KEGG ENZYME: 2.3.1.194

ENZYME: 2.3.1.194

Entry

EC 2.3.1.194                Enzyme

Name

acetoacetyl-CoA synthase;
NphT7

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:malonyl-CoA C-acetyltransferase (decarboxylating)

Reaction(IUBMB)

acetyl-CoA + malonyl-CoA = acetoacetyl-CoA + CoA + CO2 [RN:R09527]

Reaction(KEGG)

R09527

Substrate

acetyl-CoA [CPD:C00024];
malonyl-CoA [CPD:C00083]

Product

acetoacetyl-CoA [CPD:C00332];
CoA [CPD:C00010];
CO2 [CPD:C00011]

Comment

The enzyme from the soil bacterium Streptomyces sp. CL190 produces acetoacetyl-CoA to be used for mevalonate production via the mevalonate pathway.
Unlike the homologous EC 2.3.1.180 (beta-ketoacyl-[acyl-carrier-protein] synthase III), this enzyme does not accept malonyl-[acyl-carrier-protein] as a substrate.

History

EC 2.3.1.194 created 2011

Orthology

K21378

acetoacetyl-CoA synthase

Genes

PJU:	L1P09_23580

AGZ:	M0C34_04365

DOE:	DENOEST_2906

MUL:	MUL_3531(fabH_1)

MMI:	MMAR_3221(fabH_1)

MMAE:

MMARE11_31210(fabH_1)

MLI:	MULP_03448(fabH_1)

MPSE:

MPSD_33000(fabH-1)

MSHO:

MSHO_46320(fabH-1)

NBR:	O3I_033200

NIE:	KV110_32250

SVL:	Strvi_3790

SBH:

SBI_01378

SDV:	BN159_7956(fabH5)

SALS:

SLNWT_0281

SGU:	SGLAU_17330(nphT7)

STRM:

M444_04515

SPAV:

Spa2297_32700

SGM:	GCM10017557_24430(fabH-1)

SCAD:

DN051_13605

SPHW:

NFX46_18825

SLS:	SLINC_8377

SSIA:

A7J05_00465

SPUN:

BFF78_11395

SFK:

KY5_7817c

SQZ:	FQU76_00370 FQU76_33370

SKA:	CP970_00360

SVN:	CP980_14890

SSPB:

CP982_28325

SNF:	JYK04_00151(nphT7)

STUI:

GCM10017668_35440(fabH)

SHUN:

DWB77_00552(nphT7)

SCYG:

S1361_04940(nphT7)

SDW:	K7C20_10900

SROI:

IAG44_00125

SNIG:

HEK616_55620(fabH-1)

SCT:	SCAT_p1096

SCY:	SCATT_p06400

KSK:	KSE_59090(fabH4)

STRI:

C7M71_014720

STRH:

GXP74_01205

AUS:	IPK37_18440

NDA:

Ndas_3368

SNAH:

OUQ99_07025

AGRA:

AGRA3207_007749

FRA:	Francci3_0990

SACC:

EYD13_07800(nphT7)

AMYC:

CU254_12895

AMYY:

YIM_32850(nphT2)

SSYI:

EKG83_10425(fabH)

AHM:	TL08_19815

ACTI:

UA75_17080 UA75_23345

ACAD:

UA74_16550 UA74_22835

AHG:	AHOG_20700(nphT7)

PMAD:

BAY61_22975

MICB:

MicB006_2931

MICH:

FJK98_16190

ACTN:

L083_4421

AFS:

AFR_19640

AIH:	Aiant_54280(fabH_1)

ACTR:

Asp14428_01880(fabH-1)

PFLA:

Pflav_056930

PSUU:

Psuf_000190(fabH-1) Psuf_016510(fabH-2)

PRY:	Prubr_58570(fabH_2)

DVC:	Dvina_05840

DFU:	Dfulv_24035

DMAT:

Dmats_05320

CCAZ:

COUCH_23990

» show all

Reference

1 [PMID:20534558]

Authors

Okamura E, Tomita T, Sawa R, Nishiyama M, Kuzuyama T

Title

Unprecedented acetoacetyl-coenzyme A synthesizing enzyme of the thiolase superfamily involved in the mevalonate pathway.

Journal

Proc Natl Acad Sci U S A 107:11265-70 (2010)
DOI:10.1073/pnas.1000532107

Sequence

[ag:BAJ10048]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.194

IUBMB Enzyme Nomenclature:

2.3.1.194

ExPASy - ENZYME nomenclature database:

2.3.1.194

BRENDA, the Enzyme Database:

2.3.1.194

All links

Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (76)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (73)   
   KEGG MGENES (2)   
Protein sequence (45)   
   UniProt (44)   
   SWISS-PROT (1)   
DNA sequence (51)   
   GenBank (26)   
   EMBL (25)   
Protein domain (3)   
   InterPro (3)   
All databases (182)   

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