KEGG ENZYME: 2.3.1.206

ENZYME: 2.3.1.206

Entry

EC 2.3.1.206                Enzyme

Name

3,5,7-trioxododecanoyl-CoA synthase;
TKS (ambiguous);
olivetol synthase (incorrect)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

malonyl-CoA:hexanoyl-CoA malonyltransferase (3,5,7-trioxododecanoyl-CoA-forming)

Reaction(IUBMB)

3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2 [RN:R10171]

Reaction(KEGG)

R10171

Substrate

malonyl-CoA [CPD:C00083];
hexanoyl-CoA [CPD:C05270]

Product

CoA [CPD:C00010];
3,5,7-trioxododecanoyl-CoA [CPD:C20413];
CO2 [CPD:C00011]

Comment

A polyketide synthase catalysing the first committed step in the cannabinoids biosynthetic pathway of the plant Cannabis sativa. The enzyme was previously thought to also function as a cyclase, but the cyclization is now known to be catalysed by EC 4.4.1.26, olivetolic acid cyclase.

History

EC 2.3.1.206 created 2012

Pathway

ec00999

Biosynthesis of various plant secondary metabolites

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K20503

3,5,7-trioxododecanoyl-CoA synthase