| Entry |
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| Name |
acetyl-S-ACP:malonate ACP transferase;
acetyl-S-ACP:malonate ACP-SH transferase;
acetyl-S-acyl-carrier protein:malonate acyl-carrier-protein-transferase;
MdcA;
MadA;
ACP transferase;
malonate/acetyl-CoA transferase;
malonate:ACP transferase;
acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase
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| Reaction(IUBMB) |
an acetyl-[acyl-carrier protein] + malonate = a malonyl-[acyl-carrier protein] + acetate [RN: R08944]
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| Reaction(KEGG) |
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| Substrate |
acetyl-[acyl-carrier protein] [CPD: C03939];
malonate [CPD: C00383]
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| Product |
malonyl-[acyl-carrier protein] [CPD: C01209];
acetate [CPD: C00033]
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| Comment |
This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 7.2.4.4). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].
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| History |
EC 2.3.1.187 created 2008, modified 2018
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| Orthology |
| K13929 | malonate decarboxylase alpha subunit |
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| Genes |
» show all
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| Reference |
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| Authors |
Hilbi H, Dimroth P |
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| Title |
Purification and characterization of a cytoplasmic enzyme component of the Na+-activated malonate decarboxylase system of Malonomonas rubra: acetyl-S-acyl carrier protein: malonate acyl carrier protein-SH transferase. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Hoenke S, Schmid M, Dimroth P |
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| Title |
Sequence of a gene cluster from Klebsiella pneumoniae encoding malonate decarboxylase and expression of the enzyme in Escherichia coli. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Koo JH, Kim YS |
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| Title |
Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus. |
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| Journal |
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| Reference |
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| Authors |
Chohnan S, Akagi K, Takamura Y |
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| Title |
Functions of malonate decarboxylase subunits from Pseudomonas putida. |
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| Journal |
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| Reference |
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| Authors |
Dimroth P, Hilbi H |
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| Title |
Enzymic and genetic basis for bacterial growth on malonate. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.187 |
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