Entry
Name
beta-ketodecanoyl-[acyl-carrier-protein] synthase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
octanoyl-CoA:malonyl-[acyl-carrier protein] C-heptanoylltransferase (decarboxylating, CoA-forming)
Reaction(IUBMB)
octanoyl-CoA + a malonyl-[acyl-carrier protein] = a 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 [RN:
R10172 ]
Reaction(KEGG)
Substrate
octanoyl-CoA [CPD:
C01944 ];
malonyl-[acyl-carrier protein] [CPD:
C01209 ]
Product
Comment
This enzyme, which has been characterized from the bacterium Pseudomonas aeruginosa PAO1, catalyses the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl-[acp], forming 3-oxodecanoyl-[acp], an intermediate of the fatty acid elongation cycle. The enzyme provides a shunt for beta-oxidation degradation intermediates into de novo fatty acid biosynthesis.
History
EC 2.3.1.207 created 2012
Orthology
K16872 beta-ketodecanoyl-[acyl-carrier-protein] synthase
Genes
PSHI : SAMEA2665130_0711(fabH_1)
PAEB : NCGM1900_2994(fabH-2)
PPRC : PFLCHA0_c15710(fabH1)
PFC : PflA506_3851(fabH_2)
PMUD : NCTC8068_01420(fabH1)
PFW : PF1751_v1c40400(fabH)
PPUU : PputUW4_03987(fabH2)
PTAE : NCTC10697_03045(fabH1)
PSYC : DABAL43B_1409(fabH)
MCAT : MC25239_00867(fabH)
MCUN : NCTC10297_01441(fabH)
AMAC : MASE_14315 MASE_14365
AEL : NCTC12917_03044(fabH_2)
PLG : NCTC10937_04148(fabH1)
MESU : LHFGNBLO_003101 LHFGNBLO_006542
NIY : FQ775_02560 FQ775_15415
AAK : AA2016_2776 AA2016_5202
AMIH : CO731_02758(fabH_1) CO731_04799(fabH_4)
AMIS : Amn_14040 Amn_36630
BVY : NCTC9239_00693(fabH_2)
TSV : DSM104635_02587(fabH_2)
RCP : RCAP_rcc01145(fabH1)
MMR : Mmar10_0799 Mmar10_0802
HYT : HXX25_07785 HXX25_07790
TMK : QGN29_08270 QGN29_08275
GSO : PH603_06625 PH603_06630
» show all
Taxonomy
Reference
Authors
Yuan Y, Leeds JA, Meredith TC
Title
Pseudomonas aeruginosa directly shunts beta-oxidation degradation intermediates into de novo fatty acid biosynthesis.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 2.3.1.207