KEGG ENZYME: 2.3.1.223

ENZYME: 2.3.1.223

Entry

EC 2.3.1.223                Enzyme

Name

3-oxo-5,6-didehydrosuberyl-CoA thiolase;
paaJ (gene name)

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

2,3-didehydroadipoyl-CoA:acetyl-CoA C-didehydroadipoyltransferase (double bond migration)

Reaction(IUBMB)

2,3-didehydroadipoyl-CoA + acetyl-CoA = CoA + 3-oxo-5,6-didehydrosuberoyl-CoA [RN:R09839]

Reaction(KEGG)

R09839

Substrate

2,3-didehydroadipoyl-CoA;
acetyl-CoA [CPD:C00024]

Product

CoA [CPD:C00010];
3-oxo-5,6-didehydrosuberoyl-CoA [CPD:C19945]

Comment

The enzyme acts in the opposite direction. The enzymes from the bacteria Escherichia coli and Pseudomonas sp. Y2 also have the activity of EC 2.3.1.174 (3-oxoadipyl-CoA thiolase).

History

EC 2.3.1.223 created 2013

Pathway

ec00360

Phenylalanine metabolism

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K02615

3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase

Genes

ECO:	b1397(paaJ)

ECJ:	JW1392(paaJ)

ECD:	ECDH10B_1522(paaJ)

EBW:	BWG_1226(paaJ)

ECOC:

C3026_08150

EOI:	ECO111_1791(paaJ)

EOJ:	ECO26_2001(paaJ)

EOH:	ECO103_1534(paaJ)

ESL:

O3K_13485

ESO:

O3O_12145

ESM:

O3M_13460

ECK:	EC55989_1533(paaE)

ELH:

ETEC_1472

ECW:	EcE24377A_1582(pcaF)

EUN:	UMNK88_1804(pcaF)

ECOA:

APECO78_10720

ECX:	EcHS_A1484(pcaF)

ECY:

ECSE_1482

ECR:	ECIAI1_1397(paaE)

ECL:	EcolC_2258

EKO:	EKO11_2416

EKF:	KO11_15245(paaJ)

EDH:	EcDH1_2248

EDJ:	ECDH1ME8569_1341(paaJ)

ELW:	ECW_m1531(paaE)

ELL:	WFL_07480(paaJ)

ELP:	P12B_c1729(paaJ)

ECOL:

LY180_07305(fadA)

EFE:	EFER_1599(paaE)

ENC:

ECL_02144

ENL:	A3UG_10385

ECLG:

EC036_20150

ECLE:

ECNIH2_10960

ECLN:

ECNIH4_12375

ECLI:

ECNIH5_11680

ECLX:

LI66_10290

ECLY:

LI62_11085

ECLZ:

LI64_10435

ECLO:

ENC_11610

EHM:	AB284_14710

EXF:	BFV63_10475

ECLA:

ECNIH3_10110

ECLC:

ECR091_10080

EAU:	DI57_08490

EKB:	BFV64_10715

ENO:	ECENHK_10350

EEC:	EcWSU1_02062(paaJ)

ELG:	BH714_06565

ECAN:

CWI88_12185(pcaF)

ERN:	BFV67_09870

ECHG:

FY206_11755(pcaF)

ESH:	C1N69_10565(pcaF)

EPT:	HWQ17_02335(pcaF)

EAS:	Entas_2035

ENX:	NI40_010475

LNI:	CWR52_01805(pcaF)

EBG:	FAI37_18900(pcaF)

END:	A4308_14985

ENZ:	G0034_10475(pcaF)

ENS:	HWQ15_18975(pcaF)

ENK:	LOC22_20740(pcaF)

EHU:	D5067_0012385(pcaF)

EMOR:

L6Y89_10150(pcaF)

ENB:	ELK40_10675(pcaF)

EQU:	OM418_10210(pcaF)

EPU:	QVH39_10640(pcaF)

EDY:	F0320_10080(pcaF)

KPN:	KPN_01478(paaJ)

KPU:	KP1_2481(paaJ)

KPM:	KPHS_23780

KPP:

A79E_2761

KPH:	KPNIH24_16325

KPZ:	KPNIH27_11595

KPV:	KPNIH29_11820

KPW:	KPNIH30_12360

KPY:	KPNIH31_11445

KPG:	KPNIH32_12200

KPC:	KPNIH10_11905

KPQ:	KPR0928_11915

KPT:	VK055_1032(pcaF2)

KPO:	KPN2242_10170

KPR:	KPR_2865(paaJ)

KPJ:

N559_2853

KPI:	D364_07240

KPA:	KPNJ1_03019

KPS:	KPNJ2_03019

KPX:	PMK1_03796(paaJ)

KPB:	FH42_03285

KPNE:

KU54_014300

KPNU:

LI86_14235

KPNK:

BN49_2540(paaJ)

KVA:

Kvar_2889

KPE:	KPK_2991(paaJ)

KPK:	A593_21895

KVD:	KR75_19720

KVQ:	SP68_00755

KQU:	AVR78_16440

KQV:	B8P98_15225(pcaF)

KOX:

KOX_19465

KOE:

A225_2763

KOM:	HR38_17795

KMI:	VW41_11785

KOK:	KONIH1_13535

KOC:	AB185_21665

EAE:

EAE_20470

EAR:

CCG29786

KLL:	BJF97_13680

KLW:	DA718_15530(pcaF)

KAR:	LGL98_13920(pcaF)

KGR:	JJJ10_15215(pcaF)

KPAS:

LUW96_19980(pcaF)

KLC:	K7H21_13200(pcaF)

KLM:	BWI76_13135

REE:	electrica_02710(paaJ)

KLP:	GUC22_14205(pcaF)

ROR:	RORB6_07500

RON:	TE10_13035

RPLN:

B1209_14625

RAO:	DSD31_14125(pcaF)

CYO:	CD187_14230(pcaF)

CPOT:

FOB25_01975(pcaF)

CENS:

P2W74_11660(pcaF)

CITR:

GUC46_14405(pcaF)

EBT:	EBL_c16650(paaJ)

CNT:	JT31_00510

CEM:	LH23_16500

CEN:	LH86_15490

PGE:	LG71_17815

ESC:	Entcl_2413

KLE:	AO703_10170

KIE:	NCTC12125_01344(paaJ)

KAS:	KATP_22180

KLU:	K7B04_17200(pcaF)

KCY:	RIN60_11655(pcaF)

LAX:	APT61_10070

LEI:	C2U54_17495(pcaF)

LEH:	C3F35_22350(pcaF)

LEE:	DVA44_10910(pcaF)

LER:	GNG29_12035(pcaF)

LEA:	GNG26_12275(pcaF)

LPNU:

KQ929_09245(pcaF)

LEY:	DVA43_05280(pcaF)

LAZ:	A8A57_10350

LEF:	LJPFL01_2009

LEW:	DAI21_16085(pcaF)

BUF:	D8682_03060(pcaF)

BAGE:

BADSM9389_21450(pcaF)

BFT:	MNO13_12410(pcaF)

BSEL:

RHD99_11690(pcaF)

YRE:	HEC60_05185(pcaF)

SGOE:

A8O29_012285(pcaF)

PSGC:

G163CM_13720(paaJ)

TOE:	QMG90_10770(pcaF)

EBF:

D782_2323

EBU:	CUC76_03660(pcaF)

EBB:

F652_219

SMAR:

SM39_2563(paaJ)

SMAC:

SMDB11_2355(paaJ)

SMW:	SMWW4_v1c31030(paaJ)

SPE:

Spro_3081

SPLY:

Q5A_016025(paaJ)

SMAF:

D781_2889

SLQ:	M495_15715

SERF:

L085_13115

SERS:

SERRSCBI_14890

SFW:	WN53_24250

SFG:	AV650_19985

SRZ:	AXX16_2183

SERM:

CLM71_15005(pcaF)

SQU:	E4343_00615(pcaF)

SFJ:	SAMEA4384070_3131(paaJ)

SOF:	NCTC11214_03713(paaJ)

SSUR:

ATE40_012045

SURI:

J0X03_08535(pcaF)

SRHZ:

FO014_18875(pcaF)

SENP:

KHA73_15190(pcaF)

SNEM:

NLX84_15565(pcaF)

SNEV:

OI978_16950(pcaF)

SGRI:

SGBXF1_03099(paaJ)

SSAR:

SSARUM_002996(pcaF)

SFO:	Z042_17400

TATU:

EFZ10_15610(pcaF)

XBO:	XBJ1_0118(paaJ)

XBV:	XBW1_0155(paaJ)

XNE:	XNC1_4626(paaJ)

XNM:	XNC2_4467(paaJ)

XDO:	XDD1_3927(paaJ)

XHO:	A9255_15725

XBU:	HGO23_00615(pcaF)

XGR:	QL128_00565(pcaF)

PSI:

S70_09380

PSX:	DR96_1306(pcaF)

PSTA:

BGK56_12395

PTHA:

OI982_13720(pcaF)

PRG:	RB151_002340(paaJ)

PALA:

CO695_03810(pcaF)

PHEI:

NCTC12003_00246(paaJ)

PRQ:	CYG50_15075(pcaF)

PRJ:	NCTC6933_00251(paaJ)

PVC:	G3341_00960(pcaF)

PMAG:

JI723_01370(pcaF)

PHAG:

PZ638_00855(pcaF)

HAV:	AT03_05990

HPAR:

AL518_19650(pcaF)

OPO:	DSM2777_20480

VIB:	VspSTUT11_39290

HASO:

B2G49_09430

GSO:	PH603_13300(pcaF)

RCG:	N7E81_16020(pcaF)

RSR:	T7867_13960(pcaF)

» show all

Reference

1 [PMID:20660314]

Authors

Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G

Title

Bacterial phenylalanine and phenylacetate catabolic pathway revealed.

Journal

Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107

Sequence

[eco:b1397]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.223

IUBMB Enzyme Nomenclature:

2.3.1.223

ExPASy - ENZYME nomenclature database:

2.3.1.223

BRENDA, the Enzyme Database:

2.3.1.223

DBGET integrated database retrieval system