KEGG ENZYME: 2.3.1.229

ENZYME: 2.3.1.229

Entry

EC 2.3.1.229                Enzyme

Name

4-coumaroyl-homoserine lactone synthase;
p-coumaryl-homoserine lactone synthase;
RpaI

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

4-coumaroyl-CoA:S-adenosyl-L-methionine trans-4-coumaroyltranserase (lactone-forming, methylthioadenosine-releasing)

Reaction(IUBMB)

4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone [RN:R10529]

Reaction(KEGG)

R10529

Substrate

4-coumaroyl-CoA [CPD:C00223];
S-adenosyl-L-methionine [CPD:C00019]

Product

CoA [CPD:C00010];
S-methyl-5'-thioadenosine [CPD:C00170];
N-(4-coumaroyl)-L-homoserine lactone [CPD:C20677]

Comment

The enzyme is found in the bacterium Rhodopseudomonas palustris, which produces N-(4-coumaroyl)-L-homoserine lactone as a quorum-sensing signal.

History

EC 2.3.1.229 created 2013

Orthology

K18096

acyl-homoserine lactone synthase

Genes

MLO:	mlr5638 mlr9546

MLN:	A9174_33415

MCI:	Mesci_2559 Mesci_5994

MCIC:

A4R28_28615 A4R28_32030

MOP:	Mesop_2739 Mesop_2831 Mesop_6641

MAM:	Mesau_02680 Mesau_06035

MAMO:

A6B35_07925

MESW:

A9K65_013700 A9K65_032155

MESM:

EJ066_11350 EJ066_20355

MHUA:

MCHK_0049

MJR:	EB229_34195 EB229_34600

MERD:

EB233_31980

MESR:

FGU64_08000

MOH:	IHQ72_35230

MMEI:

LRP31_32305

MESJ:

MJ8_08900 MJ8_48420

MESI:

LGH82_14140

MESU:

LHFGNBLO_000227

NIY:	FQ775_07800

MESO:

BSQ44_20295

MES:

Meso_2312

AAK:	AA2016_6360

AMIH:

CO731_00370(bjaI_1)

AMIS:

Amn_pb02150

AGC:	BSY240_834

AVI:

Avi_9666

RLE:	pRL100164(rhiI)

RLU:	RLEG12_00720

RHL:	LPU83_pLPU83c0631

RJG:	CCGE525_36400

RII:	FFM53_032970

RHID:

FFM81_031975

RLN:	J0663_30455

RRG:	J3P73_35610

RLS:	HB780_09580

RROS:

D4A92_16435

RLW:	RlegWSM1455_27280

RRHO:

PR018_26770

RTU:	PR017_18045

NEN:	NCHU2750_12520

NPM:	QEO92_06490

HOE:	IMCC20628_01503

BJA:	blr1063(blr1063)

BJU:	BJ6T_10890

BJP:	RN69_05315

BRA:

BRADO0941

BBT:

BBta_7113

BRS:

S23_67510

AOL:	S58_60330 S58_66860

BRC:	BCCGELA001_34325

BRO:	BRAD285_0435

BRK:	CWS35_37480

BOT:	CIT37_08970

BRQ:	CIT40_30110

BGQ:	X265_34710

BGZ:	XH91_33100

BSYM:

CIT39_29245

BBET:

F8237_13100 F8237_34755

BARH:

WN72_46260

BVZ:	BRAD3257_8661(bjaI)

BDG:	LPJ38_02210

BSEI:

KMZ68_23880

BBAN:

J4G43_003685

BCAN:

BcanWSM471_35510

BAUT:

QA635_33965

BCOU:

IC761_34700

BXN:	I3J27_37650

BRAZ:

LRP30_42210

BOY:	LQG66_20095

BRAY:

ML401_32720

RPA:	TX73_001660(rpaI)

RPB:	RPB_0417 RPB_3320

RPC:

RPC_0701

RPD:	RPD_0403 RPD_2175

RPE:

RPE_2323

RPT:	Rpal_0322 Rpal_2331

RPX:	Rpdx1_0306 Rpdx1_2086

RBK:	E0H22_12665

RHOL:

RBJ75_17635 RBJ75_29120

NWI:

Nwi_0626

NHA:	Nham_0959 Nham_4466

OCA:

OCAR_7682

OCG:	OCA5_pHCG300170(solI) OCA5_pOC16701320

OCO:	OCA4_pHCG3B00170(solI) OCA4_pOC167B01320

VGO:	GJW-30_1_04004(bjaI)

TRB:	HB776_06360

TALZ:

RPMA_16385

BVV:	BHK69_08180 BHK69_31115

BVES:

QO058_16175

BOI:	BLM15_21180 BLM15_29660 BLM15_30405

BOSE:

RMR04_26775

APOL:

K9D25_24260

MEA:	Mex_1p4961(mlaI) Mex_2p0693(msaI)

MDI:

METDI5550

MEX:

Mext_4513

MCH:

Mchl_4976

MPO:

Mpop_5028

MZA:	B2G69_04550

MRD:	Mrad2831_4020 Mrad2831_5763 Mrad2831_6377 Mrad2831_6407

MET:

M446_5461

MNO:	Mnod_0283 Mnod_1765

MOR:	MOC_6267(solI)

META:

Y590_23010

MAQU:

Maq22A_1p31045(lasI) Maq22A_c03535(lasI)

MPHY:

MCBMB27_04977

MEE:	DA075_07640 DA075_25820

METD:

C0214_24845

METX:

A3862_02270

METS:

DK389_13805

METI:

DK427_22570

MMES:

MMSR116_10765

MTEA:

DK419_10610 DK419_27810

MIND:

mvi_38440(bjaI) mvi_41110 mvi_63760

MECL:

CLZ_22610

MFUJ:

ABC766_11005

MIV:	C4E04_04460

MICO:

GDR74_14865

MTEZ:

HPT29_005830 HPT29_020790

MLD:	U0023_03365

MEDK:

QEV83_18710

BBAR:

RHAL1_P00105

CHEL:

AL346_15205 AL346_16885

MCG:

GL4_0847

DEI:	C4375_05150

DEA:	FPZ08_21260

DSAL:

K1X15_01365

BVR:

BVIR_1467

BLAG:

BLTE_10030

JAV:	OXU80_18350

PSIN:

CAK95_24600

PHR:	C6569_18320

PAQT:

E8L99_01335

MFLG:

ABS361_17400 ABS361_18920

CMB:	CSW64_05505 CSW64_17930

CFH:	C1707_25605

CAUF:

CSW63_05715

PZU:

PHZ_p0006

CAUL:

KCG34_09810

PSAP:

JHX88_21865

PAEZ:

PAE61_04890

TMO:	TMO_c0698(rhlI)

ECOG:

FIV45_06260

» show all

Reference

1 [PMID:18563084]

Authors

Schaefer AL, Greenberg EP, Oliver CM, Oda Y, Huang JJ, Bittan-Banin G, Peres CM, Schmidt S, Juhaszova K, Sufrin JR, Harwood CS

Title

A new class of homoserine lactone quorum-sensing signals.

Journal

Nature 454:595-9 (2008)
DOI:10.1038/nature07088

Sequence

[rpa:TX73_001660]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.229

IUBMB Enzyme Nomenclature:

2.3.1.229

ExPASy - ENZYME nomenclature database:

2.3.1.229

BRENDA, the Enzyme Database:

2.3.1.229

DBGET integrated database retrieval system