KEGG   ENZYME: 2.3.1.189
Entry
EC 2.3.1.189                Enzyme                                 

Name
mycothiol synthase;
MshD
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:desacetylmycothiol O-acetyltransferase
Reaction(IUBMB)
desacetylmycothiol + acetyl-CoA = CoA + mycothiol [RN:R09622]
Reaction(KEGG)
R09622
Substrate
desacetylmycothiol [CPD:C19703];
acetyl-CoA [CPD:C00024]
Product
CoA [CPD:C00010];
mycothiol [CPD:C06717]
Comment
This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium [1]. The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs) [2]. The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate [3].
History
EC 2.3.1.189 created 2010
Orthology
K15520  mycothiol synthase
Genes
MXA: MXAN_1686
CCX: COCOR_01822
MFU: LILAB_24905
MMAS: MYMAC_003377
VIN: AKJ08_2366
HOH: Hoch_0457
RPOD: E0E05_05915
BRK: CWS35_03445
BCQ: BCQ_3264
BCER: BCK_17940
BTM: MC28_2605
LSP: Bsph_0868
PMW: B2K_13485
LPIL: LIP_2440
MTU: Rv0819(mshD)
MTV: RVBD_0819
MTC: MT0841
MRA: MRA_0829
MTUR: CFBS_0860
MTD: UDA_0819
MTUB: MT7199_0838(mshD)
MTUC: J113_05750
MTUE: J114_04360
MTUL: TBHG_00808
MTUT: HKBT1_0861
MTUU: HKBT2_0861
MBO: BQ2027_MB0842(mshD)
MBB: BCG_0871
MBT: JTY_0841
MBX: BCGT_0619
MAF: MAF_08290
MMIC: RN08_0915
MCQ: BN44_10893(mshD)
MCV: BN43_20262(mshD)
MCX: BN42_20581(mshD)
MCZ: BN45_20088(mshD)
MLE: ML2193
MLB: MLBr02193
MPA: MAP_0650
MAO: MAP4_3216
MAVI: RC58_15955
MAVU: RE97_15985
MAV: MAV_0761
MIT: OCO_06660
MIA: OCU_06710
MID: MIP_01176
MYO: OEM_06750
MIR: OCQ_06810
MMAL: CKJ54_03265(mshD)
MLP: MLM_0882
MUL: MUL_0436(mshD)
MMC: Mmcs_4524
MKM: Mkms_4611
MJL: Mjls_4907
MMI: MMAR_4864(mshD)
MMAE: MMARE11_46720(mshD)
MMM: W7S_03275
MLI: MULP_05097(mshD)
MHAD: B586_05445
MSHG: MSG_04364(mshD)
MFJ: MFLOJ_42580(mshD)
MSTO: MSTO_46560(mshD)
MGRO: FZ046_01970(mshD)
MXE: MYXE_07490(mshD)
MNV: MNVI_10620(mshD)
MPAG: C0J29_26615(mshD)
MNM: MNVM_25400(mshD)
MGOR: H0P51_24850(mshD)
MCOO: MCOO_25070(mshD)
MBAI: MB901379_04255(mshD)
MSEO: MSEO_32810(mshD)
MVA: Mvan_5096
MGI: Mflv_1651
MFT: XA26_10530(mshD)
MPHL: MPHLCCUG_00716(mshD_1)
MVQ: MYVA_4948
MTHN: 4412656_03920(mshD)
MHAS: MHAS_03592(mshD_3)
MDU: MDUV_50940(mshD)
MDR: MDOR_31860(mshD)
MAUU: NCTC10437_04856(mshD)
MMAG: MMAD_46860(mshD)
MMOR: MMOR_13860(mshD)
MFX: MFAL_35330(mshD)
MAIC: MAIC_07230(mshD)
MIJ: MINS_41230(mshD)
MALV: MALV_44180(mshD)
MTY: MTOK_24510(mshD)
MPSC: MPSYJ_17640(mshD)
MARZ: MARA_49830(mshD)
MGAD: MGAD_35570(mshD)
MHEV: MHEL_29480(mshD)
MSAR: MSAR_09460(mshD)
MANY: MANY_31120(mshD)
MAUB: MAUB_39360(mshD)
MPOF: MPOR_52090(mshD)
MAB: MAB_0745
MABB: MASS_0714
MCHE: BB28_03585
MSTE: MSTE_00704(mshD)
MSAL: DSM43276_00664(mshD_1)
MJD: JDM601_3540(mshD)
MTER: 4434518_03510(mshD)
MMIN: MMIN_10730(mshD)
MHIB: MHIB_29320(mshD)
ASD: AS9A_0748(mshD)
MKR: MKOR_37500(mshD)
CGL: NCgl2487(Cgl2576)
CGB: cg2847
CGU: WA5_2487(MshD)
CGT: cgR_2479
CGM: cgp_2847(mshD)
CGJ: AR0_12395
CEF: CE2468
CDI: DIP1911
CDP: CD241_1822(mshD)
CDH: CDB402_1777(mshD)
CDT: CDHC01_1824(mshD)
CDE: CDHC02_1812(mshD)
CDR: CDHC03_1793(mshD)
CDA: CDHC04_1796(mshD)
CDZ: CD31A_1907(mshD)
CDB: CDBH8_1883(mshD)
CDS: CDC7B_1881(mshD)
CDW: CDPW8_1878(mshD)
CDV: CDVA01_1757(mshD)
CDIP: ERS451417_01932(mshD)
CJK: jk0376
CUR: cu1609
CUA: CU7111_1550(mshD)
CAR: cauri_2155(mshD)
CPL: Cp3995_1763(mshD)
CPG: CP316_08890(mshD)
CPP: CpP54B96_1744(mshD)
CPK: CP1002_04460(mshD)
CPQ: CPC231_08685(mshD)
CPX: CPI19_08690(mshD)
CPZ: CpPAT10_1715(mshD)
COR: Cp267_1784(mshD)
COP: CP31_09105(mshD)
COD: Cp106_1672(mshD)
COS: Cp4202_1704(mshD)
COI: CPCIP5297_08900(mshD)
COE: CP258_08900(mshD)
COU: CP162_08885(mshD)
CPSE: CPTA_00093
CPSU: CPTB_01434
CPSF: CPTC_01104
CRD: CRES_0111(mshD)
CUL: CULC22_01890(mshD)
CUC: CULC809_01788(mshD)
CUE: CULC0102_1931(mshD)
CUN: Cul210932_1905(mshD2)
CUS: CulFRC11_1801(mshD2)
CUQ: Cul210931_1799(mshD2)
CUZ: Cul05146_1896(mshD2)
CUJ: CUL131002_1823c(mshD2)
CVA: CVAR_0578(mshD)
CTER: A606_02605
CGY: CGLY_13040(mshD)
COA: DR71_697(mshD)
CSX: CSING_11145(mshD)
CMQ: B840_10550(mshD)
CKU: UL82_02875(mshD)
CCJ: UL81_09640(mshD)
CMV: CMUST_12905(mshD)
CEI: CEPID_10370(mshD)
CTED: CTEST_11175(mshD)
CUT: CUTER_09195(mshD)
CDX: CDES_11710(mshD)
CSP: WM42_1860(mshD)
CPHO: CPHO_02500
CGV: CGLAU_10450(mshD2)
CAQU: CAQU_10385
CAMG: CAMM_10850
CMIN: NCTC10288_00413(mshD)
CPEG: CPELA_02155(mshD)
CXE: FOB82_03600(mshD)
CEE: CENDO_09465(mshD2)
CSAN: E3227_05825(mshD)
CGK: CGERO_02060(mshD)
CRL: NCTC7448_00371(mshD)
CCHO: CCHOA_01990(mshD2)
CPRE: Csp1_21550(mshD)
CPSO: CPPEL_02050(mshD)
CSUR: N24_2658(mshD)
CCYS: SAMEA4530656_0247(mshD)
CMAT: HBA49_04600(mshD)
CYZ: C3B44_09750(mshD)
CKF: I6I12_02880(mshD)
NFA: NFA_5990(mshD)
NFR: ERS450000_03621(mshD)
NSR: NS506_01398(mshD)
NTP: CRH09_03895(mshD)
NOZ: DMB37_24295(mshD)
NOD: FOH10_28020(mshD)
NAH: F5544_03285(mshD)
NAD: NCTC11293_01376(mshD)
NWL: NWFMUON74_06120(mshD)
RER: RER_48050(mshD)
REY: O5Y_22760
RQI: C1M55_24490(mshD)
ROP: ROP_17780 ROP_49430(mshD)
REQ: REQ_08610(mshD)
RBY: CEJ39_06425(mshD)
RHB: NY08_2607
RFA: A3L23_00766(mshD_2)
RHS: A3Q41_02586(mshD_5)
RRZ: CS378_20800(mshD)
RHU: A3Q40_02787(mshD_5)
RRT: 4535765_00796(mshD)
RCR: NCTC10994_01920(mshD)
RTM: G4H71_06445(mshD)
GBR: Gbro_3934
GPO: GPOL_c40580(mshD)
GOC: CXX93_06775(mshD)
GIT: C6V83_04540(mshD)
GRU: GCWB2_03215(mshD2) GCWB2_19765(mshD5)
GOM: D7316_02318(mshD_2) D7316_04317(mshD_4)
GOD: GKZ92_18690(mshD)
TPR: Tpau_3544
SRT: Srot_3047
DIT: C3V38_09800(mshD)
DIZ: CT688_03730(mshD)
TOY: FO059_05320(mshD)
SCO: SCO4151(SCD84.18c)
SMA: SAVERM_4058(mshD)
SGB: WQO_15905
SHY: SHJG_4932
SMAL: SMALA_3540
SCT: SCAT_2559(mshD)
SBH: SBI_05018
SVE: SVEN_3908
STRP: F750_0247 F750_3895(mshD)
SLV: SLIV_17620(mshD)
SGU: SGLAU_15955(mshD)
SLD: T261_3527
SAMB: SAM23877_3532(mshD)
SRW: TUE45_04686(mshD_4)
SLE: sle_38040(sle_38040)
SRN: A4G23_00317(mshD_1) A4G23_02540(mshD_3)
SGM: GCM10017557_39210(mshD)
SLAU: SLA_4003
SLX: SLAV_14035(mshD2) SLAV_17920(mshD3) SLAV_37605
SGE: DWG14_00782(mshD_1) DWG14_04540(mshD_7) DWG14_08192(mshD_14)
SLK: SLUN_18470(mshD)
SDX: C4B68_21710(mshD)
SNQ: CP978_16280(mshD)
SNK: CP967_15720(mshD)
SHAW: CEB94_19205(mshD)
SVR: CP971_14960(mshD)
SPAD: DVK44_14370(mshD)
SFY: GFH48_21945(mshD)
SCAV: CVT27_17910(mshD)
SSEO: D0Z67_13465(mshD)
SBY: H7H31_19510(mshD)
SCIN: CP977_18800(mshD)
SFUG: CNQ36_16160(mshD)
KSK: KSE_11000 KSE_43360(mshD)
STRI: C7M71_013525(mshD)
TWH: TWT_659
TWS: TW682
LXL: KDY119_00488(mshD)
CMI: CMM_2502
CMC: CMN_02455(mshD)
RRY: C1O28_02480(mshD)
RIA: C7V51_08670(mshD)
RFS: C1I64_01435(mshD)
RTE: GSU10_11445(mshD)
CUG: C1N91_14555(mshD)
CRY: B7495_13650(mshD)
MYL: C3E77_10890(mshD)
SALC: C2138_01545(mshD)
SALD: FVA74_12015(mshD)
HUW: FPZ11_08490(mshD)
LEU: Leucomu_02640(mshD)
LTR: EVS81_12425(mshD)
LEB: G7066_12695(mshD)
LDN: H9L06_09620(mshD)
LVI: G7068_06555(mshD)
LINS: G7067_00115(mshD)
HEA: HL652_01780(mshD)
FRN: F1C15_06580(mshD)
GLN: F1C58_13590(mshD)
AGX: AGREI_2321(mshD)
ARN: CGK93_17010(mshD)
ARTH: C3B78_14420(mshD)
ARTP: E5206_06870(mshD)
AAGI: NCTC2676_1_02368(mshD)
ACH: Achl_2725
PSNI: NIBR502771_10665(mshD)
PSEY: GU243_09790(mshD)
GLU: F0M17_11710(mshD)
KRH: KRH_05710(mshD)
KII: KocCE7_02930(mshD)
KRS: EQG70_05625(mshD)
KOD: HBK84_03130(mshD)
KVR: CIB50_0000118(mshD)
MICK: B1A86_00008700(mshD)
RDN: HMPREF0733_10355(mshD)
RTER: IDM49_02970(mshD)
RAMA: IDM48_02875(mshD)
AUL: DCC27_000195(mshD)
JDE: Jden_2234
DAY: FV141_11115(mshD)
XCE: Xcel_0316
IDO: I598_0418(mshD_1) I598_1982(mshD_4)
CFI: Celf_2159
TEH: GKE56_14670(mshD)
BLIN: BLSMQ_3335
BRI: FDF13_05880(mshD)
BLUT: EW640_08265(mshD)
BCAU: I6G59_01080(mshD)
AUS: IPK37_11155(mshD)
MPH: MLP_40120 MLP_47690(mshD)
TLA: TLA_TLA_00209(ypeA) TLA_TLA_02247(mshD_2)
RAIN: Rai3103_10105(mshD)
PRV: G7070_04965(mshD)
NDK: I601_1724(mshD_2)
NOY: EXE57_14670(mshD)
NOI: FCL41_02020(mshD)
NDP: E2C04_02630(mshD)
NBE: Back2_14270(mshD)
NARO: CFH99_20770(mshD)
AEZ: C3E78_02515(mshD)
AEB: C6I20_13370(mshD)
AEF: GEV26_02655(mshD)
MGG: MPLG2_3704(mshD)
MUZ: H4N58_02570(mshD)
TFU: Tfu_2739
NDA: Ndas_4378
NAL: B005_1560(mshD)
NGV: CDO52_04525(mshD)
NFE: HUT17_02785(mshD)
STRR: EKD16_01615(mshD1)
TCU: Tcur_0594
ACTW: F7P10_14245(mshD)
TBI: Tbis_0451
FAL: FRAAL0935
ACE: Acel_2026
NAK: EH165_13725(mshD)
BSD: BLASA_1027(ypeA) BLASA_4534(mshD)
MMAR: MODMU_1244 MODMU_5050(mshD)
KRA: Krad_0878
SEN: SACE_4333 SACE_7100(mshD)
SACE: GIY23_21500(mshD)
SACG: FDZ84_10290(mshD)
SACC: EYD13_20950(mshD2)
AMD: AMED_9007
AMN: RAM_46200
AMM: AMES_8871
AMZ: B737_8872
AMQ: AMETH_3199(mshD) AMETH_6921(mshD)
AMYY: YIM_11860 YIM_46265(mshD7)
PDX: Psed_0460
PAUT: Pdca_05230(mshD)
PBRO: HOP40_05560(mshD)
APRE: CNX65_33740(mshD)
AMI: Amir_6822
ACTI: UA75_29645
ACAD: UA74_29115
AHG: AHOG_26885(mshD7)
ACTA: C1701_12185(mshD)
MSAG: GCM10017556_19730(mshD)
MCRA: ID554_17915(mshD)
VER: HUT12_29740(mshD)
CAI: Caci_8254
SNA: Snas_6377
NAV: JQS30_14900(mshD)
TBW: NCTC13354_01322(mshD)
FLH: EJ997_07870(mshD)
AEY: CDG81_21635(mshD)
ABAM: B1s21122_05850(mshD)
AFO: Afer_1462
AYM: YM304_22590(mshD)
ERZ: ER308_12135(mshD)
LET: O77CONTIG1_04097(mshD)
PAGH: NIES204_04260(mshD)
CALH: IJ00_04735
ATM: ANT_04400
TTR: Tter_2571
DGE: Dgeo_0369
MRB: Mrub_0056
ROL: CA51_32970(mshD)
PND: Pla175_20320(mshD_1)
PLH: VT85_25145(mshD)
GPN: Pan110_09750(mshD_1)
SDYN: Mal52_33970(mshD)
SACI: Sinac_7563
PBOR: BSF38_02534(mshD_2) BSF38_03408(mshD_4)
AGV: OJF2_76320(mshD_3)
KOL: Kole_1814
BARC: AOA65_1748
 » show all
Reference
1  [PMID:8076641]
  Authors
Spies HS, Steenkamp DJ
  Title
Thiols of intracellular pathogens. Identification of ovothiol A in Leishmania donovani and structural analysis of a novel thiol from Mycobacterium bovis.
  Journal
Eur J Biochem 224:203-13 (1994)
DOI:10.1111/j.1432-1033.1994.tb20013.x
Reference
2  [PMID:12375100]
  Authors
Koledin T, Newton GL, Fahey RC
  Title
Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes.
  Journal
Arch Microbiol 178:331-7 (2002)
DOI:10.1007/s00203-002-0462-y
  Sequence
Reference
3  [PMID:12930994]
  Authors
Vetting MW, Roderick SL, Yu M, Blanchard JS
  Title
Crystal structure of mycothiol synthase (Rv0819) from Mycobacterium tuberculosis  shows structural homology to the GNAT family of N-acetyltransferases.
  Journal
Protein Sci 12:1954-9 (2003)
DOI:10.1110/ps.03153703
  Sequence
[mtu:Rv0819]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.189
IUBMB Enzyme Nomenclature: 2.3.1.189
ExPASy - ENZYME nomenclature database: 2.3.1.189
BRENDA, the Enzyme Database: 2.3.1.189

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