KEGG ENZYME: 2.3.1.221

ENZYME: 2.3.1.221

Entry

EC 2.3.1.221                Enzyme

Name

noranthrone synthase;
polyketide synthase A (ambiguous);
PksA (ambiguous);
norsolorinic acid anthrone synthase

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

malonyl-CoA:hexanoate malonyltransferase (norsolorinic acid anthrone-forming)

Reaction(IUBMB)

7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O [RN:R10239]

Reaction(KEGG)

R10239

Substrate

malonyl-CoA [CPD:C00083];
hexanoyl-[acyl-carrier protein] [CPD:C05749]

Product

CoA [CPD:C00010];
norsolorinic acid anthrone [CPD:C20453];
[acyl-carrier protein] [CPD:C00229];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

A multi-domain polyketide synthase involved in the synthesis of aflatoxins in the fungus Aspergillus parasiticus. The hexanoyl starter unit is provided to the acyl-carrier protein (ACP) domain by a dedicated fungal fatty acid synthase [1].

History

EC 2.3.1.221 created 2013

Pathway

ec00254

Aflatoxin biosynthesis

ec01100

Metabolic pathways

ec01110

Biosynthesis of secondary metabolites

Orthology

K15316

noranthrone synthase

Genes

PAN:	PODANSg8570

GLZ:	GLAREA_01150

ANI:

AN7825.2

AOR:	AO090026000009

AFV:	AFLA_006311

APUU:

APUU_20037A

CIM:	CIMG_08569

CPW:	CPC735_062240

FFU:	CLAFUR5_14164

BCOM:

BAUCODRAFT_62024

Reference

1 [PMID:18403714]

Authors

Crawford JM, Thomas PM, Scheerer JR, Vagstad AL, Kelleher NL, Townsend CA

Title

Deconstruction of iterative multidomain polyketide synthase function.

Journal

Science 320:243-6 (2008)
DOI:10.1126/science.1154711

Reference

2 [PMID:19847268]

Authors

Crawford JM, Korman TP, Labonte JW, Vagstad AL, Hill EA, Kamari-Bidkorpeh O, Tsai SC, Townsend CA

Title

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.

Journal

Nature 461:1139-43 (2009)
DOI:10.1038/nature08475

Reference

3 [PMID:20332208]

Authors

Korman TP, Crawford JM, Labonte JW, Newman AG, Wong J, Townsend CA, Tsai SC

Title

Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.

Journal

Proc Natl Acad Sci U S A 107:6246-51 (2010)
DOI:10.1073/pnas.0913531107

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.221

IUBMB Enzyme Nomenclature:

2.3.1.221

ExPASy - ENZYME nomenclature database:

2.3.1.221

BRENDA, the Enzyme Database:

2.3.1.221

DBGET integrated database retrieval system