KEGG   ENZYME: 2.3.1.218
Entry
EC 2.3.1.218                Enzyme                                 
Name
phenylpropanoylacetyl-CoA synthase;
phenylpropanoyl-diketide-CoA synthase;
DCS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
phenylpropanoyl-CoA:malonyl-CoA phenylpropanoyl-transferase (decarboxylating)
Reaction(IUBMB)
(1) feruloyl-CoA + malonyl-CoA = feruloylacetyl-CoA + CO2 + CoA [RN:R08806];
(2) 4-coumaroyl-CoA + malonyl-CoA = (4-coumaroyl)acetyl-CoA + CO2 + CoA [RN:R08805]
Reaction(KEGG)
R08805 R08806
Substrate
feruloyl-CoA [CPD:C00406];
malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223]
Product
feruloylacetyl-CoA [CPD:C17741];
CO2 [CPD:C00011];
CoA [CPD:C00010];
(4-coumaroyl)acetyl-CoA [CPD:C17740]
Comment
The enzyme has been characterized from the plant Curcuma longa (turmeric). It prefers feruloyl-CoA, and has no activity with cinnamoyl-CoA.
History
EC 2.3.1.218 created 2013
Pathway
ec00945  Stilbenoid, diarylheptanoid and gingerol biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K13233  phenylpropanoylacetyl-CoA synthase
Genes
MUS: 135605878
ZOF: 121988370 122021150 122024688 122038700 122042917 122047442
Reference
1  [PMID:19258320]
  Authors
Katsuyama Y, Kita T, Funa N, Horinouchi S
  Title
Curcuminoid biosynthesis by two type III polyketide synthases in the herb Curcuma longa.
  Journal
J Biol Chem 284:11160-70 (2009)
DOI:10.1074/jbc.M900070200
  Sequence
[ag:BAH56225]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.218
IUBMB Enzyme Nomenclature: 2.3.1.218
ExPASy - ENZYME nomenclature database: 2.3.1.218
BRENDA, the Enzyme Database: 2.3.1.218

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (9)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (8)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (4)   
   InterPro (4)   
All databases (30)   

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