KEGG   ENZYME: 2.3.1.22Help
Entry
EC 2.3.1.22                 Enzyme                                 

Name
2-acylglycerol O-acyltransferase;
acylglycerol palmitoyltransferase;
monoglyceride acyltransferase;
acyl coenzyme A-monoglyceride acyltransferase;
monoacylglycerol acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
acyl-CoA:2-acylglycerol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 2-acylglycerol = CoA + diacylglycerol [RN:R01368]
Reaction(KEGG)
Substrate
acyl-CoA [CPD:C00040];
2-acylglycerol [CPD:C02112]
Product
CoA [CPD:C00010];
diacylglycerol [CPD:C00165]
Comment
Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate.
History
EC 2.3.1.22 created 1972, modified 1986, modified 1989
Pathway
ec00561  Glycerolipid metabolism
Orthology
K14456  2-acylglycerol O-acyltransferase 3
K14457  2-acylglycerol O-acyltransferase 2
K14458  2-acylglycerol O-acyltransferase 1
Genes
HSA: 116255(MOGAT1) 346606(MOGAT3) 80168(MOGAT2)
PTR: 466713(MOGAT2) 470662(MOGAT1) 472468(MOGAT3)
PPS: 100969446(MOGAT3) 100977021(MOGAT1) 100987539(MOGAT2)
GGO: 101150469(MOGAT3) 101154398(MOGAT1)
PON: 100433710(MOGAT1) 100439588(MOGAT3) 100441845(MOGAT2)
NLE: 100596253(MOGAT3) 100604531 100605131(MOGAT1)
MCC: 696347(MOGAT2) 705924(MOGAT1) 714110(MOGAT3)
MCF: 102116598(MOGAT3) 102126160(MOGAT2) 102137110(MOGAT1)
CSAB: 103217942(MOGAT1) 103246692(MOGAT3) 103248064(MOGAT2)
RRO: 104655897(MOGAT1) 104665099(MOGAT2) 104681186(MOGAT3)
RBB: 108518949(MOGAT3) 108520489(MOGAT1) 108545118
CJC: 100408165(MOGAT1) 100414557(MOGAT2) 100415057(MOGAT3)
SBQ: 101041944(MOGAT1) 101044301(MOGAT3) 101049123(MOGAT2)
MMU: 233549(Mogat2) 68393(Mogat1)
RNO: 363261(Mogat1) 681211(Mogat2)
CGE: 100761111(Mogat1) 100766858(Mogat2) 100769277(Mogat3)
NGI: 103727773(Mogat1) 103733547(Mogat3) 103743020(Mogat2)
HGL: 101699301(Mogat2) 101724867(Mogat1) 106008984(Mogat3)
CCAN: 109680680(Mogat2) 109698829(Mogat1)
TUP: 102471587(MOGAT3) 102491887(MOGAT1) 102493711(MOGAT2)
CFA: 485186(MOGAT2) 488548(MOGAT1) 608245(MOGAT3)
AML: 100469063(MOGAT2) 100475025(MOGAT1) 100484228(MOGAT3)
UMR: 103662727(MOGAT1) 103670128(MOGAT3) 103678125(MOGAT2)
ORO: 101364619(MOGAT1) 101380300(MOGAT3) 101384933(MOGAT2)
FCA: 101083285(MOGAT1) 101089413(MOGAT3) 101091142(MOGAT2)
PTG: 102952433(MOGAT2) 102961119(MOGAT1) 102971732(MOGAT3)
AJU: 106975907(MOGAT1) 106976448(MOGAT2) 106988105(MOGAT3)
BTA: 407225(MOGAT1) 407226(MOGAT2) 614494(MOGAT2) 618076 785379
PHD: 102324291(MOGAT1) 102324317(MOGAT3) 102339596(MOGAT2) 102341020 102341659
SSC: 100312975(MOGAT2) 100524113(MOGAT1) 100624333
CFR: 102503858(MOGAT2) 102507541(MOGAT1) 102519554(MOGAT3)
CDK: 105092399(MOGAT3) 105097228 105106977(MOGAT1)
BACU: 103016634(MOGAT1) 103017989(MOGAT2) 103018879(MOGAT3)
LVE: 103074779(MOGAT2) 103081075(MOGAT1)
OOR: 101275555(MOGAT1) 101278069(MOGAT3) 101283107(MOGAT2)
ECB: 100056612(MOGAT1) 100060232(MOGAT3) 100064445(MOGAT2)
EPZ: 103547278(MOGAT1) 103566972(MOGAT3)
EAI: 106832474(MOGAT1) 106839343(MOGAT3)
MYB: 102249575(MOGAT3) 102259678(MOGAT1) 102262485(MOGAT2)
MYD: 102753751(MOGAT2) 102755787(MOGAT3) 102772777(MOGAT1)
HAI: 109385008(MOGAT3) 109386313(MOGAT2) 109396193(MOGAT1)
RSS: 109444813(MOGAT2) 109458775(MOGAT3) 109459323(MOGAT1)
PALE: 102880645(MOGAT1) 102881221(MOGAT3) 102884303(MOGAT2)
LAV: 100657481(MOGAT2) 100668790(MOGAT1)
MDO: 100011167(MOGAT2) 100015756(MOGAT1) 100017805(MOGAT3)
SHR: 100920462(MOGAT1) 100922391(MOGAT3) 100927776(MOGAT2)
OAA: 100087222(MOGAT2) 100089507(MOGAT3)
GGA: 424811(MOGAT1) 426437(MOGAT2)
MGP: 100548635(MOGAT2) 100550553(MOGAT1)
CJO: 107308595(MOGAT2) 107318019(MOGAT1)
APLA: 101796902(MOGAT1) 101799311(MOGAT2)
ACYG: 106036259(MOGAT1) 106042376(MOGAT2)
TGU: 100220494(MOGAT1) 100229675(MOGAT2)
GFR: 102035698(MOGAT2) 102037615(MOGAT1)
FAB: 101810912(MOGAT2) 101815861(MOGAT1)
PHI: 102103506(MOGAT1) 102107960(MOGAT2)
PMAJ: 107206366(MOGAT2) 107208886(MOGAT1)
CCW: 104686962(MOGAT2) 104693028(MOGAT1)
FPG: 101921029(MOGAT2) 101922229(MOGAT1)
FCH: 102051941(MOGAT2) 102055779(MOGAT1)
CLV: 102090921(MOGAT1) 102091066(MOGAT2)
EGZ: 104124769(MOGAT2) 104135472(MOGAT1)
AAM: 106485847(MOGAT1) 106500355(MOGAT2)
ASN: 102371385(MOGAT2) 102382527(MOGAT1) 112551244
AMJ: 102559021(MOGAT1) 102562878(MOGAT3) 106737648(MOGAT2)
PSS: 102443911(MOGAT3) 102449089(MOGAT1) 102453102(MOGAT2)
CMY: 102931086 102946170(MOGAT1)
CPIC: 101938904(MOGAT3) 101947245(MOGAT1) 101954169(MOGAT2)
ACS: 100551757(mogat2) 100560178(mogat1)
PVT: 110077436(MOGAT3) 110079961(MOGAT1) 110087793(MOGAT2)
XLA: 380391(mogat1.L) 496214(mogat2.1.L) 735031(mogat2.2.L)
XTR: 100145079(mogat2.2) 496754(mogat2.1) 734060(mogat1)
NPR: 108796932(MOGAT1)
DRE: 100142647(mogat3a) 450063(mogat2)
SRX: 107747029
SANH: 107686211
SGH: 107579037
IPU: 108277044(mogat2)
AMEX: 103044205(mogat2)
LCO: 104931788(mogat2)
MZE: 101485302(mogat2)
OLA: 101155218(mogat2)
XMA: 102228168 102236854(mogat2)
PRET: 103476121(mogat2)
NFU: 107374388
KMR: 108244706(mogat2)
CSEM: 103394817(mogat2)
LCF: 108892326
SDU: 111222387(mogat2) 111236836
HCQ: 109531185
MALB: 109972878(mogat2)
ELS: 105010983(mogat2)
SFM: 108936124(mogat2)
LCM: 102350286(MOGAT2)
CMK: 103175310(mogat1) 103188599
CIN: 100187260
DME: Dmel_CG1941(CG1941) Dmel_CG1942(CG1942) Dmel_CG1946(CG1946)
DWI: 6640009
AAG: 5571189
AME: 409905
NVI: 100118277
MDL: 103568751
TCA: 664032
BMOR: 101735542
API: 100158996
CEL: CELE_K07B1.4(K07B1.4) CELE_W01A11.2(dgtr-1)
BMY: Bm1_55350
TSP: Tsp_09229
MYI: 110463449
OBI: 106881532
LAK: 106177365
SCE: YOR245C(DGA1)
ERC: Ecym_2398
NCS: NCAS_0B01630(NCAS0B01630)
NDI: NDAI_0E01160(NDAI0E01160)
TPF: TPHA_0D01250(TPHA0D01250)
TBL: TBLA_0C01870(TBLA0C01870)
NCR: NCU02665
MGR: MGG_00503
MAW: MAC_04591
MAJ: MAA_00233
BFU: BCIN_01g02790(Bcdga1)
ANI: AN8287.2
ANG: ANI_1_6114(An13g00040)
SPO: SPCC1235.15(dga1)
CNE: CNF00540
CNB: CNBF4150
LBC: LACBIDRAFT_182082(DAGAT-4)
MGL: MGL_2591
DDI: DDB_G0290279(dgat2)
 » show all
Taxonomy
Reference
1  [PMID:4016575]
  Authors
Manganaro F, Kuksis A.
  Title
Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells.
  Journal
Can J Biochem Cell Biol 63:341-7 (1985)
DOI:10.1139/o85-050
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.22
IUBMB Enzyme Nomenclature: 2.3.1.22
ExPASy - ENZYME nomenclature database: 2.3.1.22
BRENDA, the Enzyme Database: 2.3.1.22
CAS: 9055-17-8

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