KEGG ENZYME: 2.3.1.203

ENZYME: 2.3.1.203

Entry

EC 2.3.1.203                Enzyme

Name

UDP-N-acetylbacillosamine N-acetyltransferase;
UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase;
pglD (gene name)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

acetyl-CoA:UDP-4-amino-4,6-dideoxy-N-acetyl-alpha-D-glucosamine N-acetyltransferase

Reaction(IUBMB)

acetyl-CoA + UDP-N-acetylbacillosamine = CoA + UDP-N,N'-diacetylbacillosamine [RN:R10099]

Reaction(KEGG)

R10099

Substrate

acetyl-CoA [CPD:C00024];
UDP-N-acetylbacillosamine [CPD:C04630]

Product

CoA [CPD:C00010];
UDP-N,N'-diacetylbacillosamine [CPD:C20357]

Comment

The product, UDP-N,N'-diacetylbacillosamine, is an intermediate in protein glycosylation pathways in several bacterial species, including N-linked glycosylation of certain L-asparagine residues in Campylobacter species [1,2] and O-linked glycosylation of certain L-serine residues in Neisseria species [3].

History

EC 2.3.1.203 created 2012, modified 2013

Pathway

ec00520

Amino sugar and nucleotide sugar metabolism

ec01100

Metabolic pathways

Orthology

K15913

UDP-N-acetylbacillosamine N-acetyltransferase

Genes

VQI:	CCZ37_12405

COLW:

A3Q33_07445

COLA:

DBO93_00785

CBER:

B5D82_08985

FPM:

LA56_930

FNA:

OOM_0807

FNL:	M973_08250

AHA:

AHA_2896

ADH:	CK627_11330

NAW:	LVJ86_05665

USU:	LVJ78_05080

UTE:	LVJ83_05805

CHEA:

PVE73_20020

SKU:	Sulku_2411

CJE:	Cj1123c(pglD)

CJB:	BN148_1123c(pglD)

CJJ:	CJJ81176_1140(pglD)

CJU:	C8J_1063(pglD)

CJN:	ICDCCJ07001_1078

CJI:	CJSA_1065(pglD)

CJM:	CJM1_1101(pglD)

CJS:

CJS3_1169

CJP:	A911_05440

CJEJ:

N564_01091

CJEU:

N565_01134

CJEN:

N755_01127

CJEI:

N135_01160

CJER:

H730_06585

CJV:	MTVDSCj20_1126(pglD)

CJY:	QZ67_01200(pglD)

CJQ:	UC78_1080(pglD)

CJL:	PJ17_05755

CJW:	PJ18_05570

CJR:	CJE1265(pglD)

CJD:	JJD26997_0598(pglD)

CJZ:	M635_01320

CJX:	BN867_11140

CFF:	CFF8240_1380

CFT:	CFF04554_1395(pglD)

CFV:	CFVI03293_1418(pglD)

CFX:	CFV97608_1518(pglD)

CFZ:

CSG_15170

CAMP:

CFT03427_1343(pglD)

CFP:	CR44_06795

CCV:	CCV52592_1210(pglD)

CHA:	CHAB381_0951

CCO:	CCC13826_0449(pglD)

CCOC:

CCON33237_1462(pglD)

CLA:	CLA_1256(pglD)

CLR:	UPTC16701_1239(pglD)

CLM:	UPTC16712_1257(pglD)

CLQ:	UPTC4110_1241(pglD)

CLN:	UPTC3659_1476(pglD)

CLL:	CONCH_1207(pglD)

CCOL:

BN865_10060

CCC:	G157_03320

CCQ:	N149_1064(pglD)

CCF:

YSQ_03355

CCY:

YSS_06080

CCOI:

YSU_03390

CCOF:

VC76_05510(pglD)

CCOO:

ATE51_01358(pglD_3)

CAJ:	CIG1485E_1389(pglD)

CIS:	CINS_1221(pglD)

CVO:	CVOL_1235(pglD)

CPEL:

CPEL_1362(pglD)

CAMR:

CAQ16704_1267(pglD)

CSM:	CSUB8521_1443(pglD)

CSF:	CSUB8523_1539(pglD)

CGRA:

CGRAC_1487(pglD)

CURE:

CUREO_1371(pglD)

CHYO:

CHH_0380(pglD)

CHV:	CHELV3228_0557(pglD)

CSPF:

CSF_0890(pglD)

CPIN:

CPIN18020_0865(pglD)

CCUN:

CCUN_1174(pglD)

CLX:	CLAN_0357(pglD)

CAVI:

CAV_0413(pglD)

CHW:	A2J15_001365

CAMZ:

CVIC12175_1319(pglD)

CAMY:

CSUIS_0202(pglD)

COJ:	CORN_1326(pglD)

CUX:	CUP3940_1134(pglD)

CRX:	CRECT_1673(pglD)

CGEO:

CGEO_1571(pglD)

CCOR:

CCORG_0296(pglD)

CARM:

CARM_1289(pglD)

CMUC:

CMCT_0320(pglD)

CSHO:

CSHOW_1515(pglD)

CINF:

CINF_0566(pglD)

CNV:	CNZW441b_1126(pglD)

CVU:	CVULP_0495(pglD)

CDEV:

CIGN_1240(pglD)

CCAQ:

CCAL_1427(pglD)

AFC:	AFAEC_1299

AHS:	AHALO_0832

AMAR:

AMRN_0897

HBV:

ABIV_0885

SINU:

IMZ28_10320

PSN:	Pedsa_3203

ALM:	AO498_13855

GRL:	LPB144_06680

MART:

BTR34_08465

MARB:

CJ263_08145

DRM:

Dred_3128

MHU:

Mhun_2125

» show all

Reference

1 [PMID:17087520]

Authors

Olivier NB, Chen MM, Behr JR, Imperiali B

Title

In vitro biosynthesis of UDP-N,N'-diacetylbacillosamine by enzymes of the Campylobacter jejuni general protein glycosylation system.

Journal

Biochemistry 45:13659-69 (2006)
DOI:10.1021/bi061456h

Sequence

[cje:Cj1123c]

Reference

2 [PMID:18198901]

Authors

Rangarajan ES, Ruane KM, Sulea T, Watson DC, Proteau A, Leclerc S, Cygler M, Matte A, Young NM

Title

Structure and active site residues of PglD, an N-acetyltransferase from the bacillosamine synthetic pathway required for N-glycan synthesis in Campylobacter jejuni.

Journal

Biochemistry 47:1827-36 (2008)
DOI:10.1021/bi702032r

Sequence

[cje:Cj1123c]

Reference

3 [PMID:21542610]

Authors

Hartley MD, Morrison MJ, Aas FE, Borud B, Koomey M, Imperiali B

Title

Biochemical characterization of the O-linked glycosylation pathway in Neisseria gonorrhoeae responsible for biosynthesis of protein glycans containing N,N'-diacetylbacillosamine.

Journal

Biochemistry 50:4936-48 (2011)
DOI:10.1021/bi2003372

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.203

IUBMB Enzyme Nomenclature:

2.3.1.203

ExPASy - ENZYME nomenclature database:

2.3.1.203

BRENDA, the Enzyme Database:

2.3.1.203

DBGET integrated database retrieval system