KEGG   ENZYME: 2.3.1.235Help
Entry
EC 2.3.1.235                Enzyme                                 

Name
tetracenomycin F2 synthase;
TCM PKS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
BRITE hierarchy
Sysname
malonyl-CoA:acetate malonyltransferase (tetracenomycin F2 forming)
Reaction(IUBMB)
10 malonyl-CoA = tetracenomycin F2 + 10 CoA + 10 CO2 + 2 H2O [RN:R10960]
Reaction(KEGG)
R10960;
(other) R06643 R09269
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Substrate
malonyl-CoA [CPD:C00083]
Product
tetracenomycin F2 [CPD:C12366];
CoA [CPD:C00010];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Comment
A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens. It involves a ketosynthase complex (TcmKL), an acyl carrier protein (TcmM), a malonyl CoA:ACP acyltransferase (MAT), and a cyclase (TcmN). A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit. Additional two-carbon units are added from nine more malonyl-CoA molecules.
History
EC 2.3.1.235 created 2014
Pathway
ec01056  Biosynthesis of type II polyketide backbone
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K05551  minimal PKS ketosynthase (KS/KS alpha)
K05552  minimal PKS chain-length factor (CLF/KS beta)
K15886  multifunctional cyclase / dehydratase / O-methyltransferase
Genes
MBD: MEBOL_003040 MEBOL_003041
ABF: AMK58_25510
SPAE: E2C16_10950
MSAO: MYCSP_12695 MYCSP_12700
MSAL: DSM43276_02542 DSM43276_02543
NBR: O3I_007445 O3I_007450 O3I_015110 O3I_015115
NNO: NONO_c10800 NONO_c10810
NTP: CRH09_08670 CRH09_08675
NOZ: DMB37_03465 DMB37_03470
SCO: SCO5087(actIORF1) SCO5088(actIORF2)
SMA: SAVERM_2375(pks9-3) SAVERM_2376(pks9-4)
STRP: F750_1305(whiE-KS) F750_1306(whiE-CLF)
STRM: M444_36340
SALJ: SMD11_0675(actI1) SMD11_0676(actI2) SMD11_1144(actI2) SMD11_6044(actI1) SMD11_6045(actI2)
AMD: AMED_5434(fabF) AMED_5435(fabF)
AMM: AMES_5369(fabF) AMES_5370(fabF)
AMZ: B737_5369(fabF) B737_5370(fabF)
 » show all
Taxonomy
Reference
1  [PMID:9609708]
  Authors
Bao W, Wendt-Pienkowski E, Hutchinson CR
  Title
Reconstitution of the iterative type II polyketide synthase for tetracenomycin F2 biosynthesis.
  Journal
Biochemistry 37:8132-8 (1998)
DOI:10.1021/bi980466i
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.235
IUBMB Enzyme Nomenclature: 2.3.1.235
ExPASy - ENZYME nomenclature database: 2.3.1.235
BRENDA, the Enzyme Database: 2.3.1.235

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