KEGG ENZYME: 2.3.1.174

ENZYME: 2.3.1.174

Entry

EC 2.3.1.174                Enzyme

Name

3-oxoadipyl-CoA thiolase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

succinyl-CoA:acetyl-CoA C-succinyltransferase

Reaction(IUBMB)

succinyl-CoA + acetyl-CoA = CoA + 3-oxoadipyl-CoA [RN:R00829]

Reaction(KEGG)

R00829

Substrate

succinyl-CoA [CPD:C00091];
acetyl-CoA [CPD:C00024]

Product

CoA [CPD:C00010];
3-oxoadipyl-CoA [CPD:C02232]

Comment

The enzyme from the bacterium Escherichia coli also has the activity of EC 2.3.1.223 (3-oxo-5,6-dehydrosuberyl-CoA thiolase).

History

EC 2.3.1.174 created 2005, modified 2013

Pathway

ec00360

Phenylalanine metabolism

ec00362

Benzoate degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K02615

3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase

K07823

3-oxoadipyl-CoA thiolase

Genes

ECO:	b1397(paaJ)

ECJ:	JW1392(paaJ)

ECD:	ECDH10B_1522(paaJ)

EBW:	BWG_1226(paaJ)

EOI:	ECO111_1791(paaJ)

EOJ:	ECO26_2001(paaJ)

EOH:	ECO103_1534(paaJ)

ESL:

O3K_13485

ESO:

O3O_12145

ESM:

O3M_13460

ECK:	EC55989_1533(paaE)

ELH:

ETEC_1472

ECW:	EcE24377A_1582(pcaF)

EUN:	UMNK88_1804(pcaF)

ECOA:

APECO78_10720

ECX:	EcHS_A1484(pcaF)

ECY:

ECSE_1482

ECR:	ECIAI1_1397(paaE)

ECL:	EcolC_2258

EKO:	EKO11_2416

EKF:	KO11_15245(paaJ)

EDH:	EcDH1_2248

EDJ:	ECDH1ME8569_1341(paaJ)

ELW:	ECW_m1531(paaE)

ELL:	WFL_07480(paaJ)

ELP:	P12B_c1729(paaJ)

ECOL:

LY180_07305(fadA)

EFE:	EFER_1599(paaE)

ENC:

ECL_02144

ENL:	A3UG_10385

ECLG:

EC036_20150

ECLE:

ECNIH2_10960

ECLN:

ECNIH4_12375

ECLI:

ECNIH5_11680

ECLX:

LI66_10290

ECLY:

LI62_11085

ECLZ:

LI64_10435

ECLO:

ENC_11610

EHM:	AB284_14710

EXF:	BFV63_10475

ECLA:

ECNIH3_10110

ECLC:

ECR091_10080

EAU:	DI57_08490

EKB:	BFV64_10715

ENO:	ECENHK_10350

EEC:	EcWSU1_02062(paaJ)

ELG:	BH714_06565

ECAN:

CWI88_12185(pcaF)

ERN:	BFV67_09870

ECHG:

FY206_11755(pcaF)

ESH:	C1N69_10565(pcaF)

EAS:	Entas_2035

ENX:	NI40_010475

LNI:	CWR52_01805(pcaF)

EBG:	FAI37_18900(pcaF)

END:	A4308_14985

ENZ:	G0034_10475(pcaF)

ENS:	HWQ15_18975(pcaF)

ENK:	LOC22_20740(pcaF)

EHU:	D5067_0012385(pcaF)

EMOR:

L6Y89_10150(pcaF)

ENB:	ELK40_10675(pcaF)

KPN:	KPN_01478(paaJ)

KPU:	KP1_2481(paaJ)

KPM:	KPHS_23780

KPP:

A79E_2761

KPH:	KPNIH24_16325

KPZ:	KPNIH27_11595

KPV:	KPNIH29_11820

KPW:	KPNIH30_12360

KPY:	KPNIH31_11445

KPG:	KPNIH32_12200

KPC:	KPNIH10_11905

KPQ:	KPR0928_11915

KPT:	VK055_1032(pcaF2)

KPO:	KPN2242_10170

KPR:	KPR_2865(paaJ)

KPJ:

N559_2853

KPI:	D364_07240

KPA:	KPNJ1_03019

KPS:	KPNJ2_03019

KPX:	PMK1_03796(paaJ)

KPB:	FH42_03285

KPNE:

KU54_014300

KPNU:

LI86_14235

KPNK:

BN49_2540(paaJ)

KVA:

Kvar_2889

KPE:	KPK_2991(paaJ)

KPK:	A593_21895

KVD:	KR75_19720

KVQ:	SP68_00755

KOX:

KOX_19465

KOE:

A225_2763

KOM:	HR38_17795

KMI:	VW41_11785

KOK:	KONIH1_13535

KOC:	AB185_21665

KQU:	AVR78_16440

EAE:

EAE_20470

EAR:

CCG29786

KQV:	B8P98_15225(pcaF)

KLL:	BJF97_13680

KLW:	DA718_15530(pcaF)

KAR:	LGL98_13920(pcaF)

KGR:	JJJ10_15215(pcaF)

KPAS:

LUW96_19980(pcaF)

ROR:	RORB6_07500

RON:	TE10_13035

RPLN:

B1209_14625

RAO:	DSD31_14125(pcaF)

RTG:	NCTC13098_04015(paaJ_3)

REE:	electrica_02710(paaJ)

CYO:	CD187_14230(pcaF)

CPOT:

FOB25_01975(pcaF)

EBT:	EBL_c16650(paaJ)

CNT:	JT31_00510

CEM:	LH23_16500

CEN:	LH86_15490

PGE:	LG71_17815

ESC:	Entcl_2413

KLE:	AO703_10170

KIE:	NCTC12125_01344(paaJ)

KAS:	KATP_22180

KLU:	K7B04_17200(pcaF)

LAX:	APT61_10070

LEI:	C2U54_17495(pcaF)

LEH:	C3F35_22350(pcaF)

LEE:	DVA44_10910(pcaF)

LER:	GNG29_12035(pcaF)

LEA:	GNG26_12275(pcaF)

LPNU:

KQ929_09245(pcaF)

LAZ:	A8A57_10350

LEF:	LJPFL01_2009

LEW:	DAI21_16085(pcaF)

BUF:	D8682_03060(pcaF)

BAGE:

BADSM9389_21450(pcaF)

BFT:	MNO13_12410(pcaF)

YRE:	HEC60_05185(pcaF)

SGOE:

A8O29_012285(pcaF)

PSGC:

G163CM_13720(paaJ)

EBF:

D782_2323

EBU:	CUC76_03660(pcaF)

SMAR:

SM39_2563(paaJ)

SMAC:

SMDB11_2355(paaJ)

SMW:	SMWW4_v1c31030(paaJ)

SPE:

Spro_3081

SPLY:

Q5A_016025(paaJ)

SMAF:

D781_2889

SLQ:	M495_15715

SERF:

L085_13115

SERS:

SERRSCBI_14890

SFW:	WN53_24250

SFG:	AV650_19985

SRZ:	AXX16_2183

SERM:

CLM71_15005(pcaF)

SQU:	E4343_00615(pcaF)

SFJ:	SAMEA4384070_3131(paaJ)

SOF:	NCTC11214_03713(paaJ)

SSUR:

ATE40_012045

SURI:

J0X03_08535(pcaF)

SRHZ:

FO014_18875(pcaF)

SENP:

KHA73_15190(pcaF)

SNEM:

NLX84_15565(pcaF)

SFO:	Z042_17400

XBO:	XBJ1_0118(paaJ)

XBV:	XBW1_0155(paaJ)

XNE:	XNC1_4626(paaJ)

XNM:	XNC2_4467(paaJ)

XDO:	XDD1_3927(paaJ)

XHO:	A9255_15725

XBU:	HGO23_00615(pcaF)

PSI:

S70_09380

PSX:	DR96_1306(pcaF)

PSTA:

BGK56_12395

PRG:	RB151_002340(paaJ)

PALA:

CO695_03810(pcaF)

PHEI:

NCTC12003_00246(paaJ)

PRQ:	CYG50_15075(pcaF)

PRJ:	NCTC6933_00251(paaJ)

PVC:	G3341_00960(pcaF)

PMAG:

JI723_01370(pcaF)

HAV:	AT03_05990

HPAR:

AL518_19650(pcaF)

OPO:	DSM2777_20480

XCC:	XCC0366(pcaF)

XCB:

XC_0378

XCA:	xcc-b100_0392(pcaF)

XCP:	XCR_4149(pcaF)

XCV:	XCV0380(pcaF)

XAX:	XACM_0354(pcaF)

XAC:	XAC0366(pcaF)

XCI:	XCAW_00773(pcaF)

XCT:	J151_00488

XCJ:	J158_00485

XCU:	J159_00485

XCN:	J169_00484

XCW:	J162_00484

XCR:	J163_00484

XCM:	J164_00484

XCF:	J172_00479

XFU:	XFF4834R_chr03500(pcaF)

XAO:	XAC29_01890

XOM:	XOO0447(XOO0447)

XOO:	XOO0481(pcaF)

XOP:	PXO_02905(pcaF)

XOY:	AZ54_22660

XOR:	XOC_4546(pcaF)

XOZ:	BE73_00800

XAL:	XALC_3031(pcaF)

XSA:	SB85_14110

XVE:	BJD12_14565

XPE:	BJD13_15115

XHR:	XJ27_17645

XGA:	BI317_22045

XPH:	XppCFBP6546_09990(pcaF)

XVA:	C7V42_01810(pcaF)

XAN:	AC801_01720

XAR:	XB05_18460

XHY:	FZ025_04760(pcaF)

XCZ:	EBN15_01830(pcaF)

XTH:	G4Q83_18265(pcaF)

XEU:	XSP_000376(pcaF)

XHD:	LMG31886_04130(pcaF)

XPR:	MUG10_08445(pcaF)

SLM:	BIZ42_17465

STEM:

CLM74_09150(pcaF)

SINC:

DAIF1_17880(pcaF)

SPAQ:

STNY_R17460(pcaF)

STEQ:

ICJ04_10940(pcaF)

LCP:	LC55x_1055(pcaF)

LARE:

HIV01_016375(pcaF)

RHD:	R2APBS1_0801

DTX:	ATSB10_15470

VNA:	PN96_18700

VJP:	NP165_19400(pcaF)

VOS:	KNV97_16530(pcaF)

PGH:	FH974_15970(pcaF)

PAE:	PA0228(pcaF)

PAEV:

N297_234(pcaF)

PAEI:

N296_234(pcaF)

PAU:	PA14_02790(pcaF)

PAP:	PSPA7_0314(pcaF)

PAG:	PLES_02251(pcaF)

PAF:	PAM18_0224(pcaF)

PNC:	NCGM2_0234(pcaF)

PAEB:

NCGM1900_0219(pcaF)

PDK:	PADK2_01125

PSG:	G655_01125

PRP:	M062_01120

PAEP:

PA1S_01175

PAER:

PA1R_gp3742

PAEM:

U769_01140

PAEL:

T223_01130

PAES:

SCV20265_0232

PAEU:

BN889_00276(pcaF)

PAEG:

AI22_02770

PAEC:

M802_233(pcaF)

PAEO:

M801_234(pcaF)

PMK:

MDS_4160

PRE:	PCA10_26030(pcaF)

PFUW:

KF707C_28360

PCQ:	PcP3B5_32730(pcaF)

PMUI:

G4G71_11665(pcaF)

PNT:	G5B91_06985(pcaF) G5B91_12985(pcaF)

PPAA:

B7D75_01165(pcaF)

PPU:	PP_1377(pcaF-I)

PPF:

Pput_4346

PPG:	PputGB1_4437

PPW:	PputW619_1017

PPT:

PPS_4276

PPB:	PPUBIRD1_4183

PPI:

YSA_02904

PPX:	T1E_0234(pcaF)

PPUH:

B479_13025 B479_21505

PPUT:

L483_26575

PPUN:

PP4_09250(pcaF)

PPUD:

DW66_4664

PFV:	Psefu_1301 Psefu_2037

PMON:

X969_21050

PMOT:

X970_20685

PMOS:

O165_000225

PPJ:	RK21_00249

POR:	APT59_19265

PMOL:

CLJ08_07595(pcaF)

PST:	PSPTO_4307(catF)

PSB:

Psyr_4011

PSYR:

N018_05095

PSP:	PSPPH_4017(pcaF)

PSAV:

PSA3335_05820

PAMG:

BKM19_023740(pcaF)

PCI:	PCH70_41210

PAVL:

BKM03_23330(pcaF)

PVD:	CFBP1590__1263(pcaF)

PCAB:

JGS08_21035(pcaF)

PCOF:

POR16_05285(pcaF)

PTRE:

I9H09_18865(pcaF)

PSYI:

MME58_20535(pcaF)

PAST:

N015_21205(pcaF)

PLIJ:

KQP88_19455(pcaF)

PFL:	PFL_1319(pcaF)

PPRC:

PFLCHA0_c13550(pcaF)

PPRO:

PPC_1373

PFE:	PSF113_1340

PFN:	HZ99_24560

PFO:	Pfl01_1269

PFS:	PFLU_1365(pcaF)

PFC:	PflA506_1322(pcaF)

PPZ:	H045_03605

PFB:

VO64_4523

PMAN:

OU5_2146

PTV:	AA957_07285

PCG:	AXG94_22275

PVR:	PverR02_07015

PAZO:

AYR47_14070

POI:	BOP93_06535

PRX:	HRH33_07615(pcaF)

PMED:

E3Z27_06680(pcaF)

PFW:	PF1751_v1c13160(pcaF)

PFF:	PFLUOLIPICF701480

PFX:	A7318_06025

PEN:	PSEEN1165(pcaF)

PLUL:

FOB45_09635(pcaF)

PBA:	PSEBR_a1267

PBC:	CD58_07105

PPUU:

PputUW4_01203(pcaF)

PDR:	H681_11395

PSV:	PVLB_04905

PSK:	U771_07995

PKC:	PKB_2950(pcaF)

PCH:	EY04_06050

PCZ:	PCL1606_47620

PCP:	JM49_23590

PFZ:	AV641_05350

PLQ:	AA042_19080

PALK:

PSAKL28_10000

PRH:	LT40_04390

PSW:	LK03_01285

PPV:	NJ69_13120

PSES:

PSCI_2950

PSEM:

TO66_06705

PSEC:

CCOS191_4273(pcaF2)

PPSY:

AOC04_02085

PSOS:

POS17_1340

PKR:	AYO71_09100

PFK:	PFAS1_18020

PANR:

A7J50_1505

PPSL:

BJP27_11185

PSET:

THL1_2518

PSIL:

PMA3_05395

PYM:	AK972_4615

PKE:	DLD99_07090(pcaF)

PALL:

UYA_20355

PUM:	HGP31_06870(pcaF)

POJ:	PtoMrB4_30820(pcaF)

PGG:	FX982_00488

PPSH:

G5J76_08135(pcaF)

PGY:	AWU82_22710(pcaF)

PLAL:

FXN65_15065(pcaF)

PSEJ:

HNQ25_05330(pcaF)

PVK:	EPZ47_06900(pcaF)

PEZ:	HWQ56_23595(pcaF)

PBZ:	GN234_11550(pcaF)

PTY:	JWV26_06425(pcaF)

PMAO:

PMYSY11_2188(paaJ)

PATA:

JWU58_21205(pcaF)

PDW:	BV82_4560(pcaF)

PZE:	HU754_007850(pcaF)

PMOE:

HV782_007390(pcaF)

PSEP:

C4K39_1379

PVW:	HU752_007660(pcaF)

PTRT:

HU722_0007905(pcaF)

PXA:	KSS93_08525(pcaF)

PSAM:

HU731_022760(pcaF)

PTZ:	HU718_007540(pcaF)

PQI:	KH389_21635(pcaF)

PSHH:

HU773_007135(pcaF)

PXN:	HU772_005090(pcaF)

PHV:	HU739_011160(pcaF)

PPRG:

HU725_004685(pcaF)

PANH:

HU763_019685(pcaF)

PASG:

KSS96_07630(pcaF)

PFAK:

KSS94_05285(pcaF)

PMUY:

KSS95_08120(pcaF)

PMAM:

KSS90_20745(pcaF)

PAZE:

KSS91_06895(pcaF)

PALV:

KSS97_22200(pcaF)

PORY:

EJA05_05325(pcaF)

PWZ:	J7655_17840(pcaF)

PTK:	EXN22_22270(pcaF)

PTW:	TUM18999_29810(pcaF)

PZA:	HU749_007895(pcaF)

PIE:	HU724_007115(pcaF)

PWY:	HU734_006115(pcaF)

PTAE:

NCTC10697_01040(pcaF_1)

PGF:	J0G10_07670(pcaF)

PCAV:

D3880_08640(pcaF)

PJU:	L1P09_20245(pcaF)

PPHN:

HU825_10290(pcaF)

PIZ:	LAB08_R12040(pcaF)

PPEG:

KUA23_06940(pcaF)

PSII:

NF676_06820(pcaF)

PSIH:

LOY51_05220(pcaF)

PCAS:

LOY40_22045(pcaF)

PFIT:

KJY40_07520(pcaF)

PASI:

LG197_28380(pcaF)

PSA:	PST_1256(pcaF)

PSZ:	PSTAB_1164(pcaF)

PSR:	PSTAA_1220(pcaF)

PSC:	A458_05910

PSJ:	PSJM300_11755

PSH:	Psest_3070

PSTU:

UIB01_15885

PSTT:

CH92_10345

PSED:

DM292_13015(pcaF)

PCHL:

LLJ08_14905(pcaF)

PBM:	CL52_07400

PKG:	LW136_07090(pcaF)

SDEG:

GOM96_15635(pcaF)

AVN:	Avin_38200(pcaF)

AVL:	AvCA_38200(pcaF)

AVD:	AvCA6_38200(pcaF)

ACX:	Achr_12050(pcaF)

PBAU:

OS670_04530(pcaF)

ACI:	ACIAD1450(catF)

HBH:	E4T21_16315(pcaF)

ZDF:	AN401_12590

PLG:	NCTC10937_01259(pcaF)

HPSE:

HPF_08110(paaJ1)

HYN:	F9K07_05595(pcaF)

SNN:	EWH46_19545(pcaF)

AON:	DEH84_14465(pcaF)

KMN:	HW532_07395(pcaF)

PSCQ:

KHQ08_01180(pcaF)

BJA:	blr0925(pcaF)

BJU:	BJ6T_09400

BJP:	RN69_04585

BRA:

BRADO0538

BBT:

BBta_7640

BRS:	S23_68870(pcaF)

AOL:

S58_71060

BRC:	BCCGELA001_35045

BRAD:

BF49_7261

BIC:	LMTR13_01380

BRO:	BRAD285_7772

BRK:	CWS35_04605(pcaF)

BOT:	CIT37_09715(pcaF)

BRQ:	CIT40_30890(pcaF)

BGQ:	X265_35375(pcaF)

BGZ:	XH91_33775(pcaF)

BSYM:

CIT39_29955(pcaF)

BBET:

F8237_13730(pcaF)

BARH:

WN72_46965(pcaF)

BVZ:	BRAD3257_8808(pcaF)

BEL:	BE61_10950(pcaF)

BDG:	LPJ38_02900(pcaF)

BSEP:

HAP48_0017320(pcaF)

BQB:	J4P68_0020865(pcaF)

BSEI:

KMZ68_25485(pcaF)

BBAN:

J4G43_051480(pcaF)

BCAN:

BcanWSM471_36205(pcaF)

RPA:	RPA0513(pcaF)

RPB:

RPB_0525

RPD:

RPD_0320

RPE:

RPE_0248

RPT:

Rpal_0514

RPX:	Rpdx1_0544

RBK:	E0H22_22415(pcaF)

VGO:	GJW-30_1_00413(pcaF_1)

TRB:	HB776_27695(pcaF)

XDI:	EZH22_14560(pcaF)

MET:

M446_2398

MNO:

Mnod_2813

MAQU:

Maq22A_c07750(paaJ)

MEE:	DA075_27275(pcaF)

MTEA:

DK419_13910(pcaF)

MIND:

mvi_42250(pcaF)

RHZ:	RHPLAN_69900

PSIN:

CAK95_06150

PHR:	C6569_18635(pcaF)

PSTG:

E8M01_13115(pcaF)

CCR:

CC_2407

CCS:	CCNA_02490

CFH:	C1707_23050(pcaF)

CAUF:

CSW63_08175(pcaF)

BRF:	E4M01_02180(pcaF)

NPP:	PP1Y_Mpl8370

NRE:	BES08_24510

SPHK:

SKP52_13160(pcaF)

SPHO:

C3E99_15615(pcaF) C3E99_19335(pcaF)

SWI:

Swit_4336

RDI:	CMV14_08185(pcaF)

SPHM:

G432_15070

STAX:

MC45_16670

SPAN:

AWL63_04250

SECH:

B18_06770

SNAP:

PQ455_04020(pcaF)

SCH:	Sphch_3489

SSY:	SLG_28040(pcaF)

SBD:	ATN00_07705

SPHB:

EP837_03815(paaJ)

SPHT:

K426_21674

SCLO:

SCLO_6000230

SAMI:

SAMIE_4000240

SPPH:

KFK14_17505(pcaF)

SPHJ:

BSL82_04360

PALG:

HFP57_16235(pcaF)

ALB:	AEB_P0136 AEB_P2449

AAY:	WYH_01881(pcaF)

ASZ:	ASN_1367(paaE)

ATO:	CIW82_05220(pcaF)

RAP:	RHOA_0333(paaJ)

AOZ:	HUE56_29175(pcaF)

KOZ:	KFF44_01490(pcaF)

SUR:	STAUR_1339(pcaF)

AVM:	JQX13_22460(pcaF)

PARH:

I5S86_06125(pcaF)

BPAB:

PSE45_23880

PTHI:

NDS46_05055

ETM:	CE91St48_25680(paaJ)

CGT:

cgR_0653

CGS:	C624_03320

CGG:	C629_03320

CGJ:

AR0_03320

CGQ:	CGLAR1_03180

CMD:	B841_12455

CAZ:	CARG_06485

TEH:	GKE56_02660

ABA:	Acid345_3492

ORP:	MOP44_06410(pcaF)

SRHO:

HH216_17325(pcaF)

HTB:	MTX78_24395(pcaF)

FEH:	LZF87_00395(pcaF)

AIC:	JK629_08130(pcaF)

MARX:

INR76_06690(pcaF)

BIA:	GMA17_09395(pcaF)

» show all

Reference

1 [PMID:11741862]

Authors

Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W.

Title

Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase.

Journal

J Bacteriol 184:207-15 (2002)
DOI:10.1128/JB.184.1.207-215.2002

Sequence

[pkc:PKB_2950]

Reference

2 [PMID:11741863]

Authors

Gobel M, Kassel-Cati K, Schmidt E, Reineke W

Title

Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: cloning, characterization, and analysis of sequences encoding 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase.

Journal

J Bacteriol 184:216-23 (2002)
DOI:10.1128/JB.184.1.216-223.2002

Sequence

[pkc:PKB_2950]

Reference

3 [PMID:20660314]

Authors

Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G

Title

Bacterial phenylalanine and phenylacetate catabolic pathway revealed.

Journal

Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107