| Entry |
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| Name |
UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase;
WbpD;
WlbB
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| Class |
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
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| Sysname |
acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase
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| Reaction(IUBMB) |
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [RN: R10100]
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| Reaction(KEGG) |
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| Substrate |
acetyl-CoA [CPD: C00024];
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD: C20359]
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| Product |
CoA [CPD: C00010];
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD: C19725]
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| Comment |
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.
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| History |
EC 2.3.1.201 created 2012
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| Pathway |
| ec00520 | Amino sugar and nucleotide sugar metabolism |
| ec00541 | O-Antigen nucleotide sugar biosynthesis |
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| Orthology |
| K13018 | UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase |
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| Genes |
» show all
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| Reference |
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| Authors |
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS |
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| Title |
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Larkin A, Imperiali B |
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| Title |
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 2.3.1.201 |
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