Entry Name 3,5-dihydroxybiphenyl synthase;
Class Transferases;BRITE hierarchy
Sysname malonyl-CoA:benzoyl-CoA malonyltransferase
Reaction(IUBMB) 3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2 [RN:
R09621 ]
Reaction(KEGG) Substrate Product Comment A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC
2.3.1.208 , 4-hydroxycoumarin synthase) [2]. This enzyme uses the same starter substrate as EC
2.3.1.151 , benzophenone synthase.
History EC 2.3.1.177 created 2006, modified 2012
Orthology K21384 3,5-dihydroxybiphenyl/4-hydroxycoumarin synthase
Genes PPER : 109948444 18780920 18781256
PMUM : 103326884 103326885
MDM : 103418590 103455021 103456249 103456250 114819163
PXB : 103945211 103945212 103946755 103946756 103946757 103946758 103946760 103946761
Taxonomy Reference Authors Liu B, Beuerle T, Klundt T, Beerhues L
Title Biphenyl synthase from yeast-extract-treated cell cultures of Sorbus aucuparia.
Journal Sequence Reference Authors Liu B, Raeth T, Beuerle T, Beerhues L
Title Biphenyl synthase, a novel type III polyketide synthase.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.3.1.177
