Entry Name curcumin synthase;
Class Transferases;BRITE hierarchy
Sysname feruloyl-CoA:feruloylacetyl-CoA feruloyltransferase (curcumin-forming)
Reaction(IUBMB) feruloyl-CoA + feruloylacetyl-CoA + H2O = 2 CoA + curcumin + CO2 [RN:
R08810 ]
Reaction(KEGG) Substrate Product Comment A polyketide synthase from the plant Curcuma longa (turmeric). Three isoforms exist, CURS1, CURS2 and CURS3. While CURS1 and CURS2 prefer feruloyl-CoA as a starter substrate, CURS3 can accept 4-coumaroyl-CoA equally well [2] (see EC
2.3.1.219 , demethoxycurcumin synthase).
History EC 2.3.1.217 created 2013
Pathway ec00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology K17211 curcumin/demethoxycurcumin synthase
Genes ZOF : 122020719 122021391 122024435 122025085
Taxonomy Reference Authors Katsuyama Y, Kita T, Funa N, Horinouchi S
Title Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
Journal Sequence Reference Authors Katsuyama Y, Kita T, Horinouchi S
Title Identification and characterization of multiple curcumin synthases from the herb Curcuma longa.
Journal Sequence Reference Authors Katsuyama Y, Miyazono K, Tanokura M, Ohnishi Y, Horinouchi S
Title Structural and biochemical elucidation of mechanism for decarboxylative condensation of beta-keto acid by curcumin synthase.
Journal Sequence Other DBs ExPASy - ENZYME nomenclature database: 2.3.1.217
