KEGG   ENZYME: 2.3.1.190
Entry
EC 2.3.1.190                Enzyme                                 
Name
acetoin dehydrogenase system;
acetoin dehydrogenase complex;
acetoin dehydrogenase enzyme system;
AoDH ES;
acetoin dehydrogenase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:acetoin O-acetyltransferase
Reaction(IUBMB)
acetoin + CoA + NAD+ = acetaldehyde + acetyl-CoA + NADH + H+ [RN:R09524]
Reaction(KEGG)
R09524 > R13177
Substrate
acetoin [CPD:C00466];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
acetaldehyde [CPD:C00084];
acetyl-CoA [CPD:C00024];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
Requires thiamine diphosphate. It belongs to the 2-oxoacid dehydrogenase system family, which also includes EC 1.2.1.104, pyruvate dehydrogenase system, EC 1.2.1.105, 2-oxoglutarate dehydrogenase system, EC 1.2.1.25, branched-chain alpha-keto acid dehydrogenase system, and EC 1.4.1.27, glycine cleavage system. With the exception of the glycine cleavage system, which contains 4 components, the 2-oxoacid dehydrogenase systems share a common structure, consisting of three main components, namely a 2-oxoacid dehydrogenase (E1), a dihydrolipoamide acyltransferase (E2), and dihydrolipoamide dehydrogenase (E3).
History
EC 2.3.1.190 created 2010, modified 2020
Pathway
ec00660  C5-Branched dibasic acid metabolism
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:2061286]
  Authors
Priefert H, Hein S, Kruger N, Zeh K, Schmidt B, Steinbuchel A
  Title
Identification and molecular characterization of the Alcaligenes eutrophus H16 aco operon genes involved in acetoin catabolism.
  Journal
J Bacteriol 173:4056-71 (1991)
DOI:10.1128/JB.173.13.4056-4071.1991
Reference
2  [PMID:8110297]
  Authors
Oppermann FB, Steinbuchel A
  Title
Identification and molecular characterization of the aco genes encoding the Pelobacter carbinolicus acetoin dehydrogenase enzyme system.
  Journal
J Bacteriol 176:469-85 (1994)
DOI:10.1128/JB.176.2.469-485.1994
Reference
3  [PMID:8206840]
  Authors
Kruger N, Oppermann FB, Lorenzl H, Steinbuchel A
  Title
Biochemical and molecular characterization of the Clostridium magnum acetoin dehydrogenase enzyme system.
  Journal
J Bacteriol 176:3614-30 (1994)
DOI:10.1128/JB.176.12.3614-3630.1994
Reference
4  [PMID:7813883]
  Authors
Huang M, Oppermann FB, Steinbuchel A
  Title
Molecular characterization of the Pseudomonas putida 2,3-butanediol catabolic pathway.
  Journal
FEMS Microbiol Lett 124:141-50 (1994)
DOI:10.1111/j.1574-6968.1994.tb07276.x
Reference
5  [PMID:10368162]
  Authors
Huang M, Oppermann-Sanio FB, Steinbuchel A
  Title
Biochemical and molecular characterization of the Bacillus subtilis acetoin catabolic pathway.
  Journal
J Bacteriol 181:3837-41 (1999)
DOI:10.1128/JB.181.12.3837-3841.1999
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.190
IUBMB Enzyme Nomenclature: 2.3.1.190
ExPASy - ENZYME nomenclature database: 2.3.1.190
BRENDA, the Enzyme Database: 2.3.1.190

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (5)   
   KEGG REACTION (2)   
   KEGG RCLASS (3)   
Protein sequence (116)   
   UniProt (114)   
   RefSeq(pep) (2)   
DNA sequence (164)   
   RefSeq(nuc) (1)   
   GenBank (81)   
   EMBL (82)   
All databases (297)   

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