KEGG   ENZYME: 2.3.1.208
Entry
EC 2.3.1.208                Enzyme                                 
Name
4-hydroxycoumarin synthase;
BIS2;
BIS3
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:2-hydroxybenzoyl-CoA malonyltransferase
Reaction(IUBMB)
malonyl-CoA + 2-hydroxybenzoyl-CoA = 2 CoA + 4-hydroxycoumarin + CO2 [RN:R10173]
Reaction(KEGG)
R10173
Substrate
malonyl-CoA [CPD:C00083];
2-hydroxybenzoyl-CoA [CPD:C20394]
Product
CoA [CPD:C00010];
4-hydroxycoumarin [CPD:C20414];
CO2 [CPD:C00011]
Comment
The enzyme, a polyketide synthase, can also accept benzoyl-CoA as substrate, which it condenses with 3 malonyl-CoA molecules to form 3,5-dihydroxybiphenyl (cf. EC 2.3.1.177, biphenyl synthase) [1].
History
EC 2.3.1.208 created 2012
Orthology
K21384  3,5-dihydroxybiphenyl/4-hydroxycoumarin synthase
Genes
FVE: 101312122 101312413
RCN: 112169554 112173282
PPER: 109948444 18780920 18781256
PMUM: 103326884 103326885
PAVI: 110755238
PDUL: 117624590
MDM: 103418590 103455021 103456249 103456250 114819163
MSYL: 126598538 126601534 126601535 126605162 126605164
PXB: 103945211 103945212 103946755 103946756 103946757 103946758 103946760 103946761
Reference
1  [PMID:19757094]
  Authors
Liu B, Raeth T, Beuerle T, Beerhues L
  Title
A novel 4-hydroxycoumarin biosynthetic pathway.
  Journal
Plant Mol Biol 72:17-25 (2010)
DOI:10.1007/s11103-009-9548-0
  Sequence
[ag:ACW82504 ACW82505]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.208
IUBMB Enzyme Nomenclature: 2.3.1.208
ExPASy - ENZYME nomenclature database: 2.3.1.208
BRENDA, the Enzyme Database: 2.3.1.208

  All links  
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (32)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (2)   
Protein domain (4)   
   InterPro (4)   
All databases (48)   

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