KEGG ENZYME: 2.3.1.212

ENZYME: 2.3.1.212

Entry

EC 2.3.1.212                Enzyme

Name

benzalacetone synthase;
BAS

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

4-coumaroyl-CoA:malonyl-CoA 4-coumaryltransferase (4-hydroxybenzalacetone-forming)

Reaction(IUBMB)

4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2 [RN:R10234]

Reaction(KEGG)

R10234

Substrate

4-coumaroyl-CoA [CPD:C00223];
malonyl-CoA [CPD:C00083];
H2O [CPD:C00001]

Product

CoA [CPD:C00010];
4-hydroxybenzalacetone [CPD:C12088];
CO2 [CPD:C00011]

Comment

A polyketide synthase that catalyses the C6-C4 skeleton of phenylbutanoids in higher plants.

History

EC 2.3.1.212 created 2013

Reference

1 [PMID:12226219]

Authors

Borejsza-Wysocki W, Hrazdina G

Title

Aromatic Polyketide Synthases (Purification, Characterization, and Antibody Development to Benzalacetone Synthase from Raspberry Fruits).

Journal

Plant Physiol 110:791-799 (1996)
DOI:10.1104/pp.110.3.791

Sequence

[ag:ABV54602]

Reference

2 [PMID:11389739]

Authors

Abe I, Takahashi Y, Morita H, Noguchi H

Title

Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum.

Journal

Eur J Biochem 268:3354-9 (2001)
DOI:10.1046/j.1432-1327.2001.02255.x

Sequence

[ag:AAK82824]

Reference

3 [PMID:18068110]

Authors

Zheng D, Hrazdina G

Title

Molecular and biochemical characterization of benzalacetone synthase and chalcone synthase genes and their proteins from raspberry (Rubus idaeus L.).

Journal

Arch Biochem Biophys 470:139-45 (2008)
DOI:10.1016/j.abb.2007.11.013

Sequence

[ag:ABV54602]

Reference

4 [PMID:20080733]

Authors

Morita H, Shimokawa Y, Tanio M, Kato R, Noguchi H, Sugio S, Kohno T, Abe I

Title

A structure-based mechanism for benzalacetone synthase from Rheum palmatum.

Journal

Proc Natl Acad Sci U S A 107:669-73 (2010)
DOI:10.1073/pnas.0909982107

Sequence

[ag:AAK82824]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.212

IUBMB Enzyme Nomenclature:

2.3.1.212

ExPASy - ENZYME nomenclature database:

2.3.1.212

BRENDA, the Enzyme Database:

2.3.1.212

All links

Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Protein sequence (6)   
   UniProt (4)   
   SWISS-PROT (2)   
DNA sequence (4)   
   GenBank (2)   
   EMBL (2)   
Protein domain (5)   
   InterPro (5)   
All databases (23)   

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