248
EDJECDH1ME8569_1341(paaJ)
ELWECW_m1531(paaE)
ELLWFL_07480(paaJ)
ELPP12B_c1729(paaJ)
ECOLLY180_07305(fadA)
EFEEFER_1599(paaE)
ENCECL_02144
ENLA3UG_10385
ECLGEC036_20150
ECLEECNIH2_10960
ECLNECNIH4_12375
ECLIECNIH5_11680
ECLXLI66_10290
ECLYLI62_11085
ECLZLI64_10435
ECLOENC_11610
EHMAB284_14710
EXFBFV63_10475
ECLAECNIH3_10110
ECLCECR091_10080
EAUDI57_08490
EKBBFV64_10715
ENOECENHK_10350
EECEcWSU1_02062(paaJ)
ELGBH714_06565
ECANCWI88_12185(pcaF)
ERNBFV67_09870
ECHGFY206_11755(pcaF)
ESHC1N69_10565(pcaF)
EASEntas_2035
ENXNI40_010475
LNICWR52_01805(pcaF)
EBGFAI37_18900(pcaF)
ENDA4308_14985
ENZG0034_10475(pcaF)
ENSHWQ15_18975(pcaF)
ENKLOC22_20740(pcaF)
KPNKPN_01478(paaJ)
KPUKP1_2481(paaJ)
KPMKPHS_23780
KPPA79E_2761
KPHKPNIH24_16325
KPZKPNIH27_11595
KPVKPNIH29_11820
KPWKPNIH30_12360
KPYKPNIH31_11445
KPGKPNIH32_12200
KPCKPNIH10_11905
KPQKPR0928_11915
KPTVK055_1032(pcaF2)
KPOKPN2242_10170
KPRKPR_2865(paaJ)
KPJN559_2853
KPID364_07240
KPAKPNJ1_03019
KPSKPNJ2_03019
KPXPMK1_03796(paaJ)
KPBFH42_03285
KPNEKU54_014300
KPNULI86_14235
KPNKBN49_2540(paaJ)
KVAKvar_2889
KPEKPK_2991(paaJ)
KPKA593_21895
KVDKR75_19720
KVQSP68_00755
KOXKOX_19465
KOEA225_2763
KOMHR38_17795
KMIVW41_11785
KOKKONIH1_13535
KOCAB185_21665
KQUAVR78_16440
EAEEAE_20470
EARCCG29786
KQVB8P98_15225(pcaF)
KLLBJF97_13680
KLWDA718_15530(pcaF)
KARLGL98_13920(pcaF)
KGRJJJ10_15215(pcaF)
RORRORB6_07500
RONTE10_13035
RPLNB1209_14625
RAODSD31_14125(pcaF)
RTGNCTC13098_04015(paaJ_3)
REEelectrica_02710(paaJ)
CYOCD187_14230(pcaF)
CPOTFOB25_01975(pcaF)
EBTEBL_c16650(paaJ)
CNTJT31_00510
CEMLH23_16500
CENLH86_15490
PGELG71_17815
ESCEntcl_2413
KLEAO703_10170
KIENCTC12125_01344(paaJ)
KASKATP_22180
LAXAPT61_10070
LEIC2U54_17495(pcaF)
LEHC3F35_22350(pcaF)
LEEDVA44_10910(pcaF)
LERGNG29_12035(pcaF)
LEAGNG26_12275(pcaF)
LAZA8A57_10350
LEFLJPFL01_2009
LEWDAI21_16085(pcaF)
BUFD8682_03060(pcaF)
BAGEBADSM9389_21450(pcaF)
YREHEC60_05185(pcaF)
SGOEA8O29_012285(pcaF)
PSGCG163CM_13720(paaJ)
EBFD782_2323
EBUCUC76_03660(pcaF)
SMARSM39_2563(paaJ)
SMACSMDB11_2355(paaJ)
SMWSMWW4_v1c31030(paaJ)
SPESpro_3081
SPLYQ5A_016025(paaJ)
SMAFD781_2889
SLQM495_15715
SERFL085_13115
SERSSERRSCBI_14890
SFWWN53_24250
SFGAV650_19985
SRZAXX16_2183
SERMCLM71_15005(pcaF)
SQUE4343_00615(pcaF)
SFJSAMEA4384070_3131(paaJ)
SOFNCTC11214_03713(paaJ)
SSURATE40_012045
SURIJ0X03_08535(pcaF)
SRHZFO014_18875(pcaF)
SFOZ042_17400
XBOXBJ1_0118(paaJ)
XBVXBW1_0155(paaJ)
XNEXNC1_4626(paaJ)
XNMXNC2_4467(paaJ)
XDOXDD1_3927(paaJ)
XHOA9255_15725
XBUHGO23_00615(pcaF)
PSIS70_09380
PSXDR96_1306(pcaF)
PSTABGK56_12395
PRGRB151_002340(paaJ)
PALACO695_03810(pcaF)
PHEINCTC12003_00246(paaJ)
PRQCYG50_15075(pcaF)
PRJNCTC6933_00251(paaJ)
PVCG3341_00960(pcaF)
HAVAT03_05990
HPARAL518_19650(pcaF)
OPODSM2777_20480
XCCXCC0366(pcaF)
XCBXC_0378
XCAxcc-b100_0392(pcaF)
XCPXCR_4149(pcaF)
XCVXCV0380(pcaF)
XAXXACM_0354(pcaF)
XACXAC0366(pcaF)
XCIXCAW_00773(pcaF)
XCTJ151_00488
XCJJ158_00485
XCUJ159_00485
XCNJ169_00484
XCWJ162_00484
XCRJ163_00484
XCMJ164_00484
XCFJ172_00479
XFUXFF4834R_chr03500(pcaF)
XAOXAC29_01890
XOMXOO0447(XOO0447)
XOOXOO0481(pcaF)
XOPPXO_02905(pcaF)
XOYAZ54_22660
XORXOC_4546(pcaF)
XOZBE73_00800
XALXALC_3031(pcaF)
XSASB85_14110
XVEBJD12_14565
XPEBJD13_15115
XHRXJ27_17645
XGABI317_22045
XPHXppCFBP6546_09990(pcaF)
XVAC7V42_01810(pcaF)
XANAC801_01720
XARXB05_18460
XHYFZ025_04760(pcaF)
XCZEBN15_01830(pcaF)
XTHG4Q83_18265(pcaF)
XEUXSP_000376(pcaF)
XHDLMG31886_04130(pcaF)
SLMBIZ42_17465
STEMCLM74_09150(pcaF)
SINCDAIF1_17880(pcaF)
SPAQSTNY_R17460(pcaF)
LCPLC55x_1055(pcaF)
LAREHIV01_016375(pcaF)
RHDR2APBS1_0801
DTXATSB10_15470
VNAPN96_18700
PGHFH974_15970(pcaF)
PAEPA0228(pcaF)
PAEVN297_234(pcaF)
PAEIN296_234(pcaF)
PAUPA14_02790(pcaF)
PAPPSPA7_0314(pcaF)
PAGPLES_02251(pcaF)
PAFPAM18_0224(pcaF)
PNCNCGM2_0234(pcaF)
PAEBNCGM1900_0219(pcaF)
PDKPADK2_01125
PSGG655_01125
PRPM062_01120
PAEPPA1S_01175
PAERPA1R_gp3742
PAEMU769_01140
PAELT223_01130
PAESSCV20265_0232
PAEUBN889_00276(pcaF)
PAEGAI22_02770
PAECM802_233(pcaF)
PAEOM801_234(pcaF)
PMKMDS_4160
PREPCA10_26030(pcaF)
PFUWKF707C_28360
PCQPcP3B5_32730(pcaF)
PMUIG4G71_11665(pcaF)
PPUPP_1377(pcaF-I)
PPFPput_4346
PPGPputGB1_4437
PPWPputW619_1017
PPTPPS_4276
PPBPPUBIRD1_4183
PPIYSA_02904
PPXT1E_0234(pcaF)
PPUHB479_13025 B479_21505
PPUTL483_26575
PPUNPP4_09250(pcaF)
PPUDDW66_4664
PFVPsefu_1301 Psefu_2037
PMONX969_21050
PMOTX970_20685
PMOSO165_000225
PPJRK21_00249
PORAPT59_19265
PMOLCLJ08_07595(pcaF)
PSTPSPTO_4307(catF)
PSBPsyr_4011
PSYRN018_05095
PSPPSPPH_4017(pcaF)
PSAVPSA3335_05820
PAMGBKM19_023740(pcaF)
PCIPCH70_41210
PAVLBKM03_23330(pcaF)
PVDCFBP1590__1263(pcaF)
PCABJGS08_21035(pcaF)
PFLPFL_1319(pcaF)
PPRCPFLCHA0_c13550(pcaF)
PPROPPC_1373
PFEPSF113_1340
PFNHZ99_24560
PFOPfl01_1269
PFSPFLU_1365(pcaF)
PFCPflA506_1322(pcaF)
PPZH045_03605
PFBVO64_4523
PMANOU5_2146
PTVAA957_07285
PCGAXG94_22275
PVRPverR02_07015
PAZOAYR47_14070
POIBOP93_06535
PRXHRH33_07615(pcaF)
PFWPF1751_v1c13160(pcaF)
PFFPFLUOLIPICF701480
PFXA7318_06025
PENPSEEN1165(pcaF)
PSAPST_1256(pcaF)
PSZPSTAB_1164(pcaF)
PSRPSTAA_1220(pcaF)
PSCA458_05910
PSJPSJM300_11755
PSHPsest_3070
PSTUUIB01_15885
PSTTCH92_10345
PCHLLLJ08_14905(pcaF)
PBMCL52_07400
PLULFOB45_09635(pcaF)
PBAPSEBR_a1267
PBCCD58_07105
PPUUPputUW4_01203(pcaF)
PDRH681_11395
PSVPVLB_04905
PSKU771_07995
PKCPKB_2950(pcaF)
PCHEY04_06050
PCZPCL1606_47620
PCPJM49_23590
PFZAV641_05350
PLQAA042_19080
PALKPSAKL28_10000
PRHLT40_04390
PSWLK03_01285
PPVNJ69_13120
PSESPSCI_2950
PSEMTO66_06705
PSECCCOS191_4273(pcaF2)
PPSYAOC04_02085
PSOSPOS17_1340
PKRAYO71_09100
PFKPFAS1_18020
PANRA7J50_1505
PPSLBJP27_11185
PSETTHL1_2518
PSILPMA3_05395
PYMAK972_4615
PSEDDM292_13015(pcaF)
PKEDLD99_07090(pcaF)
PALLUYA_20355
PUMHGP31_06870(pcaF)
POJPtoMrB4_30820(pcaF)
PGGFX982_00488
PPSHG5J76_08135(pcaF)
PGYAWU82_22710(pcaF)
PLALFXN65_15065(pcaF)
PSEJHNQ25_05330(pcaF)
PVKEPZ47_06900(pcaF)
PEZHWQ56_23595(pcaF)
PBZGN234_11550(pcaF)
PTYJWV26_06425(pcaF)
PMAOPMYSY11_2188(paaJ)
PATAJWU58_21205(pcaF)
PDWBV82_4560(pcaF)
PZEHU754_007850(pcaF)
PMOEHV782_007390(pcaF)
PSEPC4K39_1379
PVWHU752_007660(pcaF)
PTRTHU722_0007905(pcaF)
PXAKSS93_08525(pcaF)
PSAMHU731_022760(pcaF)
PTZHU718_007540(pcaF)
PQIKH389_21635(pcaF)
PSHHHU773_007135(pcaF)
PXNHU772_005090(pcaF)
PHVHU739_011160(pcaF)
PPRGHU725_004685(pcaF)
PANHHU763_019685(pcaF)
PASGKSS96_07630(pcaF)
PFAKKSS94_05285(pcaF)
PMUYKSS95_08120(pcaF)
PMAMKSS90_20745(pcaF)
PAZEKSS91_06895(pcaF)
PALVKSS97_22200(pcaF)
PORYEJA05_05325(pcaF)
PWZJ7655_17840(pcaF)
PTKEXN22_22270(pcaF)
PTWTUM18999_29810(pcaF)
PZAHU749_007895(pcaF)
PIEHU724_007115(pcaF)
PWYHU734_006115(pcaF)
PTAENCTC10697_01040(pcaF_1)
AVNAvin_38200(pcaF)
AVLAvCA_38200(pcaF)
AVDAvCA6_38200(pcaF)
ACXAchr_12050(pcaF)
ACIACIAD1450(catF)
ZDFAN401_12590
PLGNCTC10937_01259(pcaF)
HPSEHPF_08110(paaJ1)
HYNF9K07_05595(pcaF)
AONDEH84_14465(pcaF)
SNNEWH46_19545(pcaF)
SURSTAUR_1339(pcaF)
AVMJQX13_22460(pcaF)
KMNHW532_07395(pcaF)
PSCQKHQ08_01180(pcaF)
BJAblr0925(pcaF)
BJUBJ6T_09400
BJPRN69_04585
BRABRADO0538
BBTBBta_7640
BRSS23_68870(pcaF)
AOLS58_71060
BRCBCCGELA001_35045
BRADBF49_7261
BICLMTR13_01380
BROBRAD285_7772
BRKCWS35_04605(pcaF)
BOTCIT37_09715(pcaF)
BRQCIT40_30890(pcaF)
BGQX265_35375(pcaF)
BGZXH91_33775(pcaF)
BSYMCIT39_29955(pcaF)
BBETF8237_13730(pcaF)
BARHWN72_46965(pcaF)
BVZBRAD3257_8808(pcaF)
BELBE61_10950(pcaF)
BDGLPJ38_02900(pcaF)
BSEPHAP48_0017320(pcaF)
BQBJ4P68_0020865(pcaF)
RPARPA0513(pcaF)
RPBRPB_0525
RPDRPD_0320
RPERPE_0248
RPTRpal_0514
RPXRpdx1_0544
RBKE0H22_22415(pcaF)
VGOGJW-30_1_00413(pcaF_1)
TRBHB776_27695(pcaF)
XDIEZH22_14560(pcaF)
METM446_2398
MNOMnod_2813
MAQUMaq22A_c07750(paaJ)
MEEDA075_27275(pcaF)
MTEADK419_13910(pcaF)
MINDmvi_42250(pcaF)
RHZRHPLAN_69900
PSINCAK95_06150
PHRC6569_18635(pcaF)
PSTGE8M01_13115(pcaF)
CCRCC_2407
CCSCCNA_02490
CFHC1707_23050(pcaF)
CAUFCSW63_08175(pcaF)
BRFE4M01_02180(pcaF)
NPPPP1Y_Mpl8370
NREBES08_24510
SPHKSKP52_13160(pcaF)
SPHOC3E99_15615(pcaF) C3E99_19335(pcaF)
SWISwit_4336
RDICMV14_08185(pcaF)
SPHMG432_15070
STAXMC45_16670
SPANAWL63_04250
SECHB18_06770
SCHSphch_3489
SSYSLG_28040(pcaF)
SBDATN00_07705
SPHBEP837_03815(paaJ)
SPHTK426_21674
SCLOSCLO_6000230
SAMISAMIE_4000240
SPPHKFK14_17505(pcaF)
SPHJBSL82_04360
PALGHFP57_16235(pcaF)
ALBAEB_P0136 AEB_P2449
AAYWYH_01881(pcaF)
ASZASN_1367(paaE)
ATOCIW82_05220(pcaF)
AOZHUE56_29175(pcaF)
PARHI5S86_06125(pcaF)
ETMCE91St48_25680(paaJ)
CGTcgR_0653
CGSC624_03320
CGGC629_03320
CGJAR0_03320
CGQCGLAR1_03180
CMDB841_12455
CAZCARG_06485
TEHGKE56_02660
ABAAcid345_3492
SRHOHH216_17325(pcaF)
AICJK629_08130(pcaF)
MARXINR76_06690(pcaF)
BIAGMA17_09395(pcaF)
 » show all
Reference
1  [PMID:11741862]
  Authors
Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W.
  Title
Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase.
  Journal
J Bacteriol 184:207-15 (2002)
DOI:10.1128/JB.184.1.207-215.2002
  Sequence
[pkc:PKB_2950]
Reference
2  [PMID:11741863]
  Authors
Gobel M, Kassel-Cati K, Schmidt E, Reineke W
  Title
Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase.
  Journal
J Bacteriol 184:216-23 (2002)
DOI:10.1128/JB.184.1.216-223.2002
  Sequence
[pkc:PKB_2950]
Reference
3  [PMID:20660314]
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
  Sequence
[eco:b1397]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.174
IUBMB Enzyme Nomenclature: 2.3.1.174
ExPASy - ENZYME nomenclature database: 2.3.1.174
BRENDA, the Enzyme Database: 2.3.1.174
CAS: 403496-07-1

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