KEGG   ENZYME: 2.3.1.22
Entry
EC 2.3.1.22                 Enzyme                                 

Name
2-acylglycerol O-acyltransferase;
acylglycerol palmitoyltransferase;
monoglyceride acyltransferase;
acyl coenzyme A-monoglyceride acyltransferase;
monoacylglycerol acyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acyl-CoA:2-acylglycerol O-acyltransferase
Reaction(IUBMB)
acyl-CoA + 2-acylglycerol = CoA + diacylglycerol [RN:R01368]
Reaction(KEGG)
R01368 > R03838;
(other) R03755 R03756
Substrate
acyl-CoA [CPD:C00040];
2-acylglycerol [CPD:C02112]
Product
CoA [CPD:C00010];
diacylglycerol [CPD:C00165]
Comment
Various 2-acylglycerols can act as acceptor; palmitoyl-CoA and other long-chain acyl-CoAs can act as donors. The sn-1 position and the sn-3 position are both acylated, at about the same rate.
History
EC 2.3.1.22 created 1972, modified 1986, modified 1989
Pathway
ec00561  Glycerolipid metabolism
Orthology
K14456  2-acylglycerol O-acyltransferase 3
K14457  2-acylglycerol O-acyltransferase 2
K14458  2-acylglycerol O-acyltransferase 1
Genes
HSA: 116255(MOGAT1) 346606(MOGAT3) 80168(MOGAT2)
PTR: 466713(MOGAT2) 470662(MOGAT1) 472468(MOGAT3)
PPS: 100969446(MOGAT3) 100977021(MOGAT1) 100987539(MOGAT2)
GGO: 101150469(MOGAT3) 101154398(MOGAT1) 109025074(MOGAT2)
PON: 100433710(MOGAT1) 100439588(MOGAT3) 100441845(MOGAT2)
NLE: 100590333(MOGAT2) 100596253(MOGAT3) 100605131(MOGAT1)
MCC: 696347(MOGAT2) 705924(MOGAT1) 714110(MOGAT3)
MCF: 102116598(MOGAT3) 102126160(MOGAT2) 102137110(MOGAT1)
CSAB: 103217942(MOGAT1) 103246692(MOGAT3) 103248064(MOGAT2)
RRO: 104655897(MOGAT1) 104665099(MOGAT2) 104681186(MOGAT3)
RBB: 108518949(MOGAT3) 108520489(MOGAT1) 108545118
CJC: 100408165(MOGAT1) 100414557(MOGAT2) 100415057(MOGAT3)
SBQ: 101041944(MOGAT1) 101044301(MOGAT3) 101049123(MOGAT2)
MMU: 233549(Mogat2) 68393(Mogat1)
MCAL: 110299317(Mogat2) 110303698(Mogat1)
MPAH: 110313167(Mogat3) 110322495(Mogat1) 110335239(Mogat2)
RNO: 363261(Mogat1) 681211(Mogat2) 685560(Mogat3)
MUN: 110566219(Mogat2)
CGE: 100761111(Mogat1) 100766858(Mogat2) 100769277(Mogat3)
NGI: 103727773(Mogat1) 103733547(Mogat3) 103743020(Mogat2)
HGL: 101699301(Mogat2) 101702032 101724867(Mogat1) 106008984(Mogat3)
CCAN: 109680680(Mogat2) 109698829(Mogat1)
OCU: 100337776 100338028 100338285 100338537 100338786 100339034 100339280 100339783 100340033 100340292 100340546 100355098(MOGAT2) 100358092(MOGAT1) 100358919 100359181 103345697 103345701
TUP: 102471587(MOGAT3) 102491887(MOGAT1) 102493711(MOGAT2)
CFA: 485186(MOGAT2) 488548(MOGAT1) 608245(MOGAT3)
VVP: 112922501(MOGAT1) 112928600(MOGAT2) 112935765(MOGAT3)
AML: 100469063(MOGAT2) 100475025(MOGAT1) 100484228(MOGAT3)
UMR: 103662727(MOGAT1) 103670128(MOGAT3) 103678125(MOGAT2)
UAH: 113250405(MOGAT1) 113267836(MOGAT3) 113269333(MOGAT2)
ORO: 101364619(MOGAT1) 101380300(MOGAT3) 101384933(MOGAT2)
ELK: 111141502 111145496 111159631
FCA: 101083285(MOGAT1) 101089413(MOGAT3) 101091142(MOGAT2)
PTG: 102952433(MOGAT2) 102961119(MOGAT1) 102971732(MOGAT3)
PPAD: 109250532(MOGAT3) 109264993(MOGAT1) 109267216(MOGAT2)
AJU: 106975907(MOGAT1) 106976448(MOGAT2) 106988105(MOGAT3)
BTA: 407225(MOGAT1) 407226(MOGAT2) 614494(MOGAT2) 618076 785379
BOM: 102264976(MOGAT2) 102269078 102269354 102269633 102283176 102283747 102285668(MOGAT1) 102286214
BIU: 109569294 109569305 109571263(MOGAT1) 109578860
BBUB: 102394721 102396022 102404551 102405208 102410065(MOGAT1) 102413012(MOGAT2) 102415643 112577784
CHX: 102172465 102173866(MOGAT2) 102179090 102185127(MOGAT1) 102190037 108633223 108633884
OAS: 101107135(MOGAT2) 101107387 101110266 101116385(MOGAT1) 101117229 101122246 101122934
SSC: 100312975(MOGAT2) 100524113(MOGAT1) 100624333
CFR: 102503858 102507541(MOGAT1) 102508299(MOGAT2) 102519554(MOGAT3)
CDK: 105092399(MOGAT3) 105097228 105106977(MOGAT1)
BACU: 103016634(MOGAT1) 103017989(MOGAT2) 103018879(MOGAT3)
LVE: 103074779(MOGAT2) 103081075(MOGAT1)
OOR: 101275555(MOGAT1) 101278069(MOGAT3) 101283107(MOGAT2)
DLE: 111172101(MOGAT1) 111182288(MOGAT3) 111184878(MOGAT2)
PCAD: 102976311(MOGAT1) 102991702(MOGAT2) 114484866
ECB: 100056612(MOGAT1) 100060232(MOGAT3) 100064445(MOGAT2)
EPZ: 103547278(MOGAT1) 103566972(MOGAT3)
EAI: 106832474(MOGAT1) 106839343(MOGAT3)
MYB: 102238718 102249575(MOGAT3) 102259678(MOGAT1) 102262485(MOGAT2)
MYD: 102753751(MOGAT2) 102755787(MOGAT3) 102772777(MOGAT1)
MNA: 107524490(MOGAT2) 107526563(MOGAT3) 107526683(MOGAT1)
HAI: 109385007 109385008(MOGAT3) 109386313(MOGAT2) 109396193(MOGAT1)
DRO: 112307992(MOGAT1) 112315048(MOGAT3) 112316112(MOGAT2)
PALE: 102880645(MOGAT1) 102881221(MOGAT3) 102884303(MOGAT2)
RAY: 107511755(MOGAT3) 107516779(MOGAT1)
MJV: 108395761 108395765 108398000(MOGAT1) 108404468(MOGAT2)
LAV: 100657481(MOGAT2) 100668790(MOGAT1)
TMU: 101342282 101356627 101361625
MDO: 100011167(MOGAT2) 100015756(MOGAT1) 100017805(MOGAT3)
SHR: 100920462(MOGAT1) 100922391(MOGAT3) 100927776(MOGAT2)
PCW: 110194267(MOGAT3) 110210562 110219480(MOGAT1)
OAA: 100087222(MOGAT2) 100089507(MOGAT3) 100090636
GGA: 424811(MOGAT1) 426437(MOGAT2)
MGP: 100548635(MOGAT2) 100550553(MOGAT1)
CJO: 107308595(MOGAT2) 107318019(MOGAT1)
NMEL: 110392124(MOGAT2) 110398341(MOGAT1)
APLA: 101796902(MOGAT1) 101799311(MOGAT2)
ACYG: 106036259(MOGAT1) 106042376(MOGAT2)
TGU: 100220494(MOGAT1) 100229675(MOGAT2)
LSR: 110471659(MOGAT2) 110483629(MOGAT1) 116184728
SCAN: 103815447(MOGAT1) 103823760(MOGAT2)
GFR: 102035698(MOGAT2) 102037615(MOGAT1)
FAB: 101810912(MOGAT2) 101815861(MOGAT1)
PHI: 102103506(MOGAT1) 102107960(MOGAT2)
PMAJ: 107206366(MOGAT2) 107208886(MOGAT1)
CCAE: 111933560(MOGAT1) 111941001(MOGAT2)
CCW: 104686962(MOGAT2) 104693028(MOGAT1)
ETL: 114059637(MOGAT2) 114067629(MOGAT1)
FPG: 101921029(MOGAT2) 101922229(MOGAT1)
FCH: 102051941(MOGAT2) 102055779(MOGAT1)
CLV: 102090921(MOGAT1) 102091066(MOGAT2)
EGZ: 104124769(MOGAT2) 104135472(MOGAT1)
NNI: 104012999(MOGAT1) 104022723(MOGAT2)
ACUN: 113480313(MOGAT2) 113483368(MOGAT1)
PADL: 103915172(MOGAT2) 103917849(MOGAT1)
AAM: 106485847(MOGAT1) 106500355(MOGAT2)
ASN: 102371385(MOGAT2) 102382527(MOGAT1) 112551244
AMJ: 102559021(MOGAT1) 102562878(MOGAT3) 106737648(MOGAT2)
PSS: 102443911(MOGAT3) 102449089(MOGAT1) 102453102(MOGAT2)
CMY: 102931086(MOGAT2) 102946170(MOGAT1)
CPIC: 101938632 101938904(MOGAT3) 101947245(MOGAT1) 101954169(MOGAT2)
ACS: 100551757(mogat2) 100560178(mogat1)
PVT: 110077435 110077436(MOGAT3) 110079961(MOGAT1) 110087793(MOGAT2)
PBI: 103057622 103062413 103062657
PMUR: 107285034(MOGAT3) 107285035 107298265
PMUA: 114582565 114582882 114582883 114582884 114583635 114595552(MOGAT2) 114597794(MOGAT1)
XLA: 380391(mogat1.L) 496214(mogat2.1.L) 735031(mogat2.2.L)
XTR: 100145079(mogat2.2) 496754(mogat2.1) 734060(mogat1)
NPR: 108796932(MOGAT1)
DRE: 100142647(mogat3a) 450063(mogat2)
SRX: 107737975 107747029 107751377
SANH: 107681651 107686211 107691703
SGH: 107566544 107572974 107579037 107589716
IPU: 108275695 108277044(mogat2)
PHYP: 113524169 113525607
AMEX: 103035469 103044205(mogat2)
EEE: 113589527(mogat2)
TRU: 101069338 101078703
TNG: GSTEN00016293G001
LCO: 104931788(mogat2)
MZE: 101474401 101485302(mogat2)
ONL: 100709478 100711434(mogat2)
OLA: 101155218(mogat2)
XMA: 102228168 102236854(mogat2)
XCO: 114140606 114152537(mogat2)
PRET: 103476121(mogat2)
CVG: 107097474(mogat2)
NFU: 107374388 107386009(mogat2)
KMR: 108228928(mogat3a) 108244706(mogat2)
ALIM: 106517202(mogat2) 106535571
AOCE: 111572616(mogat2)
CSEM: 103392138 103394817(mogat2)
POV: 109628351(mogat2)
LCF: 108882206 108892326 108894038(mogat2)
SDU: 111222387(mogat2) 111236836
SLAL: 111663489(mogat2) 111673615
HCQ: 109516537 109531185
BPEC: 110160252 110165147(mogat2)
MALB: 109962023 109972878(mogat2)
SASA: 106567949 106581313
OTW: 112222911 112233380 112245079 112257828 112267252
SALP: 111950228 111960759 111981044 111982555 112072501
ELS: 105008562 105010983(mogat2)
SFM: 108923191 108936124(mogat2)
PKI: 111834967
LCM: 102350286(MOGAT2)
CMK: 103175310(mogat1) 103188599 103190917
RTP: 109921416(mogat1)
BFO: 118428158
CIN: 100187260
SPU: 575101 584537
DME: Dmel_CG1941(CG1941) Dmel_CG1942(Dgat2) Dmel_CG1946(CG1946)
DER: 6541593 6542039 6542428
DSE: 6608047 6608048 6608049
DSI: Dsimw501_GD10504(Dsim_GD10504) Dsimw501_GD10505(Dsim_GD10505) Dsimw501_GD15355(Dsim_GD15355)
DYA: Dyak_GE19144 Dyak_GE19145 Dyak_GE19146
DAN: 6496040 6496041
DSR: 110185096 110191640 110191655
DPO: Dpse_GA15142 Dpse_GA15143 Dpse_GA24395
DPE: 6590849 6590850 6590975
DMN: 108158657 108158658 108160190 117190967 117191418
DWI: 6640009
DGR: Dgri_GH20316
DMO: Dmoj_GI19988
DAZ: 108615548
DNV: 108653670
DHE: 111595315
DVI: 6626307
LCQ: 111679543
AGA: AgaP_AGAP005949
AAG: 5571189
AALB: 109403232
CQU: CpipJ_CPIJ017146 CpipJ_CPIJ020206
AME: 409905
SOC: 105198598
MPHA: 105829206
ACEP: 105625934
PBAR: 105425401
OBO: 105276184
NVI: 100118277
MDL: 103568751
TCA: 664032
ATD: 109603917
BMOR: 101735542
BMAN: 114253298
API: 100158996
DNX: 107163290
AGS: 114121812
RMD: 113560406
BTAB: 109038694
PHU: Phum_PHUM441210
PVM: 113824685
DPTE: 113794015
CEL: CELE_K07B1.4(K07B1.4) CELE_W01A11.2(dgtr-1)
CBR: CBG18949 CBG19252
BMY: Bm1_55350
TSP: Tsp_09229
MYI: 110463449
OBI: 106881532
LAK: 106177365
SMM: Smp_158510
NVE: 5509933 5510156 5512671 5512972 5517920
EPA: 110241442
PDAM: 113673846
SPIS: 111340240
HMG: 100211438 100213541
TAD: TRIADDRAFT_63184
SCE: YOR245C(DGA1)
AGO: AGOS_ACR140C
ERC: Ecym_2398
KLA: KLLA0_F11165g
LTH: KLTH0D11198g
VPO: Kpol_1013p5
ZRO: ZYRO0F07348g
CGR: CAGL0J03674g
NCS: NCAS_0B01630(NCAS0B01630)
NDI: NDAI_0E01160(NDAI0E01160)
TPF: TPHA_0D01250(TPHA0D01250)
TBL: TBLA_0C01870(TBLA0C01870)
ZMK: HG535_0A06120
PPA: PAS_chr3_0218
DHA: DEHA2C12122g
PIC: PICST_42763
LEL: LELG_02307
CLU: CLUG_00755
CLUS: A9F13_10g00099
BNN: FOA43_001463 FOA43_001464
NCR: NCU02665
NTE: NEUTE1DRAFT119028(NEUTE1DRAFT_119028)
SMP: SMAC_04324
PAN: PODANSg4167
MGR: MGG_00503
NHE: NECHADRAFT_74422
MAW: MAC_04591
MAJ: MAA_00233
BFU: BCIN_01g02790(Bcdga1)
ANI: AN8287.2
AFM: AFUA_7G03700
ACT: ACLA_005370
NFI: NFIA_024650
AOR: AO090026000845
ANG: ANI_1_6114(An13g00040)
PCS: Pc20g09020
PDP: PDIP_01780
TMF: PMAA_069560
TRG: TRUGW13939_09667
CIM: CIMG_07462
CPW: CPC735_044480
PBL: PAAG_00834
PBN: PADG_03998
URE: UREG_07811
ABE: ARB_00957
AJE: HCAG_04081
BGH: BDBG_01688
PNO: SNOG_03871
PTE: PTT_14559
BZE: COCCADRAFT_108963
BSC: COCSADRAFT_183068
BOR: COCMIDRAFT_5096
AALT: CC77DRAFT_1040090
TML: GSTUM_00011528001
SPO: SPCC1235.15(dga1)
CNE: CNF00540
CNB: CNBF4150
CGI: CGB_F6040C
TASA: A1Q1_05353
LBC: LACBIDRAFT_182082(DAGAT-4)
CCI: CC1G_09880
SCM: SCHCODRAFT_53861
UMA: UMAG_03937
MGL: MGL_2591
MRT: MRET_0496
MSYM: MSY001_0243
MBR: MONBRDRAFT_25681
DDI: DDB_G0290279(dgat2)
DPP: DICPUDRAFT_50994
TGO: TGME49_226370
PTM: GSPATT00018247001
PIF: PITG_19730
EHX: EMIHUDRAFT_112304
GTT: GUITHDRAFT_100420
TBR: Tb927.3.1700
TBG: TbgDal_III1540
TCR: 510421.260
LMA: LMJF_25_1630
LIF: LINJ_25_1690
LDO: LDBPK_251690
LMI: LMXM_25_1630
LPAN: LPMP_251690
 » show all
Reference
1  [PMID:4016575]
  Authors
Manganaro F, Kuksis A.
  Title
Purification and preliminary characterization of 2-monoacylglycerol acyltransferase from rat intestinal villus cells.
  Journal
Can J Biochem Cell Biol 63:341-7 (1985)
DOI:10.1139/o85-050
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.22
IUBMB Enzyme Nomenclature: 2.3.1.22
ExPASy - ENZYME nomenclature database: 2.3.1.22
BRENDA, the Enzyme Database: 2.3.1.22
CAS: 9055-17-8

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Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (7)   
   KEGG REACTION (4)   
   KEGG RCLASS (3)   
Gene (5639)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (567)   
   KEGG MGENES (81)   
   RefGene (4988)   
Protein sequence (125)   
   UniProt (73)   
   SWISS-PROT (14)   
   RefSeq(pep) (38)   
DNA sequence (64)   
   RefSeq(nuc) (42)   
   GenBank (16)   
   EMBL (6)   
Protein domain (3)   
   InterPro (3)   
All databases (5848)   

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