KEGG ENZYME: 2.3.1.233

ENZYME: 2.3.1.233

Entry

EC 2.3.1.233                Enzyme

Name

1,3,6,8-tetrahydroxynaphthalene synthase;
PKS1;
THNS;
SCO1206;
RppA

Class

Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups

Sysname

malonyl-CoA C-acyl transferase (1,3,6,8-tetrahydroxynaphthalene-forming)

Reaction(IUBMB)

5 malonyl-CoA = 1,3,6,8-tetrahydroxynaphthalene + 5 CoA + 5 CO2 + H2O [RN:R10965]

Reaction(KEGG)

R10965

Substrate

malonyl-CoA [CPD:C00083]

Product

1,3,6,8-tetrahydroxynaphthalene [CPD:C04033];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

Isolated from the fungus Colletotrichum lagenarium [1], and the bacteria Streptomyces coelicolor [2,3] and Streptomyces peucetius [4]. It only uses malonyl-CoA, without invovement of acetyl-CoA.

History

EC 2.3.1.233 created 2014

Orthology

K19580

1,3,6,8-tetrahydroxynaphthalene synthase

Genes

AAPT:

QNH14_09020

SGL:

SG2219

SOD:

Sant_4045

SLIG:

GTU79_29240

DCS:	ISN74_02010

PCI:	PCH70_45330

PLIJ:

KQP88_21630

PSIL:

PMA3_00670

RSM:	CMR15_mp20430(rppA)

SCL:	sce2133(rppA)

RHAW:

RHABOEDO_001898

MBAI:

MB901379_04487

NOZ:	DMB37_37085

NAH:	F5544_31840

NWL:	NWFMUON74_26480

SCO:	SCO1206(2SCG58.06)

SALB:

XNR_5808

SMA:	SAVERM_7131(rppA)

SGR:	SGR_6620(rppA)

SGB:

WQO_01985

SFI:

SFUL_520

SANL:

KZO11_01760

SCYE:

R2B67_34145

SHY:

SHJG_2645

SHO:	SHJGH_2409

SVE:

SVEN_5367

SDV:	BN159_7379 BN159_7943(rppA)

SCI:	B446_06310

SLV:	SLIV_31765

STRE:

GZL_02842

SLD:

T261_1658

SLC:	SL103_26615

SXI:	SXIM_50920

STRC:

AA958_24285 AA958_24385

SCZ:	ABE83_32960

SRW:	TUE45_01597

SLE:	sle_24280(sle_24280)

SRN:	A4G23_05456

STRT:

A8713_04005

SCLF:

BB341_01080

SGS:	AVL59_31505

SKY:	D0C37_31290

SGM:	GCM10017557_72060

SCAD:

DN051_02190

SLS:	SLINC_1366

SNR:	SNOUR_12210

SALU:

DC74_5959

SALL:

SAZ_30875

SPLU:

LK06_002210

STRD:

NI25_33220

SNW:	BBN63_02150 BBN63_05640

SSIA:

A7J05_03060

SVU:	B1H20_01555

SPUN:

BFF78_35595

SGV:	B1H19_32665

SLAU:

SLA_5577

SALJ:

SMD11_3072(phlD)

STRO:

STRMOE7_29070

SRJ:

SRO_6251

SDX:	C4B68_35495

SGD:	ELQ87_33740

SQZ:	FQU76_00230 FQU76_00295 FQU76_33445 FQU76_33510

SNQ:	CP978_05715

STIR:

DDW44_24850

SGZ:	C0216_11400

SVN:	CP980_05720

SHAW:

CEB94_06400

SRK:	FGW37_00690 FGW37_18135

SSPO:

DDQ41_26490

SVR:	CP971_25810 CP971_28520

SPAD:

DVK44_19645 DVK44_34305 DVK44_34915

SFY:	GFH48_34420

SAQU:

EJC51_08470

SGF:	HEP81_06602

SCAV:

CVT27_01680

SSEO:

D0Z67_03140

SBY:	H7H31_02845

STSU:

B7R87_02915

SBAT:

G4Z16_02020

SPLA:

CP981_02965

SBRO:

GQF42_08480

STUI:

GCM10017668_08020

SATA:

C5746_19045

SCHF:

IPT68_05170

SHUN:

DWB77_04183(rppA_2)

SHAR:

HUT13_25705

SCYG:

S1361_06195

SLIA:

HA039_01310

SDW:	K7C20_02890

SCAL:

I6J39_01660

SAUH:

SU9_002175

SFB:	CP974_29040

SMOB:

J7W19_17885 J7W19_27675

SPRA:

CP972_29065

SROI:

IAG44_34395

SXN:	IAG42_30915

SHK:	J2N69_10815

SANU:

K7396_19690 K7396_32570

STRY:

EQG64_01595

SDD:	D9753_30945

SMAO:

CAG99_01335

SGOB:

test1122_10195

SINE:

KI385_05065

SLF:	JEQ17_39910

SRUG:

F0345_01605

SNIG:

HEK616_51490

SVIO:

HWN34_29370

SSPN:

LXH13_05460

SCIR:

STRCI_000703 STRCI_001130

SXT:	KPP03845_300039

SLON:

LGI35_42715

STUD:

STRTU_006694

SENG:

OJ254_30560

SYUN:

MOV08_12045

SARG:

HKX69_30295

SOV:	QZH56_15095

SHAU:

K9S39_02685

SKG:	KJK29_33435

SCOA:

QU709_37875

SLAI:

P8A22_01930

SROC:

RGF97_07805

SCHG:

NRO40_28115

SINN:

ABB07_32765

SARM:

DVA86_16920

SPRF:

K4G22_13800 K4G22_28830

STPB:

QR97_20280

SRPA:

HEP86_04385

SMIB:

SMIR_34210

SCAJ:

O1G22_35770 O1G22_43440 O1G22_43880

STRW:

QHG49_30080

STRL:

HEP84_10560

STSD:

HEP87_10300

SRPZ:

HEP85_06840

SCHE:

QRN89_27260

SABD:

N8I86_06810

SCT:	SCAT_5029(rppA)

SCY:	SCATT_50210

KAB:	B7C62_01380

KAU:	B6264_20365 B6264_23215

KCH:	O1G21_29845 O1G21_32710

STRI:

C7M71_025590

STRH:

GXP74_18780

ABRY:

NYE86_28120

AGLA:

OIE69_39090

AREV:

RVR_4160(fur1)

FSY:	FsymDg_2598

FRI:	FraEuI1c_2478

SEN:	SACE_1243(rppA)

SACG:

FDZ84_31500 FDZ84_37515

SSYI:

EKG83_13095

SACX:

IOD16_08675

KPHY:

AOZ06_26075

MICH:

FJK98_31510

MENO:

Jiend_53530

PLK:	CIK06_12480

PSUU:

Psuf_091470

» show all

Reference

1 [PMID:10913297]

Authors

Fujii I, Mori Y, Watanabe A, Kubo Y, Tsuji G, Ebizuka Y

Title

Enzymatic synthesis of 1,3,6,8-tetrahydroxynaphthalene solely from malonyl coenzyme A by a fungal iterative type I polyketide synthase PKS1.

Journal

Biochemistry 39:8853-8 (2000)
DOI:10.1021/bi000644j

Reference

2 [PMID:12905073]

Authors

Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel JP, Moore BS

Title

Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2).

Journal

J Ind Microbiol Biotechnol 30:510-5 (2003)
DOI:10.1007/s10295-003-0075-8

Sequence

[sco:SCO1206]

Reference

3 [PMID:15265863]

Authors

Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore BS, Noel JP

Title

Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates.

Journal

J Biol Chem 279:45162-74 (2004)
DOI:10.1074/jbc.M406567200

Sequence

[sco:SCO1206]

Reference

4 [PMID:18612244]

Authors

Ghimire GP, Oh TJ, Liou K, Sohng JK

Title

Identification of a cryptic type III polyketide synthase (1,3,6,8-tetrahydroxynaphthalene synthase) from Streptomyces peucetius ATCC 27952.

Journal

Mol Cells 26:362-7 (2008)

Sequence

[ag:ABY71276]

Other DBs

ExplorEnz - The Enzyme Database:

2.3.1.233

IUBMB Enzyme Nomenclature:

2.3.1.233

ExPASy - ENZYME nomenclature database:

2.3.1.233

BRENDA, the Enzyme Database:

2.3.1.233

DBGET integrated database retrieval system