KEGG   ENZYME: 2.3.1.22Help
Entry
EC 2.3.1.22                 Enzyme                                 

Name
2-acylglycerol O-acyltransferase;
acylglycerol palmitoyltransferase;
monoglyceride acyltransferase;
acyl coenzyme A-monoglyceride acyltransferase;
monoacylglycerol acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:2-acylglycerol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 2-acylglycerol = CoA + diacylglycerol [RN:R01368]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
2-acylglycerol [CPD:C02112]
Product
CoA [CPD:C00010];
diacylglycerol [CPD:C00165]
Comment
Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate.
History
EC 2.3.1.22 created 1972, modified 1986, modified 1989
Pathway
ec00561  Glycerolipid metabolism
Orthology
K14456  2-acylglycerol O-acyltransferase 3
K14457  2-acylglycerol O-acyltransferase 2
K14458  2-acylglycerol O-acyltransferase 1
Genes
HSA: 116255(MOGAT1) 346606(MOGAT3) 80168(MOGAT2)
PTR: 466713(MOGAT2) 470662(MOGAT1) 472468(MOGAT3)
PPS: 100969446(MOGAT3) 100977021(MOGAT1) 100987539(MOGAT2)
GGO: 101150469(MOGAT3) 101154398(MOGAT1)
PON: 100433710(MOGAT1) 100439588(MOGAT3) 100441845(MOGAT2)
NLE: 100596253(MOGAT3) 100605131(MOGAT1)
MCC: 696347(MOGAT2) 705924(MOGAT1) 714110(MOGAT3)
MCF: 102116598(MOGAT3) 102126160(MOGAT2) 102137110(MOGAT1)
CSAB: 103217942(MOGAT1) 103246692(MOGAT3) 103248064(MOGAT2)
RRO: 104655897(MOGAT1) 104665099(MOGAT2) 104681186(MOGAT3)
RBB: 108518949(MOGAT3) 108520489(MOGAT1) 108545118
CJC: 100408165(MOGAT1) 100414557(MOGAT2) 100415057(MOGAT3)
SBQ: 101041944(MOGAT1) 101044301(MOGAT3) 101049123(MOGAT2)
MMU: 233549(Mogat2) 68393(Mogat1)
MCAL: 110299317(Mogat2) 110303698(Mogat1)
MPAH: 110313167(Mogat3) 110322495(Mogat1) 110335239(Mogat2)
RNO: 363261(Mogat1) 681211(Mogat2)
MUN: 110566219(Mogat2)
CGE: 100761111(Mogat1) 100766858(Mogat2) 100769277(Mogat3)
NGI: 103727773(Mogat1) 103733547(Mogat3) 103743020(Mogat2)
HGL: 101699301(Mogat2) 101724867(Mogat1) 106008984(Mogat3)
CCAN: 109680680(Mogat2) 109698829(Mogat1)
OCU: 100337776 100338028 100338285 100338537 100338786 100339034 100339280 100339783 100340033 100340292 100340546 100355098(MOGAT2) 100358092(MOGAT1) 100358919 103345701
TUP: 102471587(MOGAT3) 102491887(MOGAT1) 102493711(MOGAT2)
CFA: 485186(MOGAT2) 488548(MOGAT1) 608245(MOGAT3)
VVP: 112922501(MOGAT1) 112928600(MOGAT2) 112935765(MOGAT3)
AML: 100469063(MOGAT2) 100475025(MOGAT1) 100484228(MOGAT3)
UMR: 103662727(MOGAT1) 103670128(MOGAT3) 103678125(MOGAT2)
UAH: 113250405(MOGAT1) 113267836(MOGAT3) 113269333(MOGAT2)
ORO: 101364619(MOGAT1) 101380300(MOGAT3) 101384933(MOGAT2)
FCA: 101083285(MOGAT1) 101089413(MOGAT3) 101091142(MOGAT2)
PTG: 102952433(MOGAT2) 102961119(MOGAT1) 102971732(MOGAT3)
PPAD: 109250532(MOGAT3) 109264993(MOGAT1) 109267216(MOGAT2)
AJU: 106975907(MOGAT1) 106976448(MOGAT2) 106988105(MOGAT3)
BTA: 407225(MOGAT1) 407226(MOGAT2) 614494(MOGAT2) 618076 785379
BOM: 102264976(MOGAT2) 102269078 102269354 102269633 102283747 102285668(MOGAT1) 102286214
BIU: 109569305 109571263(MOGAT1) 109578860
BBUB: 102394721 102396022 102404551 102410065(MOGAT1) 102413012(MOGAT2) 102415643 112577784
CHX: 102172465 102173866(MOGAT2) 102185127(MOGAT1) 108633223 108633884
OAS: 101107135(MOGAT2) 101116385(MOGAT1) 101117229 101122246
SSC: 100312975(MOGAT2) 100524113(MOGAT1) 100624333
CFR: 102503858(MOGAT2) 102507541(MOGAT1) 102519554(MOGAT3)
CDK: 105092399(MOGAT3) 105097228 105106977(MOGAT1)
BACU: 103016634(MOGAT1) 103017989(MOGAT2) 103018879(MOGAT3)
LVE: 103074779(MOGAT2) 103081075(MOGAT1)
OOR: 101275555(MOGAT1) 101278069(MOGAT3) 101283107(MOGAT2)
DLE: 111172101(MOGAT1) 111182288(MOGAT3) 111184878(MOGAT2)
PCAD: 102976311(MOGAT1) 102991702(MOGAT2) 114484866
ECB: 100056612(MOGAT1) 100060232(MOGAT3) 100064445(MOGAT2)
EPZ: 103547278(MOGAT1) 103566972(MOGAT3)
EAI: 106832474(MOGAT1) 106839343(MOGAT3)
MYB: 102249575(MOGAT3) 102259678(MOGAT1) 102262485(MOGAT2)
MYD: 102753751(MOGAT2) 102755787(MOGAT3) 102772777(MOGAT1)
MNA: 107524490(MOGAT2) 107526563(MOGAT3) 107526683(MOGAT1)
HAI: 109385008(MOGAT3) 109386313(MOGAT2) 109396193(MOGAT1)
DRO: 112299548 112307992(MOGAT1) 112315048(MOGAT3) 112316112(MOGAT2)
PALE: 102880645(MOGAT1) 102881221(MOGAT3) 102884303(MOGAT2)
RAY: 107511755(MOGAT3) 107516779(MOGAT1)
MJV: 108395761 108398000(MOGAT1) 108404468(MOGAT2)
LAV: 100657481(MOGAT2) 100668790(MOGAT1)
TMU: 101342282 101356627 101361625
MDO: 100011167(MOGAT2) 100015756(MOGAT1) 100017805(MOGAT3)
SHR: 100920462(MOGAT1) 100922391(MOGAT3) 100927776(MOGAT2)
PCW: 110194267(MOGAT3) 110210562 110219480(MOGAT1)
OAA: 100087222(MOGAT2) 100089507(MOGAT3)
GGA: 424811(MOGAT1) 426437(MOGAT2)
MGP: 100548635(MOGAT2) 100550553(MOGAT1)
CJO: 107308595(MOGAT2) 107318019(MOGAT1)
NMEL: 110392124(MOGAT2) 110398341(MOGAT1)
APLA: 101796902(MOGAT1) 101799311(MOGAT2)
ACYG: 106036259(MOGAT1) 106042376(MOGAT2)
TGU: 100220494(MOGAT1) 100229675(MOGAT2)
LSR: 110471659(MOGAT2) 110483629(MOGAT1)
SCAN: 103815447(MOGAT1) 103823760(MOGAT2)
GFR: 102035698(MOGAT2) 102037615(MOGAT1)
FAB: 101810912(MOGAT2) 101815861(MOGAT1)
PHI: 102103506(MOGAT1) 102107960(MOGAT2)
PMAJ: 107206366(MOGAT2) 107208886(MOGAT1)
CCAE: 111933560(MOGAT1) 111941001(MOGAT2)
CCW: 104686962(MOGAT2) 104693028(MOGAT1)
ETL: 114059637(MOGAT2) 114067629(MOGAT1)
FPG: 101921029(MOGAT2) 101922229(MOGAT1)
FCH: 102051941(MOGAT2) 102055779(MOGAT1)
CLV: 102090921(MOGAT1) 102091066(MOGAT2)
EGZ: 104124769(MOGAT2) 104135472(MOGAT1)
NNI: 104012999(MOGAT1) 104022723(MOGAT2)
ACUN: 113480313(MOGAT2) 113483368(MOGAT1)
PADL: 103915172(MOGAT2) 103917849(MOGAT1)
AAM: 106485847(MOGAT1) 106500355(MOGAT2)
ASN: 102371385(MOGAT2) 102382527(MOGAT1) 112551244
AMJ: 102559021(MOGAT1) 102562878(MOGAT3) 106737648(MOGAT2)
PSS: 102443911(MOGAT3) 102449089(MOGAT1) 102453102(MOGAT2)
CMY: 102931086 102946170(MOGAT1)
CPIC: 101938904(MOGAT3) 101947245(MOGAT1) 101954169(MOGAT2)
ACS: 100551757(mogat2) 100560178(mogat1)
PVT: 110077436(MOGAT3) 110079961(MOGAT1) 110087793(MOGAT2)
PBI: 103057622 103062413
PMUR: 107285034(MOGAT3) 107298265
PMUA: 114582882 114582883 114582884 114583635 114595552(MOGAT2) 114597794(MOGAT1)
XLA: 380391(mogat1.L) 496214(mogat2.1.L) 735031(mogat2.2.L)
XTR: 100145079(mogat2.2) 496754(mogat2.1) 734060(mogat1)
NPR: 108796932(MOGAT1)
DRE: 100142647(mogat3a) 450063(mogat2)
SRX: 107747029
SANH: 107686211
SGH: 107579037
IPU: 108277044(mogat2)
PHYP: 113524169
AMEX: 103044205(mogat2)
EEE: 113589527(mogat2)
TRU: 101069338 101078703
LCO: 104931788(mogat2)
MZE: 101485302(mogat2)
ONL: 100711434(mogat2)
OLA: 101155218(mogat2)
XMA: 102228168 102236854(mogat2)
XCO: 114152537(mogat2)
PRET: 103476121(mogat2)
NFU: 107374388
KMR: 108244706(mogat2)
AOCE: 111572616(mogat2)
CSEM: 103394817(mogat2)
LCF: 108892326
SDU: 111222387(mogat2) 111236836
SLAL: 111663489(mogat2)
HCQ: 109531185
MALB: 109972878(mogat2)
SASA: 106567949 106581313
OTW: 112233380 112267252
SALP: 111950228 111960759
ELS: 105010983(mogat2)
SFM: 108936124(mogat2)
LCM: 102350286(MOGAT2)
CMK: 103175310(mogat1) 103188599
BFO: BRAFLDRAFT_206726
CIN: 100187260
SPU: 575101 584537
DME: Dmel_CG1941(CG1941) Dmel_CG1942(Dgat2) Dmel_CG1946(CG1946)
DER: 6541593 6542039 6542428
DSE: Dsec_GM20976 Dsec_GM20977 Dsec_GM20978
DYA: Dyak_GE19144 Dyak_GE19145 Dyak_GE19146
DAN: Dana_GF13197 Dana_GF13198 Dana_GF13199
DSR: 110185096 110191640 110191655
DPO: Dpse_GA15142 Dpse_GA15143 Dpse_GA24395
DPE: 6590849 6590850 6590975
DMN: 108158658 108160190
DWI: 6640009
DGR: Dgri_GH20316
DMO: Dmoj_GI19988
DAZ: 108615548
DNV: 108653670
DHE: 111595315
DVI: Dvir_GJ21238
LCQ: 111679543
AGA: AgaP_AGAP005949
AAG: 5571189
AALB: 109403232
CQU: CpipJ_CPIJ017146 CpipJ_CPIJ020206
AME: 409905
MPHA: 105829206
OBO: 105276184
NVI: 100118277
MDL: 103568751
TCA: 664032
ATD: 109603917
BMOR: 101735542
API: 100158996
AGS: 114121812
RMD: 113560406
PHU: Phum_PHUM441210
DPTE: 113794015
CEL: CELE_K07B1.4(K07B1.4) CELE_W01A11.2(dgtr-1)
CBR: CBG18949 CBG19252
BMY: Bm1_55350
TSP: Tsp_09229
MYI: 110463449
OBI: 106881532
LAK: 106177365
SMM: Smp_158510
NVE: NEMVE_v1g234918 NEMVE_v1g244419
PDAM: 113673846
SPIS: 111340240
HMG: 100211438 100213541
TAD: TRIADDRAFT_63184
SCE: YOR245C(DGA1)
AGO: AGOS_ACR140C
ERC: Ecym_2398
KLA: KLLA0_F11165g
LTH: KLTH0D11198g
VPO: Kpol_1013p5
ZRO: ZYRO0F07348g
CGR: CAGL0J03674g
NCS: NCAS_0B01630(NCAS0B01630)
NDI: NDAI_0E01160(NDAI0E01160)
TPF: TPHA_0D01250(TPHA0D01250)
TBL: TBLA_0C01870(TBLA0C01870)
PPA: PAS_chr3_0218
DHA: DEHA2C12122g
PIC: PICST_42763
LEL: LELG_02307
CLU: CLUG_00755
CLUS: A9F13_10g00099
NCR: NCU02665
PAN: PODANSg4167
MGR: MGG_00503
NHE: NECHADRAFT_74422
MAW: MAC_04591
MAJ: MAA_00233
BFU: BCIN_01g02790(Bcdga1)
ANI: AN8287.2
AFM: AFUA_7G03700
ANG: ANI_1_6114(An13g00040)
AFV: AFLA_097500
ACT: ACLA_005370
NFI: NFIA_024650
PCS: Pc20g09020
CIM: CIMG_07462
CPW: CPC735_044480
PBL: PAAG_00834
URE: UREG_07811
AJE: HCAG_04081
PNO: SNOG_03871
BZE: COCCADRAFT_108963
TML: GSTUM_00011528001
SPO: SPCC1235.15(dga1)
CNE: CNF00540
CNB: CNBF4150
CGI: CGB_F6040C
LBC: LACBIDRAFT_182082(DAGAT-4)
CCI: CC1G_09880
SCM: SCHCODRAFT_53861
UMA: UMAG_03937
MGL: MGL_2591
MBR: MONBRDRAFT_25681
DDI: DDB_G0290279(dgat2)
DPP: DICPUDRAFT_50994
TGO: TGME49_226370
PTM: GSPATT00018247001
PTI: PHATRDRAFT_43469
PIF: PITG_19730
EHX: EMIHUDRAFT_112304
GTT: GUITHDRAFT_100420
TBR: Tb927.3.1700
TCR: 510421.260
LMA: LMJF_25_1630
LIF: LINJ_25_1690
 » show all
Taxonomy
Reference
1  [PMID:4016575]
  Authors
Manganaro F, Kuksis A.
  Title
Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells.
  Journal
Can J Biochem Cell Biol 63:341-7 (1985)
DOI:10.1139/o85-050
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.22
IUBMB Enzyme Nomenclature: 2.3.1.22
ExPASy - ENZYME nomenclature database: 2.3.1.22
BRENDA, the Enzyme Database: 2.3.1.22
CAS: 9055-17-8

  All links  
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (7)   
   KEGG REACTION (4)   
   KEGG RCLASS (3)   
Gene (5502)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (467)   
   KEGG MGENES (44)   
   RefGene (4988)   
Protein sequence (128)   
   UniProt (90)   
   SWISS-PROT (12)   
   RefSeq(pep) (26)   
DNA sequence (51)   
   RefSeq(nuc) (30)   
   GenBank (15)   
   EMBL (6)   
All databases (5698)   

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