Entry
Name
diaminobutyrate acetyltransferase;
L-2,4-diaminobutyrate acetyltransferase;
L-2,4-diaminobutanoate acetyltransferase;
EctA;
diaminobutyric acid acetyltransferase;
DABA acetyltransferase;
2,4-diaminobutanoate acetyltransferase;
DAB acetyltransferase;
DABAcT;
acetyl-CoA:L-2,4-diaminobutanoate 4-N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acetyl-CoA:L-2,4-diaminobutanoate N4-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + L-2,4-diaminobutanoate = CoA + (2S)-4-acetamido-2-aminobutanoate [RN:
R06978 ]
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:
C00024 ];
L-2,4-diaminobutanoate [CPD:
C03283 ]
Product
CoA [CPD:
C00010 ];
(2S)-4-acetamido-2-aminobutanoate [CPD:
C06442 ]
Comment
Requires Na+ or K+ for maximal activity [3]. Ornithine, lysine, aspartate, and alpha-, beta- and gamma-aminobutanoate cannot act as substrates [3]. However, acetyl-CoA can be replaced by propanoyl-CoA, although the reaction proceeds more slowly [3]. Forms part of the ectoine-biosynthesis pathway.
History
EC 2.3.1.178 created 2006
Pathway
ec00260 Glycine, serine and threonine metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
K06718 L-2,4-diaminobutyric acid acetyltransferase
Genes
VAU : VANGNB10_cII0773c(ectA)
VIB : VspSTUT11_16700(ectA)
VIS : VspSTUT16_17600(ectA)
VIO : AB2S62_18795 AB2S62_20500(ectA)
MSHE : MAALD49_01440(ectA)
MECH : Q9L42_005585(ectA) Q9L42_007045(ectA)
TIB : THMIRHAM_02720(ectA)
TSE : THMIRHAS_05360(ectA)
TZO : THMIRHAT_14650(ectA)
HASO : B2G49_00810 B2G49_07205
HPIS : P1P91_08415(ectA) P1P91_12105
HAAH : HALA3H3_880089(ectA)
HAMC : HNO52_10395(ectA) HNO52_14910(ectA)
HAAZ : HaloA020_30390(ectA)
CDIZ : CEDIAZO_01591(ectA)
BTRM : SAMEA390648704059(ectA)
AXX : ERS451415_01954(ectA)
SINL : DSM14862_03233(ectA)
RMM : ROSMUCSMR3_02179(ectA)
AHT : ANTHELSMS3_02975(ectA)
SPAG : sphantq_04070(ectA)
LCRE : Pla8534_45090(ectA)
BFD : NCTC4823_00263(ectA)
AHAL : FTX54_008625(ectA) FTX54_016360(ectA)
ANR : Ana3638_20820 Ana3638_21190
MPHL : MPHLCCUG_01415(ectA)
MTHN : 4412656_01030(ectA)
MFLV : NCTC10271_01045(ectA)
MBUG : MU0053_000969(ectA)
MSAL : DSM43276_01970(ectA)
MTER : 4434518_02645(ectA)
NFR : ERS450000_01381(ectA)
NTP : CRH09_08815(ectA) CRH09_28095(ectA)
NAD : NCTC11293_04317(ectA)
NWL : NWFMUON74_21390(ectA)
NSPU : IFM12276_27580(ectA)
RCR : NCTC10994_01028(ectA)
TPUL : TPB0596_30450(ectA)
STRP : F750_0927 F750_1723
SAMB : SAM23877_1938(ectA)
SRW : TUE45_01705(ectA_1) TUE45_02345(ectA_2)
SLE : sle_52700(sle_52700)
SCLF : BB341_11440 BB341_22640
STSI : A4E84_09405 A4E84_36775
SALW : CP975_00990(ectA) CP975_07880(ectA)
SGM : GCM10017557_63890(ectA)
SALJ : SMD11_5129(ectA) SMD11_6809
SGD : ELQ87_00235(ectA) ELQ87_30225(ectA)
STUI : GCM10017668_14610(ectA)
STRY : EQG64_06105(ectA) EQG64_12880(ectA)
SGOB : test1122_02410(ectA)
SVIO : HWN34_13160 HWN34_25055(ectA)
SXT : KPP03845_100693(ectA)
STTN : BSL84_29495 BSL84_30160
SLUO : PS467_11200(ectA) PS467_30545(ectA)
STPB : QR97_21640 QR97_38600
SGLY : P8A20_28520(ectA) P8A20_32945(ectA)
AGRA : AGRA3207_006987(ectA)
ABAR : AMYBAR_006834(ectA)
ACTU : Actkin_00428(ectA_1) Actkin_03236(ectA_2)
AEY : CDG81_02190(ectA) CDG81_13695(ectA)
MFEG : GCM10025860_05080(ectA)
» show all
Taxonomy
Reference
1
Authors
Peters P, Galinski EA, Truper HG.
Title
The biosynthesis of ectoine.
Journal
FEMS Microbiol Lett 71:157-162 (1990)
Reference
Authors
Ono H, Sawada K, Khunajakr N, Tao T, Yamamoto M, Hiramoto M, Shinmyo A, Takano M, Murooka Y.
Title
Characterization of biosynthetic enzymes for ectoine as a compatible solute in a moderately halophilic eubacterium, Halomonas elongata.
Journal
Sequence
Reference
Authors
Reshetnikov AS, Mustakhimov II, Khmelenina VN, Trotsenko YA.
Title
Cloning, purification, and characterization of diaminobutyrate acetyltransferase from the halotolerant methanotroph Methylomicrobium alcaliphilum 20Z.
Journal
Reference
Authors
Kuhlmann AU, Bremer E.
Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
Journal
Sequence
Reference
Authors
Louis P, Galinski EA
Title
Characterization of genes for the biosynthesis of the compatible solute ectoine from Marinococcus halophilus and osmoregulated expression in Escherichia coli.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.178