KEGG ENZYME: 2.3.1.183

ENZYME: 2.3.1.183

Entry

EC 2.3.1.183                Enzyme

Name

phosphinothricin acetyltransferase;
PAT (ambiguous);
PPT acetyltransferase;
Pt-N-acetyltransferase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:phosphinothricin N-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + phosphinothricin = CoA + N-acetylphosphinothricin [RN:R08938]

Reaction(KEGG)

R08938;
(other) R08871

Substrate

acetyl-CoA [CPD:C00024];
phosphinothricin [CPD:C04650]

Product

CoA [CPD:C00010];
N-acetylphosphinothricin [CPD:C17952]

Comment

The substrate phosphinothricin is used as a nonselective herbicide and is a potent inhibitor of EC 6.3.1.2, glutamine synthetase, a key enzyme of nitrogen metabolism in plants [2].

History

EC 2.3.1.183 created 2007

Pathway

ec00440

Phosphonate and phosphinate metabolism

ec01110

Biosynthesis of secondary metabolites

Orthology

K03823

phosphinothricin acetyltransferase

Genes

VCH:

VC_A0387

VCF:	IR04_01735

VCE:	Vch1786_II0131

VCQ:	EN18_00605

VCJ:	VCD_000902

VCI:

O3Y_15323

VCO:	VC0395_0935

VCR:	VC395_A0337

VPH:	VPUCM_1431

VEX:	VEA_003223

VDB:	AL552_17220

VSP:

VS_1280

VCY:	IX92_06020

VCT:	JV59_32675

VEU:	IXK98_25610

VGI:	MID13_08975

VSL:	LTQ54_15840

VCRA:

IS519_00950

GHO:	AL542_16205

SALY:

E8E00_06170 E8E00_07560

SKS:	FCN78_07210

SCOT:

HBA18_07525

SPRO:

N7E60_06295 N7E60_07670

MMAA:

FR932_05245

LSS:	NCTC12082_01565(yncA)

MMW:	Mmwyl1_0488 Mmwyl1_0493

MARD:

IBG28_02175

MFOI:

JSY38_10985

MPRF:

J8N69_09390

MRHI:

KDW99_02270

RFO:	REIFOR_00005

CDIZ:

CEDIAZO_01076(bar_1)

PMOB:

HG718_07830

KMN:	HW532_20060

RBS:	RHODOSMS8_00830(bar)

SVC:	STVA_27230

HFL:	PUV54_00930

MPAA:

MKK62_18715

MMEH:

M5I08_09000

SCO:	SCO3203(bar)

SALB:

XNR_2143

SMA:	SAVERM_3695(bar)

SCB:	SCAB_52901

SSX:	SACTE_2662

SHY:

SHJG_4675

SHO:	SHJGH_4437

SFA:

Sfla_3685

SALS:

SLNWT_4368

SFI:

SFUL_4404

SLV:	SLIV_21675(bar)

STRE:

GZL_05219

SLD:

T261_4846

SLC:	SL103_03180

SXI:	SXIM_43020

STRC:

AA958_19955

SPRI:

SPRI_4346

SCX:	AS200_26305

SRW:	TUE45_04449(pat_2)

STRF:

ASR50_19280

SPAV:

Spa2297_13945

SGS:	AVL59_43885

STSI:

A4E84_16850

SKY:	D0C37_12550

SALW:

CP975_14770

SGM:	GCM10017557_33280(bar)

SCAD:

DN051_22560

SPHW:

NFX46_37010

SNR:	SNOUR_24255

SALU:

DC74_3670

SALL:

SAZ_19480

STRD:

NI25_22705

SNW:	BBN63_20220

SSIA:

A7J05_20630

SPUN:

BFF78_24325

SGV:	B1H19_17760

SALJ:

SMD11_5982(pat)

STRO:

STRMOE7_01175 STRMOE7_16770 STRMOE7_36645

SFK:

KY5_3412

SGE:	DWG14_04848(bar)

SRJ:	SRO_4275 SRO_7411

SDX:	C4B68_23120

SQZ:	FQU76_12825

SCYA:

EJ357_19345

SAST:

CD934_19325

SKA:	CP970_01750 CP970_25190

SNK:	CP967_20085

SHAW:

CEB94_17470

SRK:	FGW37_32600

SGAL:

CP966_15470

SFY:	GFH48_23420

SGF:	HEP81_04444 HEP81_07732

SSEO:

D0Z67_12115

SBY:	H7H31_06280

SRIM:

CP984_23780

SPHV:

F9278_19685

SFUG:

CNQ36_14670

SPAC:

B1H29_21450

STSU:

B7R87_12385

SCHA:

CP983_25065

SCOE:

CP976_18770

SBAT:

G4Z16_18880

SSPB:

CP982_18845

SNF:	JYK04_03797(bar)

SPLA:

CP981_16475

STUI:

GCM10017668_29200(bar)

SATA:

C5746_17635

SCHF:

IPT68_15795

SHUN:

DWB77_04450(bar)

SHAR:

HUT13_21440

SCYG:

S1361_17220(pat1)

SFEU:

IM697_04880

SDW:	K7C20_15770

SAUH:

SU9_013940

SMOB:

J7W19_03745

SPEU:

CGZ69_14775

SROI:

IAG44_23770

SXN:	IAG42_20305

SHK:	J2N69_14995

SANU:

K7396_21090

SDD:	D9753_20470

SACT:

DMT42_16955

SGOB:

test1122_09365

SINE:

KI385_19550

SLF:	JEQ17_19885

SDEC:

L3078_19450

SDUR:

M4V62_24475

SAKB:

K1J60_25540

SNIG:

HEK616_00970(bar)

SVIO:

HWN34_11415

SCT:	SCAT_p1305(bar)

SCY:	SCATT_p04190

ABRY:

NYE86_04320

NOQ:	LN652_00785

STP:	Strop_0082

ATL:	Athai_63860(bar)

ASER:

Asera_11590(bar)

GLY:	K3N28_14315

RLC:	K227x_21050(yncA)

» show all

Reference

1 [PMID:1864506]

Authors

Botterman J, Gossele V, Thoen C, Lauwereys M.

Title

Characterization of phosphinothricin acetyltransferase and C-terminal enzymatically active fusion proteins.

Journal

Gene 102:33-7 (1991)
DOI:10.1016/0378-1119(91)90534-I

Reference

2 [PMID:12232195]

Authors

Droge-Laser W, Siemeling U, Puhler A, Broer I.

Title

The Metabolites of the Herbicide L-Phosphinothricin (Glufosinate) (Identification, Stability, and Mobility in Transgenic, Herbicide-Resistant, and Untransformed Plants).

Journal

Plant Physiol 105:159-166 (1994)
DOI:10.1104/pp.105.1.159

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.183

IUBMB Enzyme Nomenclature:

2.3.1.183

ExPASy - ENZYME nomenclature database:

2.3.1.183

BRENDA, the Enzyme Database:

2.3.1.183

DBGET integrated database retrieval system