KEGG   ENZYME: 2.3.1.201
Entry
EC 2.3.1.201                Enzyme                                 

Name
UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase;
WbpD;
WlbB
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [RN:R10100]
Reaction(KEGG)
R10100
Substrate
acetyl-CoA [CPD:C00024];
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate [CPD:C20359]
Product
CoA [CPD:C00010];
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate [CPD:C19725]
Comment
This enzyme participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of B-band lipopolysaccharide.
History
EC 2.3.1.201 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec00541  O-Antigen nucleotide sugar biosynthesis
ec01100  Metabolic pathways
Orthology
K13018  UDP-2-acetamido-3-amino-2,3-dideoxy-glucuronate N-acetyltransferase
Genes
ESZ: FEM44_00040
CMW: AFK63_05485
CLAP: NCTC11466_01515
KCO: BWI95_20050
KPSE: IP581_01910
LEE: DVA44_07940
BRB: EH207_15385
PLU: plu4798(wblC)
PLUM: A4R40_23865
PAY: PAU_04313(wblC)
XBO: XBJ1_4315
XNE: XNC1_0113
XNM: XNC2_0115
MSU: MS1499(wbbJ)
ASU: Asuc_0109
AVT: NCTC3438_01789(dapH)
VPB: VPBB_0207
VAN: VAA_02499
PAE: PA3156(wbpD)
PAEV: N297_3267(wlbB)
PAEI: N296_3267(wlbB)
PAEC: M802_3265(wlbB)
PAEO: M801_3132(wlbB)
PMY: Pmen_1859
PMK: MDS_1835
PPUH: B479_06910
PPUN: PP4_39920
PSES: PSCI_2867
PSOS: POS17_4988
PSIL: PMA3_20875
PALI: A3K91_0720
ACB: A1S_0054
ACC: BDGL_002973(wbpD)
SDN: Sden_2659
SAZ: Sama_2258
SSE: Ssed_2971
SVO: SVI_1483
SPSW: Sps_03727
PSEO: OM33_04955
PSPO: PSPO_a0411(wbpD)
MARJ: MARI_04650(wbpD)
SDE: Sde_0871
CBU: CBU_0828
CBD: CBUD_0893
CBG: CbuG_1173
CBC: CbuK_0696
LFA: LFA_0789(wbpD)
LOK: Loa_02106
LSS: NCTC12082_00068(lpxD_1)
TMC: LMI_2891
FPM: LA56_921
FPZ: LA55_1653
FPJ: LA02_880
FNA: OOM_0826
TNI: TVNIR_0689(dapH_[H])
ADI: B5T_01709(wbbJ)
MFOI: JSY38_06735(wbpD)
NZO: SAMEA4504057_0085(dapH)
NANI: NCTC12227_01673(dapH)
NMUS: H7A79_1728
CVI: CV_4125
CHAE: CH06BL_04750(wlbB) CH06BL_39680(bplB)
PSE: NH8B_0415
AMAH: DLM_4448
REH: H16_B0032(wbpD)
PPNO: DA70_17275
LMIR: NCTC12852_00301(dapH)
BPE: BP0092(bplB)
BPC: BPTD_0088(bplB)
BPER: BN118_0161(wlbB)
BPET: B1917_0095(bplB)
BPEU: Q425_2050(bplB)
BPAR: BN117_0152(wlbB)
BPA: BPP0154(bplB)
BBH: BN112_3257(wlbB)
BBR: BB0154(bplB)
BBM: BN115_0143(wlbB)
BBX: BBS798_0153(bplB)
BPT: Bpet4817(wlbB)
BAV: BAV0097(wlbB)
BHO: D560_1329(wlbB)
BHM: D558_1318(wlbB)
BHZ: ACR54_00109(wbpD_1)
BTRM: SAMEA390648701341(bplB)
AXX: ERS451415_06024(dapH)
TEA: KUI_0408
TEG: KUK_0146
ODI: ODI_R2825
PNA: Pnap_3128
AAV: Aave_0951
AJS: Ajs_3016
VEI: Veis_0692
HYB: Q5W_21480
CBAB: SMCB_0530
MMS: mma_2279
LCH: Lcho_0290
RGE: RGE_41560(wbpD)
MMB: Mmol_0911
HMS: HMU06620
HCP: HCN_0855
WSU: WS2187(WBPD)
CJU: C8J_1080
CCF: YSQ_03250
CCOI: YSU_03285
CAVI: CAV_1325
CBLA: CBLAS_0712
ABU: Abu_0663
AELL: AELL_2270
AAQI: AAQM_2033
ALK: ALEK_2538
AMYT: AMYT_0869
AMAR: AMRN_0881
HBV: ABIV_0865
PACO: AACT_0951
SDL: Sdel_1783
SUN: SUN_0094
GME: Gmet_1324(fdtC_fdtA)
GLO: Glov_1509
GEB: GM18_1434
GBM: Gbem_1609(fdtC_fdtA)
DFL: DFE_2302
LIP: LIC094
LIR: LAW_30092
DBA: Dbac_3256
DSF: UWK_02404
DLI: dnl_42420
SCL: sce7345
HOH: Hoch_6855
DBR: Deba_2421
RBS: RHODOSMS8_00381(wbpD)
RLG: Rleg_6224
LABT: FIU93_11860(fdtC)
SPHU: SPPYR_1649(wbpD)
MGRY: MSR1_39220(wbpD)
MAI: MICA_316(wlbB)
MAN: A11S_300
BBAC: EP01_04560
CBK: CLL_A3371
CBT: CLH_3117
CBE: Cbei_4881
CBZ: Cbs_4881
CBEI: LF65_05486
CKR: CKR_2805
CSR: Cspa_c55380(wbpD)
CSB: CLSA_c43280(wbpD)
CSQ: CSCA_4790
CTYK: CTK_C08670
AMT: Amet_3445
OVA: OBV_05490
BPB: bpr_I0385
SWO: Swol_0704
SLP: Slip_0031
PTH: PTH_0380
ELM: ELI_2559
TTE: TTE0654(WbbJ)
CSC: Csac_1805
ATE: Athe_1240
FMA: FMG_0583
STED: SPTER_42260(fdtC)
MMAG: MMAD_48090
CAQU: CAQU_12180
SGR: SGR_4950
SGB: WQO_10740
SFA: Sfla_4290
STRP: F750_2418
SFI: SFUL_2162
SRN: A4G23_01665(wbpD)
SLAU: SLA_0633
SGE: DWG14_01261(wbpD)
SNF: JYK04_06565(wbpD)
KSK: KSE_29490
ART: Arth_4052
ARM: ART_1664
AAGI: NCTC2676_1_02021(dapH)
AAU: AAur_2679
ACH: Achl_2425
LMOI: VV02_09905
XCE: Xcel_2688
SERJ: SGUI_0552
DCO: SAMEA4475696_2256(dapH)
PAC: PPA0134
PACC: PAC1_00730
PACH: PAGK_0139
CACN: RN83_01125
ACIJ: JS278_02850(wbpD)
MPH: MLP_25800
TLA: TLA_TLA_01298(wbpD)
NCA: Noca_4209
NDK: I601_1771(wbpD)
PSIM: KR76_03375
ACE: Acel_1940
GOB: Gobs_4289
AMYY: YIM_44895(fdtC)
PDX: Psed_1885
PAUT: Pdca_01340
AMI: Amir_1738
SESP: BN6_25320
ALO: CRK60328
SAQ: Sare_1692
MIL: ML5_2204
AFS: AFR_15890
CAI: Caci_7631
TPYO: X956_02570
TBW: NCTC13354_00628(dapH)
AHW: NCTC11636_02344(dapH)
ASLA: NCTC11923_02579(dapH)
AVC: NCTC10951_01536(dapH)
ELE: Elen_0641
SYNW: SynWH8103_00501(wlbB)
AMR: AM1_3623
HHG: XM38_017740(glmU_2)
GLJ: GKIL_0480(wbpD)
CALH: IJ00_16860
MRB: Mrub_0357
PUV: PUV_00140
WCH: wcw_0167(wbbJ) wcw_1824(wblC)
PSL: Psta_1438
RUL: UC8_09450(fdtC) UC8_50380(wbpD)
ROL: CA51_14950(fdtC_1)
AHEL: Q31a_30440(fdtC) Q31a_44990(wbpD)
LCRE: Pla8534_69430(wbpD)
FMR: Fuma_05220(fdtC_2)
PBAS: SMSP2_01882(wbpD)
ALUS: STSP2_02796(wbpD)
VBL: L21SP4_02280(fdtC)
TPED: TPE_0188
EPO: Epro_1246
TLI: Tlie_1825
GAU: GAU_1967
GBA: J421_2474
BOA: Bovatus_01174(fdtC)
BCEL: BcellWH2_04368(fdtC)
PGI: PG_0002
PGN: PGN_0002
PMUC: ING2E5A_2032(fdtC)
PDI: BDI_2184
TFO: BFO_1995
BLQ: L21SP5_01620(wbpD)
RMR: Rmar_1673
CPI: Cpin_4761
SGN: SGRA_0090
PHE: Phep_0550
MUC: MuYL_1748
GFL: GRFL_0099
FJG: BB050_02168(fdtC)
ZGA: ZOBELLIA_1738(fdtC)
TJE: TJEJU_1134(wbpD)
TMAR: MARIT_2955(wbpD)
SPON: HME9304_01539(wbpD)
KAN: IMCC3317_17150(fdtC)
EAO: BD94_0260
ELB: VO54_03335(fdtC)
CHZ: CHSO_0187
IAL: IALB_2461(wbpD)
MRO: MROS_2686
CPRV: CYPRO_3323
CABY: Cabys_3435
DTU: Dtur_0577
NJA: NSJP_4163
MVO: Mvol_0243
MFC: BRM9_0459
FPL: Ferp_2378
GAH: GAH_01470
PFI: PFC_02995
PAB: PAB0773
TGA: TGAM_2149
TSI: TSIB_2027
THM: CL1_0824
TLT: OCC_01404
MTP: Mthe_1458
MCJ: MCON_2575
TPE: Tpen_0895
BARB: AOA66_1111
 » show all
Reference
1  [PMID:19282284]
  Authors
Westman EL, McNally DJ, Charchoglyan A, Brewer D, Field RA, Lam JS
  Title
Characterization of WbpB, WbpE, and WbpD and reconstitution of a pathway for the biosynthesis of UDP-2,3-diacetamido-2,3-dideoxy-D-mannuronic acid in Pseudomonas aeruginosa.
  Journal
J Biol Chem 284:11854-62 (2009)
DOI:10.1074/jbc.M808583200
  Sequence
[pae:PA3156]
Reference
2  [PMID:19348502]
  Authors
Larkin A, Imperiali B
  Title
Biosynthesis of UDP-GlcNAc(3NAc)A by WbpB, WbpE, and WbpD: enzymes in the Wbp pathway responsible for O-antigen assembly in Pseudomonas aeruginosa PAO1.
  Journal
Biochemistry 48:5446-55 (2009)
DOI:10.1021/bi900186u
  Sequence
[pae:PA3156]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.201
IUBMB Enzyme Nomenclature: 2.3.1.201
ExPASy - ENZYME nomenclature database: 2.3.1.201
BRENDA, the Enzyme Database: 2.3.1.201

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