KEGG   ENZYME: 2.3.1.212Help
Entry
EC 2.3.1.212                Enzyme                                 

Name
benzalacetone synthase;
BAS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (4-hydroxybenzalacetone-forming)
Reaction(IUBMB)
4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2 [RN:R10234]
Reaction(KEGG)
Substrate
4-coumaroyl-CoA [CPD:C00223];
malonyl-CoA [CPD:C00083];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
4-hydroxybenzalacetone;
CO2 [CPD:C00011]
Comment
A polyketide synthase that catalyses the C6-C4 skeleton of phenylbutanoids in higher plants.
History
EC 2.3.1.212 created 2013
Reference
1  [PMID:12226219]
  Authors
Borejsza-Wysocki W, Hrazdina G
  Title
Aromatic Polyketide Synthases (Purification, Characterization, and Antibody Development to Benzalacetone Synthase from Raspberry Fruits).
  Journal
Plant Physiol 110:791-799 (1996)
DOI:10.1104/pp.110.3.791
  Sequence
Reference
2  [PMID:11389739]
  Authors
Abe I, Takahashi Y, Morita H, Noguchi H
  Title
Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in  the biosynthesis of phenylbutanones in Rheum palmatum.
  Journal
Eur J Biochem 268:3354-9 (2001)
DOI:10.1046/j.1432-1327.2001.02255.x
  Sequence
Reference
3  [PMID:18068110]
  Authors
Zheng D, Hrazdina G
  Title
Molecular and biochemical characterization of benzalacetone synthase and chalcone synthase genes and their proteins from raspberry (Rubus idaeus L.).
  Journal
Arch Biochem Biophys 470:139-45 (2008)
DOI:10.1016/j.abb.2007.11.013
  Sequence
Reference
4  [PMID:20080733]
  Authors
Morita H, Shimokawa Y, Tanio M, Kato R, Noguchi H, Sugio S, Kohno T, Abe I
  Title
A structure-based mechanism for benzalacetone synthase from Rheum palmatum.
  Journal
Proc Natl Acad Sci U S A 107:669-73 (2010)
DOI:10.1073/pnas.0909982107
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.212
IUBMB Enzyme Nomenclature: 2.3.1.212
ExPASy - ENZYME nomenclature database: 2.3.1.212
BRENDA, the Enzyme Database: 2.3.1.212

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