KEGG ENZYME: 2.3.1.216

ENZYME: 2.3.1.216

Entry

EC 2.3.1.216                Enzyme

Name

5,7-dihydroxy-2-methylchromone synthase;
pentaketide chromone synthase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

malonyl-CoA:malonyl-CoA malonyltransferase (5,7-dihydroxy-2-methyl-4H-chromen-4-one-forming)

Reaction(IUBMB)

5 malonyl-CoA = 5 CoA + 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + H2O [RN:R10238]

Reaction(KEGG)

Substrate

malonyl-CoA [CPD:C00083]

Product

CoA [CPD:C00010];
5,7-dihydroxy-2-methyl-4H-chromen-4-one [CPD:C20462];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

A polyketide synthase from the plant Aloe arborescens (aloe).

History

EC 2.3.1.216 created 2013

Orthology

5,7-dihydroxy-2-methylchromone synthase

Genes

AOF:

109833799

Reference

1 [PMID:15686354]

Authors

Abe I, Utsumi Y, Oguro S, Morita H, Sano Y, Noguchi H

Title

A plant type III polyketide synthase that produces pentaketide chromone.

Journal

J Am Chem Soc 127:1362-3 (2005)
DOI:10.1021/ja0431206

Sequence

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

All links

Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
All databases (2)   

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