KEGG   ENZYME: 2.3.1.229
Entry
EC 2.3.1.229                Enzyme                                 

Name
4-coumaroyl-homoserine lactone synthase;
p-coumaryl-homoserine lactone synthase;
RpaI
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
4-coumaroyl-CoA:S-adenosyl-L-methionine trans-4-coumaroyltranserase (lactone-forming, methylthioadenosine-releasing)
Reaction(IUBMB)
4-coumaroyl-CoA + S-adenosyl-L-methionine = CoA + S-methyl-5'-thioadenosine + N-(4-coumaroyl)-L-homoserine lactone [RN:R10529]
Reaction(KEGG)
R10529
Substrate
4-coumaroyl-CoA [CPD:C00223];
S-adenosyl-L-methionine [CPD:C00019]
Product
CoA [CPD:C00010];
S-methyl-5'-thioadenosine [CPD:C00170];
N-(4-coumaroyl)-L-homoserine lactone [CPD:C20677]
Comment
The enzyme is found in the bacterium Rhodopseudomonas palustris, which produces N-(4-coumaroyl)-L-homoserine lactone as a quorum-sensing signal.
History
EC 2.3.1.229 created 2013
Orthology
K18096  acyl-homoserine lactone synthase
Genes
MLO: mlr5638 mlr9546
MLN: A9174_33415
MCI: Mesci_2559 Mesci_5994
MOP: Mesop_2739 Mesop_2831 Mesop_6641
MAM: Mesau_02680 Mesau_06035
MAMO: A6B35_07925
MESO: BSQ44_20295
MESW: A9K65_013700 A9K65_032155
MESM: EJ066_11350 EJ066_20355
MHUA: MCHK_0049
MES: Meso_2312
AMIH: CO731_00370(bjaI_1)
AVI: Avi_9666
RLE: pRL100164(rhiI)
BJA: blr1063(blr1063)
BRA: BRADO0941
BBT: BBta_7113
BRS: S23_67510
BARH: WN72_46260
BVZ: BRAD3257_8661(bjaI)
RPA: RPA0320
RPC: RPC_0701
RPE: RPE_2323
NWI: Nwi_0626
OCA: OCAR_7682
VGO: GJW-30_1_04004(bjaI)
MEA: Mex_1p4961(mlaI) Mex_2p0693(msaI)
MDI: METDI5550
MEX: Mext_4513
MCH: Mchl_4976
MPO: Mpop_5028
MET: M446_5461
MOR: MOC_6267(solI)
META: Y590_23010
MAQU: Maq22A_1p31045(lasI) Maq22A_c03535(lasI)
MCG: GL4_0847
BVR: BVIR_1467
BLAG: BLTE_10030
PZU: PHZ_p0006
TMO: TMO_c0698(rhlI)
 » show all
Reference
1  [PMID:18563084]
  Authors
Schaefer AL, Greenberg EP, Oliver CM, Oda Y, Huang JJ, Bittan-Banin G, Peres CM, Schmidt S, Juhaszova K, Sufrin JR, Harwood CS
  Title
A new class of homoserine lactone quorum-sensing signals.
  Journal
Nature 454:595-9 (2008)
DOI:10.1038/nature07088
  Sequence
[rpa:RPA0320]
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.229
IUBMB Enzyme Nomenclature: 2.3.1.229
ExPASy - ENZYME nomenclature database: 2.3.1.229
BRENDA, the Enzyme Database: 2.3.1.229

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