KEGG   ENZYME: 2.3.1.177
Entry
EC 2.3.1.177                Enzyme                                 
Name
3,5-dihydroxybiphenyl synthase;
BIS1;
biphenyl synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:benzoyl-CoA malonyltransferase
Reaction(IUBMB)
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 [RN:R09621]
Reaction(KEGG)
R09621
Substrate
malonyl-CoA [CPD:C00083];
benzoyl-CoA [CPD:C00512]
Product
CoA [CPD:C00010];
3,5-dihydroxybiphenyl [CPD:C19750];
CO2 [CPD:C00011]
Comment
A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase.
History
EC 2.3.1.177 created 2006, modified 2012
Orthology
K21384  3,5-dihydroxybiphenyl/4-hydroxycoumarin synthase
Genes
FVE: 101312122 101312413
RCN: 112169554 112173282
PPER: 109948444 18780920 18781256
PMUM: 103326884 103326885
PAVI: 110755238
PDUL: 117624590
MDM: 103418590 103455021 103456249 103456250 139187402
MSYL: 126598538 126601534 126601535 126605162 126605164
PXB: 103945211 103945212 103946755 103946756 103946757 103946758 103946760 103946761
PCOX: 137737675 137737686 137743782 137745164 137745466 137747235
Reference
1  [PMID:14595561]
  Authors
Liu B, Beuerle T, Klundt T, Beerhues L
  Title
Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia.
  Journal
Planta 218:492-6 (2004)
DOI:10.1007/s00425-003-1144-y
  Sequence
[ag:ABB89212]
Reference
2  [PMID:17109150]
  Authors
Liu B, Raeth T, Beuerle T, Beerhues L
  Title
Biphenyl synthase, a novel type III polyketide synthase.
  Journal
Planta 225:1495-503 (2007)
DOI:10.1007/s00425-006-0435-5
  Sequence
[ag:ABB89212]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.177
IUBMB Enzyme Nomenclature: 2.3.1.177
ExPASy - ENZYME nomenclature database: 2.3.1.177
BRENDA, the Enzyme Database: 2.3.1.177
CAS: 1217551-24-0

  All links  
Protein sequence (16)   
   UniProt (11)   
   SWISS-PROT (1)   
   PDBSTR (4)   
DNA sequence (16)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (4)   
   InterPro (4)   
All databases (38)   

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