KEGG   ENZYME: 2.3.1.211
Entry
EC 2.3.1.211                Enzyme                                 

Name
bisdemethoxycurcumin synthase;
CUS;
curcuminoid synthase (ambiguous)
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (bisdemethoxycurcumin-forming)
Reaction(IUBMB)
2 4-coumaroyl-CoA + malonyl-CoA + H2O = 3 CoA + bisdemethoxycurcumin + 2 CO2 [RN:R10233]
Reaction(KEGG)
R10233
Substrate
4-coumaroyl-CoA [CPD:C00223];
malonyl-CoA [CPD:C00083];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
bisdemethoxycurcumin [CPD:C17743];
CO2 [CPD:C00011]
Comment
A polyketide synthase characterized from the plant Oryza sativa (rice) that catalyses the formation of the C6-C7-C6 diarylheptanoid scaffold of bisdemethoxycurcumin. Unlike the process in the plant Curcuma longa (turmeric), where the conversion is carried out via a diketide intermediate by two different enzymes (EC 2.3.1.218, phenylpropanoylacetyl-CoA synthase and EC 2.3.1.217, curcumin synthase), the diketide intermediate formed by this enzyme remains within the enzyme's cavity and is not released to the environment.
History
EC 2.3.1.211 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K17212  bisdemethoxycurcumin synthase
Genes
AJM: 119054186
OSA: 107276120 107276706 107276873 107278066 4338103 4342896 4343313 4343430 4343431 4343432 4348146 4348180 4350633 4350634 4350635
DOSA: Os05t0212600-00(Os05g0212600) Os05t0212900-00(Os05g0212900) Os05t0213100-00(Os05g0213100) Os07t0271500-01(Os07g0271500) Os07t0501100-01(Os07g0501100) Os07t0525500-00(Os07g0525500) Os07t0525900-00(Os07g0525900) Os07t0526400-01(Os07g0526400) Os10t0158400-00(Os10g0158400) Os10t0162856-00(Os10g0162856) Os10t0167900-00(Os10g0167900) Os10t0168300-00(Os10g0168300) Os10t0168500-00(Os10g0168500) Os10t0177300-00(Os10g0177300) Os11t0529500-00(Os11g0529500) Os11t0529800-00(Os11g0529800)
OBR: 102700556 102703597 102703882 102704434 102706796 102707711 102715335 102717542 102717654 102717817 102721773
BDI: 100829126 100834852 100835138 100840879 100840881 100842932
ATS: 109734579 109739828 109739833 109747018 109755590 109759063 109765137 109765413 109768737 109770988 109770996 109771086 109772782 109782591
TDC: 119289266 119289823 119289825 119289826 119293030 119293199 119295516 119297968 119297970 119297971 119298470 119301023 119301039 119306583 119310160 119314905 119319037 119319257 119322210 119325182 119325577 119325838 119334584 119335697 119343513 119344226 119344637 119345768 119347449 119348997 119349006 119353258 119358583 119358621 119358657 119359730 119360255 119360418 119366792 119366798 119366799 119366801 119367015
SBI: 8056971 8056973 8056974 8057988 8062654 8062655 8064807 8064810 8064811 8068873 8068891 8074891 8077473 8080715 8080716 8084297
ZMA: 100272924 103626945 103650032 103650033 103650038 103654408 103654409 109940988
SITA: 101754841 101755242 101758341 101759154 101759479 101759670 101759838 101760477 101764244 101776434 101777243 101777759
 » show all
Reference
1  [PMID:21041675]
  Authors
Morita H, Wanibuchi K, Nii H, Kato R, Sugio S, Abe I
  Title
Structural basis for the one-pot formation of the diarylheptanoid scaffold by curcuminoid synthase from Oryza sativa.
  Journal
Proc Natl Acad Sci U S A 107:19778-83 (2010)
DOI:10.1073/pnas.1011499107
  Sequence
[osa:4342896]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.211
IUBMB Enzyme Nomenclature: 2.3.1.211
ExPASy - ENZYME nomenclature database: 2.3.1.211
BRENDA, the Enzyme Database: 2.3.1.211

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