KEGG   ENZYME: 2.3.1.233
Entry
EC 2.3.1.233                Enzyme                                 

Name
1,3,6,8-tetrahydroxynaphthalene synthase;
PKS1;
THNS;
SCO1206;
RppA
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA C-acyl transferase (1,3,6,8-tetrahydroxynaphthalene-forming)
Reaction(IUBMB)
5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO2 + H2O [RN:R10965]
Reaction(KEGG)
R10965
Substrate
malonyl-CoA [CPD:C00083]
Product
1,3,6,8-tetrahydroxynaphthalene [CPD:C04033];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
Isolated from the fungus Colletotrichum lagenarium [1], and the bacteria Streptomyces coelicolor [2,3] and Streptomyces peucetius [4]. It only uses malonyl-CoA, without invovement of acetyl-CoA.
History
EC 2.3.1.233 created 2014
Orthology
K19580  1,3,6,8-tetrahydroxynaphthalene synthase
Genes
SGL: SG2219
SOD: Sant_4045
DCS: ISN74_02010
PCI: PCH70_45330
PSIL: PMA3_00670
RSM: CMR15_mp20430(rppA)
SCL: sce2133(rppA)
MBAI: MB901379_04487
NOZ: DMB37_37085
NAH: F5544_31840
SCO: SCO1206(2SCG58.06)
SALB: XNR_5808
SMA: SAVERM_7131(rppA)
SGR: SGR_6620(rppA)
SGB: WQO_01985
SHY: SHJG_2645
SCT: SCAT_5029(rppA)
SVE: SVEN_5367
SFI: SFUL_520
SALU: DC74_5959
SALL: SAZ_30875
STRE: GZL_02842
SLD: T261_1658
SLE: sle_24280(sle_24280)
STRD: NI25_33220
SLAU: SLA_5577
SALJ: SMD11_3072(phlD)
SRJ: SRO_6251
SHUN: DWB77_04183(rppA_2)
SEN: SACE_1243(rppA)
 » show all
Reference
1  [PMID:10913297]
  Authors
Fujii I, Mori Y, Watanabe A, Kubo Y, Tsuji G, Ebizuka Y
  Title
Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1.
  Journal
Biochemistry 39:8853-8 (2000)
DOI:10.1021/bi000644j
Reference
2  [PMID:12905073]
  Authors
Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel JP, Moore BS
  Title
Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2).
  Journal
J Ind Microbiol Biotechnol 30:510-5 (2003)
DOI:10.1007/s10295-003-0075-8
  Sequence
[sco:SCO1206]
Reference
3  [PMID:15265863]
  Authors
Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore BS, Noel JP
  Title
Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.
  Journal
J Biol Chem 279:45162-74 (2004)
DOI:10.1074/jbc.M406567200
  Sequence
[sco:SCO1206]
Reference
4  [PMID:18612244]
  Authors
Ghimire GP, Oh TJ, Liou K, Sohng JK
  Title
Identification of a cryptic type III polyketide synthase (1,3,6,8-tetrahydroxynaphthalene synthase) from Streptomyces peucetius ATCC 27952.
  Journal
Mol Cells 26:362-7 (2008)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.233
IUBMB Enzyme Nomenclature: 2.3.1.233
ExPASy - ENZYME nomenclature database: 2.3.1.233
BRENDA, the Enzyme Database: 2.3.1.233

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