KEGG   ENZYME: 2.3.1.200
Entry
EC 2.3.1.200                Enzyme                                 
Name
lipoyl amidotransferase;
LipL (gene name, ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
[glycine cleavage system H]-N6-lipoyl-L-lysine:[lipoyl-carrier protein]-N6-L-lysine lipoyltransferase
Reaction(IUBMB)
[glycine cleavage system H]-N6-lipoyl-L-lysine + a [lipoyl-carrier protein] = glycine cleavage system H + a [lipoyl-carrier protein]-N6-lipoyl-L-lysine [RN:R12426]
Reaction(KEGG)
R12426
Substrate
[glycine cleavage system H]-N6-lipoyl-L-lysine [CPD:C02051];
[lipoyl-carrier protein]
Product
glycine cleavage system H [CPD:C22157];
[lipoyl-carrier protein]-N6-lipoyl-L-lysine
Comment
In the bacterium Listeria monocytogenes the enzyme takes part in a pathway for scavenging of lipoic acid. The enzyme is bound to 2-oxo-acid dehydrogenases such as the pyruvate dehydrogenase complex, where it transfers the lipoyl moiety from lipoyl-[glycine cleavage system H] to the E2 subunits of the complexes.
History
EC 2.3.1.200 created 2012
Pathway
ec00785  Lipoic acid metabolism
ec01100  Metabolic pathways
Orthology
K18821  lipoyl amidotransferase
Genes
ASEDIRT44_02690
NAMPKPF49_07155
LMOlmo2566
LMNLM5578_2761
LMYLM5923_2710
LMTLMRG_02703
LMOCLMOSLCC5850_2570
LMOEBN418_3034
LMOBBN419_3048
LMODLMON_2581
LMOWAX10_06905
LMOQLM6179_1634(lipL)
LMRLMR479A_2694(lipL)
LMOMIJ09_11965
LMFLMOf2365_2538
LMCLm4b_02534
LMOGBN389_25270(lipL)
LMPMUO_12810
LMOLLMOL312_2525
LMOJLM220_21230
LMOZLM1816_15977
LMOXAX24_10790
LMHLMHCC_0030
LMQLMM7_2609
LMLlmo4a_2567
LMGLMKG_02947
LMSLMLG_2526
LMJLMOG_03020
LMWLMOSLCC2755_2572
LMXLMOSLCC2372_2630
LMZLMOSLCC2482_2571
LMONLMOSLCC2376_2459
LMOSLMOSLCC7179_2478
LMOOLMOSLCC2378_2569
LMOYLMOSLCC2479_2629
LMOTLMOSLCC2540_2600
LMOALMOATCC19117_2575
LMOKCQ02_13025
LMVY193_02875
LINlin2711
LWElwe2516(lplA)
LSGlse_2473
LIVLIV_2479
LIIJL52_13060
LIWAX25_13260
LIAJL58_13260
LIOJL53_13745
LWIUE46_02270
LGZNCTC10812_02569(lipL)
LMARLAX80_012420
 » show all
Reference
1  [PMID:21768091]
  Authors
Christensen QH, Hagar JA, O'Riordan MX, Cronan JE
  Title
A complex lipoate utilization pathway in Listeria monocytogenes.
  Journal
J Biol Chem 286:31447-56 (2011)
DOI:10.1074/jbc.M111.273607
  Sequence
[lmo:lmo2566]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.200
IUBMB Enzyme Nomenclature: 2.3.1.200
ExPASy - ENZYME nomenclature database: 2.3.1.200
BRENDA, the Enzyme Database: 2.3.1.200

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