Transferring groups other than aminoacyl groups
an acyl-CoA + tropine = CoA + an O-acyltropine [RN:
This enzyme exhibits absolute specificity for the endo/3alpha configuration found in tropine as pseudotropine (tropan-3beta-ol; see EC
, pseudotropine acyltransferase) is not a substrate . Acts on a wide range of aliphatic acyl-CoA derivatives, with tigloyl-CoA and acetyl-CoA being the best substrates. It is probably involved in the formation of the tropane alkaloid littorine, which is a precursor of hyoscyamine .
EC 220.127.116.11 created 2008
ec00960 Tropane, piperidine and pyridine alkaloid biosynthesis
Robins RJ, Bachmann P, Robinson T, Rhodes MJ, Yamada Y.
The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases.
Robins, R.J., Bachmann,P., Peerless, A.C.J. and Rabot, S.
Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures.
Plant Cell, Tissue Organ Cult 38:241-247 (1994)
Boswell HD, Drager B, McLauchlan WR, Portsteffen A, Robins DJ, Robins RJ, Walton NJ.
Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura.
Li R, Reed DW, Liu E, Nowak J, Pelcher LE, Page JE, Covello PS.
Functional genomic analysis of alkaloid biosynthesis in Hyoscyamus niger reveals a cytochrome P450 involved in littorine rearrangement.
ExPASy - ENZYME nomenclature database: 18.104.22.168
CAS: 138440-79-6 162535-29-7